Congenital Diaphragmatic Repair
Conditions
Brief summary
In case of CDH, the incomplete development of a part of the diaphragm allows abdominal viscera to herniate into thorax cavity during fetal development and impaired lung and heart development. After birth, CDH patients who survived thanks to an active reanimation management undergo diaphragmatic repair. In case of large defect, a patch is needed to complete diaphragmatic closure. Thanks to primary cell culture from foreskin, peritoneal epithelium or cremaster dedicated to incineration investigators want to analyse biological integration of actually used prothesis and others innovations.
Interventions
PROCEDUREForeskin resection
During the pediatric surgery consultation, the doctor will decide between Foreskin resection, orchidopexie or inguinal hernia repair.
Sponsors
University Hospital, Strasbourg, France
Study design
Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
0 Years to 14 Years
Healthy volunteers
No
Inclusion criteria
* Minor aged 0 (day of birth) to 14 years * Patient for whom an indication of posthectomy and / or cure of inguinal hernia and / or testicular ectopy is retained * Patient whose legal representatives have agreed to the use of operational waste from mesenchymal tissues (foreskin, cremaster and peritoneum) destined for incineration. * Patient affiliated to a social security scheme
Exclusion criteria
\- parents don't agree to the use of its operating waste for research purposes
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| cell colonization | samples are processed immediately after sampling | Study cell colonization |
| quality of the extracellular matrix | samples are processed immediately after sampling | Quality of the extracellular matrix produced in vitro in contact with the currently used implant materials compared to biomaterials under development |
Countries
France
Outcome results
None listed