Pre-Eclampsia
Conditions
Brief summary
Pre-eclampsia is an hypertensive disorder appearing during pregnancy, inducing serious maternal, fetal and neonatal mortality and morbidity. Twenty four hours proteinuria is a key element to define pre-eclampsia severity but is delaying the result by 24 hours and constraining for the patient. A simple and rapid indicator for severe preeclampsia would help clinicians to make appropriate decision in patient management. We hypothesized that urinary podocyturia is correlated to preeclampsia severity. This is a prospective, non-interventional, monocentric study.
Interventions
OTHERDosage of urinary podocyturia
Dosage of urinary podocyturia at admission, delivery and post-partum visit
Sponsors
Hospices Civils de Lyon
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* women aged 18 years or more * single pregnancy * admission for pre-eclampsia * patient receiving information and non-opposition to participate
Exclusion criteria
* multiple pregnancy * in utero fetal demise excepted if associated with pre-eclampsia * antecedent of nephropathy * fetal malformation, chromosomal anomalies * inability to understand information provided * prisoner or under administrative supervision
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Severity of pre-eclampsia | at childbirth (maximum 10 months) | Severe preeclampsia is defined by preeclampsia with at least one of the following criteria : * severe hypertension (PAS ≥ 160 mmHg et/ou PAD ≥ 110 mmHg) * Renal impairment with: oliguria \<500 ml / 24h or creatinine\> 135 μmol / L or proteinuria\> 5 g/d * acute lung edema or persistent epigastric bar or HELLP syndrome * eclampsia or rebellious neurological disorders (visual disturbances, polykinetic ROT, headache), * thrombocytopenia \<100 G / L * Retro Placental Hematoma (HRP) or fetal repercussion. |
Countries
France
Outcome results
None listed