Pregnancy
Conditions
Keywords
Dietary nitrate, Nitrate, Flow-mediated dilation, Tissue oxygen saturation
Brief summary
Adequate macro and microvascular endothelial function during pregnancy is essential for the normal placental development and growing fetus. Beetroot juice (BJ) promotes improvement ins this parameters in no-pregnant individuals, however the beneficial effect did not avaliated in pregnant. The present study evaluated effects of BJ on macro and microvascular endothelial function in pregnant. Twelve pregnant were submitted to BJ and nitrate-depleted juice (PLA) interventions. Brachial flow-mediated dilation (FMD) and muscle oxygenation were measured 120 min after interventions. Urinary nitrate, nitrite were measured at baseline and 120 min after interventions.
Interventions
OTHERBeetroot juice
140 mL of beetroot juice cointaning approximately 9 mmol of nitrate
OTHERPlacebo
140 mL of beetroot juice isent of nitrate
Sponsors
Universidade Federal do Rio de Janeiro
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Masking description
Double blind
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* gestation between 20 and 35 weeks; * over 18 years
Exclusion criteria
* diabetes mellitus and gestational diabetes; * hypertensive syndromes; * HIV positive; * liver or kidney disease; * beetroot allergy; * use of antioxidants and medicament that alter endothelial function; * use of antibiotics up to 2 weeks before the visits and using.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Macro endothelial function | Evaluated 120 minutes after the nutritional intervention | Flow-mediated dilation (FMD) |
| Micro endothelial function | Evaluated 140 minutes after the nutritional intervention | Tissue oxygen saturation parameters |
| Nitrate urinary | Evaluated 150 minutes after the nutritional intervention | — |
Outcome results
None listed