Cardiovascular Risk Factor, Coronary Arteriosclerosis, Coronary Artery Disease
Conditions
Keywords
SYNTAX score, Coronary Atherosclerosis, Coronary Artery Disease, SNPs, Genetics, Genetic Risk Score, Personalized Medicine
Brief summary
The purpose of the research project is to investigate the potential association of 6 genetic polymorphisms with the complexity and the severity of coronary artery disease (SYNTAX score). The aim of the study is to combine genetic, clinical and laboratory data in order to create a prognostic tool that will enable an individualized therapeutic patient approach.
Detailed description
This study focus on the prediction of future risk of cardiovascular events, assessing the severity and complexity of coronary artery disease by incorporating genetic information into the SYNTAX score and providing personalized therapeutic guidance to patients. The ultimate goal of the study would be to identify, design and develop a panel of genetic markers that in combination with clinical and angiographic information will be a reliable tool for predicting cardiovascular risk for future adverse events. Clinical and genetic patient information are systematically collected in a fashion that will enable also retrospective evaluation.
Interventions
GENETICSNPs associated with CAD
Genotyping will be carried out by Real-Time PCR
Sponsors
LABNET IAE - Private Reference Diagnostic Laboratory
Aristotle University Of Thessaloniki
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
1. Patients who are admitted in the Department of Cardiology in the AHEPA University General Hospital of Thessaloniki and undergo coronary angiography for clinical purposes 2. Patients giving voluntary written consent to participate in the study 3. Male or female patients between 18 years to 90 years at entry 4. Patients without previous history of CAD
Exclusion criteria
1. Patients \< 18 years old and \> 90 years old at time of coronary angiography 2. Patients with a previous history of CAD 3. Cardiac Arrest at admission 4. Patients with serious concurrent disease and life expectancy of \< 1 year 5. Patients who refuse to give written consent for participation in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Relationship between genetic risk variants and the SYNTAX score [All-comers population] | 12 months | The investigators will evaluate the effects of 6 known genetic variants associated with risk of Coronary Artery Disease on the extend and severity of coronary atherosclerosis \[as assessed by the SYNTAX score\] in patients with significant CAD on coronary angiography, both individually and combined in a Genetic Risk Score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Predictive value of combining a Genetic Risk Score & SYNTAX score for the prediction of 1-year MACCEs | 12 months | A Genetic Risk Score will be calculated as the weighted sum of alleles of 6 single nucleotide polymorphisms previously associated with CAD \[The GRS will be constructed by summing the number of risk alleles (0/1/2) for each of the 6 SNPs weighted by their estimated effect sizes\]. SYNTAX score is a coronary lesion complexity scoring system and represented by a single number. |
| Ankle-Brachial Index | At hospital admission | A tool for diagnosing peripheral artery disease but also an indicator of systemic atherosclerosis \[represented by a single number\] |
| Left Ventricular Ejection Fraction | At hospital admission & 12 months after discharge from hospital | LVEF \[%\] as assessed by echocardiography |
| Neutrophil to Lymphocyte Ratio | At hospital admission | NLR \[represented by a single number\] |
| MACCEs | 12 months | Cardiovascular death, myocardial infarction, stent thrombosis, any re-intervention and stroke |
| Mean Platelet Volume | At hospital admission | MPV \[fL\] |
| Glomerular Filtration Rate | At hospital admission | GFR as assessed by CKD-EPI formula \[mL/min/1.73m²\] |
| High Density Lipoprotein | At hospital admission | HDL \[mg/dL\] |
| Red Cell Distribution Width | At hospital admission | RDW \[%\] |
Countries
Greece
Outcome results
None listed