Prevalence of Wound Healing Disturbances in Geriatric Inpatients (WONDER Study)

Prevalence of Wound Healing Disturbances in Geriatric Inpatients With Specific Focus on Malnutrition, Other Nutritional Parameters and the Frailty Syndrome (WONDER Study)

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03314350

Enrollment

517

Registered

2017-10-19

Start date

2017-11-01

Completion date

2021-01-31

Last updated

2019-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malnutrition, Wound Healing Disorder

Keywords

Geriatrics, Frailty

Brief summary

In geriatric patients, there is a plethora of nutritional and illness-related parameters, resulting in a complex situation which hampers identification of risk factors.In the planned prospective study, the point and period prevalence of wound healing disorders (WHD) is examined at admission and at discharge in a cohort of 517 male and female geriatric patients. As the investigators are also interested to study the occurrence of WHD in patients with malnutrition (and other geriatric phenomena) compared to the prevalence of WHD in patients with a good nutritional Status.

Detailed description

The investigators will determine the prevalence of impaired wound healing upon admission to the hospital as well as the incidence of new wound healing disorders during hospital stay with specific focus on malnutrition and other important nutritional parameters in geriatric patients. Therefore the investigators intend to study consecutively admitted patients both at admission and at discharge and monitor them during hospital stay. The investigators will investigate the associations between the individual nutritional status and body composition parameters (such as sarcopenia) and WHD in geriatric patients, taking both medical variables and the frailty syndrome into account.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age ≥ 60 years * Informed written consent * Normal cognitive status according to Mini-Mental State Examination (MMSE ≥ 24 points) * Life expectancy of \> 3 months according to treating doctor * Proficient in German

Exclusion criteria

* Lack or incapacity of informed consent * MMSE \< 24 * Life expectancy \< 3 months according to assessment by the attending physician * Short term patients (\< 3 days of hospital stay) * Lack of German language

Design outcomes

Primary

Measure	Time frame	Description
Prevalence of wound healing disturbances	Baseline	Number of wound healing disturbances upon admission to the hospital in General

Secondary

Measure	Time frame	Description
Functional Parameter	Baseline and up to 3 weeks	Timed Up & Go Test
Strength Parameter	Baseline and up to 3 weeks	Hand grip strength
Nutritional Parameter	Baseline and up to 3 weeks	Mini Nutritional Assessment - Short Form (questionnaire)
Index of quality of life	Baseline and up to 3 weeks, after 3 months and after 6 months	EQ-5D-5L (questionnaire) to measure quality of life
Body composition	Baseline and up to 3 weeks	Bioelectric impedance analysis
Frailty	Baseline and up to 3 weeks	Frailty Status according to Fried criteria

Countries

Germany

Contacts

Primary ContactKristina Norman, PD Dr.

kristina.norman@charite.de0049/30450565139

Backup ContactKristina Franz, MScIS

kristina.franz@charite.de0049/30450565137

Outcome results