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the Effect of Three Different Analgesic Techniques on the Incidence of Postoperative Nausea and Vomiting

Comparative Study of the Effect of Three Different Analgesic Techniques on the Incidence of Postoperative Nausea and Vomiting After Scleral Buckling Under General Anesthesia

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT03313479
Enrollment
75
Registered
2017-10-18
Start date
2017-10-30
Completion date
2018-01-01
Last updated
2017-10-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Operative Nausea and Vomiting

Keywords

Nausea, vomiting

Brief summary

Postoperative nausea and vomiting (PONV) is a distressing adverse effect that may result in postoperative complications including bleeding, wound dehiscence, aspiration pneumonitis, as well as fluid and electrolyte imbalances Incidence of PONV after general anesthesia is about 30% in all post-surgical patients but up to 80% in high-risk patients despite advances in anesthetics and anesthesia techniques

Detailed description

Postoperative nausea and vomiting (PONV) is a distressing adverse effect that may result in postoperative complications including bleeding, wound dehiscence, aspiration pneumonitis, as well as fluid and electrolyte imbalances. The incidence of PONV after general anesthesia is about 30% in all post-surgical patients but up to 80% in high-risk patients despite advances in anesthetics and anesthesia techniques. Despite new antiemetic drugs the overall incidences remain high especially in subjects with increased patient-related risk-factors such as in female gender, non-smoking status, a history of motion sickness or previous PONV, inhalational anesthetics, certain types of surgery, and opioid use. Scleral buckling (SB) which is still thought to be the most efficacious and cost-effective primary procedure for the treatment of uncomplicated retinal detachment is often associated with postoperative pain as well as nausea and vomiting. Preoperative injections of local anesthetics via retrobulbar, peribulbar, or subtenon routes in patients undergoing vitreoretinal surgery under general anesthesia (GA) have been reported to reduce postoperative pain, nausea, and vomiting. Topical lidocaine drops have also has been used intraoperatively to decrease the incidence and severity of the OCR and to prevent pain and PONV after strabismus surgery and vitrectomy without scleral buckling . The current study was designed to compare the effect of three different analgesic techniques ; IV analgesia , peribulbar block and topical xylocaine jel on the incidence of ponv after scleral buckling under general anesthesia.

Interventions

DRUGDexmedetomidine

Dexmedetomidine will be given with GS

Sponsors

Cairo University
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No

Inclusion criteria

* males or females * aged between 18-80 years * ASA physical status Ι&II -indicated for repair of retinal detachment with scleral buckling. -

Exclusion criteria

* Patients with cardiac, liver and/or kidney diseases * coagulation defects or receiving anticoagulants * hypersensitivity to the used drugs * history of motion sickness or PONV * diabetes mellitus * gastrointestinal disease * smokers * menstruating ladies * ASA status more than II

Design outcomes

Primary

MeasureTime frameDescription
PONV8 hours post operativeincidence of post operative nausea and vomiting

Countries

Egypt

Contacts

Primary ContactHassan Ali, lecturer
hassan364@hotmail.com1001733687
Backup ContactAhmed Badwy, lecturer
hassan364@hotmail.com1001733687

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026