Preeclampsia
Conditions
Keywords
magnetic resonance imaging, myocard, preeclampsia
Brief summary
Preeclampsia is a systemic pregnancy disorder and is associated with an increased cardiovascular risk later in life. This study will characterize myocardial tissue in patients after preeclampsia compared to controls and investigate potential functional and structural changes in the heart of preeclamptic women primarily with two methods: cardiovascular magnetic resonance imaging and echocardiography. A comparison between these two methods, where appropriate, is also envisaged.
Interventions
None listed
Sponsors
Charite University, Berlin, Germany
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
* postpartal window: 0.5 - 20 years * cases: diagnosis of preeclampsia during the index pregnancy * controls: age and BMI matched
Exclusion criteria
* metal implants * kidney insufficiency (GFR \< 30 ml/min/) * claustrophobia * contrast medium allergy * current pregnancy/ lactation * chronic hypertension (\> 140/90) * diagnosis of previous cardiovascular disease * body weight over 120 kg * big tattoos in thorax area
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| any structural or functional change of the heart (combined outcome) | 0.5 - 20 years after delivery | Combined outcome: myocardial fibrosis, edema, fat infiltrates, inflammation, reduced ejection fraction, hypertrophy |
Secondary
| Measure | Time frame |
|---|---|
| myocardial edema | 0.5 - 20 years after delivery |
| myocardial fat infiltrates | 0.5 - 20 years after delivery |
| myocardial fibrosis | 0.5 - 20 years after delivery |
| myocardial hypertrophy | 0.5 - 20 years after delivery |
| reduced ejection fraction | 0.5 - 20 years after delivery |
| myocardial inflammation | 0.5 - 20 years after delivery |
Countries
Germany
Outcome results
None listed