Diabetes Mellitus in Pregnancy, Preeclampsia, Pregnancy Complications
Conditions
Brief summary
This study will investigate the interplay of different immune cells and placental cells as well as their potential for the development of pregnancy complications. In particular, the translation of the uteroplacental syndrome into a maternal syndrome, considered in the multifactorial pregnancy disorder preeclampsia, will be investigated. Immune cell subtypes are causally involved in the formation and translation of preeclampsia by inducing an endothelial dysfunction which leads to cardiovascular damage.
Interventions
None listed
Sponsors
Charite University, Berlin, Germany
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* healthy pregnant women after giving informed consent * pregnant with diagnosis of preeclampsia, gestational hypertension or gestational diabetes
Exclusion criteria
* infections * alcohol and drug abuse * manifest and chronic diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| T cell population content at the time of preeclampsia diagnosis compared to controls and verified by flow cytometry | at the time of preeclampsia diagnosis compared to controls at the same time point in pregnancy |
Countries
Germany
Contacts
Primary ContactFlorian Herse, PhD
Outcome results
None listed