Renal Insufficiency, Acute
Conditions
Keywords
Tissue Transit Time
Brief summary
Determination of Tissue Transit Time (TTT) as a parameter with high prognostic value to predict the functional course of the differential renal function and the development of the differential renal function after pyeloplasty
Detailed description
The ureteropelvic junction obstruction occurs in around 13% of children with antenatally diagnosed hydronephrosis. It remains a controversial topic what prognostic factors may be predictive for deterioration of the differential renal function. The tissue transit time (TTT) in the 99mTc- MAG3 diuretic renogram seems to be a predictive factor for the deterioration of the differential renal function in these patients. We therefore analyze the tissue transit time in the 99mTc- MAG3 diuretic renogram in a prospective multicenter observational study to determine it as a prognostic and diagnostic factor. Aim of the study is to differentiate which children could be treated conservatively and which will benefit from operative pyeloplasty
Interventions
DIAGNOSTIC_TESTTissue Transit Time
Determination of Tissue Transit Time as a prognostic and diagnostic factor
Sponsors
University Hospital Tuebingen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 3 Months
Healthy volunteers
No
Inclusion criteria
* unilateral, isolated hydronephrosis \>= grade III (SFU) * age \<= 3 months
Exclusion criteria
* associated malformation of the urogenital tract * global kidney insufficiency proven by creatinine examination * prematurity * no informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Sensitivity and Specificity | 3 to 6 months | Estimation of Sensitivity and Specificity of a delayed tissue transit time as a diagnostic factor concerning worsening of the differential renal function in patients with congenital ureteropelvic junction obstruction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Examination of ultrasound findings | 3 to 6 months | Relationship between ultrasound findings and the development of the differential renal function |
| Examination of renal drainage | 3 to 6 months | Relationship between initial quality of renal drainage and the development of the differential renal function |
| Examination of initial differential renal function | 3 to 6 months | Relationship between initial differential renal function and the development of the differential renal function |
Countries
Germany, Switzerland
Outcome results
None listed