Predictive Significance of TEG on END in Patients With Acute Ischemic Stroke

Predictive Significance of Thrombelastography on Early Neurological Deterioration in Patients With Acute Ischemic Stroke

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03310931

Enrollment

200

Registered

2017-10-16

Start date

2016-06-01

Completion date

2017-09-30

Last updated

2017-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Ischemic Stroke

Brief summary

The purpose of this study is to evaluate whether Thromboelastography (TEG) parameters on admission might be predictive for early neurological deterioration in acute ischemic stroke patients, specifically for the DWI lesion evolution within the first week after stroke onset.

Detailed description

Early neurological deterioration (END ) is a major concern in stroke care, consistently associated with adverse clinical outcomes.END is a heterogeneous complex of pathophysiological and clinical entities. Despite some straight forward causes, DWI lesion growth is reportedly a primary underlying mechanism. Early recognition of END risk would allow for timely identification and proper intervention, improving stroke health care. Thromboelastography (TEG) measures the coagulation process from initial clotting cascade to clot strength, providing an integrated picture of two separate but simultaneously occuring components of coagulation, thrombosis and lysis. It has been reported to be associated with short and long-term outcome in patients with trauma, coronary artery diseases , pulmonary embolism and, most recently, stroke prevention.The purposes of this study is to evaluate how effective TEG is on predicting END, by producing a range of TEG values correlated with clinical and radiological assessment.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* acute ischemic stroke within 24 hours after symptom onset * first ever stroke * give informed consent

Exclusion criteria

* receiving thrombolysis * cardiogenic embolism * contradiction to serial MRI studies * taking hemostatic agents (warfarin, oral anticoagulants and etc. )

Design outcomes

Primary

Measure	Time frame	Description
END	fist week after admission	increase of NIHSS \>=2

Secondary

Measure	Time frame	Description
DWI lesion growth	7 days	Large volume or new lesions on followup DWI than the baseline DWI

Countries

China

Outcome results