Aortic Stenosis, Arteriosclerosis, Conventional Transthoracic Echocardiogram, Familial Hypercholesterolemia
Conditions
Brief summary
Aortic stenosis (AE) is a disease that has been increasing steadily in recent years in most countries, including Spain.Risk factors for the development of AE include age, hypercholesterolemia, diabetes mellitus and arterial hypertension, the classic risk factors for the development of atherosclerosis. However, lipid-lowering therapy with statins and ezetimibe has not been shown to reduce the risk of long-term progression of AE by unknown mechanisms. All this suggests that subjects with HFhe have a high risk of developing AD, which has not been shown by the high coronary mortality in this population that precedes aortic calcification
Detailed description
The study includes a single clinical visit with collection of clinical data, blood extraction and the performance of a transthoracic echocardiogram. This visit may be made on different days, but always within 30 days of signing the informed consent.
Interventions
PROCEDUREEchocardiogram
Conventional transthoracic echocardiogram by an echocardiographer trained to perform and centered on aortic valve Pick up from: * Mean transvalvular pressure gradient * Aortic valve * Aortic valve opening area * Aortic valve opening area adjusted for body mass index * Bicuspid or tricuspid aorta * Thickness of the upper valve\> 3 mm
Sponsors
Instituto Aragones de Ciencias de la Salud
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
55 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Cases: * Age ≥ 65 years at the time of cardiac ultrasound * Genetically diagnosed HFH or in a first-degree relative * History of hypercholesterolemia with LDLc levels\> 220 mg / dL without lipid-lowering treatment Controls: * Genetically Similar * Siblings of the normoccholesterolemic case, defined by LDLc \<190 mg / dl without lipid-lowering treatment. * In the absence of available siblings, first cousins may be included. * In the presence of several siblings available, the same sex will be included, * Environmentally similar * Stable partner of the case with cohabitation\> 25 years \* Each case will have at least one control.
Exclusion criteria
\- Personal history of cardiac rheumatic disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in age-adjusted prevalence of EA assessed by transthoracic echocardiography between cases and controls | 1 YEAR |
Secondary
| Measure | Time frame |
|---|---|
| Differences in age-adjusted prevalence of AD assessed by transthoracic echocardiography between cases and controls | 1 YEAR |
| Difference in aortic surface between cases and controls | 1 YEAR |
| Difference in the mean transvalvular gradient between cases and controls | 1 YEAR |
| Difference between maximum aortic jet velocity between cases and controls | 1 YEAR |
Countries
Spain
Contacts
Primary ContactFernando Civeira
Outcome results
None listed