Lung and Gut Microbiome in Chronic Obstructive Pulmonary Disease

The Relationship Between Lung and Gut Microbiome in Chronic Obstructive Pulmonary Disease

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03310164

Enrollment

120

Registered

2017-10-16

Start date

2014-06-15

Completion date

2016-02-15

Last updated

2017-10-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Obstructive Pulmonary Disease

Brief summary

Increasing evidence have implied that microbiota from airway and gut might be involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, the cross-talk between respiratory and gastrointestinal microbiome in COPD is still undetermined. The study is aimed to investigate the interaction between lung and gut flora, and their role in the process of COPD.

Detailed description

Despite the high prevalence of chronic obstructive pulmonary disease (COPD), there continues to be a large gap in our understanding of disease pathogenesis and mechanisms accounting for large variability in disease phenotype. Cigarette smoking is the principal cause of COPD, but only approximately 15% of adults with substantial tobacco exposure develop clinical COPD. Besides, bacterial colonization or infection is also considered as an important factor in COPD. There are very limited data from microbiome studies that suggest that respiratory and gastrointestinal microbiota may be involved in the pathogenesis of COPD. However, the cross-talk between between lung and gut microbiome, and their relationship with various clinical phenotypes of COPD. Here, we conducted 16S rRNA-based pyrosequencing to evaluate the link between the lung-gut axis and the clinical phenotypes of COPD, such as lung function, emphysema, symptoms, exacerbations, inflammation levels and metabolic features.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

MALE

Age

40 Years to 80 Years

Healthy volunteers

Yes

Inclusion criteria

1. males aged 40-80; 2. diagnosed with COPD according to the GOLD guidelines; 3. clinically stable patients without medication changes or exacerbation in two months; 4. smoking history of more than 10 pack years

Exclusion criteria

1. diagnosed with unstable cardiovascular diseases, significant renal or hepatic dysfunction or mental incompetence; 2. diagnosed with asthma, active pulmonary tuberculosis, diffuse panbronchiolitis, cystic fibrosis, clinically significant bronchiectasis, exacerbation of COPD or pneumonia in two months; 3. prescribed immunosuppressive medications.

Design outcomes

Primary

Measure	Time frame	Description
Microbiota that can predict the progress of lung function	6 months	The study is aimed to investigate the relationship between the microbiota and the progress of lung function in COPD

Secondary

Measure	Time frame	Description
Bacteria related to inflammatory factors	6 months	The association between microbiota and inflammatory factors from host is also investigated
Bacteria related to metabolomics	6 months	The association between microbiota and metabolites from host is also investigated

Countries

China

Outcome results