ARDS, Human
Conditions
Brief summary
This is a prospective single-center cohort trial to compare regional bronchial recruitment, bronchial distention and alveolar recruitment in 6 patients with acute respiratory distress syndrome (ARDS). The investigators used CT scan images as the imaging modality, and the subjects were scanned on end-expiratory lung volume with different positive end-expiratory pressures. Those images were post-processed to evaluate the airways.
Interventions
PROCEDURERepeated CT scan
CT scan of chest on different PEEP levels, 4 in total
DEVICECT scan
CT scan
Sponsors
University Hospital, Antwerp
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* mechanically ventilated * moderate or severe ARDS, as defined by the Berlin criteria
Exclusion criteria
* pregnancy * hemodynamic instability * obesity (BMI \>30)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Regional bronchial recruitment | Through study completion, within 24 hours after inclusion | The difference in bronchial tree volume increase from one PEEP level to the other |
| Regional bronchial dilation | Through study completion, within 24 hours after inclusion | The difference in bronchial diameter from one PEEP level to the other |
| Regional alveolar recruitment | Through study completion, within 24 hours after inclusion | The difference in alveolar volume from one PEEP level to the other |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between parenchymal recruitment and bronchial recruitment | Through study completion, within 24 hours after inclusion | Correlation between parenchymal recruitment (in milliliter) and bronchial (in milliliter) recruitment for each type of ARDS (focal versus diffuse) |
Countries
Belgium
Outcome results
None listed