Effect of Oxytocin Infusion on Blood Loss During Abdominal Myomectomy

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03308643

Enrollment

100

Registered

2017-10-12

Start date

2017-10-01

Completion date

2018-05-10

Last updated

2018-05-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myomectomy

Keywords

myomectomy, oxytocin, blood loss

Brief summary

To evaluate the effects of oxytocin infusion during abdominal myomectomy.

Detailed description

Myomectomy is indicated for symptomatic uterine fibroids. Fibroids have blood supply and 20% of the abdominal myomectomy cases might require blood transfusion because of the nature of the surgery. Oxytocin infusion is one of the intervention to decrease blood loss during myomectomy. To evaluate the effects and benefits of oxytocin infusion during abdominal myomectomy we decide to conduct this randomized study.

Interventions

DRUGOxytocin

Patients will receive intravenous oxytocin infusion just before the surgery after the induction of general anesthesia.

OTHERsaline

Patients will receive intravenous normal saline infusion just before the surgery after the induction of general anesthesia.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Investigator)

Masking description

Randomization will be performed by an online software and the list will be given to anesthesiologist so that neither the surgeon nor patient will know which intervention was performed. Randomized cards will be in sealed envelopes and will be open by anesthesiologist at the time of surgery.

Intervention model description

The abdominal myomectomy cases will be randomized into 2 separate groups in a parallel fashion using an online software at 1:1 ratio.

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Age 18-50 * Patients who are candidate for abdominal myomectomy

Exclusion criteria

* History of previous myomectomy. * Suspected malignancy * Patients with preoperative anemia * Patients using hormonal treatments before the surgery.

Design outcomes

Primary

Measure	Time frame	Description
Blood loss during surgery	2 hours	estimated blood loss during the surgery measured by aspiration fluid.

Secondary

Measure	Time frame	Description
Blood loss after abdominal myomectomy	1 hour postoperatively	change in Hematocrit Percentage (before and after the surgery)

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026