Prediction of Coronary Artery Disease Severity by Epicardial Adipose Tissue Thickness

Predictive Value of Epicardial Fat Thickness for Disease Severity in Coronary Artery Disease Patients

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03308539

Enrollment

200

Registered

2017-10-12

Start date

2017-11-01

Completion date

2018-09-01

Last updated

2017-10-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Infarction

Brief summary

is to test the hypotheses that epicardial adipose tissue can be a marker of severity of coronary artery disease in myocardial infarction patients

Detailed description

epicardial adipose tissue is defined as the adipose tissue between the visceral pericardium and the outer margin of the myocardium which can be considered an endocrine organ that secretes pro-inflammatory and anti-inflammatory cytokines and chemokines including adiponectin.as investigators know, inflammatory response is an important factor in the coronary atherogenesis. Therefore,epicardial adipose tissue is likely to be connected with the severity of coronary artery disease.Recent studies showed that the thickness of the epicardial adipose tissue in patients with coronary artery disease was greater than that with normal coronary arteries. epicardial adipose tissue will be assessed using transthoracic echocardiography and cardiac magnetic resonance which allows for an accurate volumetric quantification of epicardial fat.

Interventions

RADIATIONechocardiography and cardiac magnetic resonance

transthoracic echocardiography and magnetic resonance imaging of the heart

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

No minimum to 90 Years

Healthy volunteers

Yes

Inclusion criteria

1. Normal thoracic shape 2. Sinus rhythm 3. without severe respiratory diseases

Exclusion criteria

1. contraindication for cardiac magnetic resonance. 2. Patients who previously underwent coronary artery bypass grafting or percutaneous coronary angiography prior to admission 3. history of chronic kidney disease with glomerular filtration rate \<30 mL/min 4. pericardial and/or pleural effusion.

Design outcomes

Primary

Measure	Time frame	Description
measurement of epicardial adipose tissue as marker of severity of coronary artery disease in myocardial infarction patients.	one year	epicardial adipose tissue measurement using transthoracic echocardiography and cardiac magnetic resonance

Countries

Egypt

Contacts

Primary Contactjacqueline george, master

jacquelinegeorge@yahoo.com01275502685

Backup Contacthosam hassan el araby, pofessor

hosam_hasan@hotmail.com01223971327

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026