Constipation, Gut Microbiota
Conditions
Keywords
difficult defecation, fecal microbiota transplantation, stool pattern
Brief summary
Difficult defecation is a common symptom involving with patients'life quality. The stool pattern of these patients might be related to the contribution of gut microbiota. This pilot study proposed hypothesis that stool pattern could be used as a simple index to screen the potential candidates of fecal microbiota transplantation in patients with difficult defecation.
Detailed description
Difficult defecation is a common symptom involving with patients'life quality. The stool pattern of these patients might be related to the contribution of gut microbiota. This pilot study proposed hypothesis that stool pattern could be used as a simple index to screen the potential candidates of fecal microbiota transplantation in patients with difficult defecation. Patients underwent single FMT in this study were divided into hard-stool group and loose-stool group. All patients were assessed before FMT and during 12-week follow-up after FMT.
Interventions
The prepared microbiota suspension was infused into mid-gut.
Sponsors
The Second Hospital of Nanjing Medical University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
14 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. age between 14-80 years old; 2. difficult defecation with more than six months (a. straining during defecation; b. sensation of incomplete evacuation; c. sensation of anorectal blockage; d. manual maneuvers to facilitate defecation).
Exclusion criteria
1. difficult defecation due to secondary factors (e.g. drugs, pelvic surgery, psychiatric disorders); 2. with history of gastrointestinal diseases such as cancer, inflammatory bowel diseases (IBD); 3. pregnant or breast-feeding women; 4. infection with pathogenic bacteria. Enrolled patients were divided into hard-stool group and loose-stool group according to their stool patterns. All patients were followed up for 12 weeks.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| defecation frequency | 12 weeks | frequency of defecation per week |
| stool consistency | 12 weeks | The category of stool consistency score based on the BSS (Bristol Stool Form Scale) |
Countries
China
Outcome results
None listed