Overweight and Obesity, Metabolic Syndrome
Conditions
Keywords
Exercise, Strength Training, Health Promotion, Inflammation, Body Composition
Brief summary
The main purpose of this study is to compare the effects of whole-body electromyostimulation versus a conventional low-volume strength-training program, each combined with an individualized, weight-reducing diet, on the cardiometabolic risk profile, muscle strength, body composition, inflammatory markers and subjective health outcomes in overweight individuals at increased cardiometabolic risk.
Interventions
OTHERControl
Individualized, weight-reducing nutritional therapy and counseling, during a study period of 12 weeks
OTHERStandard Strength Training
Procedures: Nutritional therapy (individualized, weight-reducing nutritional therapy and counseling) during a study period of 12 weeks combined with a standard strength training program: * 5 strength training exercises (chest, upper/lower back, abdominals, legs) * 3 sets per exercise * time-effort per session: \ 90 min * 2 training sessions per week * duration of exercise intervention: 12 weeks
OTHERLow-volume Strength Training
Procedures: Nutritional therapy (individualized, weight-reducing nutritional therapy and counseling) during a study period of 12 weeks combined a low-volume strength training program: * 5 strength training exercises (chest, upper/lower back, abdominals, legs) * 1 set per exercise * time-effort per session: \ 20 min * 2 training sessions per week * duration of exercise intervention: 12 weeks
Procedures: Nutritional therapy (individualized, weight-reducing nutritional therapy and counseling) during a study period of 12 weeks combined with WB-EMS: * time-effort per session: \ 20 min * duration of exercise intervention: 12 weeks
Sponsors
University of Erlangen-Nürnberg Medical School
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
Outcome Assessors involved in data analysis will not be aware of the arm to which the participants were allocated (single-blinded masking).
Intervention model description
parallel-group, randomized-controlled study
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Body Mass Index \>25 * presence of at least 2 cardiometabolic risk factors
Exclusion criteria
* Healthy persons or patients under age * Overweight persons without any additional cardiometabolic risk factors * Pregnancy, Lactation * Psychological disorders, epilepsy, sever neurological disorders * Participation in other exercise- or nutrition studies within the last 6 months * acute cardiovascular disease * malignant disease * Rheuma * Intake of anabolic drugs, * Skin injuries in the area of electrode placements * Electronic implants (defibrillator, pacemaker) * Persons in mental hospitals by order of authorities or jurisdiction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Metabolic Syndrome Z-Score (MetS-Z-Score) | 12 weeks (baseline to 12 week follow-up assessment) | MetS-Z-Score will be calculated from each individual's measures of waist circumference, mean arterial blood pressure, triglycerides, and HDL-cholesterol, based on equations specific to sex. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body Composition | 12 weeks (baseline to 12 week follow-up assessment) | Muscle mass, fat mass and body water will be measured by Bioelectrical Impedance Analysis (BIA) |
| Cardiorespiratory Fitness (CRF) | 12 weeks (baseline to 12 week follow-up assessment) | CRF will be assessed by measuring Maximum Oxygen uptake (VO2max) |
| Inflammation status | 12 weeks (baseline to 12 week follow-up assessment) | Inflammation will be assessed by measuring Levels of CRP and inflammatory cytokines and other inflammatory blood markers |
| Muscle strength | 12 weeks (baseline to 12 week follow-up assessment) | Muscle strength of the five major muscle groups (chest, upper back, lower back, abdominals, legs) will be assessed by using specific strength-training devices (Butterfly, Pull-down, Hyperextension, Abdominal Crunch, Leg-Press) |
| Pain scores | 12 weeks (baseline to 12 week follow-up assessment) | Pain scores will be assessed by using the standardized and validated Chronic Pain Grade Questionnaire (CPGQ) |
| Perceived stress | 12 weeks (baseline to 12 week follow-up assessment) | Perceived stress will be assessed by using the standardized and validated Perceived Stress Questionnaire (PSQ) |
| Subjective work ability | 12 weeks (baseline to 12 week follow-up assessment) | Subjective work ability will be assessed by using the standardized and validated Work Ability Index Questionnaire (WAI) |
| Health-related quality of life | 12 weeks (baseline to 12 week follow-up assessment) | Health-related quality of life will be assessed by using the standardized and validated EQ-5D-5L Questionnaire |
Countries
Germany
Contacts
Primary ContactDejan Reljic, Dr.
Backup ContactYurdaguel Zopf, Prof.
Outcome results
None listed