Determinants of Formate Concentrations

Lifestyle, Metabolite and Genetic Determinants of Formate Concentrations in a Cross-sectional Study of Young, Healthy Adults

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03305900

Enrollment

1701

Registered

2017-10-10

Start date

2012-12-01

Completion date

2013-11-26

Last updated

2017-10-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

formate, one-carbon metabolism

Brief summary

Formate is an important metabolite, serving as a donor of one-carbon groups to the intracellular tetrahydrofolate pool. However, little is known of its circulating concentrations or of their determinants. This study seeks to define formate levels and their determinants in a young, healthy population. Serum formate will be measured in 1701 subjects from the Trinity Student Study. The subjects, males and females, aged 18 to 28 years, were enrolled at Trinity College, Dublin. Formate levels will be compared with other one-carbon metabolites, vitamin status, potential formate precursors, genetic polymorphisms, and lifestyle factors.

Interventions

OTHERNo Intervention

Cross-sectional study requiring a single serum sample

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 28 Years

Healthy volunteers

Yes

Inclusion criteria

* Trinity College Dublin students with Irish grandparents

Exclusion criteria

* None

Design outcomes

Primary

Measure	Time frame	Description
Formate concentrations	Single baseline measurement; cross sectional, observational study	Formate concentrations in study population

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 7, 2026