Hypertension, Pediatric Disorder
Conditions
Keywords
Hypertension
Brief summary
Pediatric hypertension is increasingly common and is a precursor for adult cardiovascular and renal disease. But even during childhood, hypertension is associated with significant morbidity, including cognitive impairment and organ damage. However, the cause of pediatric hypertension, the response to treatment, and the mechanisms behind organ damage are incompletely understood. Due to these limitations, there are no first-line medications, and treatment is often inadequate. An improved comprehension of the course of pediatric hypertension could enhance clinical care. The goal of this proposal is to create a registry of patients with hypertension to better enable research into this important disease. This patient registry will enhance the investigators ability to quickly collect and analyze data for research studies.
Detailed description
The investigators will include all subjects evaluated at the Brenner Children's Hospital Pediatric Nephrology clinic since January 1st, 2013 with a diagnosis of high blood pressure confirmed with three separate blood pressure measurements \>=90th percentile for age, sex, and height, or \>120/80 mmHg. The investigators will exclude patients whose initial evaluation occurred on or after their 18th birthday.
Interventions
None listed
Sponsors
Wake Forest University Health Sciences
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
No minimum to 17 Years
Healthy volunteers
No
Inclusion criteria
\- Patients at one of the following : Wake Forest Baptist Health Brenner Children's Hospital Pediatric Nephrology clinic Emory University Pediatric Nephrology * Diagnosis of hypertension confirmed with three separate blood pressure measurements * Diagnosis after January 2013 * \>90th percentile for age, sex, height, or \>120/80.
Exclusion criteria
\- Patients whose initial evaluation occurred on or after their 18th birthday.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure | 10 years | Auscultated blood pressure measurements in clinic |
| Left ventricular hypertrophy | 10 years | Left ventricular hypertrophy and other cardiac structural/function changes on echocardiograms |
| Albuminuria | 10 years | Urinary albumin-to-creatinine (\>30 mg/g) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ambulatory blood pressure | 10 years | Ambulatory blood pressure monitoring data |
| Renal function | 10 years | Glomerular filtration rate |
| Uric acid | 10 years | Serum uric acid |
Countries
United States
Outcome results
None listed