Pain, Neuropathic, Trigeminal Neuralgia
Conditions
Brief summary
To investigate the brain activations related to TN, using fMRI, and to evaluate changes in these activations following the application of pulsed and thermal Radiofrequency lesioning to the gasserien ganglion.
Interventions
PROCEDUREpulsed Radiofrequency
sensory stimulation will be carried out at 50 Hz. The definitive position of the electrode will be verified by inducing paresthesia with sensory stimulation between 0.1-0.3 V in the affected painful area, then pulsed radiofrequency will be applied for 10 patients for 10 mins
PROCEDUREthermal Radiofrequency
sensory stimulation will be carried out at 50 Hz. The definitive position of the electrode will be verified by inducing paresthesia with sensory stimulation between 0.1-0.3 V in the affected painful area, then Thermal lesion will be applied for 10 patients for 2 cycles of 90 seconds
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Age 20 - 65 years * Primary trigeminal neuralgia * Maxillary and/or mandibular affection only * Failure of medical treatment
Exclusion criteria
* 2ry trigeminal neuralgia * Recurrent trigeminal neuralgia * Ophthalmic branch affection * Contraindication for intervention (sepsis, coagulopathy, infection at entery point, local anesthetic allergy,…) * Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| pain alleviation | 1 month | pain assessment by functional MRI |
Outcome results
None listed