Overall Diet Quality and Breast Cancer Risk

Diet Quality Scores and Risk of Incident Breast Cancer in Healthy Women

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03304171

Enrollment

96959

Registered

2017-10-06

Start date

1995-10-31

Completion date

2011-12-31

Last updated

2017-10-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Incident Breast Cancer, Invasive Breast Cancer

Brief summary

The purpose of this study was to examine the relationship between indices of overall diet quality and incident breast cancer risk in a large prospective cohort of women.

Detailed description

This study examined the role of overall diet quality on the risk of developing invasive breast cancer among 96,959 women in the California Teachers Study, in which 4,826 women were diagnosed with breast cancer during follow-up (1995-2011). Participants' dietary habits were recorded at baseline (1995) using a 103-item Block95 Food Frequency Questionnaire to allow for the assessment of overall diet quality. Specifically, diet quality was characterized by the Alternate Mediterranean Diet (aMED), Alternative Healthy Eating Index-2010 (AHEI-2010), Dietary Approaches to Stop Hypertension (DASH), and Paleolithic Index scores. Associations between diet quality and the risk of developing breast cancer were examined using multivariate Cox proportional hazard regression models to provide hazard ratios and corresponding 95% confidence intervals.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Inclusion criteria

* Participants with no history of cancer diagnosis prior to baseline. * Participants with no history of myocardial infarction prior to baseline. * Participants with no history of stroke prior to baseline. * Participants with no history of diabetes prior to baseline. * Participants who are not missing excessive dietary data. * Participants with energy intake values at ≥1% and ≤99% of the population distribution.

Design outcomes

Primary

Measure	Time frame	Description
Incident Invasive Breast Cancer	1995-2011	All incident cancer cases were identified through linkage with the California Cancer Registry (CCR) records, which is a population-based cancer registry for California residents.

Outcome results