Cerebral Hypoxia
Conditions
Keywords
Hypoxia, Brain, Cerebral vaso-reactivity, EEG, Concentration performance, Cerebral oxygenation, Cerebral blood-flow, Heart rate variability
Brief summary
The investigators will investigate the effect of hypobaria and hypoxia on physiological responses such as: oxygen saturation, heart rate, cerebral blood flow, cerebral oxygenation, brain's activity and concentration performance.
Detailed description
The main goal of this project is to investigate how hypoxia affects cognitive functions. The KLT-R test asses the concentration level of a person. Subjects will do this test at different simulated altitude level in the hypobaric chamber at the FAI in Dübendorf. Investigators' first hypothesis is that concentration level will be altered by hypoxia. The higher altitude the subjects are, the more the concentration would be altered. KLT-R performance would be impaired by hypoxia compare to sea level performance. The primary endpoint of this project is to investigate how KLT-R performance is affected by the different hypoxic conditions. KLT-R test will be passed nine times in total during the test visit. There will be a pre-test; a test at each of the conditions (3000m HH, 5500m HH, 5500m NH and 5500m HN); between each condition at sea level (to have a new baseline before each condition) and a post-test at the end of the protocol. To avoid influence of fatigue, all conditions will be randomized. The second endpoint of this study is how the brain electrical activity is modulated by hypoxia. Micro-states also will be measure during hypobaric hypoxia conditions (3000m HH and 5500m HH).
Interventions
OTHERHypoxia
No drug or product will be used in this study. No medication will be give to the participants. No arm will be used for product administration.
Sponsors
Fliegerärztliches Institut
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
Single-Blind study.
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* No history of flight sickness * No relevant medical diseases * Age 18 - 40 years * Written consent acceptance
Exclusion criteria
* Known pathologies * Relevant medical disorders * Drug addiction * Anemia or poor health * People who have already had problems with elevation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration performance | 4 minutes per test | Performance of concentration at different altitude levels. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| EEG micro-states | 5 minutes per record | 5 minutes recording in each conditions, eyes closed, at rest. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Cerebral vaso-reactivity | 8 Minutes per test | Cerebral vasoreactivity after 1 minute hyperventilation and 3 minutes breathing of 5% CO2 mixture. |
Countries
Switzerland
Outcome results
None listed