Physical Activity, Autonomic Nervous System Imbalance
Conditions
Keywords
Nursing home residents, Brisk walking
Brief summary
It is well established that physical activity reduces the physiological effects of ageing. Among them, the decrease of the autonomic nervous system activity (ANS) is associated with the increase of cardiovascular events and sleep disorders occurence. It has been shown that high intensity cycle training can enhance the ANS activity by 30% in people aged of 70 years old. However, such trainings were done by old athletes used to train at intensities that could not be handled by nursing home elderly. Thus, an adapted activity such as brisk walking shall be defined to make it practicable for the many in convalescent homes. The investigators hypothesize that long term brisk walking training could lead to reactivate ANS in people living in convalescent homes.
Detailed description
The investigators aim to compare the effects of a 9 month brisk walking training (1 time a week or 3 times a week) on the ANS of nursing home residents.
Interventions
BEHAVIORALBrisk walking
Prospective randomized clinical trial with 2 intervention groups and 1 control group.
Sponsors
University Hospital of Saint-Etienne
University of Lyon
Clinique Mutualiste Chirurgicale de la Loire
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
60 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Being over 60 years old * Living in a nursing home of Mutualité Française de la Loire, France * Being able to walk without human aid * Being able to speak and write French * Being inactive (less than 1 hours of physical activity per week) * Having a normal sinus rhythm * Being affiliated to the social welfare system * Signing the informed consent form
Exclusion criteria
* Having serious balance disorders * Suffering from cardiac or respiratory pathologies that contraindicate physical activity * Serious comorbidities contraindicating physical activity * Diagnosed cardiac pathologies that prevent heart rate variability analysis: congestive heart failure, cardiac pacemaker, implantable cardioverter defibrillator, serious ventricular rhythm troubles, atrial fibrillation, atrial flutter. * Persons under legal protection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| SDNN value | 9 months | Standard deviation of all normal nocturnal RR intervals |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Baroreflex sensitivity (BRS) | 9 months | BRS slope variation measured at rest |
| Maximum oxygen uptake (VO2max) | 9 months | Cardiopulmonary exercise testing |
| Daily physical activity | 9 months | Actimetry (Actigraph-GT3X) |
| Sedentary periods | 9 months | Actimetry (Actigraph GT3X) |
| Muscular force | 9 months | Lower limbs maximum voluntary force test measured on force chair |
| Heart rate variability parameters | 9 months | Autonomic nervous system balance (RMSSD) |
| Muscular volume gains | 9 months | Lower limbs muscular magnetic resonance imaging (MRI) |
| Plasmatic dosages of inflammatory molecules | 9 months | CRP |
| Cognitive improvements | 9 months | Neuropsychological evaluation with a neuropsychologist. |
| Quality of life | 9 months | SF-36 questionnaire |
| Muscular endurance | 9 months | Lower limbs endurance test measured on force chair |
Countries
France
Contacts
Primary ContactDavid HUPIN, MD, PhD
Outcome results
None listed