Lung Cancer
Conditions
Brief summary
The objective of the trial was to evaluate velocity-associated parameters of pulsed-wave Doppler ultrasound at induction, discharge from the post-anaesthesia care unit and during inspiratory cough in addition to the consumption of phenylephrine during the operation in patients undergoing video-assisted thoracic surgery with three types of anaesthesia management.
Detailed description
The objective of the trial was to evaluate velocity-associated parameters of pulsed-wave Doppler ultrasound at induction, discharge from the post-anaesthesia care unit and during inspiratory cough in addition to the consumption of phenylephrine during the operation in patients undergoing video-assisted thoracic surgery with three types of anaesthesia management. The patients in this trial were visited during the entire operation and just before leaving the post-anaesthesia care unit. Velocity-associated data related to pulsed-wave Doppler ultrasound and the consumption of phenylephrine were collected.
Interventions
DRUG0.5% ropivacaine paravertebral block
The investigators designed a study to assess whether there were any blood flow indexes change during induction with doppler ultrasonography after 0.5% ropivacaine paravertebral block
DRUG0.25% ropivacaine epidural block
A 4-5 ml bolus of 0.25% ropivacaine was administered 1 h after the initiation of TEB.
DRUG0.5% ropivacaine local anaesthesia
local anaesthesia at the incision was induced by 0.5% ropivacaine by the surgeon just before the surgery.
Sponsors
China Medical University, China
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Intervention model description
Doppler Ultrasonography Assessed Vascular Changes
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. ethnic Chinese; 2. age, 18 to 65 years old; 3. American Society of Anaesthesiologists (ASA) physical status I or II; 4. required VATS for lung surgery and one lung ventilation .
Exclusion criteria
body mass index exceeding 30 kg/m2; Patients with a history of hypertension, diabetes mellitus or arteriosclerosis; and any allergy to drugs used in the study. Patients with arrhythmias or implanted cardiac pacemakers were excluded. Patients with diseases of the central or peripheral nervous system were excluded. Patients taking medications affecting the autonomic nervous system, such as b-blockers and calcium channel blockers
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The Change of end-diastolic velocity | baseline and 10 minutes after induction | The primary outcome was the end-diastolic velocity at 12 time points of anaesthesia induction among the three groups. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| pulsed-wave Doppler ultrasound | before leaving the PACU, up to 5 minutes | other data related to pulsed-wave Doppler ultrasound and acquired during anaesthesia induction, before leaving the PACU and during inspiratory cough |
| intraoperative consumption of phenylephrine | through study completion, an average of 3 hours | intraoperative consumption of phenylephrine |
Countries
China
Outcome results
None listed