The Effects of Mood on Cerebral Perfusion

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03302130

Enrollment

Registered

2017-10-04

Start date

2016-01-08

Completion date

2017-11-17

Last updated

2022-11-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cerebral Perfusion

Brief summary

Measuring brain perfusion is biased by a inter- and intrasubject variability, caused by physiological and lifestyle factors. In this study, the investigators want to investigate the effects of a different mood state (neutral, positive and negative mood), induced using subjects own memories, on both global and regional cerebral perfusion, measured with arterial spin labeling.

Interventions

BEHAVIORALMood induction (using own memories)

Subjects deliver three positive, three negative and three neutral memories 30 seconds reliving a memory - answering questions about the memory - reliving memory for 2 minutes during ASL-MRI

DEVICEArterial spin labeling MRI

Single PLD PCASL

DEVICEPhysiological monitoring

During MRI: heart rate, end-tidal CO2, respiratory rate and skin conductance

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 30 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy university students * between 18 and 30 years old

Exclusion criteria

* No informed consent * Not using hormonal contraception * MRI-contraindications * Claustrophobia * Pregnancy * Chronic diseases and chronic medication use

Design outcomes

Primary

Measure	Time frame	Description
Regional Cerebral perfusion (ml/100g/min) after neutral mood induction	2 minutes (ASL scan after mood state induction)	Effect of neutral mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
Regional Cerebral perfusion (ml/100g/min) during positive mood induction	2 minutes (ASL scan during mood state induction)	Effect of positive mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
Regional Cerebral perfusion (ml/100g/min) during negative mood induction	2 minutes (ASL scan during mood state induction)	Effect of negative mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
Regional Cerebral perfusion (ml/100g/min) during neutral mood induction	2 minutes (ASL scan during mood state induction)	Effect of neutral mood induction (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
Regional Cerebral perfusion (ml/100g/min) after positive mood induction	2 minutes (ASL scan after mood state induction)	Effect of positive mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.
Regional Cerebral perfusion (ml/100g/min) after negative mood induction	2 minutes (ASL scan after mood state induction)	Effect of negative mood (using volunteer's own memories) on cerebral perfusion using arterial spin labeling MRI.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026