Coronary Artery Disease
Conditions
Brief summary
The coronary images of selective angiography and optical coherence tomography with FFR(Fractional Flow Reserve) values of the intermediate lesions (40-70% stenosis) will be prospectively registered.
Detailed description
The patients with intermediate lesions after CT angiography and invasive coronary angiography will be screened, and optical coherence tomography, FFR and selective CT angiography will be performed. The coronary images and FFR values will be registered, and the patients will be followed-up up to 2 years to investigate the adverse clinical events.
Interventions
Coronary images by OCT and selective CTA and FFR values will be registered.
OTHERCoronary CTA
Coronary images by OCT and Coronary CTA and FFR values will be registered.
OTHERFFR
Coronary images by OCT and selective CTA and FFR values will be registered.
Sponsors
Yonsei University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients who underwent coronary CT angiography because of chest pain * Patients who need OCT or FFR evaluation because of intermediate lesions according to invasive angiography (diameter stenosis of 40-70%) * Age: 20-80 yrs * Patients who consent and fully understand the protocol * Patients who consent the clinical follow-up * Patients who can be followed-up
Exclusion criteria
* Patients who had contrast allergy * Patients who had unstable blood pressure needing the vasopressors * Patients who had severe left ventricular function (left ventricular ejection fraction\<30%) * Chronic kidney disease who had Cr level of greater than 2.0 mg/dl * Patients whose expected survival is less than 12 months * Patients who had a severe valvular disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of plaque on coronary CTA for during 2 years | at registration |
| Change of plaque on coronary OCT for during 2 years | at registration |
| Change of FFR value during 2 years | at registration |
| Comparison of computational FFR derived from OCT to invasive FFR | at registration |
Secondary
| Measure | Time frame |
|---|---|
| Power of plaque characteristics on coronary CTA for predicting adverse events | within 2 years after registration |
| Power of plaque characteristics on OCT for predicting adverse events | within 2 years after registration |
| Adverse event for 2 years (myocardial infarction, cardiovascular death) | within 2 years after registration |
Countries
South Korea
Outcome results
None listed