Depression
Conditions
Keywords
electroconvulsive therapy, computer modelling
Brief summary
This study will generate new information on how to optimise brain targets with ECT stimulation.
Detailed description
This study will differentiate the brain regions which are related to the effectiveness of electroconvulsive therapy (ECT) as a treatment, from the brain regions associated with memory impairment, with ECT stimulation. This will be done by 1) testing effects on memory of 4 different forms of ECT, which stimulate the brain differently; 2) in a subset of participants, use computer modelling to assess the pattern of brain stimulation with the 4 forms of ECT, and match these results to memory outcomes.
Interventions
PROCEDUREBrief Temporoparietal ECT
Electroconvulsive Therapy (Brief pulse width, Temporoparietal) The intervention in this study is different combinations of pulse width and ECT electrode placements.
PROCEDUREUltrabrief Temporoparietal ECT
Electroconvulsive Therapy (Ultrabrief pulse width, Temporoparietal) The intervention in this study is different combinations of pulse width and ECT electrode placements.
PROCEDUREBrief Frontoparietal ECT
Electroconvulsive Therapy (Brief pulse width, Frontoparietal) The intervention in this study is different combinations of pulse width and ECT electrode placements.
PROCEDUREUltrabrief Frontoparietal ECT
Electroconvulsive Therapy (Ultrabrief pulse width, Frontoparietal) The intervention in this study is different combinations of pulse width and ECT electrode placements.
Sponsors
Wesley Mission
The University of New South Wales
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
Both participants and the outcome assessor will be blinded.
Intervention model description
Each participant will be randomly allocated to a sequence of treatments using designs for crossover studies with fewer periods (3) than treatments (4) involving two sets of ECT electrode placements and two sets of pulse width.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Aged ≥18 years; right-handed * DSM-5 Major Depressive Episode * Prescribed with a course of ECT
Exclusion criteria
* Diagnosis (as defined by DSM-V) of psychotic disorder (apart from Major Depressive Episode with Psychotic features), current drug or alcohol abuse or dependence; * ECT treatments in last 3 months from a prior course of ECT; * Score \<23 on the Montreal Cognitive Assessment Battery (MoCA); * Past or current neurological illness or injury, medical illness which may significantly affect neuropsychological function; * Inability to give informed consent or comply with study procedures; or * Not having worked or studied in an English speaking background (to ensure validity of neuropsychological testing). * Not be claustrophobic (if having an MRI brain scan). * Not have any metal in your head or body (if having an MRI brain scan). * Likely non response to RUL forms of ECT, as indicated by past non response to RUL ECT
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| HVLT-R | Approximately 30 min after ECT treatment | Hopkins Verbal Learning Test-Revised |
| BVMT-R | Approximately 30 min after ECT treatment | Brief Visual Memory Test-Revised |
Countries
Australia
Contacts
Primary ContactFeng Lin, MD
Backup ContactColleen Loo, MBBS
Outcome results
None listed