Obesity
Conditions
Keywords
Obesity, Exercise, Cardiac Fat, Cardiac Magnetic Resonance, Vascular Health
Brief summary
The overall goal of this project is to study the effects of exercise energy expenditure matched vigorous dynamic resistance training and aerobic training on cardiac fat, and its relationship to cardiac function and geometry using cardiac Magnetic Resonance Imaging.
Detailed description
Exercise-induced weight-loss is one of the most common strategies for reducing excess fat in overweight and obese individuals. Although vigorous intensity may be more favorable promoting positive cardiac adaptations compared to low-moderate intensity, evidence of the positive effects of different exercise modes needs to be explored to allow for realistic comparisons with other strategies. Research using cardiac Magnetic Resonance Imaging that compares the effects of different modes of exercise - matched by exercise energy expenditure - on epicardial adipose tissue and paracardial adipose tissue, and how these interventions modify cardiac function and geometry have not been previously explored in obesity.
Interventions
OTHERResistance training
The resistance training group
The aerobic interval training group
Sponsors
Southern Illinois University Edwardsville
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Sedentary * Caucasian * BMI \>30 kg/m2 and \< 39.9 kg/m2
Exclusion criteria
* Known cardiovascular, metabolic, pulmonary disease or conditions * Muscular-skeletal injuries * Taking medications that affect endocrine or cardiovascular function * Hypertension * Being engaged in low intensity strength training more than two times per week or moderate-high intensity of any type of frequency * Being pregnant * Cigarette smoking * Having non-removable pieces or devices incompatible with DXA and CMR assessment.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Epicardial adipose tissue (EAT) | 2 assessment points: at baseline and week 4 | EAT will be measured using cardiac Magnetic Resonance |
| Changes in Vascular Health | 2 assessment points: at baseline and week 4 | Atrial stiffness will be measured using a pulse wave analysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Paracardial adipose tissue (PAT) | 2 assessment points: at baseline and week 4 | PAT will be measured using cardiac Magnetic Resonance |
| Changes in Body Composition | 2 assessment points: at baseline and week 4 | Body composition will be measured using dual-energy x-ray absorptiometry |
| Changes in Cardiorespiratory Function | 2 assessment points: at baseline and week 4 | Cardiorespiratory Function will be measured on a treadmill with a metabolic cart |
| Changes in Muscular Strength | 2 assessment points: at baseline and week 4 | Muscular Strength will be assessed by 1 repetition maximum (1RM) test |
Countries
United States
Outcome results
None listed