Obesity
Conditions
Keywords
Obesity
Brief summary
This study focus on the cause of obesity and impacts of bariatric surgery on it.
Interventions
None listed
Sponsors
The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
1. Body mass index ≥18 kg/m2 2. already received bariatric surgery or abdonimal surgery
Exclusion criteria
1. acute stroke or acute myocardial infarction in 6 months 2. autoimmune disease 3. long-term use of non-steroidal anti-inflammatory drugs, corticosteroids and immunosuppressive drugs 4. pregnancy 5. consists with other endocrine diseases 6. acute infection in2 weeks 7. cancer 8. use of antibiotics in 3 months 9. chronic digestive inflammations 9
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Immunity cells | up to 5 years | Ratio of immunity cells in circulating and adipose or liver tissue |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Insulin | up to 5 years | Insulin (mIU/L) concentartions in serum and adipose tissue |
| Cytokine | up to 5 years | Cytokines concentrations in circulating and adipose or liver tissue |
| Cognitive Assessment (MMSE) | up to five years | Mini-Mental State Examination (MMSE) scores from 0-30, and the test means better cognition with a higher score. |
| Cognitive Assessment (MoCA) | up to 5 years | The Montreal Cognitive Assessment (MoCA) scores from 0-30, and the test means better cognition with a higher score. |
| Body weight and height | up to 5 years | Body weight and height will be combined to report BMI in kg/m\^2 |
| Cognitive Assessment (processing speed) | up to 5 years | The Trial Making Test (TMT) provides a measure of processing speed, which consists of part A and part B (TMT-A and TMT-B). The time limits for performing the TMT-A and TMT-B are 180 and 300 seconds, respectively. Processing speed is estimated by the sum of the consuming time to complete TMT-A and TMT-B such that less time indicate faster processing speed. |
| Cognitive Assessment (executive function) | up to 5 years | The Victoria Stroop Color-Word Test is a well-known measure of executive functioning. There are three indices including Stroop-dot, Stroop-word and Stroop-color word in the test. The color task consists of colored dots; the word task comprises ordinary words that are unrelated to the meaning of color; the color-word task consists of words written in color that indicate the meaning of the color, but the color of these words differs from the meaning of the word itself. The participants were asked to quickly read the color of the dots or Chinese words on the cards. The sum of consuming time taken to read the three cards is used as an index of executive function performance. Less time indicates better executive function. |
| brain structure and activation in fMRI | up to 5 years | All patients underwent odor-induced task fMRI on a 3.0T MR scanner |
| Cognitive Assessment (RBANS) | up to 5 years | The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) scores from 0-800, and the test means better cognition with a higher score. |
Countries
China
Outcome results
None listed