Huntington Disease
Conditions
Brief summary
The purpose of this project is to study Huntington's disease by metabolomic approach.
Interventions
BIOLOGICALblood sample
blood sample for metabolome analyse
Sponsors
University Hospital, Angers
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
For all groups: * age between 20 and 70 years * signature of the informed consent * covered by social security For presymptomatic group: * positive genetic test with CAG repeat length ≥ 37 in HTT gene * Unified Huntington Disease Rating Scale ≤ 5 For symptomatic group: * positive genetic test with CAG repeat length ≥ 37 in HTT gene * The Unified Huntington's Disease Rating Scale motor score ≥ 6 * The Total Functional Capacity score ≥ 11
Exclusion criteria
for all groups: * participation in another therapeutic trial (3 months exclusion period) * pregnancy and breastfeeding * persons deprived of their liberty by judicial or administrative decision
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| metabolite mass | at baseline | by chromatography and mass spectrometry |
Countries
France
Contacts
Primary ContactChristophe Verny, PU-PH
Backup ContactDominique Bonneau, PU-PH
Outcome results
None listed