Arnold-Chiari Malformation, Type 1
Conditions
Keywords
Arnold-Chiari Malformation, Type 1, Multifrequency tympanometry, Inner ear pressure
Brief summary
The aim of this study is to compare the value of multifrequency tympanometry between patients with surgical indication of treatment for a Chiari type I malformation and healthy volunteers.
Detailed description
Prevalence of Chiari type I malformation in population is between 0.1% and 0.5%. Chiari type I malformation is responsive in perturbation of the cerebro spinal fluid flow at the cranio-cervical junction. Those perturbations caused headaches, and various otological symptoms (dizziness, tinnitus, vertigo, nystagmus, hypoacousis…). The surgical treatment consists in an occipital craniotomy to restore the cerebro spinal fluid flow at the cranio-cervical junction. Symptoms are due to increasing of the pressure in the cerebellar fossa. 81% of the patients with Chiari type 1 malformation suffer of sub clinical otological perturbations especially alteration of the vestibular test. In the literature, hearing performance could be normalized after posterior fossa decompression. Furthermore, the multifrequency tympanometry measurement and particularly the width of conductance tympanograms at 2 kHz shows that variations of the cerebro spinal fluid pressure have consequences on the pressure of the perilymph. Investigator's hypothesis is that tympanometry (conductance) could be an effective test to show the variation of the cerebro spinal fluid pressure.
Interventions
DIAGNOSTIC_TESTMultifrequency tympanometry at Inclusion
Multifrequency tympanometry measurement and particularly width of conductance tympanograms at 2 kHz will be performed for both group at inclusion
DIAGNOSTIC_TESTMultifrequency tympanometry 6 month after surgery
Multifrequency tympanometry measurement and particularly width of conductance tympanograms at 2 kHz will be performed 6 months after surgery for Chiari type I malformation patient
Sponsors
University Hospital, Bordeaux
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Chiari type I malformation proved at MRI or CT-scan with an indication of cranio cervical decompression. * Patients between 18 and 60 years old. * Patient should benefit of the national health care system * Agreement of the patient Inclusion criteria for healthy volunteers: * Between 18 and 60 years old. * Free of otologic pathology * Benefit of the national health care system * Agreement of the volunteers
Exclusion criteria
* Acute hydrocephaly * Other type of Chiari disease (induced…) * Medical history of neurosurgery * Contraindication for MRI * Cophosis * Chronic otitis * Medical history of ontological surgery * Tympanic perforation * Disturbance of tonal audiometry with air bone more than 20dB in 4 frequencies with abolition of stapedial reflex * Pregnant women or nursing women * Protected adults by French laws
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Width of conductance tympanograms at 2 kHz measurement | Inclusion |
Secondary
| Measure | Time frame |
|---|---|
| Resonance frequency | Inclusion and 6 months after surgery for patients with an indication of surgical management for a Chiari type I malformation |
| Audiometric parameters | Inclusion and 6 months after surgery for patients with an indication of surgical management for a Chiari type I malformation |
| Multifrequency tympanometry | Inclusion and 6 months after surgery for patients with an indication of surgical management for a Chiari type I malformation |
| Pain measurement with Headache Impact Test | Inclusion and 6 months after surgery for patients with an indication of surgical management for a Chiari type I malformation |
| Cerebro spinal fluid pressure of the cranio cervical junction | Inclusion and 6 months after surgery for patients with an indication of surgical management for a Chiari type I malformation |
| Otological symptoms | Inclusion and 6 months after surgery for patients with an indication of surgical management for a Chiari type I malformation |
Countries
France
Outcome results
None listed