Neuromuscular Block, Residual
Conditions
Brief summary
Compare the reversal effect of neostigmine and sugammadex using quantitative neuromuscular monitoring
Detailed description
At the end of surgery, decide the dosage of reversal referring to quantitative neuromuscular monitoring value (TOF). After the administration of reversal, the anesthesiologist who are going to manage the participant should not check the quantitative neuromuscular monitoring and determine the timing of extubation only with his (or her) judgement. After entering post-anaesthesia care unit (PACU) measure the TOF value and check the incidence of TOF ratio \> 0.9 between the neostigmine group and sugammadex group.
Interventions
DRUGNeostigmine
Referring to the randomisation allocation program, participants allocated to group neostigmine, administrate neostigmine as reversal
DRUGSugammadex
Referring to the randomisation allocation program, participants allocated to group sugammadex, administrate sugammadex as reversal
Sponsors
Seoul National University Bundang Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients aged over 18 years, planned to undergoing elective laparoscopic surgery under general anesthesia
Exclusion criteria
* Obesity BMI over 30 kg/m2 * Impairment of renal or/and liver function * Allergy to rocuronium, sugammadex * (Familial) history of malignant hyperthermia * Taking medicines which is affecting neuromuscular function
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the incidence of postoperative residual curarization | Immediately after entering PACU | definition of postoperative residual curarization: TOF ration is 0.9 or over 0.9 |
Countries
South Korea
Outcome results
None listed