Progestrone and Doppler Indices

The Effect of Vaginal Progestrone on Fetal and Maternal Doppler Indices

Status

Completed

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03292939

Enrollment

Registered

2017-09-26

Start date

2017-01-01

Completion date

2017-10-01

Last updated

2017-10-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm Labor

Keywords

progestrone, doppler indices

Brief summary

The aim of our study is to assess the effect of vaginal progestrone on fetal and maternal doppler indices

Detailed description

A complete Doppler ﬂow assessment of the maternal and fetal circulation was conducted by an independent investigator blinded to the treatment, before and 48 hours after the ﬁrst administration of 400mg of vaginal progesterone, Voluson E8 (GE Healthcare, Zipf, Austria) ultrasound machine,equipped with a 3.5- MHz curvilinear abdominal transducer with color imaging capabilities, was used in all cases.

Interventions

DIAGNOSTIC_TESTA complete Doppler ﬂow assessment of the maternal and fetal circulation

A complete Doppler ﬂow assessment of the maternal and fetal circulation was conducted by an independent investigator blinded to the treatment, 48 hours after receiving 400mg of vaginal progestrone .Voluson E8 (GE Healthcare, Zipf, Austria) ultrasound machine ,equipped with a 3.5-MHz curvilinear abdominal transducer with color imaging capabilities, was used in all cases.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Inclusion criteria

* Gestational age: 18-33 weeks * Willing and able to give informed consent * History of preterm labor (\<34 weeks) * At risk for preterm labor ( increased amniotic fluid volume) * Short cervical length (\<25mm) as incidental finding * Presenting with actual cervical changes ( dilatation and\\or effacement) in current pregnancy

Exclusion criteria

* PPROM * Contraindication to progesterone use * Diabetic patients, have glucose intolerance * Multiple pregnancies

Design outcomes

Primary

Measure	Time frame	Description
change of ultrasound doppler indices.	before and 48 hours after progestrone admistration	A complete Doppler ﬂow assessment of the maternaland fetal circulation was conducted by an independent investigator blinded to the treatment, before and 48 hours after the ﬁrst administration of progesterone, Voluson E8 (GE Healthcare, Zipf, Austria) ultrasoundmachine,equippedwitha3.5-MHzcurvilinearabdominaltransducer with color imaging capabilities, was used in all cases.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026