Myopia
Conditions
Brief summary
The investigators are analyzing outcomes of topography-guided LASIK surgery in participants with myopia and myopic astigmatism
Detailed description
The investigators are analyzing outcomes of topography-guided LASIK surgery in participants with myopia and myopic astigmatism. The investigators will be monitoring changes in anterior segment optical coherence tomography epithelial thickness maps. The investigators will compare preoperative maps to postoperative maps at one, three, six and twelve months. In addition, the investigators will measure changes in epithelial maps from postoperative month through twelve months to help understand what is happening to the corneal epithelium to try to explain why UDVA and CDVA improves over time
Interventions
PROCEDURETopography-guided LASIK
LASIK surgery
Sponsors
Stanford University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Masking description
N0ne
Intervention model description
Topography guided
Eligibility
Sex/Gender
ALL
Age
18 Years to 59 Years
Healthy volunteers
Yes
Inclusion criteria
* Subjects age 18 and older with healthy eyes. Nearsightedness between -0.50 diopters and -8.00 diopters. * Subjects with up to 3.00 diopters of astigmatism. * Subjects with a spherical equivalent of up to -9.00 diopters.
Exclusion criteria
* Subjects under the age of 18. * Subjects with excessively thin corneas. * Subjects with topographic evidence of keratoconus. * Subjects with ectatic eye disorders. * Subjects with autoimmune diseases. * Subjects who are pregnant or nursing. * Subjects with more than 3.00 diopters of astigmatism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Epithelial thickness maps | 12 months | Changes in anterior segment optical coherence tomography epithelial thickness maps. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Uncorrected distance visual acuity | 12 months | Uncorrected distance visual acuity (UDVA) |
| Quality of Vision | 12 months | Patient reported outcomes questionnaire |
| Predictability | 12 months | Percentage of eyes within +/-0.25, 0.50 and 1.00 diopter of the intended correction |
| Changes in corrected visual acuity | 12 months | Corrected distance visual acuity (CDVA) |
| Residual astigmatism levels after surgery | 12 months | Vector analysis of astigmatic outcomes |
| Change in refraction over time | 12 months | Change in spherical equivalent over time |
| Contrast visual acuity | 12 months | 5 and 25% ETDRS contrast acuity |
Countries
United States
Outcome results
None listed