Apnea, Postanesthetic, Hypoxemia, Sedative Overdose, Unconsciousness
Conditions
Keywords
Procedural Sedation
Brief summary
Prospectively evaluate newly established guidelines and make clinicians aware of inter-racial difference in propofol sensitivity.
Detailed description
The primary motivation in conducting this study is to conduct the implementation science, i.e., formalize and train, and retrain if needed, anesthesia providers in the standard practice of titrating infusion rate to effect and clinically evaluate the effect of race and ethnicity on propofol monotherapy sedation during GI endoscopy. The ultimate goal is to make it less likely that patients from races known to be sensitive to propofol experience inadvertent overdosing.
Interventions
PROCEDURETitrate propofol monotherapy infusion to effect
Train anesthesia providers in a standardized protocol for titrating propofol infusion to effect.
Sponsors
National Center for Advancing Translational Sciences (NCATS)
University of Florida
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing propofol sedation at Gainesville (GNV) and Jacksonville (JAX) GI Endoscopy suites * Age range 18 - 80 years old * Patients whose race can be identified from the electronic patient information chart (EPIC)
Exclusion criteria
* Patients who identify as multiracial in Epic * Patients who identify as Other in Epic * Patients who refuse to indicate their race in Epic * Patients whose race is listed as unknown in Epic
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in the recovery times among races and ethnicities | Change from baseline up to 24 hours | Monitored using aggregate data for metrics of recovery times |
Countries
United States
Outcome results
None listed