Ridge Deficiency
Conditions
Keywords
Guided Bone Regeneration, Dehydrated Human Amnion Chorion Membrane, Type I Bovine Collagen Membrane, Ridge Preservation, Ridge Healing, Teeth Extraction
Brief summary
The objective of this randomized clinical study was to evaluate the use of dehydrated human amnion-chorion membrane as an exposed barrier for guided bone regeneration (GBR) after tooth extraction and to determine whether intentional exposure of this membrane to the oral environment compromises ridge dimensions and bone vitality for implant placement.
Detailed description
Forty-three patients requiring extraction of at least one tooth and delayed implant placement were randomly assigned to either an experimental or a control group. For both groups, demineralized freeze-dried bone allograft was used to graft the socket. For the control group, Type I bovine collagen was used as a membrane; for the experimental group, human amnion-chorion membrane was used. For both groups, the barrier membranes were left exposed, and no primary closure was achieved. Patients returned for implant placement after a mean healing period of 19.5 weeks, at which time a core bone biopsy specimen 2 mm in diameter was obtained for histomorphometric analyses. Clinical ridge dimensions were measured at the times of extraction and implant placement.
Interventions
PROCEDUREGuided Bone Regeneration (GBR)
Teeth Extraction With Bone Grafting and Membrane
Sponsors
Samer Faraj
Study design
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 78 Years
Healthy volunteers
Yes
Inclusion criteria
. Patients included in the study were required: * Not to be completely edentulous. * To have at least 1 tooth that could not be saved and for which extraction and delayed implant placement were planned
Exclusion criteria
Patients were excluded if they : * Had received radiation therapy * Were taking antiresorptive medication (i.e., bisphosphonate or denosumab) * Had uncontrolled systemic disorders (such as uncontrolled diabetes, congestive heart failure, or acute odontogenic infections) * Were smokers (more than 10 cigarettes per day) * Were pregnant or breastfeeding.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Alveolar Ridge Dimensional Changes | Alveolar Ridge Dimensional Changes were taken at the extraction time and at the time of implant placement. Mean = 19.5 weeks | Clinical ridge height changes were taken with a thermoplastic triad stent, and a University of North Carolina (UNC) 15 periodontal probe. Ridge width changes measurements were taken with a metal bone caliper. Alveolar ridge dimensional changes in height and width were measured at the times of extraction and at the time of implant placement. |
| Alveolar Ridge Bone Vitality | Mean= 19.5 weeks after tooth extraction and bone grafting | a core bone biopsy specimen 2 mm in diameter was obtained from the center of the root at the time of implant placement for histomorphometric analyses |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Ridge Healing Evaluation | Two weeks form the time of the extraction | Pictures of the healing ridges were taken using clinical macro lens photography |
Outcome results
None listed