Effects of DHA on Post-operative Fibrosis of Trabulectomy Blebs in Glaucoma Surgery

Study of the Effects of Docosahexaneoic Acid (DHA) on Post-operative Fibrosis of Trabulectomy Blebs in Glaucoma Surgery

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03289806

Acronym

DHA

Enrollment

Registered

2017-09-21

Start date

2016-01-12

Completion date

2018-01-31

Last updated

2017-09-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Deep Sclerectomy, Trabulectomy

Brief summary

Post-operative fibrosis of trabulectomy blebs is a major cause of surgical failure leading to a renewed increase in intraocular pressure. The use of anti-metabolites over many years has made it possible to improve success rates for this surgery but these drugs have numerous adverse effects as they are toxic. Alternative therapies are thus necessary, and we believe that DHA could have antifibrotic effects on fibroblasts and could thus improve success rates in this surgery.

Interventions

PROCEDURESamples of fibroblasts from Tenon's capsule

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients undergoing trabulectomy or deep sclerectomy * Patients informed about the study

Exclusion criteria

\- Patients who refuse to take part in the study

Design outcomes

Primary

Measure	Time frame
Test of cell viability by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide)	At baseline
Test migration ability by video microscopy	At baseline
Test proliferation with immunohistochemistry (Ki67 staining)	At baseline
Analysis of cell cycle in flow cytometry	At baseline

Countries

France

Contacts

Primary ContactAlain BRON

alain.bron@chu-dijon.fr03 80 29 37 56

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026