Infertility, Autoimmune Thyroiditis
Conditions
Brief summary
The aim of the work is to determine whether the use of immunomodulatory drugs could improve the reproductive of outcome of infertile patients who have autoimmune thyroiditis with positive autoimmune antibodies undergoing IVF-ET.
Interventions
DRUGImmunomodulatory
Patients will receive thyroxine , low dose aspirin , low dose selenium, Calcium and vitamin D before ICSI cycle. Moreover, patients will receive a treatment course of immunomodulatory drugs for 3 -6 months before ICSI cycle: 1. Prednisnlone 40mg for 2 weeks to be lowered gradually till become 5mg after 6 weeks and to be continued 2. Hydroxychloroquine according to body weight, patients who develop hypersensitivity will be shifted to Azathioprin. 3. Immunoglobulins will be used in cases not responding to treatment.
DRUGThyroxine
Patients will receive thyroxine , low dose aspirin , low dose selenium, Calcium and vitamin D before ICSI cycle. Patients will not receive immunomodulatory drugs
Sponsors
Aljazeera Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Infertility patients who have autoimmune thyroiditis With positive autoimmune thyroiditis and TSH level above 2 IU.
Exclusion criteria
* All patients who have other autoimmune diseases especially antiphospholipid syndrome, hepatitis c viral disease. Patients who have any medical disorders ( eg. D.M. HTN .Epilepsy ….)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Number of Participants Who Achieved clinical Pregnancy | 6 weeks after embryo transfer |
Secondary
| Measure | Time frame |
|---|---|
| The Number of Participants Who Achieved Ongoing Pregnancy | 18 weeks after embryo transfer |
Countries
Egypt
Outcome results
None listed