Sepsis
Conditions
Keywords
sepsis, lymphocyte
Brief summary
There is an observational, clinical study. We recruit sepsis patients to investigate what drives peripheral lymphocyte loss in sepsis.
Detailed description
There is an observational, clinical study. We recruit patients with diagnosis of new onset sepsis within 24h, collect and record clinical characteristics： ①Demography data，diagnosis, admission source, infection source, APACHE II,SOFA scores;②Endotoxin levels and PaO2 measured;③Immune and systemic inflammatory indicators：T, RR, WBC, ALC, etc.;④Complicated organs dysfunctions: duration and therapy;⑤Incidence of ICU-acquired infection and prognosis.The blood samples were collected for apoptosis,necrosis,autophagy,pyroptosis measurements.The aim of this study is to investigate how peripheal lymphocyte loss relates to outcome and the mechanisms of peripheal lymphocyte loss in different condition.
Interventions
None listed
Sponsors
Southeast University, China
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Health volunteers
Exclusion criteria
* History of tumor, hematological or immunological disease, and treatment with chemotherapy agents or corticosteroids within 6 months prior to or during the hospitalization.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| lymphocyte loss | day of inclussion and 7th day after inclussion | ratios of T cells loss by different mechanism in different subgroups |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| prognosis | 28-day after inclussion | 28-day prognosis:survive or not |
| Complicated organ dysfunction | during 28 days after inclussion | duration and surpport therapy |
Countries
China
Contacts
Primary ContactMing Xue, MD
Outcome results
None listed