Ultra High Field Magnetic Resonance Imaging as a Biomarker for Premotor Parkinson's Disease

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03288909

Enrollment

Registered

2017-09-20

Start date

2015-09-30

Completion date

2021-01-31

Last updated

2019-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson Disease, REM Sleep Behavior Disorder

Brief summary

This is a prospective observational study investigating the utility of 7 Tesla MRI to quantify nigrosome1 signal in a cohort of individuals with recent onset Parkinson's disease and in at-risk cohorts at a premotor state of Parkinson's disease.

Interventions

OTHERMRI

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Idiopathic Parkinson's disease within 1 year of motor symptom onset. Idiopathic REM sleep behavior disorder without signs/symptoms of Parkinson's disease. Age-matched controls.

Exclusion criteria

* Atypical Parkinsonism * Contraindications for MRI

Design outcomes

Primary

Measure	Time frame
Quantitative signal analysis of nigrosome 1	1 year

Secondary

Measure	Time frame
Change in quantitative signal analysis of nigrosome 1	3 years

Countries

United States

Contacts

Primary ContactMatthew Brodsky, MD

brodskym@ohsu.edu5034949054

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026