Asthma
Conditions
Keywords
eosinophils, pharmacokinetics, First time in Human, GSK3511294, pharmacodynamics, asthma
Brief summary
GSK3511294 is a humanized monoclonal antibody antagonist of Interleukin (IL)-5 which is known to block binding of IL-5 to the IL-5 receptor complex, causing a reduction in the circulating population of eosinophils. This is a single ascending dose FTIH study to investigate safety, tolerability, immunogenicity, pharmacokinetics (PK) and pharmacodynamics (PD) of GSK3511294, administered SC in subjects with mild to moderate asthma maintained on a low-medium daily dose of inhaled corticosteroids (ICS) or ICS/long acting beta-agonist (LABA), and short acting beta-agonist (SABA). The subjects will attend a pre-screen visit of up to 12 weeks before dosing for assessment of blood eosinophils. Eligible subjects with blood eosinophils \>=200 cells per microliter (cells/µL) will undergo a screening period of up to 4 weeks. The subjects will then be randomized into 5 cohorts. In each cohort, the subjects will be randomized to receive a single dose of GSK3511294 or placebo in a ratio of 3:1. The follow-up period will be up to 40 weeks post dose and will be dose-dependent. The scheduled maximum duration for each subject will be up to 44 weeks including up to 28 days of screening.
Interventions
DRUGGSK3511294
GSK3511294 will be available as a clear or opalescent, colorless or yellow to brown solution for injection at unit dose strength of 150 milligrams per milliliter (mg/mL). GSK3511294 will be diluted in 0.9% weight by volume (w/v) sodium chloride to achieve the desired concentration for administration. GSK3511294 will be administered by SC injection.
DRUGPlacebo
Matching Placebo will consist of 0.9% w/v sodium chloride which will be administered by the SC route.
Salbutamol/albuterol will be supplied to all subjects for use as rescue medication during the study.
Sponsors
GlaxoSmithKline
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Intervention model description
This is a multi-center, double-blind study in which subjects will be allocated to five cohorts. The subjects in each cohort will be randomized to receive GSK3511294 and placebo in a ratio of 3:1. In each cohort, dosing will be staggered: one subject will receive GSK3511294 and one subject will receive placebo at least 72 hours before the remaining subjects in that cohort are dosed. The remaining subjects will be dosed if the review of all safety data up to 72 hours after dosing of the first two subjects in each cohort is satisfactory.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Subjects should be between 18 and 65 years of age inclusive, at the time of signing the informed consent. * Blood eosinophils of \>= 200 cells/µL at screening. * A physician diagnosis of asthma (mild or moderate, as defined by the Global Initiative for Asthma \[GINA\], 2017) at least 12 months prior to the start of the study. The reason for diagnosis of asthma should be documented in the subject's source data, including relevant history and investigations - specifically evidence of airway hyper-responsiveness, airflow variation (peak flow rate or forced expiratory volume in one second \[FEV1\]) or reversible airflow obstruction should also be documented in the subject's source data. * A screening pre-bronchodilator FEV1 \>= 60% of predicted normal value. * Asthma Control Test score \> 19. * hsCRP of \< 10 milligrams per liter (mg/L) at screening. * Otherwise healthy (other than the acceptable conditions of asthma and other atopic diseases, including allergic rhinitis and atopic dermatitis) based on a screening medical history, physical examination, vital signs, ECG assessment, pulmonary function testing, and clinical laboratory results. * Maintained controlled on as needed SABA and one of the following: a) stable dose of ICS; b) stable dose of combination therapy: ICS/LABA. * Body weight \>= 50 kilograms (kg), and body mass index (BMI) of 19-32 kilograms per square meter (kg/m\^2) inclusive. * Male and female subjects. a) a female subject is eligible to participate if she is not pregnant, not breastfeeding, and not a woman of childbearing potential. b) as GSK3511294 is a monoclonal antibody that is not anticipated to interact directly with Deoxyribonucleic acid (DNA) or other chromosomal material with minimal exposure through semen expected, male subjects will not be required to use contraception during the study, nor are they prohibited from donating sperm. * Capable of giving signed informed consent, which includes compliance with the requirements and restrictions of the study.
Exclusion criteria
* Any asthma exacerbation requiring systemic corticosteroids within 12 weeks of screening, or that resulted in overnight hospitalization requiring additional treatment for asthma within 6 months prior to screening. * A history of life-threatening asthma defined as an asthma episode that required intubation and/or was associated with hypercapnia, respiratory arrest or hypoxic seizures within the last 5 years. * Significant pulmonary diseases, other than asthma, including (but not limited to): pneumonia previously requiring hospital admission, pulmonary fibrosis, bronchopulmonary dysplasia, chronic bronchitis, emphysema, chronic obstructive pulmonary disease, or other significant respiratory abnormalities. * Suspected or confirmed bacterial or viral infection (including tuberculosis) of the upper or lower respiratory tract, sinus or middle ear that occurred within and/or has not resolved within 4 weeks of screening that: led to a change in asthma management or in the opinion of the Investigator, is expected to affect the subject's asthma status or the subject's ability to participate in the study. * Positive for hepatitis B surface antigen (HBsAg) at screening. * Positive hepatitis C antibody test result at screening, or within 3 months prior to first dose of study treatment. * Known immunodeficiency (other than that explained by the use of corticosteroids), including a positive test for human immunodeficiency virus (HIV) antibody at screening. * Latent or chronic infections (example, genital herpes, urinary tract infections) or at risk of infection (example, significant trauma or infection within the 90 days before screening). * Opportunistic infection within 6 months prior to screening (example, a non-tuberculous mycobacterial infection or cytomegalovirus, pneumocystosis, aspergillosis). * Parasitic infestation within 6 months prior to screening, or have travelled to a country with a high prevalence of such infections in the 6 months before screening, or intend to do so in the year after dosing. * Live vaccine within 4 weeks prior to screening, or intention to receive live vaccine during the study. * Corrected QT by Fridericia's formula (QTcF) interval \> 450 milliseconds (msec) * A personal history of severe hypertension, arrhythmia, Right Bundle Branch Block, or Left Bundle Branch Block, or a family history of sudden unexplained death, long QT, familial cardiac syndrome, or cardiomyopathy. * ALT \>1.5 times upper limit of normal (ULN). * Bilirubin \>1.5 times ULN. Isolated bilirubin \>1.5 times ULN is acceptable if bilirubin is fractionated and direct bilirubin \<35%. * Current or chronic history of liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones). * Any history or presence of clinically relevant cardiac or cardiovascular, gastrointestinal, hepatic, renal, metabolic, hematological, neurological, osteomuscular, articular, psychiatric, systemic, ocular, or infectious disease or immunodeficiency, or signs of acute illness, or any other illness or condition that, in the opinion of the investigator (in consultation with the medical monitor), would adversely affect the subject's participation in this study. * A previous history of cancer in remission for less than 5 years prior to screening (except for localized carcinoma of the skin that had been resected for cure) or current malignancy. * A positive drug/alcohol test before dosing, OR any history of drug abuse OR regular alcohol consumption within 6 months of the study defined as: An average weekly intake of \> 14 units alcohol. One unit is equivalent to 8 grams (g) of alcohol: a half-pint (equivalent to 240 milliliters \[mL\]) of beer, 1 glass (125 mL) of wine or 1 (25 mL) measure of spirits. * Current smokers or ex-smokers who have given up smoking for \< 12 months and/or have a smoking pack history of \> 5 pack years (1 pack year = 20 cigarettes per day for 1 year or 5 cigarettes per day for 4 years). * Urinary cotinine levels indicative of smoking or history or regular use of tobacco- or nicotine-containing products within 6 months prior to screening. * Anticipated non-availability and/or risk of non-compliance with study visits and procedures, or unwillingness or inability to follow the study specific procedures. * The subject has participated in a clinical trial and has received an investigational product within the following time period prior to the first dosing day in the current study: 3 months, 5 half-lives or twice the duration of the biological effect of the investigational product (whichever is longer). * Exposure to more than 4 investigational medicinal products within 12 months prior to the first dosing day. * History of sensitivity to any of the study medications, or its components, or a history of drug reaction or other allergy that, in the opinion of the investigator or Medical Monitor, contraindicates their participation. * Major surgery within 90 days prior to screening, or planned in-patient surgery or hospitalization during the study period * Donation or loss of blood or blood products in excess of 500 mL within the 3 months before dosing. * History of renal disease, abnormal kidney function or evidence of persisting or clinically relevant protein or blood on urinalysis. * History or signs of immunologically active disease (including the presence of low C3 or low C4) or thrombocytopenia. * History of vasculitis. * Subjects are excluded if they are undergoing desensitization therapy, or have received any of the following medications as indicated prior to screening: anti- Immunoglobulin E (IgE) therapy (within 6 months); anti-IL5 (within 6 months); oral or injectable corticosteroids (within 8 weeks); long acting muscarinic antagonist (LAMA) or leukotriene receptor antagonist (LTRA) therapy (within 8 weeks); drugs that can prolong the QT interval. * Subjects who are employees of the sponsor or clinical unit are excluded. * Vulnerable subjects, e.g., participants kept in detention, protected adults under guardianship, trusteeship and soldiers, or participants committed to an institution by governmental or juridical order.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of Participants With Adverse Events (AEs) and Serious AEs (SAE) | Up to Week 40 | An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of a study intervention, whether or not considered related to the study intervention. An SAE is defined as any untoward medical occurrence that, at any dose: results in death; is life-threatening; requires inpatient hospitalization or prolongation of existing hospitalization; results in persistent disability/incapacity; is a congenital anomaly/birth defect; other important medical events that may jeopardize the participant or may require medical or surgical intervention to prevent one of the other outcomes listed before; is associated with liver injury and impaired liver function. |
| Number of Participants With Adverse Events of Special Interest (AESI) | Up to Week 40 | AESIs were defined as Hypersensitivity (narrow) and Injection site reactions like hematoma and swelling. |
| Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Blood samples were collected at indicated time-points for analysis of hematology parameters like platelet count, neutrophils, lymphocytes, monocytes, eosinophils and basophils. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Change From Baseline in Red Blood Cell Count (RBC) | Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Blood samples were collected at indicated time-points for analysis of hematology parameters like RBC count. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Change From Baseline in Mean Corpuscle Volume (MCV) | Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Blood samples were collected at indicated time-points for analysis of hematology parameters like MCV. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Blood samples were collected at indicated time-points for analysis of hematology parameters like MCH. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Change From Baseline in Hemoglobin | Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Blood samples were collected at indicated time-points for analysis of hematology parameters like hemoglobin. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Change From Baseline in Hematocrit | Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Blood samples were collected at indicated time-points for analysis of hematology parameters like hematocrit. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Blood samples were collected at indicated time-points for analysis of clinical parameters like hsCRP. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Blood samples were collected at indicated time-points for analysis of clinical parameters like total protein and albumin. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Blood samples were collected at indicated time-points for analysis of clinical parameters like total bilirubin, direct bilirubin and creatinine. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Urine Specific Gravity Analysis by Dipstick Method | Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Urinary specific gravity measurement is a routine part of urinalysis. Urine specific gravity is a measure of the concentration of solutes in the urine and provides information on the kidney's ability to concentrate urine. The concentration of the excreted molecules determines the urine's specific gravity. |
| Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | Baseline and at 2 and 8 hours at Day 1; Days 2, 3, 4 and 5; Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | SBP and DBP were assessed in a supine position after 5 minutes of rest. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Change From Baseline in Temperature | Baseline and at 2 and 8 hours at Day 1; Days 2, 3, 4 and 5; Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Temperature was assessed in a supine position after 5 minutes of rest. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Change From Baseline in Heart Rate | Baseline and at 2 and 8 hours at Day 1; Days 2, 3, 4 and 5; Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Heart rate was assessed in a supine position after 5 minutes of rest. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Change From Baseline in Respiration Rate | Baseline and at 2 and 8 hours at Day 1; Days 2, 3, 4 and 5; Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Respiration rate was assessed in a supine position after 5 minutes of rest. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Baseline and at 2 and 8 hours on Day 1; Days 2, 3, 4 and 5; Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | 12-lead ECG were performed in a supine position using an automated ECG machine that calculated the heart rate and measured PR, QRS, QT and corrected QT (QTc) intervals. ECG measurements were performed in triplicate. When multiple ECGs were performed at the same planned timepoint, the average value of each parameter was used. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | Baseline and at 2 and 8 hours on Day 1; Days 2, 3, 4 and 5; Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | 12-lead ECG were performed in a supine position using an automated ECG machine that calculated PR interval, QRS interval, QT interval and QTcF interval. ECG measurements were performed in triplicate. When multiple ECGs were performed at the same planned timepoint, the average value of each parameter was used. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Blood samples were collected at indicated time-points for analysis of clinical parameters like ALP, AST and ALT. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Blood samples were collected at indicated time-points for analysis of clinical parameters like glucose, calcium, potassium, sodium, BUN, and magnesium. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value. |
| Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Urine samples were collected to analyze presence of ketones, occult blood, glucose, and protein in urine. In this dipstick test, the level of occult blood, glucose, ketones and urine protein in urine samples were recorded as negative, trace, 1+ and 2+ indicating proportional concentrations in urine. Only categories with abnormal significant values have been presented. |
| Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Urinary pH measurement is a routine part of urinalysis. Urine pH is an acid-base measurement. pH is measured on a numeric scale ranging from 0 to 14; values on the scale refer to the degree of alkalinity or acidity. A pH of 7 is neutral. A pH less than 7 is acidic, and a pH greater than 7 is basic. Normal urine has a slightly acid pH (5.0 - 6.0). |
| Absolute Values of Complement (C)3 and C4 | Baseline and at Days 2, 3, 4 and 5; Weeks 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40 | Blood samples were collected at indicated timepoints for analysis for complement (C3 and C4). Baseline was defined as latest pre-dose assessment with a non-missing value. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| CL/F of GSK3511294 300 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose | Blood samples were collected from participants at indicated time points and analyzed for CL/F. CL/F was calculated as dose divided by AUC(0-inf). Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Apparent Volume of Distribution After Subcutaneous Administration (Vd/F) of GSK3511294 2 mg and 10 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose | Blood samples were collected from participants at indicated time points and analyzed for Vd/F. Vd/F was calculated as dose divided by terminal elimination rate constant (lambda\_z) \*AUC(0-inf). Pharmacokinetic parameters were calculated by standard non compartmental analysis. |
| Vd/F of GSK3511294 30 mg and 100 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose | Blood samples were collected from participants at indicated time points and analyzed for Vd/F. Vd/F was calculated as dose divided by \[lambda\_z \*AUC(0-inf)\]. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Vd/F of GSK3511294 300 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose | Blood samples were collected from participants at indicated time points and analyzed for Vd/F. Vd/F was calculated as dose divided by \[lambda\_z \*AUC(0-inf)\]. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Terminal Phase Elimination Rate Constant (Lambda_z) of GSK3511294 2 mg and 10 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose | Blood samples were collected from participants at indicated time points and analyzed for lambda\_z. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Lambda_z of GSK3511294 30 mg and 100 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose | Blood samples were collected from participants at indicated time points and analyzed for lambda\_z. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Area Under the Curve From Time Zero to Infinity (AUC[0-inf]) of GSK3511294 2 mg and 10 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose | Blood samples were collected from participants at indicated time points and analyzed for AUC (0-inf). Pharmacokinetic parameters were calculated by standard non compartmental analysis. Pharmacokinetic Population included participants in the Safety population for whom a pharmcokinetic sample was obtained and analyzed. |
| Terminal Phase Half-life (t1/2) of GSK3511294 2 mg and 10 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose | Blood samples were collected from participants at indicated time points and analyzed for t1/2. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| T1/2 of GSK3511294 30 mg and 100 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose | Blood samples were collected from participants at indicated time points and analyzed for t1/2. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| T1/2 of GSK3511294 300 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose | Blood samples were collected from participants at indicated time points and analyzed for t1/2. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Ratio to Baseline in Absolute Blood Eosinophil Count | Baseline, Days 2, 3, 4, 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36, and 40 | Blood samples were collected at indicated time-points. Analysis was performed using a mixed model repeated measures analysis (MMRM) model on log-transformed data with fixed categorical effects of treatment, planned timepoint and treatment-by-planned timepoint interaction and fixed continuous covariates of log Baseline blood eosinophil count and log Baseline blood eosinophil count-by-planned timepoint interaction. Baseline is defined as the latest predose non-missing blood eosinophil count. Ratio to Baseline is defined as post-dose visit value divided by Baseline value. Pharmacodynamic Population included participants in the 'Safety' population for whom a post-dose pharmacodynamic (ie blood eosinophil) sample was obtained and analyzed. |
| Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Up to Week 40 | Serum samples were collected to determine the presence of anti-GSK3511294 binding antibodies using a validated bioanalytical method. Data for any time post-Baseline is reported. The results were categorized as negative, transient positive (defined as a single confirmatory positive immunogenic response that does not occur at the final study assessment) and persistent positive (defined as a confirmatory positive immunogenic response for at least 2 consecutive assessments or a single result at the final study assessment). |
| Titers of Binding ADA to GSK3511294 | Up to Week 40 | Serum samples were collected to determine the presence of anti-GSK3511294 binding antibodies using a validated bioanalytical method. Data for any time post-Baseline is reported. Titer was only measured when a positive result was found. |
| Lambda_z of GSK3511294 300 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose | Blood samples were collected from participants at indicated time points and analyzed for lambda\_z. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| AUC(0-inf) of GSK3511294 30 mg and 100 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose | Blood samples were collected from participants at indicated time points and analyzed for AUC (0-inf). Pharmacokinetic parameters were calculated by standard non compartmental analysis. |
| AUC(0-inf) of GSK3511294 300 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose | Blood samples were collected from participants at indicated time points and analyzed for AUC (0-inf). Pharmacokinetic parameters were calculated by standard non compartmental analysis. |
| Area Under the Curve From Time Zero to the Last Measurable Concentration (AUC[0-t]) of GSK3511294 2 mg and 10 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose | Blood samples were collected from participants at indicated time points and analyzed for AUC (0-t). Pharmacokinetic parameters were calculated by standard non compartmental analysis. |
| AUC(0-t) of GSK3511294 30 mg and 100 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose | Blood samples were collected from participants at indicated time points and analyzed for AUC (0-t). Pharmacokinetic parameters were calculated by standard non compartmental analysis. |
| AUC(0-t) of GSK3511294 300 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose | Blood samples were collected from participants at indicated time points and analyzed for AUC (0-t). Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Area Under the Concentration-time Curve From Time Zero to Week 4 (AUC[0-Week 4]) of GSK3511294 | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, and 4 post-dose | Blood samples were collected from participants at indicated time points and analyzed for AUC (0-Week 4). Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Area Under the Concentration-time Curve From Time Zero to Week 12 (AUC[0-Week 12]) of GSK3511294 | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8 and 12 post-dose | Blood samples were collected from participants at indicated time points and analyzed for AUC (0-Week 12). Pharmacokinetic parameters were calculated by standard non compartmental analysis. |
| Area Under the Concentration-time Curve From Time Zero to Week 26 (AUC [0-Week 26]) of GSK3511294 | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24 and 26 post-dose | Blood samples were collected from participants at indicated time points and analyzed for AUC (0-Week 26). Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Percentage of AUC (0-inf) Obtained by Extrapolation (%AUCex) of GSK3511294 2 mg and 10 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose | Blood samples were collected from participants at indicated time points and analyzed for %AUCex. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| %AUCex of GSK3511294 30 mg and 100 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose | Blood samples were collected from participants at indicated time points and analyzed for %AUCex. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| %AUCex of GSK3511294 300 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose | Blood samples were collected from participants at indicated time points and analyzed for %AUCex. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Maximum Observed Concentration (Cmax) of GSK3511294 2 mg and 10 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose | Blood samples were collected from participants at indicated time points and analyzed for Cmax. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Cmax of GSK3511294 30 mg and 100 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose | Blood samples were collected from participants at indicated time points and analyzed for Cmax. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Cmax of GSK3511294 300 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose | Blood samples were collected from participants at indicated time points and analyzed for Cmax. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Time of Occurrence of Cmax (Tmax) of GSK3511294 2 mg and 10 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose | Blood samples were collected from participants at indicated time points and analyzed for Tmax. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Tmax of GSK3511294 30 mg and 100 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose | Blood samples were collected from participants at indicated time points and analyzed for Tmax. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Tmax of GSK3511294 300 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose | Blood samples were collected from participants at indicated time points and analyzed for Tmax. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Time of Last Quantifiable Concentration (Tlast) of GSK3511294 2 mg and 10 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose | Blood samples were collected from participants at indicated time points and analyzed for Tlast. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Tlast of GSK3511294 30 mg and 100 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose | Blood samples were collected from participants at indicated time points and analyzed for Tlast. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Tlast of GSK3511294 300 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose | Blood samples were collected from participants at indicated time points and analyzed for Tlast. Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| Apparent Clearance Following Subcutaneous Dosing (CL/F) of GSK3511294 2 mg and 10 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose | Blood samples were collected from participants at indicated time points and analyzed for CL/F. CL/F was calculated as dose divided by AUC(0-inf). Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
| CL/F of GSK3511294 30 mg and 100 mg | Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose | Blood samples were collected from participants at indicated time points and analyzed for CL/F. CL/F was calculated as dose divided by AUC(0-inf). Pharmacokinetic parameters was calculated by standard non compartmental analysis. |
Countries
Germany, United Kingdom
Participant flow
Recruitment details
This was double-blind, placebo-controlled, single ascending dose study in participants with mild to moderate asthma to assess safety, tolerability, immunogenicity, pharmacokinetics and pharmcodynamics of GSK3511294 administered subcutaneously. The study was conducted in Germany and United Kingdom.
Pre-assignment details
A total of 50 participants were enrolled in this study, of which two did not receive any study treatment and 48 were included in the Safety Population.
Participants by arm
| Arm | Count |
|---|---|
| Placebo Participants were administered a single subcutaneous dose of GSK3511294 matching placebo on Day 1 | 12 |
| GSK3511294 2mg Participants were administered a single subcutaneous dose of GSK3511294 2 milligram (mg) on Day 1 | 6 |
| GSK3511294 10mg Participants were administered a single subcutaneous dose of GSK3511294 10 mg on Day 1 | 6 |
| GSK3511294 30mg Participants were administered a single subcutaneous dose of GSK3511294 30 mg on Day 1 | 9 |
| GSK3511294 100mg Participants were administered a single subcutaneous dose of GSK3511294 100 mg on Day 1 | 9 |
| GSK3511294 300mg Participants were administered a single subcutaneous dose of GSK3511294 300 mg on Day 1 | 6 |
| Total | 48 |
Baseline characteristics
| Characteristic | Placebo | GSK3511294 2mg | GSK3511294 10mg | GSK3511294 30mg | GSK3511294 100mg | GSK3511294 300mg | Total |
|---|---|---|---|---|---|---|---|
| Age, Continuous | 44.0 years STANDARD_DEVIATION 13.37 | 43.5 years STANDARD_DEVIATION 10.71 | 44.7 years STANDARD_DEVIATION 13.2 | 44.9 years STANDARD_DEVIATION 10.23 | 42.0 years STANDARD_DEVIATION 10.84 | 45.2 years STANDARD_DEVIATION 11.18 | 44.0 years STANDARD_DEVIATION 11.17 |
| Race/Ethnicity, Customized Arabic/North African Heritage | 1 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 1 Participants |
| Race/Ethnicity, Customized Black/Afr. Amer./White/Caucasian/European Heritage | 1 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 1 Participants |
| Race/Ethnicity, Customized Black or African American (Afr. Amer.) | 0 Participants | 1 Participants | 0 Participants | 1 Participants | 0 Participants | 0 Participants | 2 Participants |
| Race/Ethnicity, Customized Central/South Asian Heritage | 1 Participants | 0 Participants | 0 Participants | 1 Participants | 0 Participants | 0 Participants | 2 Participants |
| Race/Ethnicity, Customized White/Caucasian/European Heritage | 9 Participants | 5 Participants | 6 Participants | 7 Participants | 9 Participants | 6 Participants | 42 Participants |
| Sex: Female, Male Female | 0 Participants | 0 Participants | 0 Participants | 0 Participants | 1 Participants | 1 Participants | 2 Participants |
| Sex: Female, Male Male | 12 Participants | 6 Participants | 6 Participants | 9 Participants | 8 Participants | 5 Participants | 46 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk | EG002 affected / at risk | EG003 affected / at risk | EG004 affected / at risk | EG005 affected / at risk |
|---|---|---|---|---|---|---|
| deaths Total, all-cause mortality | 0 / 12 | 0 / 6 | 0 / 6 | 0 / 9 | 0 / 9 | 0 / 6 |
| other Total, other adverse events | 11 / 12 | 2 / 6 | 6 / 6 | 8 / 9 | 9 / 9 | 4 / 6 |
| serious Total, serious adverse events | 0 / 12 | 0 / 6 | 0 / 6 | 0 / 9 | 0 / 9 | 0 / 6 |
Outcome results
Primary
Absolute Values of Complement (C)3 and C4
Blood samples were collected at indicated timepoints for analysis for complement (C3 and C4). Baseline was defined as latest pre-dose assessment with a non-missing value.
Time frame: Baseline and at Days 2, 3, 4 and 5; Weeks 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (GEOMETRIC_MEAN) |
|---|---|---|---|
| Placebo | Absolute Values of Complement (C)3 and C4 | C3, Week 32,n=6,6,6,0,0,6 | 1.173 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C3, Week 2,n=12,6,6,9,9,6 | 1.136 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C3, Week 18,n=12,6,6,9,9,6 | 1.173 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C3, Week 4,n=12,6,6,9,9,6 | 1.114 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C3, Week 8,n=12,6,6,9,9,6 | 1.224 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C3, Week 12,n=12,6,6,9,9,6 | 1.117 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C4, Week 26,n=12,6,6,9,9,6 | 0.2517 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C4, Week 18,n=12,6,6,9,9,6 | 0.261 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C4, Week 12,n=12,6,6,9,9,6 | 0.2413 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C4, Week 24,n=12,6,6,8,9,6 | 0.2474 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C4, Week 40,n=2,0,0,0,0,6 | 0.1699 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C4, Week 8,n=12,6,6,9,9,6 | 0.2738 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C3, Baseline,n=12,6,6,9,9,6 | 1.149 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C3, Week 40,n=2,0,0,0,0,6 | 1.181 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C4, Week 4,n=12,6,6,9,9,6 | 0.2602 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C3, Week 24,n=12,6,6,8,9,6 | 1.15 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C3, Day 2,n=12,6,6,9,9,6 | 1.13 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C4, Week 2,n=12,6,6,9,9,6 | 0.2555 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C4, Day 5,n=12,6,6,9,9,6 | 0.2497 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C3, Day 3,n=12,6,6,9,9,6 | 1.187 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C4, Week 36,n=6,0,0,9,9,0 | 0.2844 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C4, Day 4,n=12,6,6,9,9,6 | 0.253 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C3, Day 4,n=12,6,6,9,9,6 | 1.17 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C4, Day 3,n=12,6,6,9,9,6 | 0.2647 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C4, Baseline,n=12,6,6,9,9,6 | 0.2576 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C3, Day 5,n=12,6,6,9,9,6 | 1.136 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C4, Week 32,n=6,6,6,0,0,6 | 0.2772 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C3, Week 36,n=6,0,0,9,9,0 | 1.243 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C4, Day 2,n=12,6,6,9,9,6 | 0.2525 Grams per liter |
| Placebo | Absolute Values of Complement (C)3 and C4 | C3, Week 26,n=12,6,6,9,9,6 | 1.204 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C3, Week 2,n=12,6,6,9,9,6 | 1.147 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C3, Baseline,n=12,6,6,9,9,6 | 1.182 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C3, Week 26,n=12,6,6,9,9,6 | 0.927 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C3, Week 32,n=6,6,6,0,0,6 | 1.243 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C3, Week 18,n=12,6,6,9,9,6 | 1.215 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C4, Week 4,n=12,6,6,9,9,6 | 0.1928 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C4, Day 4,n=12,6,6,9,9,6 | 0.2303 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C3, Week 4,n=12,6,6,9,9,6 | 1.05 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C4, Day 2,n=12,6,6,9,9,6 | 0.2161 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C3, Week 8,n=12,6,6,9,9,6 | 1.226 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C4, Baseline,n=12,6,6,9,9,6 | 0.2061 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C3, Week 24,n=12,6,6,8,9,6 | 1.136 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C4, Week 26,n=12,6,6,9,9,6 | 0.202 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C4, Day 5,n=12,6,6,9,9,6 | 0.1892 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C4, Day 3,n=12,6,6,9,9,6 | 0.2038 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C3, Day 2,n=12,6,6,9,9,6 | 1.27 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C4, Week 18,n=12,6,6,9,9,6 | 0.2266 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C3, Week 12,n=12,6,6,9,9,6 | 1.033 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C4, Week 12,n=12,6,6,9,9,6 | 0.1862 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C4, Week 2,n=12,6,6,9,9,6 | 0.2108 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C3, Day 5,n=12,6,6,9,9,6 | 1.122 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C4, Week 24,n=12,6,6,8,9,6 | 0.2244 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C3, Day 4,n=12,6,6,9,9,6 | 1.284 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C4, Week 8,n=12,6,6,9,9,6 | 0.2547 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C4, Week 32,n=6,6,6,0,0,6 | 0.2401 Grams per liter |
| GSK3511294 2mg | Absolute Values of Complement (C)3 and C4 | C3, Day 3,n=12,6,6,9,9,6 | 1.244 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C4, Week 2,n=12,6,6,9,9,6 | 0.1781 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C3, Week 24,n=12,6,6,8,9,6 | 1.171 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C4, Baseline,n=12,6,6,9,9,6 | 0.1919 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C4, Day 2,n=12,6,6,9,9,6 | 0.2061 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C4, Day 5,n=12,6,6,9,9,6 | 0.1866 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C4, Week 24,n=12,6,6,8,9,6 | 0.197 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C3, Baseline,n=12,6,6,9,9,6 | 1.086 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C3, Day 2,n=12,6,6,9,9,6 | 1.16 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C3, Day 3,n=12,6,6,9,9,6 | 1.236 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C3, Day 4,n=12,6,6,9,9,6 | 1.181 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C3, Day 5,n=12,6,6,9,9,6 | 1.092 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C3, Week 2,n=12,6,6,9,9,6 | 1.02 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C3, Week 4,n=12,6,6,9,9,6 | 1.111 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C3, Week 8,n=12,6,6,9,9,6 | 1.097 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C3, Week 12,n=12,6,6,9,9,6 | 1.124 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C3, Week 18,n=12,6,6,9,9,6 | 1.124 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C3, Week 26,n=12,6,6,9,9,6 | 1.142 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C3, Week 32,n=6,6,6,0,0,6 | 1.231 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C4, Day 3,n=12,6,6,9,9,6 | 0.2212 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C4, Day 4,n=12,6,6,9,9,6 | 0.2006 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C4, Week 4,n=12,6,6,9,9,6 | 0.189 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C4, Week 8,n=12,6,6,9,9,6 | 0.2045 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C4, Week 12,n=12,6,6,9,9,6 | 0.2034 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C4, Week 18,n=12,6,6,9,9,6 | 0.2025 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C4, Week 26,n=12,6,6,9,9,6 | 0.1939 Grams per liter |
| GSK3511294 10mg | Absolute Values of Complement (C)3 and C4 | C4, Week 32,n=6,6,6,0,0,6 | 0.2007 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C4, Week 8,n=12,6,6,9,9,6 | 0.2009 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C3, Week 2,n=12,6,6,9,9,6 | 1.139 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C3, Week 26,n=12,6,6,9,9,6 | 1.156 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C3, Day 5,n=12,6,6,9,9,6 | 1.113 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C3, Week 36,n=6,0,0,9,9,0 | 1.188 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C3, Day 4,n=12,6,6,9,9,6 | 1.144 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C4, Day 3,n=12,6,6,9,9,6 | 0.2142 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C3, Day 3,n=12,6,6,9,9,6 | 1.142 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C4, Day 4,n=12,6,6,9,9,6 | 0.2128 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C3, Day 2,n=12,6,6,9,9,6 | 1.114 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C4, Week 2,n=12,6,6,9,9,6 | 0.221 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C3, Baseline,n=12,6,6,9,9,6 | 1.074 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C4, Week 4,n=12,6,6,9,9,6 | 0.2063 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C4, Week 24,n=12,6,6,8,9,6 | 0.206 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C4, Baseline,n=12,6,6,9,9,6 | 0.2144 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C4, Week 36,n=6,0,0,9,9,0 | 0.2025 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C4, Week 12,n=12,6,6,9,9,6 | 0.2114 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C3, Week 18,n=12,6,6,9,9,6 | 1.184 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C4, Week 18,n=12,6,6,9,9,6 | 0.226 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C4, Day 5,n=12,6,6,9,9,6 | 0.2073 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C4, Day 2,n=12,6,6,9,9,6 | 0.2133 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C3, Week 4,n=12,6,6,9,9,6 | 1.07 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C3, Week 24,n=12,6,6,8,9,6 | 1.157 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C3, Week 8,n=12,6,6,9,9,6 | 1.117 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C4, Week 26,n=12,6,6,9,9,6 | 0.2115 Grams per liter |
| GSK3511294 30mg | Absolute Values of Complement (C)3 and C4 | C3, Week 12,n=12,6,6,9,9,6 | 1.147 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C4, Week 18,n=12,6,6,9,9,6 | 0.1678 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C4, Day 3,n=12,6,6,9,9,6 | 0.1962 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C3, Day 3,n=12,6,6,9,9,6 | 1.157 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C4, Week 36,n=6,0,0,9,9,0 | 0.206 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C3, Week 8,n=12,6,6,9,9,6 | 1.167 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C4, Day 4,n=12,6,6,9,9,6 | 0.1935 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C3, Day 2,n=12,6,6,9,9,6 | 1.188 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C4, Day 5,n=12,6,6,9,9,6 | 0.1943 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C4, Week 2,n=12,6,6,9,9,6 | 0.2018 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C3, Baseline,n=12,6,6,9,9,6 | 1.137 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C3, Week 12,n=12,6,6,9,9,6 | 1.211 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C4, Week 4,n=12,6,6,9,9,6 | 0.1872 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C4, Week 24,n=12,6,6,8,9,6 | 0.1909 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C3, Week 4,n=12,6,6,9,9,6 | 1.148 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C4, Week 8,n=12,6,6,9,9,6 | 0.1901 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C3, Week 18,n=12,6,6,9,9,6 | 1.231 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C3, Week 24,n=12,6,6,8,9,6 | 1.243 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C3, Week 2,n=12,6,6,9,9,6 | 1.174 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C4, Week 26,n=12,6,6,9,9,6 | 0.163 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C3, Week 26,n=12,6,6,9,9,6 | 1.222 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C3, Day 5,n=12,6,6,9,9,6 | 1.165 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C4, Week 12,n=12,6,6,9,9,6 | 0.196 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C3, Week 36,n=6,0,0,9,9,0 | 1.236 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C3, Day 4,n=12,6,6,9,9,6 | 1.165 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C4, Day 2,n=12,6,6,9,9,6 | 0.203 Grams per liter |
| GSK3511294 100mg | Absolute Values of Complement (C)3 and C4 | C4, Baseline,n=12,6,6,9,9,6 | 0.1939 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C4, Week 8,n=12,6,6,9,9,6 | 0.2231 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C4, Week 18,n=12,6,6,9,9,6 | 0.216 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C3, Week 32,n=6,6,6,0,0,6 | 1.204 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C3, Day 3,n=12,6,6,9,9,6 | 1.322 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C4, Day 3,n=12,6,6,9,9,6 | 0.223 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C3, Week 18,n=12,6,6,9,9,6 | 1.283 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C4, Week 12,n=12,6,6,9,9,6 | 0.2074 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C4, Week 40,n=2,0,0,0,0,6 | 0.2134 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C3, Week 24,n=12,6,6,8,9,6 | 1.222 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C4, Day 2,n=12,6,6,9,9,6 | 0.22 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C4, Day 4,n=12,6,6,9,9,6 | 0.2188 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C3, Day 2,n=12,6,6,9,9,6 | 1.286 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C4, Day 5,n=12,6,6,9,9,6 | 0.2163 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C3, Week 40,n=2,0,0,0,0,6 | 1.231 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C4, Week 26,n=12,6,6,9,9,6 | 0.226 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C3, Baseline,n=12,6,6,9,9,6 | 1.254 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C4, Week 24,n=12,6,6,8,9,6 | 0.2114 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C3, Week 12,n=12,6,6,9,9,6 | 1.28 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C4, Week 2,n=12,6,6,9,9,6 | 0.2169 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C3, Day 4,n=12,6,6,9,9,6 | 1.316 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C3, Week 8,n=12,6,6,9,9,6 | 1.34 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C4, Week 32,n=6,6,6,0,0,6 | 0.2051 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C3, Week 26,n=12,6,6,9,9,6 | 1.298 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C3, Day 5,n=12,6,6,9,9,6 | 1.305 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C4, Week 4,n=12,6,6,9,9,6 | 0.1929 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C3, Week 2,n=12,6,6,9,9,6 | 1.28 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C3, Week 4,n=12,6,6,9,9,6 | 1.22 Grams per liter |
| GSK3511294 300mg | Absolute Values of Complement (C)3 and C4 | C4, Baseline,n=12,6,6,9,9,6 | 0.215 Grams per liter |
Primary
Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP)
Blood samples were collected at indicated time-points for analysis of clinical parameters like hsCRP. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 36,n=6,0,0,9,9,0 | 0.4917 Milligrams per liter | Standard Deviation 1.3175 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 4,n=12,6,6,9,9,6 | -0.1253 Milligrams per liter | Standard Deviation 0.55902 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 1,n=11,6,6,9,9,6 | -0.2176 Milligrams per liter | Standard Deviation 0.3796 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 2,n=12,6,6,9,9,6 | 0.0638 Milligrams per liter | Standard Deviation 0.4462 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 2,n=12,6,6,9,9,6 | -0.3443 Milligrams per liter | Standard Deviation 0.44689 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 32,n=6,5,6,0,0,6 | 0.6393 Milligrams per liter | Standard Deviation 1.03514 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 26,n=12,6,6,9,9,6 | 0.2438 Milligrams per liter | Standard Deviation 0.75525 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 3,n=11,6,6,9,9,6 | -0.4376 Milligrams per liter | Standard Deviation 0.43692 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 8,n=12,6,6,9,9,6 | 0.5955 Milligrams per liter | Standard Deviation 1.62268 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 24,n=12,6,6,9,9,6 | 0.1163 Milligrams per liter | Standard Deviation 1.06052 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 4,n=12,6,6,9,9,6 | -0.4570 Milligrams per liter | Standard Deviation 0.42874 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 40,n=2,0,0,0,0,6 | -0.1450 Milligrams per liter | Standard Deviation 0.00707 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 18,n=12,6,6,9,9,6 | 0.1538 Milligrams per liter | Standard Deviation 0.54412 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 12,n=12,6,6,9,9,6 | 0.1455 Milligrams per liter | Standard Deviation 1.29507 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 5,n=12,6,6,9,9,6 | -0.3953 Milligrams per liter | Standard Deviation 0.37761 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 4,n=12,6,6,9,9,6 | 0.1433 Milligrams per liter | Standard Deviation 0.66069 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 2,n=12,6,6,9,9,6 | 0.0167 Milligrams per liter | Standard Deviation 0.21435 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 3,n=11,6,6,9,9,6 | -0.1417 Milligrams per liter | Standard Deviation 0.25818 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 1,n=11,6,6,9,9,6 | 0.2183 Milligrams per liter | Standard Deviation 0.23086 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 32,n=6,5,6,0,0,6 | 0.2860 Milligrams per liter | Standard Deviation 0.82509 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 4,n=12,6,6,9,9,6 | -0.1917 Milligrams per liter | Standard Deviation 0.23095 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 24,n=12,6,6,9,9,6 | 0.4383 Milligrams per liter | Standard Deviation 1.46248 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 2,n=12,6,6,9,9,6 | -0.1217 Milligrams per liter | Standard Deviation 0.28604 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 8,n=12,6,6,9,9,6 | 1.2817 Milligrams per liter | Standard Deviation 1.7993 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 12,n=12,6,6,9,9,6 | -0.1033 Milligrams per liter | Standard Deviation 0.36784 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 26,n=12,6,6,9,9,6 | 1.6333 Milligrams per liter | Standard Deviation 3.95614 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 18,n=12,6,6,9,9,6 | 0.1883 Milligrams per liter | Standard Deviation 0.22851 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 5,n=12,6,6,9,9,6 | -0.0117 Milligrams per liter | Standard Deviation 0.31244 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 2,n=12,6,6,9,9,6 | -0.6967 Milligrams per liter | Standard Deviation 1.30606 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 4,n=12,6,6,9,9,6 | -0.6433 Milligrams per liter | Standard Deviation 1.28969 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 8,n=12,6,6,9,9,6 | -0.3633 Milligrams per liter | Standard Deviation 1.6631 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 2,n=12,6,6,9,9,6 | -0.7367 Milligrams per liter | Standard Deviation 0.90943 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 3,n=11,6,6,9,9,6 | -0.8200 Milligrams per liter | Standard Deviation 1.10247 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 4,n=12,6,6,9,9,6 | -0.8683 Milligrams per liter | Standard Deviation 1.21224 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 5,n=12,6,6,9,9,6 | -0.7150 Milligrams per liter | Standard Deviation 1.23395 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 1,n=11,6,6,9,9,6 | -0.3033 Milligrams per liter | Standard Deviation 1.32284 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 12,n=12,6,6,9,9,6 | 0.1250 Milligrams per liter | Standard Deviation 0.61656 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 18,n=12,6,6,9,9,6 | 0.1317 Milligrams per liter | Standard Deviation 1.77035 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 24,n=12,6,6,9,9,6 | -0.6383 Milligrams per liter | Standard Deviation 1.36902 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 26,n=12,6,6,9,9,6 | -0.6383 Milligrams per liter | Standard Deviation 1.13732 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 32,n=6,5,6,0,0,6 | -0.2400 Milligrams per liter | Standard Deviation 1.63862 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 8,n=12,6,6,9,9,6 | -0.0878 Milligrams per liter | Standard Deviation 0.61243 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 4,n=12,6,6,9,9,6 | -0.5356 Milligrams per liter | Standard Deviation 0.91155 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 24,n=12,6,6,9,9,6 | 0.1356 Milligrams per liter | Standard Deviation 0.80296 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 2,n=12,6,6,9,9,6 | 0.1733 Milligrams per liter | Standard Deviation 0.86781 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 18,n=12,6,6,9,9,6 | 0.0700 Milligrams per liter | Standard Deviation 1.19067 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 1,n=11,6,6,9,9,6 | -0.5772 Milligrams per liter | Standard Deviation 0.86704 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 3,n=11,6,6,9,9,6 | -0.4367 Milligrams per liter | Standard Deviation 0.71042 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 36,n=6,0,0,9,9,0 | -0.5456 Milligrams per liter | Standard Deviation 1.15831 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 2,n=12,6,6,9,9,6 | -0.3178 Milligrams per liter | Standard Deviation 0.4588 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 5,n=12,6,6,9,9,6 | -0.5322 Milligrams per liter | Standard Deviation 0.9586 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 26,n=12,6,6,9,9,6 | 0.3344 Milligrams per liter | Standard Deviation 0.53761 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 12,n=12,6,6,9,9,6 | 0.9089 Milligrams per liter | Standard Deviation 1.31831 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 4,n=12,6,6,9,9,6 | -0.2689 Milligrams per liter | Standard Deviation 0.86847 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 5,n=12,6,6,9,9,6 | -1.4289 Milligrams per liter | Standard Deviation 2.35532 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 2,n=12,6,6,9,9,6 | 0.2478 Milligrams per liter | Standard Deviation 2.91047 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 4,n=12,6,6,9,9,6 | 2.6422 Milligrams per liter | Standard Deviation 11.57024 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 4,n=12,6,6,9,9,6 | -1.5311 Milligrams per liter | Standard Deviation 2.32545 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 12,n=12,6,6,9,9,6 | -0.4067 Milligrams per liter | Standard Deviation 3.85725 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 8,n=12,6,6,9,9,6 | -1.1656 Milligrams per liter | Standard Deviation 2.91829 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 18,n=12,6,6,9,9,6 | -1.1267 Milligrams per liter | Standard Deviation 2.89881 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 3,n=11,6,6,9,9,6 | -1.4100 Milligrams per liter | Standard Deviation 2.19445 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 36,n=6,0,0,9,9,0 | -0.1911 Milligrams per liter | Standard Deviation 3.93159 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 24,n=12,6,6,9,9,6 | -0.7989 Milligrams per liter | Standard Deviation 3.3642 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 2,n=12,6,6,9,9,6 | -1.0956 Milligrams per liter | Standard Deviation 1.50219 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 26,n=12,6,6,9,9,6 | -0.6933 Milligrams per liter | Standard Deviation 3.25344 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 1,n=11,6,6,9,9,6 | -1.3156 Milligrams per liter | Standard Deviation 2.57735 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 2,n=12,6,6,9,9,6 | -0.4867 Milligrams per liter | Standard Deviation 0.50816 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 4,n=12,6,6,9,9,6 | -0.4317 Milligrams per liter | Standard Deviation 0.54653 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 12,n=12,6,6,9,9,6 | 0.1000 Milligrams per liter | Standard Deviation 0.55274 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 32,n=6,5,6,0,0,6 | -0.1367 Milligrams per liter | Standard Deviation 0.73277 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 5,n=12,6,6,9,9,6 | -0.5867 Milligrams per liter | Standard Deviation 0.7759 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 26,n=12,6,6,9,9,6 | 0.2400 Milligrams per liter | Standard Deviation 0.76467 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 4,n=12,6,6,9,9,6 | -0.5867 Milligrams per liter | Standard Deviation 0.66476 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 8,n=12,6,6,9,9,6 | -0.2517 Milligrams per liter | Standard Deviation 0.7444 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 40,n=2,0,0,0,0,6 | 0.4333 Milligrams per liter | Standard Deviation 1.74105 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 18,n=12,6,6,9,9,6 | -0.3300 Milligrams per liter | Standard Deviation 0.53457 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 2,n=12,6,6,9,9,6 | -0.0967 Milligrams per liter | Standard Deviation 0.50091 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Day 3,n=11,6,6,9,9,6 | -0.4817 Milligrams per liter | Standard Deviation 0.53663 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 1,n=11,6,6,9,9,6 | -0.5717 Milligrams per liter | Standard Deviation 0.69534 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter: High Sensitivity C-reactive Protein (hsCRP) | Week 24,n=12,6,6,9,9,6 | -0.2142 Milligrams per liter | Standard Deviation 1.09332 |
Primary
Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium
Blood samples were collected at indicated time-points for analysis of clinical parameters like glucose, calcium, potassium, sodium, BUN, and magnesium. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 32,n=6,6,6,0,0,6 | -1.00 Millimoles per liter | Standard Deviation 0.949 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 4,n=12,6,6,9,9,6 | 1.1 Millimoles per liter | Standard Deviation 1.93 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 18,n=12,6,6,9,9,6 | 0.03 Millimoles per liter | Standard Deviation 0.548 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 5,n=12,6,6,9,9,6 | 1.3 Millimoles per liter | Standard Deviation 1.66 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 4,n=12,6,6,9,9,6 | -0.25 Millimoles per liter | Standard Deviation 1.098 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 12,n=12,6,6,9,9,6 | 0.32 Millimoles per liter | Standard Deviation 0.606 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 1,n=11,6,6,9,9,5 | 0.8 Millimoles per liter | Standard Deviation 2.14 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 2,n=12,6,5,9,9,6 | 0.06 Millimoles per liter | Standard Deviation 0.912 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 3,n=12,6,6,9,9,6 | -0.28 Millimoles per liter | Standard Deviation 0.673 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 8,n=12,6,6,9,9,6 | 0.06 Millimoles per liter | Standard Deviation 0.444 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 4,n=12,6,6,9,9,6 | -0.11 Millimoles per liter | Standard Deviation 0.712 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 4,n=12,6,6,9,9,6 | 0.19 Millimoles per liter | Standard Deviation 0.783 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 5,n=12,6,6,9,9,6 | -0.06 Millimoles per liter | Standard Deviation 0.647 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 1,n=11,6,6,9,9,5 | 0.00 Millimoles per liter | Standard Deviation 0.656 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 8,n=12,6,6,9,9,6 | -0.75 Millimoles per liter | Standard Deviation 0.989 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 2,n=12,6,6,9,9,6 | 0.03 Millimoles per liter | Standard Deviation 0.396 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 18,n=12,6,6,9,9,6 | -0.02 Millimoles per liter | Standard Deviation 0.343 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 12,n=12,6,6,9,9,6 | -0.75 Millimoles per liter | Standard Deviation 1.323 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 32,n=6,6,6,0,0,6 | 0.3 Millimoles per liter | Standard Deviation 2.25 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 4,n=12,6,6,9,9,6 | 0.00 Millimoles per liter | Standard Deviation 0.276 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 2,n=12,6,6,9,9,6 | 0.00 Millimoles per liter | Standard Deviation 0.316 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 26,n=12,6,6,9,9,6 | -0.38 Millimoles per liter | Standard Deviation 1.069 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 2,n=12,6,6,9,9,6 | 0.1 Millimoles per liter | Standard Deviation 1.51 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 1,n=11,6,6,9,9,5 | -0.02 Millimoles per liter | Standard Deviation 0.34 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 5,n=12,6,6,9,9,6 | 0.11 Millimoles per liter | Standard Deviation 0.303 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 40,n=2,0,0,0,0,6 | 0.5 Millimoles per liter | Standard Deviation 2.12 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 12,n=12,6,6,9,9,6 | 0.0 Millimoles per liter | Standard Deviation 2 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 4,n=12,6,6,9,9,6 | 0.13 Millimoles per liter | Standard Deviation 0.196 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 18,n=12,6,6,9,9,6 | 0.1 Millimoles per liter | Standard Deviation 1.51 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 24,n=12,6,6,9,9,6 | 0.3 Millimoles per liter | Standard Deviation 2.02 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 3,n=12,6,6,9,9,6 | -0.07 Millimoles per liter | Standard Deviation 0.29 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 26,n=12,6,6,9,9,6 | 0.2 Millimoles per liter | Standard Deviation 1.4 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 2,n=12,6,5,9,9,6 | -0.03 Millimoles per liter | Standard Deviation 0.23 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 36,n=6,0,0,9,9,0 | -0.3 Millimoles per liter | Standard Deviation 2.66 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 4,n=12,6,6,9,9,6 | 0.0 Millimoles per liter | Standard Deviation 2.04 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 40,n=2,0,0,0,0,6 | 0.000 Millimoles per liter | Standard Deviation 0.1131 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 36,n=6,0,0,9,9,0 | 0.000 Millimoles per liter | Standard Deviation 0.0607 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 2,n=12,6,5,9,9,6 | -0.020 Millimoles per liter | Standard Deviation 0.0467 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 3,n=12,6,6,9,9,6 | -0.012 Millimoles per liter | Standard Deviation 0.0542 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 32,n=6,6,6,0,0,6 | -0.020 Millimoles per liter | Standard Deviation 0.102 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 4,n=12,6,6,9,9,6 | -0.013 Millimoles per liter | Standard Deviation 0.075 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 5,n=12,6,6,9,9,6 | -0.017 Millimoles per liter | Standard Deviation 0.0545 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 26,n=12,6,6,9,9,6 | -0.018 Millimoles per liter | Standard Deviation 0.0731 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 1,n=11,6,6,9,9,5 | -0.004 Millimoles per liter | Standard Deviation 0.0427 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 24,n=12,6,6,9,9,6 | -0.035 Millimoles per liter | Standard Deviation 0.0452 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 2,n=12,6,6,9,9,6 | 0.005 Millimoles per liter | Standard Deviation 0.041 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 4,n=12,6,6,9,9,6 | 0.007 Millimoles per liter | Standard Deviation 0.0345 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 18,n=12,6,6,9,9,6 | 0.003 Millimoles per liter | Standard Deviation 0.0918 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 8,n=12,6,6,9,9,6 | -0.003 Millimoles per liter | Standard Deviation 0.0608 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 8,n=12,6,6,9,9,6 | 0.1 Millimoles per liter | Standard Deviation 1.93 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 12,n=12,6,6,9,9,6 | -0.017 Millimoles per liter | Standard Deviation 0.0489 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 12,n=12,6,6,9,9,6 | -0.013 Millimoles per liter | Standard Deviation 0.0492 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 40,n=2,0,0,0,0,6 | 0.030 Millimoles per liter | Standard Deviation 0.0424 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 2,n=12,6,5,9,9,6 | -0.83 Millimoles per liter | Standard Deviation 1.135 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 8,n=12,6,6,9,9,6 | 0.000 Millimoles per liter | Standard Deviation 0.0621 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 3,n=12,6,6,9,9,6 | -0.79 Millimoles per liter | Standard Deviation 1.373 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 12,n=12,6,6,9,9,6 | -0.02 Millimoles per liter | Standard Deviation 0.383 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 4,n=12,6,6,9,9,6 | -0.75 Millimoles per liter | Standard Deviation 1.357 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 4,n=12,6,6,9,9,6 | -0.040 Millimoles per liter | Standard Deviation 0.0615 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 5,n=12,6,6,9,9,6 | -0.71 Millimoles per liter | Standard Deviation 1.339 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 2,n=12,6,6,9,9,6 | -0.007 Millimoles per liter | Standard Deviation 0.0634 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 1,n=11,6,6,9,9,5 | -0.45 Millimoles per liter | Standard Deviation 1.15 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 1,n=11,6,6,9,9,5 | -0.009 Millimoles per liter | Standard Deviation 0.0745 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 5,n=12,6,6,9,9,6 | -0.023 Millimoles per liter | Standard Deviation 0.0738 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 18,n=12,6,6,9,9,6 | -1.08 Millimoles per liter | Standard Deviation 1.505 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 24,n=12,6,6,9,9,6 | -0.79 Millimoles per liter | Standard Deviation 1.389 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 32,n=6,6,6,0,0,6 | -0.010 Millimoles per liter | Standard Deviation 0.0245 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 4,n=12,6,6,9,9,6 | 0.012 Millimoles per liter | Standard Deviation 0.0658 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 18,n=12,6,6,9,9,6 | 0.017 Millimoles per liter | Standard Deviation 0.0525 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 24,n=12,6,6,9,9,6 | 0.008 Millimoles per liter | Standard Deviation 0.0422 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 26,n=12,6,6,9,9,6 | 0.002 Millimoles per liter | Standard Deviation 0.0542 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 3,n=12,6,6,9,9,6 | 0.008 Millimoles per liter | Standard Deviation 0.0833 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 8,n=12,6,6,9,9,6 | 0.18 Millimoles per liter | Standard Deviation 0.234 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 2,n=12,6,5,9,9,6 | -0.025 Millimoles per liter | Standard Deviation 0.0645 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 40,n=2,0,0,0,0,6 | 0.40 Millimoles per liter | Standard Deviation 0.566 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 36,n=6,0,0,9,9,0 | -0.58 Millimoles per liter | Standard Deviation 1.855 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium Week 36,n=6,0,0,9,9,0 | -0.013 Millimoles per liter | Standard Deviation 0.0532 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 36,n=6,0,0,9,9,0 | 0.17 Millimoles per liter | Standard Deviation 0.493 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 40,n=2,0,0,0,0,6 | -1.00 Millimoles per liter | Standard Deviation 0 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 24,n=12,6,6,9,9,6 | -0.03 Millimoles per liter | Standard Deviation 0.458 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 26,n=12,6,6,9,9,6 | -0.13 Millimoles per liter | Standard Deviation 0.36 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 32,n=6,6,6,0,0,6 | 0.40 Millimoles per liter | Standard Deviation 1.233 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 32,n=6,6,6,0,0,6 | -0.15 Millimoles per liter | Standard Deviation 0.476 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 36,n=6,0,0,9,9,0 | 0.07 Millimoles per liter | Standard Deviation 0.121 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 26,n=12,6,6,9,9,6 | 0.18 Millimoles per liter | Standard Deviation 0.506 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium Week 40,n=2,0,0,0,0,6 | -0.35 Millimoles per liter | Standard Deviation 0.495 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 2,n=12,6,5,9,9,6 | 0.8 Millimoles per liter | Standard Deviation 2.14 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 2,n=12,6,6,9,9,6 | -0.33 Millimoles per liter | Standard Deviation 1.267 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 24,n=12,6,6,9,9,6 | 0.38 Millimoles per liter | Standard Deviation 1.131 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 3,n=12,6,6,9,9,6 | 1.2 Millimoles per liter | Standard Deviation 1.75 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 2,n=12,6,6,9,9,6 | -0.003 Millimoles per liter | Standard Deviation 0.0513 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 2,n=12,6,5,9,9,6 | 0.02 Millimoles per liter | Standard Deviation 0.179 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 4,n=12,6,6,9,9,6 | -0.017 Millimoles per liter | Standard Deviation 0.0612 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 32,n=6,6,6,0,0,6 | 0.02 Millimoles per liter | Standard Deviation 0.194 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 2,n=12,6,5,9,9,6 | 0.0 Millimoles per liter | Standard Deviation 1.9 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 18,n=12,6,6,9,9,6 | -0.030 Millimoles per liter | Standard Deviation 0.0576 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 2,n=12,6,5,9,9,6 | -0.037 Millimoles per liter | Standard Deviation 0.0585 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 26,n=12,6,6,9,9,6 | -0.03 Millimoles per liter | Standard Deviation 0.48 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 3,n=12,6,6,9,9,6 | -0.043 Millimoles per liter | Standard Deviation 0.0388 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 4,n=12,6,6,9,9,6 | -0.033 Millimoles per liter | Standard Deviation 0.0589 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 32,n=6,6,6,0,0,6 | 0.027 Millimoles per liter | Standard Deviation 0.0776 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 24,n=12,6,6,9,9,6 | -0.023 Millimoles per liter | Standard Deviation 0.0585 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 4,n=12,6,6,9,9,6 | -0.020 Millimoles per liter | Standard Deviation 0.031 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 26,n=12,6,6,9,9,6 | -0.067 Millimoles per liter | Standard Deviation 0.0532 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 32,n=6,6,6,0,0,6 | -0.023 Millimoles per liter | Standard Deviation 0.0497 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 5,n=12,6,6,9,9,6 | -0.047 Millimoles per liter | Standard Deviation 0.0745 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 3,n=12,6,6,9,9,6 | -0.033 Millimoles per liter | Standard Deviation 0.1009 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 1,n=11,6,6,9,9,5 | -0.003 Millimoles per liter | Standard Deviation 0.0638 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 24,n=12,6,6,9,9,6 | -0.053 Millimoles per liter | Standard Deviation 0.0677 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 26,n=12,6,6,9,9,6 | -0.057 Millimoles per liter | Standard Deviation 0.032 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 24,n=12,6,6,9,9,6 | -0.17 Millimoles per liter | Standard Deviation 0.876 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 18,n=12,6,6,9,9,6 | -0.013 Millimoles per liter | Standard Deviation 0.0826 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 8,n=12,6,6,9,9,6 | -0.027 Millimoles per liter | Standard Deviation 0.0501 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 26,n=12,6,6,9,9,6 | -0.33 Millimoles per liter | Standard Deviation 0.983 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 12,n=12,6,6,9,9,6 | -0.060 Millimoles per liter | Standard Deviation 0.0657 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 2,n=12,6,5,9,9,6 | -0.027 Millimoles per liter | Standard Deviation 0.0615 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 8,n=12,6,6,9,9,6 | -0.007 Millimoles per liter | Standard Deviation 0.1171 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 2,n=12,6,5,9,9,6 | -0.17 Millimoles per liter | Standard Deviation 0.408 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 12,n=12,6,6,9,9,6 | -0.02 Millimoles per liter | Standard Deviation 0.387 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 3,n=12,6,6,9,9,6 | 0.00 Millimoles per liter | Standard Deviation 0.316 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 32,n=6,6,6,0,0,6 | 0.03 Millimoles per liter | Standard Deviation 0.242 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 4,n=12,6,6,9,9,6 | -0.027 Millimoles per liter | Standard Deviation 0.0766 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 18,n=12,6,6,9,9,6 | -0.02 Millimoles per liter | Standard Deviation 0.331 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 4,n=12,6,6,9,9,6 | 0.2 Millimoles per liter | Standard Deviation 1.6 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 4,n=12,6,6,9,9,6 | -0.25 Millimoles per liter | Standard Deviation 0.274 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 26,n=12,6,6,9,9,6 | -0.10 Millimoles per liter | Standard Deviation 0.346 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 5,n=12,6,6,9,9,6 | 1.7 Millimoles per liter | Standard Deviation 1.51 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 12,n=12,6,6,9,9,6 | -0.15 Millimoles per liter | Standard Deviation 0.428 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 24,n=12,6,6,9,9,6 | -0.13 Millimoles per liter | Standard Deviation 0.333 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 5,n=12,6,6,9,9,6 | -0.33 Millimoles per liter | Standard Deviation 0.816 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 1,n=11,6,6,9,9,5 | 0.8 Millimoles per liter | Standard Deviation 2.32 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 2,n=12,6,5,9,9,6 | -0.13 Millimoles per liter | Standard Deviation 0.418 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 4,n=12,6,6,9,9,6 | -0.75 Millimoles per liter | Standard Deviation 0.524 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 8,n=12,6,6,9,9,6 | -0.42 Millimoles per liter | Standard Deviation 0.585 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 3,n=12,6,6,9,9,6 | -0.10 Millimoles per liter | Standard Deviation 1.215 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 2,n=12,6,6,9,9,6 | -0.013 Millimoles per liter | Standard Deviation 0.0547 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 4,n=12,6,6,9,9,6 | 0.12 Millimoles per liter | Standard Deviation 0.987 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 26,n=12,6,6,9,9,6 | 0.0 Millimoles per liter | Standard Deviation 1.9 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 4,n=12,6,6,9,9,6 | -0.33 Millimoles per liter | Standard Deviation 0.543 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 1,n=11,6,6,9,9,5 | -0.50 Millimoles per liter | Standard Deviation 1.183 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 5,n=12,6,6,9,9,6 | -0.07 Millimoles per liter | Standard Deviation 0.612 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 4,n=12,6,6,9,9,6 | -0.07 Millimoles per liter | Standard Deviation 0.372 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 2,n=12,6,6,9,9,6 | -0.05 Millimoles per liter | Standard Deviation 0.295 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 1,n=11,6,6,9,9,5 | -0.35 Millimoles per liter | Standard Deviation 0.394 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 8,n=12,6,6,9,9,6 | 0.0 Millimoles per liter | Standard Deviation 2.53 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 8,n=12,6,6,9,9,6 | -0.17 Millimoles per liter | Standard Deviation 1.033 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 1,n=11,6,6,9,9,5 | -0.047 Millimoles per liter | Standard Deviation 0.0723 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 2,n=12,6,6,9,9,6 | -0.75 Millimoles per liter | Standard Deviation 1.037 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 12,n=12,6,6,9,9,6 | 0.17 Millimoles per liter | Standard Deviation 0.983 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 18,n=12,6,6,9,9,6 | 0.00 Millimoles per liter | Standard Deviation 0.329 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 2,n=12,6,6,9,9,6 | 0.05 Millimoles per liter | Standard Deviation 0.315 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 5,n=12,6,6,9,9,6 | -0.050 Millimoles per liter | Standard Deviation 0.0846 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 3,n=12,6,6,9,9,6 | 0.0 Millimoles per liter | Standard Deviation 0.89 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 32,n=6,6,6,0,0,6 | -0.33 Millimoles per liter | Standard Deviation 0.683 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 1,n=11,6,6,9,9,5 | 0.05 Millimoles per liter | Standard Deviation 0.451 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 24,n=12,6,6,9,9,6 | -0.02 Millimoles per liter | Standard Deviation 0.397 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 4,n=12,6,6,9,9,6 | 1.0 Millimoles per liter | Standard Deviation 1.41 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 32,n=6,6,6,0,0,6 | 0.5 Millimoles per liter | Standard Deviation 3.56 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 5,n=12,6,6,9,9,6 | 0.10 Millimoles per liter | Standard Deviation 0.276 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 4,n=12,6,6,9,9,6 | 0.05 Millimoles per liter | Standard Deviation 0.472 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 18,n=12,6,6,9,9,6 | 0.50 Millimoles per liter | Standard Deviation 1.414 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 12,n=12,6,6,9,9,6 | 1.0 Millimoles per liter | Standard Deviation 1.26 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 2,n=12,6,6,9,9,6 | 1.0 Millimoles per liter | Standard Deviation 1.26 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 8,n=12,6,6,9,9,6 | 0.00 Millimoles per liter | Standard Deviation 0.352 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 18,n=12,6,6,9,9,6 | -0.7 Millimoles per liter | Standard Deviation 2.25 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 3,n=12,6,6,9,9,6 | 0.03 Millimoles per liter | Standard Deviation 0.258 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 12,n=12,6,6,9,9,6 | -0.043 Millimoles per liter | Standard Deviation 0.0686 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 24,n=12,6,6,9,9,6 | -0.2 Millimoles per liter | Standard Deviation 1.6 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 2,n=12,6,6,9,9,6 | -0.033 Millimoles per liter | Standard Deviation 0.0855 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 2,n=12,6,5,9,9,6 | 0.44 Millimoles per liter | Standard Deviation 0.365 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 32,n=6,6,6,0,0,6 | -0.28 Millimoles per liter | Standard Deviation 0.703 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 26,n=12,6,6,9,9,6 | -0.7 Millimoles per liter | Standard Deviation 2.88 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 18,n=12,6,6,9,9,6 | 0.07 Millimoles per liter | Standard Deviation 0.234 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 4,n=12,6,6,9,9,6 | -0.007 Millimoles per liter | Standard Deviation 0.0575 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 32,n=6,6,6,0,0,6 | -1.8 Millimoles per liter | Standard Deviation 1.17 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 3,n=12,6,6,9,9,6 | 0.02 Millimoles per liter | Standard Deviation 0.204 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 12,n=12,6,6,9,9,6 | 0.17 Millimoles per liter | Standard Deviation 0.816 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 8,n=12,6,6,9,9,6 | 0.12 Millimoles per liter | Standard Deviation 0.117 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 1,n=11,6,6,9,9,5 | -1.7 Millimoles per liter | Standard Deviation 1.03 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 18,n=12,6,6,9,9,6 | 0.000 Millimoles per liter | Standard Deviation 0.0456 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 3,n=12,6,6,9,9,6 | 0.027 Millimoles per liter | Standard Deviation 0.1041 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 5,n=12,6,6,9,9,6 | 0.67 Millimoles per liter | Standard Deviation 1.169 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 2,n=12,6,5,9,9,6 | 0.008 Millimoles per liter | Standard Deviation 0.0642 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 32,n=6,6,6,0,0,6 | 0.020 Millimoles per liter | Standard Deviation 0.0867 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 4,n=12,6,6,9,9,6 | 0.017 Millimoles per liter | Standard Deviation 0.0794 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 2,n=12,6,5,9,9,6 | 0.14 Millimoles per liter | Standard Deviation 0.439 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 3,n=12,6,6,9,9,6 | -0.003 Millimoles per liter | Standard Deviation 0.0709 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 2,n=12,6,6,9,9,6 | 0.20 Millimoles per liter | Standard Deviation 0.341 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 8,n=12,6,6,9,9,6 | 0.27 Millimoles per liter | Standard Deviation 0.824 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 18,n=12,6,6,9,9,6 | 0.58 Millimoles per liter | Standard Deviation 1.068 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 24,n=12,6,6,9,9,6 | -0.017 Millimoles per liter | Standard Deviation 0.0686 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 26,n=12,6,6,9,9,6 | -0.017 Millimoles per liter | Standard Deviation 0.0463 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 4,n=12,6,6,9,9,6 | 0.000 Millimoles per liter | Standard Deviation 0.0456 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 26,n=12,6,6,9,9,6 | -0.017 Millimoles per liter | Standard Deviation 0.1255 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 24,n=12,6,6,9,9,6 | 0.03 Millimoles per liter | Standard Deviation 0.234 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 3,n=12,6,6,9,9,6 | -0.93 Millimoles per liter | Standard Deviation 1.117 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 4,n=12,6,6,9,9,6 | 0.75 Millimoles per liter | Standard Deviation 0.822 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 5,n=12,6,6,9,9,6 | -0.033 Millimoles per liter | Standard Deviation 0.0413 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 5,n=12,6,6,9,9,6 | 0.003 Millimoles per liter | Standard Deviation 0.0942 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 24,n=12,6,6,9,9,6 | 0.007 Millimoles per liter | Standard Deviation 0.0864 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 26,n=12,6,6,9,9,6 | 0.00 Millimoles per liter | Standard Deviation 0.179 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 4,n=12,6,6,9,9,6 | 0.03 Millimoles per liter | Standard Deviation 0.582 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 1,n=11,6,6,9,9,5 | 0.017 Millimoles per liter | Standard Deviation 0.048 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 4,n=12,6,6,9,9,6 | 0.0 Millimoles per liter | Standard Deviation 2.19 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 24,n=12,6,6,9,9,6 | 1.42 Millimoles per liter | Standard Deviation 1.594 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 4,n=12,6,6,9,9,6 | -0.33 Millimoles per liter | Standard Deviation 0.857 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 12,n=12,6,6,9,9,6 | 0.000 Millimoles per liter | Standard Deviation 0.0551 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 2,n=12,6,6,9,9,6 | 0.033 Millimoles per liter | Standard Deviation 0.0484 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 4,n=12,6,6,9,9,6 | -1.2 Millimoles per liter | Standard Deviation 0.98 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 18,n=12,6,6,9,9,6 | -0.033 Millimoles per liter | Standard Deviation 0.0845 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 4,n=12,6,6,9,9,6 | 0.08 Millimoles per liter | Standard Deviation 0.232 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 32,n=6,6,6,0,0,6 | 0.017 Millimoles per liter | Standard Deviation 0.048 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 4,n=12,6,6,9,9,6 | -0.33 Millimoles per liter | Standard Deviation 1.169 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 12,n=12,6,6,9,9,6 | -0.003 Millimoles per liter | Standard Deviation 0.1274 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 2,n=12,6,5,9,9,6 | -0.004 Millimoles per liter | Standard Deviation 0.0865 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 4,n=12,6,6,9,9,6 | 0.27 Millimoles per liter | Standard Deviation 0.344 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 8,n=12,6,6,9,9,6 | -0.007 Millimoles per liter | Standard Deviation 0.0484 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 8,n=12,6,6,9,9,6 | -0.5 Millimoles per liter | Standard Deviation 1.52 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 24,n=12,6,6,9,9,6 | -1.5 Millimoles per liter | Standard Deviation 1.22 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 26,n=12,6,6,9,9,6 | 0.83 Millimoles per liter | Standard Deviation 1.366 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 2,n=12,6,5,9,9,6 | 0.0 Millimoles per liter | Standard Deviation 1.58 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 8,n=12,6,6,9,9,6 | -0.003 Millimoles per liter | Standard Deviation 0.0898 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 1,n=11,6,6,9,9,5 | 0.18 Millimoles per liter | Standard Deviation 0.194 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 5,n=12,6,6,9,9,6 | 0.28 Millimoles per liter | Standard Deviation 0.958 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 26,n=12,6,6,9,9,6 | 0.62 Millimoles per liter | Standard Deviation 1.144 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 18,n=12,6,6,9,9,6 | -1.0 Millimoles per liter | Standard Deviation 1.1 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 2,n=12,6,5,9,9,6 | 0.20 Millimoles per liter | Standard Deviation 1.304 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 2,n=12,6,6,9,9,6 | 0.00 Millimoles per liter | Standard Deviation 0.525 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 32,n=6,6,6,0,0,6 | 0.75 Millimoles per liter | Standard Deviation 1.405 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 24,n=12,6,6,9,9,6 | 0.02 Millimoles per liter | Standard Deviation 0.773 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 8,n=12,6,6,9,9,6 | 1.17 Millimoles per liter | Standard Deviation 1.252 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 3,n=12,6,6,9,9,6 | -0.17 Millimoles per liter | Standard Deviation 0.931 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 1,n=11,6,6,9,9,5 | 0.50 Millimoles per liter | Standard Deviation 1.581 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 4,n=12,6,6,9,9,6 | -0.013 Millimoles per liter | Standard Deviation 0.1198 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 2,n=12,6,6,9,9,6 | -0.7 Millimoles per liter | Standard Deviation 1.51 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 3,n=12,6,6,9,9,6 | 0.3 Millimoles per liter | Standard Deviation 1.21 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 2,n=12,6,6,9,9,6 | 0.33 Millimoles per liter | Standard Deviation 1.78 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 18,n=12,6,6,9,9,6 | 0.42 Millimoles per liter | Standard Deviation 1.017 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 1,n=11,6,6,9,9,5 | -0.18 Millimoles per liter | Standard Deviation 1.28 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 32,n=6,6,6,0,0,6 | 0.12 Millimoles per liter | Standard Deviation 0.223 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 12,n=12,6,6,9,9,6 | -0.8 Millimoles per liter | Standard Deviation 1.47 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 1,n=11,6,6,9,9,5 | 0.017 Millimoles per liter | Standard Deviation 0.0916 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 12,n=12,6,6,9,9,6 | 0.13 Millimoles per liter | Standard Deviation 1.093 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 5,n=12,6,6,9,9,6 | 0.00 Millimoles per liter | Standard Deviation 0.126 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 12,n=12,6,6,9,9,6 | 0.12 Millimoles per liter | Standard Deviation 0.331 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 5,n=12,6,6,9,9,6 | -1.3 Millimoles per liter | Standard Deviation 1.86 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 1,n=11,6,6,9,9,5 | 0.1 Millimoles per liter | Standard Deviation 1.45 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 2,n=12,6,6,9,9,6 | 0.0 Millimoles per liter | Standard Deviation 1.32 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 2,n=12,6,5,9,9,6 | 0.000 Millimoles per liter | Standard Deviation 0.0361 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 5,n=12,6,6,9,9,6 | 0.007 Millimoles per liter | Standard Deviation 0.0283 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 1,n=11,6,6,9,9,5 | -0.007 Millimoles per liter | Standard Deviation 0.052 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 4,n=12,6,6,9,9,6 | 0.007 Millimoles per liter | Standard Deviation 0.0346 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 18,n=12,6,6,9,9,6 | 0.000 Millimoles per liter | Standard Deviation 0.0566 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 26,n=12,6,6,9,9,6 | 0.000 Millimoles per liter | Standard Deviation 0.0469 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium Week 36,n=6,0,0,9,9,0 | 0.004 Millimoles per liter | Standard Deviation 0.0133 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 4,n=12,6,6,9,9,6 | -0.61 Millimoles per liter | Standard Deviation 0.928 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 4,n=12,6,6,9,9,6 | 0.22 Millimoles per liter | Standard Deviation 0.972 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 8,n=12,6,6,9,9,6 | 0.06 Millimoles per liter | Standard Deviation 1.074 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 12,n=12,6,6,9,9,6 | -0.06 Millimoles per liter | Standard Deviation 0.527 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 4,n=12,6,6,9,9,6 | -1.2 Millimoles per liter | Standard Deviation 1.3 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 8,n=12,6,6,9,9,6 | -0.7 Millimoles per liter | Standard Deviation 1.94 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 12,n=12,6,6,9,9,6 | -0.2 Millimoles per liter | Standard Deviation 1.56 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 18,n=12,6,6,9,9,6 | -0.7 Millimoles per liter | Standard Deviation 1.22 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 24,n=12,6,6,9,9,6 | -0.9 Millimoles per liter | Standard Deviation 2.37 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 26,n=12,6,6,9,9,6 | -1.1 Millimoles per liter | Standard Deviation 2.15 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 36,n=6,0,0,9,9,0 | -0.9 Millimoles per liter | Standard Deviation 1.9 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 3,n=12,6,6,9,9,6 | 0.007 Millimoles per liter | Standard Deviation 0.0283 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 4,n=12,6,6,9,9,6 | -0.007 Millimoles per liter | Standard Deviation 0.0283 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 2,n=12,6,6,9,9,6 | 0.018 Millimoles per liter | Standard Deviation 0.057 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 8,n=12,6,6,9,9,6 | 0.016 Millimoles per liter | Standard Deviation 0.024 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 2,n=12,6,5,9,9,6 | -0.67 Millimoles per liter | Standard Deviation 0.791 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 3,n=12,6,6,9,9,6 | -0.72 Millimoles per liter | Standard Deviation 0.833 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 5,n=12,6,6,9,9,6 | -0.61 Millimoles per liter | Standard Deviation 0.961 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 1,n=11,6,6,9,9,5 | -0.44 Millimoles per liter | Standard Deviation 1.014 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 2,n=12,6,6,9,9,6 | 0.06 Millimoles per liter | Standard Deviation 0.726 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 18,n=12,6,6,9,9,6 | 0.39 Millimoles per liter | Standard Deviation 1.516 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 12,n=12,6,6,9,9,6 | 0.011 Millimoles per liter | Standard Deviation 0.0448 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 24,n=12,6,6,9,9,6 | 0.000 Millimoles per liter | Standard Deviation 0.0424 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 24,n=12,6,6,9,9,6 | 0.11 Millimoles per liter | Standard Deviation 1.453 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 26,n=12,6,6,9,9,6 | -0.17 Millimoles per liter | Standard Deviation 1 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 36,n=6,0,0,9,9,0 | -0.72 Millimoles per liter | Standard Deviation 1.034 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 4,n=12,6,6,9,9,6 | -0.8 Millimoles per liter | Standard Deviation 2.11 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 24,n=12,6,6,9,9,6 | 0.12 Millimoles per liter | Standard Deviation 0.291 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 26,n=12,6,6,9,9,6 | -0.01 Millimoles per liter | Standard Deviation 0.28 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 36,n=6,0,0,9,9,0 | 0.08 Millimoles per liter | Standard Deviation 0.311 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 2,n=12,6,5,9,9,6 | -0.3 Millimoles per liter | Standard Deviation 1.94 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 3,n=12,6,6,9,9,6 | 0.4 Millimoles per liter | Standard Deviation 1.33 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 5,n=12,6,6,9,9,6 | -0.2 Millimoles per liter | Standard Deviation 2.22 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 2,n=12,6,5,9,9,6 | -0.11 Millimoles per liter | Standard Deviation 0.533 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 3,n=12,6,6,9,9,6 | -0.18 Millimoles per liter | Standard Deviation 0.455 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 4,n=12,6,6,9,9,6 | 0.26 Millimoles per liter | Standard Deviation 0.94 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 5,n=12,6,6,9,9,6 | 0.01 Millimoles per liter | Standard Deviation 0.775 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 1,n=11,6,6,9,9,5 | -0.20 Millimoles per liter | Standard Deviation 0.624 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 2,n=12,6,6,9,9,6 | -0.02 Millimoles per liter | Standard Deviation 1.027 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 4,n=12,6,6,9,9,6 | -0.28 Millimoles per liter | Standard Deviation 0.678 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 8,n=12,6,6,9,9,6 | 0.04 Millimoles per liter | Standard Deviation 0.43 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 12,n=12,6,6,9,9,6 | 0.08 Millimoles per liter | Standard Deviation 0.905 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 18,n=12,6,6,9,9,6 | -0.17 Millimoles per liter | Standard Deviation 0.541 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 24,n=12,6,6,9,9,6 | -0.27 Millimoles per liter | Standard Deviation 0.654 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 26,n=12,6,6,9,9,6 | -0.09 Millimoles per liter | Standard Deviation 0.362 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 36,n=6,0,0,9,9,0 | -0.26 Millimoles per liter | Standard Deviation 0.436 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 2,n=12,6,5,9,9,6 | -0.049 Millimoles per liter | Standard Deviation 0.0736 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 3,n=12,6,6,9,9,6 | -0.011 Millimoles per liter | Standard Deviation 0.0756 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 4,n=12,6,6,9,9,6 | -0.033 Millimoles per liter | Standard Deviation 0.0762 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 5,n=12,6,6,9,9,6 | -0.040 Millimoles per liter | Standard Deviation 0.064 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 1,n=11,6,6,9,9,5 | -0.044 Millimoles per liter | Standard Deviation 0.0847 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 2,n=12,6,6,9,9,6 | -0.002 Millimoles per liter | Standard Deviation 0.0863 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 4,n=12,6,6,9,9,6 | -0.031 Millimoles per liter | Standard Deviation 0.0729 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 8,n=12,6,6,9,9,6 | -0.024 Millimoles per liter | Standard Deviation 0.0767 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 12,n=12,6,6,9,9,6 | -0.020 Millimoles per liter | Standard Deviation 0.0755 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 18,n=12,6,6,9,9,6 | 0.007 Millimoles per liter | Standard Deviation 0.086 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 24,n=12,6,6,9,9,6 | -0.016 Millimoles per liter | Standard Deviation 0.0942 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 26,n=12,6,6,9,9,6 | -0.056 Millimoles per liter | Standard Deviation 0.026 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 36,n=6,0,0,9,9,0 | -0.013 Millimoles per liter | Standard Deviation 0.0624 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 2,n=12,6,5,9,9,6 | 0.06 Millimoles per liter | Standard Deviation 0.397 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 3,n=12,6,6,9,9,6 | 0.14 Millimoles per liter | Standard Deviation 0.332 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 4,n=12,6,6,9,9,6 | 0.03 Millimoles per liter | Standard Deviation 0.218 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 5,n=12,6,6,9,9,6 | 0.11 Millimoles per liter | Standard Deviation 0.267 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 1,n=11,6,6,9,9,5 | 0.22 Millimoles per liter | Standard Deviation 0.342 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 2,n=12,6,6,9,9,6 | -0.04 Millimoles per liter | Standard Deviation 0.201 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 4,n=12,6,6,9,9,6 | -0.04 Millimoles per liter | Standard Deviation 0.283 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 8,n=12,6,6,9,9,6 | 0.00 Millimoles per liter | Standard Deviation 0.269 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 12,n=12,6,6,9,9,6 | 0.00 Millimoles per liter | Standard Deviation 0.278 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 18,n=12,6,6,9,9,6 | 0.03 Millimoles per liter | Standard Deviation 0.287 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 24,n=12,6,6,9,9,6 | -0.26 Millimoles per liter | Standard Deviation 0.928 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 24,n=12,6,6,9,9,6 | 0.022 Millimoles per liter | Standard Deviation 0.1218 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 4,n=12,6,6,9,9,6 | 0.11 Millimoles per liter | Standard Deviation 0.196 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 5,n=12,6,6,9,9,6 | -0.036 Millimoles per liter | Standard Deviation 0.0536 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 5,n=12,6,6,9,9,6 | -0.031 Millimoles per liter | Standard Deviation 0.0933 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 4,n=12,6,6,9,9,6 | -0.060 Millimoles per liter | Standard Deviation 0.049 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 2,n=12,6,6,9,9,6 | 0.09 Millimoles per liter | Standard Deviation 0.352 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 26,n=12,6,6,9,9,6 | 0.013 Millimoles per liter | Standard Deviation 0.0529 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 2,n=12,6,6,9,9,6 | -0.17 Millimoles per liter | Standard Deviation 0.612 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 26,n=12,6,6,9,9,6 | -0.22 Millimoles per liter | Standard Deviation 0.758 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 3,n=12,6,6,9,9,6 | -0.064 Millimoles per liter | Standard Deviation 0.0564 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 1,n=11,6,6,9,9,5 | 0.11 Millimoles per liter | Standard Deviation 0.782 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 26,n=12,6,6,9,9,6 | 0.22 Millimoles per liter | Standard Deviation 0.755 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 1,n=11,6,6,9,9,5 | -0.029 Millimoles per liter | Standard Deviation 0.0657 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 2,n=12,6,5,9,9,6 | 0.9 Millimoles per liter | Standard Deviation 1.76 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 36,n=6,0,0,9,9,0 | 0.029 Millimoles per liter | Standard Deviation 0.0813 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 36,n=6,0,0,9,9,0 | -1.3 Millimoles per liter | Standard Deviation 1 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 4,n=12,6,6,9,9,6 | 0.17 Millimoles per liter | Standard Deviation 1.225 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 5,n=12,6,6,9,9,6 | -0.17 Millimoles per liter | Standard Deviation 0.968 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 26,n=12,6,6,9,9,6 | -1.1 Millimoles per liter | Standard Deviation 1.54 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 2,n=12,6,5,9,9,6 | 0.016 Millimoles per liter | Standard Deviation 0.1207 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 2,n=12,6,5,9,9,6 | -0.036 Millimoles per liter | Standard Deviation 0.0623 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 2,n=12,6,5,9,9,6 | 0.18 Millimoles per liter | Standard Deviation 0.307 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 26,n=12,6,6,9,9,6 | 0.07 Millimoles per liter | Standard Deviation 0.235 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 24,n=12,6,6,9,9,6 | 0.2 Millimoles per liter | Standard Deviation 1.64 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 2,n=12,6,6,9,9,6 | 0.062 Millimoles per liter | Standard Deviation 0.0771 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 24,n=12,6,6,9,9,6 | 0.33 Millimoles per liter | Standard Deviation 1.146 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 18,n=12,6,6,9,9,6 | 0.13 Millimoles per liter | Standard Deviation 0.308 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 3,n=12,6,6,9,9,6 | 0.01 Millimoles per liter | Standard Deviation 0.136 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 4,n=12,6,6,9,9,6 | 0.00 Millimoles per liter | Standard Deviation 0.707 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 12,n=12,6,6,9,9,6 | -0.3 Millimoles per liter | Standard Deviation 1.22 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 24,n=12,6,6,9,9,6 | -0.047 Millimoles per liter | Standard Deviation 0.0557 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 8,n=12,6,6,9,9,6 | -1.1 Millimoles per liter | Standard Deviation 1.05 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 12,n=12,6,6,9,9,6 | 0.04 Millimoles per liter | Standard Deviation 0.213 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 4,n=12,6,6,9,9,6 | 0.06 Millimoles per liter | Standard Deviation 0.246 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 3,n=12,6,6,9,9,6 | -0.28 Millimoles per liter | Standard Deviation 0.755 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 18,n=12,6,6,9,9,6 | -0.036 Millimoles per liter | Standard Deviation 0.0773 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 4,n=12,6,6,9,9,6 | -0.6 Millimoles per liter | Standard Deviation 1.67 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 4,n=12,6,6,9,9,6 | 0.022 Millimoles per liter | Standard Deviation 0.0977 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 36,n=6,0,0,9,9,0 | 0.09 Millimoles per liter | Standard Deviation 0.215 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 5,n=12,6,6,9,9,6 | 0.04 Millimoles per liter | Standard Deviation 0.207 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 2,n=12,6,5,9,9,6 | -0.28 Millimoles per liter | Standard Deviation 0.833 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 3,n=12,6,6,9,9,6 | -0.022 Millimoles per liter | Standard Deviation 0.1012 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 2,n=12,6,6,9,9,6 | -0.3 Millimoles per liter | Standard Deviation 1.66 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium Week 36,n=6,0,0,9,9,0 | -0.013 Millimoles per liter | Standard Deviation 0.0447 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 26,n=12,6,6,9,9,6 | -0.036 Millimoles per liter | Standard Deviation 0.0477 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 8,n=12,6,6,9,9,6 | 0.031 Millimoles per liter | Standard Deviation 0.0906 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 24,n=12,6,6,9,9,6 | -0.04 Millimoles per liter | Standard Deviation 0.26 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 1,n=11,6,6,9,9,5 | -0.23 Millimoles per liter | Standard Deviation 1.015 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 18,n=12,6,6,9,9,6 | 0.0 Millimoles per liter | Standard Deviation 1.66 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 5,n=12,6,6,9,9,6 | -0.17 Millimoles per liter | Standard Deviation 0.728 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 1,n=11,6,6,9,9,5 | 0.07 Millimoles per liter | Standard Deviation 0.3 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 2,n=12,6,6,9,9,6 | -0.18 Millimoles per liter | Standard Deviation 0.902 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 8,n=12,6,6,9,9,6 | -0.018 Millimoles per liter | Standard Deviation 0.0338 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 12,n=12,6,6,9,9,6 | -0.011 Millimoles per liter | Standard Deviation 0.0501 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 4,n=12,6,6,9,9,6 | -0.34 Millimoles per liter | Standard Deviation 1.364 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 36,n=6,0,0,9,9,0 | 0.28 Millimoles per liter | Standard Deviation 1.228 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 12,n=12,6,6,9,9,6 | 0.036 Millimoles per liter | Standard Deviation 0.0581 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 4,n=12,6,6,9,9,6 | -0.08 Millimoles per liter | Standard Deviation 0.919 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 1,n=11,6,6,9,9,5 | -0.1 Millimoles per liter | Standard Deviation 1.69 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 3,n=12,6,6,9,9,6 | -0.21 Millimoles per liter | Standard Deviation 0.647 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 4,n=12,6,6,9,9,6 | -0.027 Millimoles per liter | Standard Deviation 0.0529 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 2,n=12,6,5,9,9,6 | -0.72 Millimoles per liter | Standard Deviation 0.948 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 4,n=12,6,6,9,9,6 | -0.007 Millimoles per liter | Standard Deviation 0.0714 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 8,n=12,6,6,9,9,6 | -0.36 Millimoles per liter | Standard Deviation 1.193 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 2,n=12,6,6,9,9,6 | -0.036 Millimoles per liter | Standard Deviation 0.0445 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 8,n=12,6,6,9,9,6 | 0.14 Millimoles per liter | Standard Deviation 0.207 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 5,n=12,6,6,9,9,6 | 0.8 Millimoles per liter | Standard Deviation 2.05 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 18,n=12,6,6,9,9,6 | 0.031 Millimoles per liter | Standard Deviation 0.0801 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 18,n=12,6,6,9,9,6 | 0.00 Millimoles per liter | Standard Deviation 0.866 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 12,n=12,6,6,9,9,6 | -0.66 Millimoles per liter | Standard Deviation 0.76 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 12,n=12,6,6,9,9,6 | 0.06 Millimoles per liter | Standard Deviation 0.682 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 4,n=12,6,6,9,9,6 | 0.3 Millimoles per liter | Standard Deviation 1.32 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 8,n=12,6,6,9,9,6 | 0.28 Millimoles per liter | Standard Deviation 1.093 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 3,n=12,6,6,9,9,6 | 0.9 Millimoles per liter | Standard Deviation 1.96 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 1,n=11,6,6,9,9,5 | -0.040 Millimoles per liter | Standard Deviation 0.0346 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 18,n=12,6,6,9,9,6 | -0.23 Millimoles per liter | Standard Deviation 0.825 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 36,n=6,0,0,9,9,0 | -0.07 Millimoles per liter | Standard Deviation 0.996 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 5,n=12,6,6,9,9,6 | 1.7 Millimoles per liter | Standard Deviation 1.75 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 4,n=12,6,6,9,9,6 | 1.3 Millimoles per liter | Standard Deviation 1.86 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 12,n=12,6,6,9,9,6 | 0.23 Millimoles per liter | Standard Deviation 0.432 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 3,n=12,6,6,9,9,6 | 2.0 Millimoles per liter | Standard Deviation 1.55 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 12,n=12,6,6,9,9,6 | 0.25 Millimoles per liter | Standard Deviation 1.037 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Day 2,n=12,6,5,9,9,6 | 1.8 Millimoles per liter | Standard Deviation 1.72 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 18,n=12,6,6,9,9,6 | 0.15 Millimoles per liter | Standard Deviation 0.288 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium Week 40,n=2,0,0,0,0,6 | 0.13 Millimoles per liter | Standard Deviation 0.356 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 24,n=12,6,6,9,9,6 | 0.50 Millimoles per liter | Standard Deviation 0.59 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 32,n=6,6,6,0,0,6 | 0.12 Millimoles per liter | Standard Deviation 0.147 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 26,n=12,6,6,9,9,6 | 0.07 Millimoles per liter | Standard Deviation 0.327 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 26,n=12,6,6,9,9,6 | 0.38 Millimoles per liter | Standard Deviation 0.445 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 24,n=12,6,6,9,9,6 | 0.07 Millimoles per liter | Standard Deviation 0.288 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 32,n=6,6,6,0,0,6 | 0.32 Millimoles per liter | Standard Deviation 0.354 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 32,n=6,6,6,0,0,6 | -0.08 Millimoles per liter | Standard Deviation 0.801 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 40,n=2,0,0,0,0,6 | 0.23 Millimoles per liter | Standard Deviation 0.769 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 26,n=12,6,6,9,9,6 | 0.08 Millimoles per liter | Standard Deviation 1.068 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 24,n=12,6,6,9,9,6 | 0.17 Millimoles per liter | Standard Deviation 0.683 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 2,n=12,6,5,9,9,6 | 0.043 Millimoles per liter | Standard Deviation 0.048 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 2,n=12,6,5,9,9,6 | -1.25 Millimoles per liter | Standard Deviation 1.084 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 3,n=12,6,6,9,9,6 | 0.070 Millimoles per liter | Standard Deviation 0.0415 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 12,n=12,6,6,9,9,6 | 0.000 Millimoles per liter | Standard Deviation 0.0456 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 8,n=12,6,6,9,9,6 | -0.58 Millimoles per liter | Standard Deviation 1.158 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 4,n=12,6,6,9,9,6 | 0.073 Millimoles per liter | Standard Deviation 0.0301 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 4,n=12,6,6,9,9,6 | -0.08 Millimoles per liter | Standard Deviation 1.114 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 2,n=12,6,6,9,9,6 | -0.33 Millimoles per liter | Standard Deviation 1.08 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Day 5,n=12,6,6,9,9,6 | 0.043 Millimoles per liter | Standard Deviation 0.0843 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 1,n=11,6,6,9,9,5 | -1.10 Millimoles per liter | Standard Deviation 1.084 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 4,n=12,6,6,9,9,6 | 0.00 Millimoles per liter | Standard Deviation 0.276 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 1,n=11,6,6,9,9,5 | -0.040 Millimoles per liter | Standard Deviation 0.0663 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 5,n=12,6,6,9,9,6 | -0.67 Millimoles per liter | Standard Deviation 1.602 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 4,n=12,6,6,9,9,6 | -0.50 Millimoles per liter | Standard Deviation 1.673 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 32,n=6,6,6,0,0,6 | -0.027 Millimoles per liter | Standard Deviation 0.0301 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 2,n=12,6,6,9,9,6 | 0.013 Millimoles per liter | Standard Deviation 0.0163 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Day 3,n=12,6,6,9,9,6 | -1.17 Millimoles per liter | Standard Deviation 1.402 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 26,n=12,6,6,9,9,6 | -0.027 Millimoles per liter | Standard Deviation 0.0432 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 4,n=12,6,6,9,9,6 | 0.033 Millimoles per liter | Standard Deviation 0.0301 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 40,n=2,0,0,0,0,6 | -0.030 Millimoles per liter | Standard Deviation 0.0329 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 8,n=12,6,6,9,9,6 | -0.003 Millimoles per liter | Standard Deviation 0.0612 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 8,n=12,6,6,9,9,6 | -0.003 Millimoles per liter | Standard Deviation 0.0585 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 4,n=12,6,6,9,9,6 | -0.017 Millimoles per liter | Standard Deviation 0.0408 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 18,n=12,6,6,9,9,6 | 0.02 Millimoles per liter | Standard Deviation 0.293 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 12,n=12,6,6,9,9,6 | -0.003 Millimoles per liter | Standard Deviation 0.0794 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 2,n=12,6,6,9,9,6 | -0.027 Millimoles per liter | Standard Deviation 0.0501 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 18,n=12,6,6,9,9,6 | 0.010 Millimoles per liter | Standard Deviation 0.069 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 1,n=11,6,6,9,9,5 | -0.032 Millimoles per liter | Standard Deviation 0.046 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 5,n=12,6,6,9,9,6 | -0.020 Millimoles per liter | Standard Deviation 0.0632 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 8,n=12,6,6,9,9,6 | -0.05 Millimoles per liter | Standard Deviation 0.207 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 24,n=12,6,6,9,9,6 | 0.027 Millimoles per liter | Standard Deviation 0.0797 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 4,n=12,6,6,9,9,6 | -0.047 Millimoles per liter | Standard Deviation 0.0628 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 24,n=12,6,6,9,9,6 | -0.003 Millimoles per liter | Standard Deviation 0.032 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 26,n=12,6,6,9,9,6 | -0.010 Millimoles per liter | Standard Deviation 0.0767 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 3,n=12,6,6,9,9,6 | -0.037 Millimoles per liter | Standard Deviation 0.0427 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Day 2,n=12,6,5,9,9,6 | -0.020 Millimoles per liter | Standard Deviation 0.031 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 32,n=6,6,6,0,0,6 | 0.010 Millimoles per liter | Standard Deviation 0.0724 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 40,n=2,0,0,0,0,6 | 0.0 Millimoles per liter | Standard Deviation 1.9 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Magnesium, Week 18,n=12,6,6,9,9,6 | 0.000 Millimoles per liter | Standard Deviation 0.0551 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Calcium, Week 40,n=2,0,0,0,0,6 | 0.043 Millimoles per liter | Standard Deviation 0.0774 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 32,n=6,6,6,0,0,6 | 0.7 Millimoles per liter | Standard Deviation 2.07 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 24,n=12,6,6,9,9,6 | 1.2 Millimoles per liter | Standard Deviation 1.72 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 2,n=12,6,5,9,9,6 | 0.17 Millimoles per liter | Standard Deviation 0.234 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 18,n=12,6,6,9,9,6 | 0.8 Millimoles per liter | Standard Deviation 1.6 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 12,n=12,6,6,9,9,6 | 1.3 Millimoles per liter | Standard Deviation 2.25 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 3,n=12,6,6,9,9,6 | 0.12 Millimoles per liter | Standard Deviation 0.194 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 8,n=12,6,6,9,9,6 | 1.5 Millimoles per liter | Standard Deviation 3.45 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 4,n=12,6,6,9,9,6 | 0.27 Millimoles per liter | Standard Deviation 0.163 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 4,n=12,6,6,9,9,6 | 1.0 Millimoles per liter | Standard Deviation 1.41 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 2,n=12,6,6,9,9,6 | 1.0 Millimoles per liter | Standard Deviation 2.28 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 12,n=12,6,6,9,9,6 | 0.03 Millimoles per liter | Standard Deviation 0.273 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Day 5,n=12,6,6,9,9,6 | 0.15 Millimoles per liter | Standard Deviation 0.217 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 2,n=12,6,6,9,9,6 | 0.02 Millimoles per liter | Standard Deviation 0.299 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 1,n=11,6,6,9,9,5 | 0.4 Millimoles per liter | Standard Deviation 2.19 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 40,n=2,0,0,0,0,6 | -0.42 Millimoles per liter | Standard Deviation 1.201 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Sodium, Week 26,n=12,6,6,9,9,6 | 1.7 Millimoles per liter | Standard Deviation 1.97 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 1,n=11,6,6,9,9,5 | 0.50 Millimoles per liter | Standard Deviation 1.345 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 5,n=12,6,6,9,9,6 | 0.05 Millimoles per liter | Standard Deviation 0.539 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 2,n=12,6,6,9,9,6 | -0.10 Millimoles per liter | Standard Deviation 0.155 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 4,n=12,6,6,9,9,6 | 0.50 Millimoles per liter | Standard Deviation 1.103 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 3,n=12,6,6,9,9,6 | 0.15 Millimoles per liter | Standard Deviation 0.521 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Potassium, Week 1,n=11,6,6,9,9,5 | 0.00 Millimoles per liter | Standard Deviation 0.2 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 4,n=12,6,6,9,9,6 | 0.33 Millimoles per liter | Standard Deviation 0.476 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Day 2,n=12,6,5,9,9,6 | 0.20 Millimoles per liter | Standard Deviation 0.352 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | BUN, Week 18,n=12,6,6,9,9,6 | -0.33 Millimoles per liter | Standard Deviation 0.983 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter Like Glucose, Calcium, Potassium, Sodium, Blood Urea Nitrogen (BUN), and Magnesium | Glucose, Week 8,n=12,6,6,9,9,6 | 0.42 Millimoles per liter | Standard Deviation 0.722 |
Primary
Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin
Blood samples were collected at indicated time-points for analysis of clinical parameters like total protein and albumin. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 1,n=11,6,6,9,9,5 | -1.6 Grams per liter | Standard Deviation 2.87 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 4,n=12,6,6,9,9,6 | -1.8 Grams per liter | Standard Deviation 4.34 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 5,n=12,6,6,9,9,6 | -1.6 Grams per liter | Standard Deviation 1.68 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 32,n=6,6,6,0,0,6 | -1.7 Grams per liter | Standard Deviation 3.93 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 2,n=12,6,6,9,9,6 | -1.8 Grams per liter | Standard Deviation 3.28 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 5,n=12,6,6,9,9,6 | -3.3 Grams per liter | Standard Deviation 2.77 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 18,n=12,6,6,9,9,6 | -0.5 Grams per liter | Standard Deviation 2.35 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 24,n=12,6,6,9,9,6 | -3.3 Grams per liter | Standard Deviation 3.79 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 4,n=12,6,6,9,9,6 | -1.3 Grams per liter | Standard Deviation 2.63 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 3,n=12,6,6,9,9,6 | -1.4 Grams per liter | Standard Deviation 3.68 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 4,n=12,6,6,9,9,6 | -2.5 Grams per liter | Standard Deviation 3.48 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 36,n=6,0,0,9,9,0 | -0.7 Grams per liter | Standard Deviation 2.94 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 24,n=12,6,6,9,9,6 | -1.7 Grams per liter | Standard Deviation 2.19 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 32,n=6,6,6,0,0,6 | -0.5 Grams per liter | Standard Deviation 3.02 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 2,n=12,6,6,9,9,6 | -0.8 Grams per liter | Standard Deviation 2.25 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 26,n=12,6,6,9,9,6 | -2.5 Grams per liter | Standard Deviation 3.55 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 8,n=12,6,6,9,9,6 | -1.0 Grams per liter | Standard Deviation 4.33 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 12,n=12,6,6,9,9,6 | -1.5 Grams per liter | Standard Deviation 1.73 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 18,n=12,6,6,9,9,6 | -1.3 Grams per liter | Standard Deviation 2.56 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 3,n=12,6,6,9,9,6 | -0.8 Grams per liter | Standard Deviation 2.7 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 4,n=12,6,6,9,9,6 | -1.8 Grams per liter | Standard Deviation 2.42 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 36,n=6,0,0,9,9,0 | -1.5 Grams per liter | Standard Deviation 4.51 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 12,n=12,6,6,9,9,6 | -2.8 Grams per liter | Standard Deviation 2.67 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 1,n=11,6,6,9,9,5 | -0.5 Grams per liter | Standard Deviation 2.34 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 2,n=12,6,5,9,9,6 | -2.1 Grams per liter | Standard Deviation 2.68 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 40,n=2,0,0,0,0,6 | -2.5 Grams per liter | Standard Deviation 3.54 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 40,n=2,0,0,0,0,6 | -1.0 Grams per liter | Standard Deviation 2.83 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 2,n=12,6,5,9,9,6 | -2.8 Grams per liter | Standard Deviation 3.74 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 8,n=12,6,6,9,9,6 | -0.8 Grams per liter | Standard Deviation 2.73 |
| Placebo | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 26,n=12,6,6,9,9,6 | -1.6 Grams per liter | Standard Deviation 2.27 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 24,n=12,6,6,9,9,6 | 0.3 Grams per liter | Standard Deviation 2.73 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 18,n=12,6,6,9,9,6 | -1.8 Grams per liter | Standard Deviation 5.23 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 32,n=6,6,6,0,0,6 | 0.0 Grams per liter | Standard Deviation 3.63 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 24,n=12,6,6,9,9,6 | -2.8 Grams per liter | Standard Deviation 4.54 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 8,n=12,6,6,9,9,6 | -0.3 Grams per liter | Standard Deviation 2.88 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 2,n=12,6,5,9,9,6 | -2.3 Grams per liter | Standard Deviation 1.97 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 26,n=12,6,6,9,9,6 | -3.5 Grams per liter | Standard Deviation 2.88 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 26,n=12,6,6,9,9,6 | -0.8 Grams per liter | Standard Deviation 1.72 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 4,n=12,6,6,9,9,6 | -1.2 Grams per liter | Standard Deviation 2.14 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 4,n=12,6,6,9,9,6 | -1.0 Grams per liter | Standard Deviation 2.28 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 12,n=12,6,6,9,9,6 | -1.3 Grams per liter | Standard Deviation 2.8 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 32,n=6,6,6,0,0,6 | 1.2 Grams per liter | Standard Deviation 3.06 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 1,n=11,6,6,9,9,5 | -0.2 Grams per liter | Standard Deviation 2.86 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 5,n=12,6,6,9,9,6 | -1.5 Grams per liter | Standard Deviation 1.87 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 5,n=12,6,6,9,9,6 | -2.7 Grams per liter | Standard Deviation 2.58 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 1,n=11,6,6,9,9,5 | -2.3 Grams per liter | Standard Deviation 4.23 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 3,n=12,6,6,9,9,6 | -2.5 Grams per liter | Standard Deviation 2.17 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 2,n=12,6,6,9,9,6 | -2.8 Grams per liter | Standard Deviation 4.26 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 4,n=12,6,6,9,9,6 | -0.5 Grams per liter | Standard Deviation 1.22 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 4,n=12,6,6,9,9,6 | -3.3 Grams per liter | Standard Deviation 3.01 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 2,n=12,6,6,9,9,6 | -0.2 Grams per liter | Standard Deviation 1.83 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 3,n=12,6,6,9,9,6 | -1.3 Grams per liter | Standard Deviation 1.97 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 8,n=12,6,6,9,9,6 | -0.8 Grams per liter | Standard Deviation 5.15 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 2,n=12,6,5,9,9,6 | -1.3 Grams per liter | Standard Deviation 2.42 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 18,n=12,6,6,9,9,6 | -0.3 Grams per liter | Standard Deviation 2.94 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 12,n=12,6,6,9,9,6 | -3.5 Grams per liter | Standard Deviation 4.59 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 1,n=11,6,6,9,9,5 | -2.8 Grams per liter | Standard Deviation 2.99 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 18,n=12,6,6,9,9,6 | -1.5 Grams per liter | Standard Deviation 1.64 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 4,n=12,6,6,9,9,6 | 0.3 Grams per liter | Standard Deviation 2.58 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 24,n=12,6,6,9,9,6 | -0.8 Grams per liter | Standard Deviation 2.32 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 26,n=12,6,6,9,9,6 | -1.8 Grams per liter | Standard Deviation 2.93 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 5,n=12,6,6,9,9,6 | -0.7 Grams per liter | Standard Deviation 4.72 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 32,n=6,6,6,0,0,6 | -0.2 Grams per liter | Standard Deviation 2.93 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 2,n=12,6,6,9,9,6 | -2.8 Grams per liter | Standard Deviation 2.99 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 4,n=12,6,6,9,9,6 | -0.8 Grams per liter | Standard Deviation 5.19 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 8,n=12,6,6,9,9,6 | 0.2 Grams per liter | Standard Deviation 4.54 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 12,n=12,6,6,9,9,6 | -0.5 Grams per liter | Standard Deviation 3.62 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 18,n=12,6,6,9,9,6 | -1.7 Grams per liter | Standard Deviation 3.2 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 24,n=12,6,6,9,9,6 | -1.0 Grams per liter | Standard Deviation 3.35 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 26,n=12,6,6,9,9,6 | -2.3 Grams per liter | Standard Deviation 3.39 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 32,n=6,6,6,0,0,6 | 0.3 Grams per liter | Standard Deviation 5.09 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 2,n=12,6,5,9,9,6 | -0.6 Grams per liter | Standard Deviation 3.36 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 2,n=12,6,5,9,9,6 | -1.6 Grams per liter | Standard Deviation 2.07 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 3,n=12,6,6,9,9,6 | -0.2 Grams per liter | Standard Deviation 2.48 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 4,n=12,6,6,9,9,6 | -0.7 Grams per liter | Standard Deviation 1.86 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 5,n=12,6,6,9,9,6 | -0.8 Grams per liter | Standard Deviation 3.54 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 3,n=12,6,6,9,9,6 | 0.2 Grams per liter | Standard Deviation 3.43 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 1,n=11,6,6,9,9,5 | 0.0 Grams per liter | Standard Deviation 2.68 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 2,n=12,6,6,9,9,6 | -1.7 Grams per liter | Standard Deviation 2.16 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 4,n=12,6,6,9,9,6 | -0.3 Grams per liter | Standard Deviation 2.88 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 8,n=12,6,6,9,9,6 | 0.7 Grams per liter | Standard Deviation 2.94 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 12,n=12,6,6,9,9,6 | 0.0 Grams per liter | Standard Deviation 2.45 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 2,n=12,6,6,9,9,6 | -1.2 Grams per liter | Standard Deviation 4.29 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 36,n=6,0,0,9,9,0 | -1.4 Grams per liter | Standard Deviation 1.67 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 24,n=12,6,6,9,9,6 | -2.0 Grams per liter | Standard Deviation 1.87 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 1,n=11,6,6,9,9,5 | -2.2 Grams per liter | Standard Deviation 2.28 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 12,n=12,6,6,9,9,6 | -1.7 Grams per liter | Standard Deviation 2.4 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 3,n=12,6,6,9,9,6 | -1.7 Grams per liter | Standard Deviation 4.18 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 4,n=12,6,6,9,9,6 | -2.2 Grams per liter | Standard Deviation 2.33 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 2,n=12,6,6,9,9,6 | -0.8 Grams per liter | Standard Deviation 2.86 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 8,n=12,6,6,9,9,6 | -3.0 Grams per liter | Standard Deviation 3.94 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 1,n=11,6,6,9,9,5 | -1.2 Grams per liter | Standard Deviation 4.29 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 5,n=12,6,6,9,9,6 | -3.2 Grams per liter | Standard Deviation 4.02 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 3,n=12,6,6,9,9,6 | -1.4 Grams per liter | Standard Deviation 2.83 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 18,n=12,6,6,9,9,6 | -0.7 Grams per liter | Standard Deviation 2.06 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 4,n=12,6,6,9,9,6 | -1.3 Grams per liter | Standard Deviation 1.87 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 26,n=12,6,6,9,9,6 | -3.7 Grams per liter | Standard Deviation 1.87 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 4,n=12,6,6,9,9,6 | -2.8 Grams per liter | Standard Deviation 3.46 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 8,n=12,6,6,9,9,6 | -2.0 Grams per liter | Standard Deviation 2.69 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 24,n=12,6,6,9,9,6 | -2.7 Grams per liter | Standard Deviation 3.04 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 18,n=12,6,6,9,9,6 | -2.0 Grams per liter | Standard Deviation 3.64 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 5,n=12,6,6,9,9,6 | -2.3 Grams per liter | Standard Deviation 2.5 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 26,n=12,6,6,9,9,6 | -2.1 Grams per liter | Standard Deviation 0.6 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 2,n=12,6,5,9,9,6 | -2.4 Grams per liter | Standard Deviation 2.01 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 36,n=6,0,0,9,9,0 | -2.6 Grams per liter | Standard Deviation 3.21 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 4,n=12,6,6,9,9,6 | -1.4 Grams per liter | Standard Deviation 3.09 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 12,n=12,6,6,9,9,6 | -2.6 Grams per liter | Standard Deviation 3.71 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 2,n=12,6,5,9,9,6 | -3.8 Grams per liter | Standard Deviation 3.56 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 18,n=12,6,6,9,9,6 | 0.2 Grams per liter | Standard Deviation 2.44 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 8,n=12,6,6,9,9,6 | 1.4 Grams per liter | Standard Deviation 3.75 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 2,n=12,6,5,9,9,6 | -0.6 Grams per liter | Standard Deviation 3.36 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 2,n=12,6,5,9,9,6 | 0.7 Grams per liter | Standard Deviation 4.9 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 4,n=12,6,6,9,9,6 | -0.4 Grams per liter | Standard Deviation 2.65 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 4,n=12,6,6,9,9,6 | -0.1 Grams per liter | Standard Deviation 4.78 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 24,n=12,6,6,9,9,6 | 0.4 Grams per liter | Standard Deviation 2.79 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 3,n=12,6,6,9,9,6 | -1.3 Grams per liter | Standard Deviation 2.06 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 1,n=11,6,6,9,9,5 | -1.1 Grams per liter | Standard Deviation 3.62 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 2,n=12,6,6,9,9,6 | 1.1 Grams per liter | Standard Deviation 4.08 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 4,n=12,6,6,9,9,6 | -1.4 Grams per liter | Standard Deviation 1.81 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 12,n=12,6,6,9,9,6 | 0.4 Grams per liter | Standard Deviation 1.33 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 5,n=12,6,6,9,9,6 | 0.1 Grams per liter | Standard Deviation 5.78 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 5,n=12,6,6,9,9,6 | -0.2 Grams per liter | Standard Deviation 3.49 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 8,n=12,6,6,9,9,6 | 0.7 Grams per liter | Standard Deviation 2.83 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 36,n=6,0,0,9,9,0 | 0.6 Grams per liter | Standard Deviation 2.4 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 1,n=11,6,6,9,9,5 | -1.4 Grams per liter | Standard Deviation 2.07 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 12,n=12,6,6,9,9,6 | 2.7 Grams per liter | Standard Deviation 2.78 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 2,n=12,6,6,9,9,6 | 0.4 Grams per liter | Standard Deviation 1.88 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 3,n=12,6,6,9,9,6 | -0.7 Grams per liter | Standard Deviation 3.16 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 26,n=12,6,6,9,9,6 | 0.1 Grams per liter | Standard Deviation 1.69 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 26,n=12,6,6,9,9,6 | 1.0 Grams per liter | Standard Deviation 2.4 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 24,n=12,6,6,9,9,6 | 0.6 Grams per liter | Standard Deviation 3.71 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 4,n=12,6,6,9,9,6 | -0.6 Grams per liter | Standard Deviation 2.19 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 18,n=12,6,6,9,9,6 | 1.7 Grams per liter | Standard Deviation 3.5 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 36,n=6,0,0,9,9,0 | 1.8 Grams per liter | Standard Deviation 3.77 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 40,n=2,0,0,0,0,6 | -0.3 Grams per liter | Standard Deviation 1.63 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 2,n=12,6,5,9,9,6 | -0.2 Grams per liter | Standard Deviation 4.4 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 4,n=12,6,6,9,9,6 | 1.7 Grams per liter | Standard Deviation 2.88 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 1,n=11,6,6,9,9,5 | -1.4 Grams per liter | Standard Deviation 1.95 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 3,n=12,6,6,9,9,6 | 0.0 Grams per liter | Standard Deviation 3.22 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Day 5,n=12,6,6,9,9,6 | 0.0 Grams per liter | Standard Deviation 3.41 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 2,n=12,6,6,9,9,6 | -1.0 Grams per liter | Standard Deviation 3.58 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 4,n=12,6,6,9,9,6 | -1.0 Grams per liter | Standard Deviation 3.41 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 8,n=12,6,6,9,9,6 | 1.2 Grams per liter | Standard Deviation 3.37 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 12,n=12,6,6,9,9,6 | 0.0 Grams per liter | Standard Deviation 2.1 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 18,n=12,6,6,9,9,6 | 1.5 Grams per liter | Standard Deviation 3.08 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 24,n=12,6,6,9,9,6 | 0.3 Grams per liter | Standard Deviation 2.73 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 26,n=12,6,6,9,9,6 | 0.3 Grams per liter | Standard Deviation 2.34 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 32,n=6,6,6,0,0,6 | -0.7 Grams per liter | Standard Deviation 2.66 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Total protein, Week 40,n=2,0,0,0,0,6 | 0.7 Grams per liter | Standard Deviation 1.63 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 2,n=12,6,5,9,9,6 | -0.5 Grams per liter | Standard Deviation 3.39 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 3,n=12,6,6,9,9,6 | -0.3 Grams per liter | Standard Deviation 2.07 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 4,n=12,6,6,9,9,6 | 0.3 Grams per liter | Standard Deviation 2.16 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Day 5,n=12,6,6,9,9,6 | -0.2 Grams per liter | Standard Deviation 2.56 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 1,n=11,6,6,9,9,5 | -1.4 Grams per liter | Standard Deviation 2.97 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 2,n=12,6,6,9,9,6 | -0.5 Grams per liter | Standard Deviation 1.52 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 4,n=12,6,6,9,9,6 | -1.3 Grams per liter | Standard Deviation 2.73 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 8,n=12,6,6,9,9,6 | 0.7 Grams per liter | Standard Deviation 2.34 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 12,n=12,6,6,9,9,6 | -0.2 Grams per liter | Standard Deviation 2.32 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 18,n=12,6,6,9,9,6 | 0.2 Grams per liter | Standard Deviation 1.94 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 24,n=12,6,6,9,9,6 | -0.2 Grams per liter | Standard Deviation 2.04 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 26,n=12,6,6,9,9,6 | -0.3 Grams per liter | Standard Deviation 2.07 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameter of Total Protein and Albumin | Albumin, Week 32,n=6,6,6,0,0,6 | -0.8 Grams per liter | Standard Deviation 2.14 |
Primary
Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST)
Blood samples were collected at indicated time-points for analysis of clinical parameters like ALP, AST and ALT. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 36,n=6,0,0,9,9,0 | -1.0 International units per Liter | Standard Deviation 4.69 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 2,n=12,6,6,9,9,6 | -1.5 International units per Liter | Standard Deviation 4.66 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 1,n=12,6,6,9,9,5 | -2.8 International units per Liter | Standard Deviation 4.12 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 5,n=12,6,6,9,9,6 | -2.6 International units per Liter | Standard Deviation 4.1 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 5,n=12,6,6,9,9,6 | 1.7 International units per Liter | Standard Deviation 7.96 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 36,n=6,0,0,9,9,0 | 9.0 International units per Liter | Standard Deviation 15.57 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 18,n=12,6,6,9,9,6 | 3.1 International units per Liter | Standard Deviation 6.82 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 12,n=12,6,6,9,9,6 | -0.6 International units per Liter | Standard Deviation 6.43 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 1,n=12,6,6,9,9,5 | 1.2 International units per Liter | Standard Deviation 7.76 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 8,n=12,6,6,9,9,6 | 1.9 International units per Liter | Standard Deviation 6.88 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 2,n=12,6,6,9,9,6 | -0.2 International units per Liter | Standard Deviation 5.57 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 3,n=12,6,6,9,9,6 | 0.3 International units per Liter | Standard Deviation 5.96 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 4,n=12,6,6,9,9,6 | 1.4 International units per Liter | Standard Deviation 4.81 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 2,n=12,6,6,9,9,6 | 1.0 International units per Liter | Standard Deviation 3.44 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 4,n=12,6,6,9,9,6 | -0.3 International units per Liter | Standard Deviation 6.43 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 1,n=12,6,6,9,9,5 | 0.2 International units per Liter | Standard Deviation 5.86 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 2,n=12,6,5,9,9,6 | -0.3 International units per Liter | Standard Deviation 5.12 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 8,n=12,6,6,9,9,6 | 0.3 International units per Liter | Standard Deviation 7.25 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 5,n=12,6,6,9,9,6 | 0.1 International units per Liter | Standard Deviation 5.74 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 12,n=12,6,6,9,9,6 | -0.9 International units per Liter | Standard Deviation 6.07 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 32,n=6,6,6,0,0,6 | -2.0 International units per Liter | Standard Deviation 8.51 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 4,n=12,6,6,9,9,6 | -1.7 International units per Liter | Standard Deviation 5.3 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 3,n=12,6,6,9,9,6 | -1.8 International units per Liter | Standard Deviation 5.66 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 18,n=12,6,6,9,9,6 | -0.1 International units per Liter | Standard Deviation 6.13 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 2,n=12,6,5,9,9,6 | -1.8 International units per Liter | Standard Deviation 4.84 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 40,n=2,0,0,0,0,6 | -7.5 International units per Liter | Standard Deviation 6.36 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 24,n=12,6,6,9,9,6 | 0.3 International units per Liter | Standard Deviation 12.11 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 26,n=12,6,6,9,9,6 | 3.2 International units per Liter | Standard Deviation 8.64 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 12,n=12,6,6,9,9,6 | -2.8 International units per Liter | Standard Deviation 2.79 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 32,n=6,6,6,0,0,6 | -2.7 International units per Liter | Standard Deviation 3.39 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 26,n=12,6,6,9,9,6 | -2.1 International units per Liter | Standard Deviation 6.13 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 4,n=12,6,6,9,9,6 | 1.0 International units per Liter | Standard Deviation 5.85 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 26,n=12,6,6,9,9,6 | -2.7 International units per Liter | Standard Deviation 4.08 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 32,n=6,6,6,0,0,6 | 1.5 International units per Liter | Standard Deviation 8.04 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 24,n=12,6,6,9,9,6 | 1.2 International units per Liter | Standard Deviation 18.52 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 36,n=6,0,0,9,9,0 | 0.3 International units per Liter | Standard Deviation 8.29 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 18,n=12,6,6,9,9,6 | -1.8 International units per Liter | Standard Deviation 4.14 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 40,n=2,0,0,0,0,6 | -3.5 International units per Liter | Standard Deviation 7.78 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 2,n=12,6,5,9,9,6 | -3.5 International units per Liter | Standard Deviation 3.55 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 40,n=2,0,0,0,0,6 | -5.5 International units per Liter | Standard Deviation 0.71 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 8,n=12,6,6,9,9,6 | -0.9 International units per Liter | Standard Deviation 7.45 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 3,n=12,6,6,9,9,6 | -3.8 International units per Liter | Standard Deviation 4.86 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 4,n=12,6,6,9,9,6 | -1.5 International units per Liter | Standard Deviation 3.97 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 4,n=12,6,6,9,9,6 | -4.3 International units per Liter | Standard Deviation 4.27 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 24,n=12,6,6,9,9,6 | 3.8 International units per Liter | Standard Deviation 12.21 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 8,n=12,6,6,9,9,6 | -1.8 International units per Liter | Standard Deviation 3.66 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 26,n=12,6,6,9,9,6 | 1.8 International units per Liter | Standard Deviation 1.6 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 2,n=12,6,5,9,9,6 | -1.2 International units per Liter | Standard Deviation 2.48 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 3,n=12,6,6,9,9,6 | -0.8 International units per Liter | Standard Deviation 4.62 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 24,n=12,6,6,9,9,6 | -1.2 International units per Liter | Standard Deviation 7.94 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 4,n=12,6,6,9,9,6 | -2.3 International units per Liter | Standard Deviation 3.83 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 24,n=12,6,6,9,9,6 | -3.5 International units per Liter | Standard Deviation 7.64 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 2,n=12,6,6,9,9,6 | -0.3 International units per Liter | Standard Deviation 4.55 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 8,n=12,6,6,9,9,6 | -3.3 International units per Liter | Standard Deviation 10.39 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 4,n=12,6,6,9,9,6 | -0.8 International units per Liter | Standard Deviation 5.08 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 2,n=12,6,5,9,9,6 | 0.3 International units per Liter | Standard Deviation 3.56 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 5,n=12,6,6,9,9,6 | -2.0 International units per Liter | Standard Deviation 3.52 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 1,n=12,6,6,9,9,5 | 0.0 International units per Liter | Standard Deviation 3.74 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 24,n=12,6,6,9,9,6 | 1.3 International units per Liter | Standard Deviation 2.73 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 4,n=12,6,6,9,9,6 | -1.3 International units per Liter | Standard Deviation 3.2 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 5,n=12,6,6,9,9,6 | -0.5 International units per Liter | Standard Deviation 5.28 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 18,n=12,6,6,9,9,6 | -2.0 International units per Liter | Standard Deviation 6.48 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 18,n=12,6,6,9,9,6 | -1.2 International units per Liter | Standard Deviation 2.86 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 5,n=12,6,6,9,9,6 | 2.0 International units per Liter | Standard Deviation 9.74 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 12,n=12,6,6,9,9,6 | -1.7 International units per Liter | Standard Deviation 4.18 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 32,n=6,6,6,0,0,6 | 0.5 International units per Liter | Standard Deviation 3.33 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 12,n=12,6,6,9,9,6 | -4.3 International units per Liter | Standard Deviation 7.09 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 32,n=6,6,6,0,0,6 | -1.7 International units per Liter | Standard Deviation 9.89 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 3,n=12,6,6,9,9,6 | -2.7 International units per Liter | Standard Deviation 2.94 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 1,n=12,6,6,9,9,5 | 1.3 International units per Liter | Standard Deviation 5.92 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 32,n=6,6,6,0,0,6 | -3.3 International units per Liter | Standard Deviation 8.5 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 8,n=12,6,6,9,9,6 | -2.0 International units per Liter | Standard Deviation 4.82 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 4,n=12,6,6,9,9,6 | 3.3 International units per Liter | Standard Deviation 11.08 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 4,n=12,6,6,9,9,6 | -8.2 International units per Liter | Standard Deviation 8.3 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 26,n=12,6,6,9,9,6 | -0.8 International units per Liter | Standard Deviation 6.79 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 2,n=12,6,6,9,9,6 | -5.3 International units per Liter | Standard Deviation 7.97 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 18,n=12,6,6,9,9,6 | -3.5 International units per Liter | Standard Deviation 7.56 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 26,n=12,6,6,9,9,6 | -6.2 International units per Liter | Standard Deviation 8.3 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 2,n=12,6,6,9,9,6 | -8.2 International units per Liter | Standard Deviation 6.52 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 2,n=12,6,5,9,9,6 | -3.3 International units per Liter | Standard Deviation 1.37 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 12,n=12,6,6,9,9,6 | -1.2 International units per Liter | Standard Deviation 1.94 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 4,n=12,6,6,9,9,6 | -4.3 International units per Liter | Standard Deviation 7.63 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 3,n=12,6,6,9,9,6 | 2.5 International units per Liter | Standard Deviation 8.17 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 1,n=12,6,6,9,9,5 | -2.2 International units per Liter | Standard Deviation 5.56 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 5,n=12,6,6,9,9,6 | 0.3 International units per Liter | Standard Deviation 4.76 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 2,n=12,6,5,9,9,6 | 4.0 International units per Liter | Standard Deviation 14.2 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 3,n=12,6,6,9,9,6 | 5.3 International units per Liter | Standard Deviation 17.94 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 4,n=12,6,6,9,9,6 | 4.2 International units per Liter | Standard Deviation 13.83 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 5,n=12,6,6,9,9,6 | 2.3 International units per Liter | Standard Deviation 8.91 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 1,n=12,6,6,9,9,5 | 2.8 International units per Liter | Standard Deviation 7.36 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 2,n=12,6,6,9,9,6 | -1.3 International units per Liter | Standard Deviation 4.32 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 4,n=12,6,6,9,9,6 | 0.7 International units per Liter | Standard Deviation 4.23 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 8,n=12,6,6,9,9,6 | 2.5 International units per Liter | Standard Deviation 6.53 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 12,n=12,6,6,9,9,6 | 0.5 International units per Liter | Standard Deviation 3.94 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 18,n=12,6,6,9,9,6 | 1.0 International units per Liter | Standard Deviation 10.3 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 24,n=12,6,6,9,9,6 | 5.2 International units per Liter | Standard Deviation 14.18 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 26,n=12,6,6,9,9,6 | -0.5 International units per Liter | Standard Deviation 6.47 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 32,n=6,6,6,0,0,6 | -1.0 International units per Liter | Standard Deviation 3.29 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 2,n=12,6,5,9,9,6 | -0.8 International units per Liter | Standard Deviation 7.19 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 3,n=12,6,6,9,9,6 | -1.2 International units per Liter | Standard Deviation 7.22 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 4,n=12,6,6,9,9,6 | -2.0 International units per Liter | Standard Deviation 4.34 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 5,n=12,6,6,9,9,6 | -1.7 International units per Liter | Standard Deviation 3.67 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 1,n=12,6,6,9,9,5 | -0.2 International units per Liter | Standard Deviation 2.32 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 2,n=12,6,6,9,9,6 | -2.5 International units per Liter | Standard Deviation 2.88 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 4,n=12,6,6,9,9,6 | 0.0 International units per Liter | Standard Deviation 6.03 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 8,n=12,6,6,9,9,6 | 0.5 International units per Liter | Standard Deviation 3.02 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 12,n=12,6,6,9,9,6 | 1.2 International units per Liter | Standard Deviation 3.71 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 18,n=12,6,6,9,9,6 | 1.3 International units per Liter | Standard Deviation 10.09 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 24,n=12,6,6,9,9,6 | 0.8 International units per Liter | Standard Deviation 5.42 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 26,n=12,6,6,9,9,6 | 0.2 International units per Liter | Standard Deviation 3.37 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 32,n=6,6,6,0,0,6 | -2.5 International units per Liter | Standard Deviation 1.52 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 2,n=12,6,5,9,9,6 | 1.0 International units per Liter | Standard Deviation 4.18 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 3,n=12,6,6,9,9,6 | 0.3 International units per Liter | Standard Deviation 8.52 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 4,n=12,6,6,9,9,6 | 0.0 International units per Liter | Standard Deviation 9.17 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 1,n=12,6,6,9,9,5 | -2.5 International units per Liter | Standard Deviation 6.06 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 2,n=12,6,6,9,9,6 | -4.2 International units per Liter | Standard Deviation 3.54 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 4,n=12,6,6,9,9,6 | -1.2 International units per Liter | Standard Deviation 3.97 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 8,n=12,6,6,9,9,6 | 1.0 International units per Liter | Standard Deviation 10.06 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 12,n=12,6,6,9,9,6 | 7.2 International units per Liter | Standard Deviation 10.46 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 18,n=12,6,6,9,9,6 | -1.7 International units per Liter | Standard Deviation 4.84 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 24,n=12,6,6,9,9,6 | -1.0 International units per Liter | Standard Deviation 4.73 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 26,n=12,6,6,9,9,6 | -2.2 International units per Liter | Standard Deviation 4.02 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 32,n=6,6,6,0,0,6 | 0.2 International units per Liter | Standard Deviation 5.31 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 36,n=6,0,0,9,9,0 | 1.3 International units per Liter | Standard Deviation 6.86 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 18,n=12,6,6,9,9,6 | 1.9 International units per Liter | Standard Deviation 8.81 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 26,n=12,6,6,9,9,6 | 0.4 International units per Liter | Standard Deviation 10.75 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 2,n=12,6,5,9,9,6 | -4.9 International units per Liter | Standard Deviation 2.8 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 4,n=12,6,6,9,9,6 | -1.2 International units per Liter | Standard Deviation 1.86 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 2,n=12,6,6,9,9,6 | 0.3 International units per Liter | Standard Deviation 4.85 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 2,n=12,6,6,9,9,6 | -0.6 International units per Liter | Standard Deviation 3.91 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 18,n=12,6,6,9,9,6 | -0.7 International units per Liter | Standard Deviation 3.64 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 2,n=12,6,5,9,9,6 | -2.6 International units per Liter | Standard Deviation 4.28 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 3,n=12,6,6,9,9,6 | -1.8 International units per Liter | Standard Deviation 3.99 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 4,n=12,6,6,9,9,6 | -2.9 International units per Liter | Standard Deviation 2.93 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 1,n=12,6,6,9,9,5 | -0.7 International units per Liter | Standard Deviation 6.18 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 12,n=12,6,6,9,9,6 | -0.4 International units per Liter | Standard Deviation 1.94 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 3,n=12,6,6,9,9,6 | -0.6 International units per Liter | Standard Deviation 2.51 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 4,n=12,6,6,9,9,6 | 1.4 International units per Liter | Standard Deviation 9.41 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 4,n=12,6,6,9,9,6 | -1.9 International units per Liter | Standard Deviation 3.62 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 1,n=12,6,6,9,9,5 | -1.9 International units per Liter | Standard Deviation 2.85 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 5,n=12,6,6,9,9,6 | -1.4 International units per Liter | Standard Deviation 5.25 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 5,n=12,6,6,9,9,6 | -3.2 International units per Liter | Standard Deviation 3.31 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 8,n=12,6,6,9,9,6 | -1.6 International units per Liter | Standard Deviation 3.4 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 18,n=12,6,6,9,9,6 | 1.9 International units per Liter | Standard Deviation 6.79 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 24,n=12,6,6,9,9,6 | -1.1 International units per Liter | Standard Deviation 5.64 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 3,n=12,6,6,9,9,6 | -1.8 International units per Liter | Standard Deviation 3.8 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 36,n=6,0,0,9,9,0 | -0.6 International units per Liter | Standard Deviation 11.19 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 8,n=12,6,6,9,9,6 | -0.2 International units per Liter | Standard Deviation 3.77 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 26,n=12,6,6,9,9,6 | 5.1 International units per Liter | Standard Deviation 19.63 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 12,n=12,6,6,9,9,6 | -1.2 International units per Liter | Standard Deviation 2.17 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 26,n=12,6,6,9,9,6 | 0.0 International units per Liter | Standard Deviation 7 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 24,n=12,6,6,9,9,6 | 1.2 International units per Liter | Standard Deviation 10.51 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 5,n=12,6,6,9,9,6 | -0.6 International units per Liter | Standard Deviation 3.64 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 12,n=12,6,6,9,9,6 | -2.8 International units per Liter | Standard Deviation 2.82 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 2,n=12,6,6,9,9,6 | 1.0 International units per Liter | Standard Deviation 9.19 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 2,n=12,6,5,9,9,6 | -1.6 International units per Liter | Standard Deviation 2.07 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 8,n=12,6,6,9,9,6 | -4.4 International units per Liter | Standard Deviation 4.03 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 24,n=12,6,6,9,9,6 | 2.2 International units per Liter | Standard Deviation 10.76 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 36,n=6,0,0,9,9,0 | -2.0 International units per Liter | Standard Deviation 4.36 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 4,n=12,6,6,9,9,6 | 0.0 International units per Liter | Standard Deviation 4.9 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 1,n=12,6,6,9,9,5 | 0.7 International units per Liter | Standard Deviation 3.61 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 4,n=12,6,6,9,9,6 | -3.2 International units per Liter | Standard Deviation 4.32 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 2,n=12,6,5,9,9,6 | -0.1 International units per Liter | Standard Deviation 3.26 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 2,n=12,6,5,9,9,6 | -3.9 International units per Liter | Standard Deviation 5.42 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 8,n=12,6,6,9,9,6 | -1.0 International units per Liter | Standard Deviation 10.58 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 24,n=12,6,6,9,9,6 | 5.8 International units per Liter | Standard Deviation 8.39 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 12,n=12,6,6,9,9,6 | -1.4 International units per Liter | Standard Deviation 6.98 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 36,n=6,0,0,9,9,0 | 5.0 International units per Liter | Standard Deviation 7.84 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 18,n=12,6,6,9,9,6 | -1.8 International units per Liter | Standard Deviation 5.56 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 24,n=12,6,6,9,9,6 | -2.8 International units per Liter | Standard Deviation 8.76 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 26,n=12,6,6,9,9,6 | 6.2 International units per Liter | Standard Deviation 13.08 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 3,n=12,6,6,9,9,6 | -1.0 International units per Liter | Standard Deviation 3.2 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 26,n=12,6,6,9,9,6 | 0.1 International units per Liter | Standard Deviation 9.21 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 24,n=12,6,6,9,9,6 | 7.3 International units per Liter | Standard Deviation 12.97 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 36,n=6,0,0,9,9,0 | -3.2 International units per Liter | Standard Deviation 6.7 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 18,n=12,6,6,9,9,6 | 4.4 International units per Liter | Standard Deviation 6.93 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 2,n=12,6,5,9,9,6 | 1.3 International units per Liter | Standard Deviation 7.28 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 12,n=12,6,6,9,9,6 | 3.0 International units per Liter | Standard Deviation 5.12 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 26,n=12,6,6,9,9,6 | 4.8 International units per Liter | Standard Deviation 8.24 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 3,n=12,6,6,9,9,6 | -0.6 International units per Liter | Standard Deviation 5.32 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 4,n=12,6,6,9,9,6 | -0.2 International units per Liter | Standard Deviation 6.34 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 8,n=12,6,6,9,9,6 | 1.8 International units per Liter | Standard Deviation 9.56 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 5,n=12,6,6,9,9,6 | 1.9 International units per Liter | Standard Deviation 9.44 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 4,n=12,6,6,9,9,6 | -2.6 International units per Liter | Standard Deviation 2.55 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 1,n=12,6,6,9,9,5 | -1.1 International units per Liter | Standard Deviation 4.62 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 2,n=12,6,6,9,9,6 | -2.3 International units per Liter | Standard Deviation 4.97 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 2,n=12,6,6,9,9,6 | 3.1 International units per Liter | Standard Deviation 5.25 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 4,n=12,6,6,9,9,6 | 2.6 International units per Liter | Standard Deviation 5.5 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 1,n=12,6,6,9,9,5 | 0.6 International units per Liter | Standard Deviation 4.98 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 8,n=12,6,6,9,9,6 | 3.7 International units per Liter | Standard Deviation 3.61 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 5,n=12,6,6,9,9,6 | 0.2 International units per Liter | Standard Deviation 3.42 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 12,n=12,6,6,9,9,6 | 3.1 International units per Liter | Standard Deviation 11.58 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 18,n=12,6,6,9,9,6 | 3.8 International units per Liter | Standard Deviation 8.27 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 5,n=12,6,6,9,9,6 | -3.7 International units per Liter | Standard Deviation 7.57 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 4,n=12,6,6,9,9,6 | -4.9 International units per Liter | Standard Deviation 6.33 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 4,n=12,6,6,9,9,6 | -0.1 International units per Liter | Standard Deviation 2.71 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 1,n=12,6,6,9,9,5 | -3.3 International units per Liter | Standard Deviation 4.53 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 2,n=12,6,6,9,9,6 | -3.8 International units per Liter | Standard Deviation 6.44 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 3,n=12,6,6,9,9,6 | -5.6 International units per Liter | Standard Deviation 6.58 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 36,n=6,0,0,9,9,0 | 7.2 International units per Liter | Standard Deviation 8.39 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 4,n=12,6,6,9,9,6 | -4.3 International units per Liter | Standard Deviation 6.87 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 40,n=2,0,0,0,0,6 | 3.0 International units per Liter | Standard Deviation 13.24 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 40,n=2,0,0,0,0,6 | 1.2 International units per Liter | Standard Deviation 8.08 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 4,n=12,6,6,9,9,6 | -2.2 International units per Liter | Standard Deviation 7.81 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 1,n=12,6,6,9,9,5 | -4.6 International units per Liter | Standard Deviation 4.39 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 18,n=12,6,6,9,9,6 | -0.7 International units per Liter | Standard Deviation 5.2 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 32,n=6,6,6,0,0,6 | -1.0 International units per Liter | Standard Deviation 7.72 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 32,n=6,6,6,0,0,6 | -3.5 International units per Liter | Standard Deviation 5.47 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 18,n=12,6,6,9,9,6 | -3.3 International units per Liter | Standard Deviation 5.61 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 8,n=12,6,6,9,9,6 | -0.8 International units per Liter | Standard Deviation 8.3 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 5,n=12,6,6,9,9,6 | 4.5 International units per Liter | Standard Deviation 5.32 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 3,n=12,6,6,9,9,6 | -3.2 International units per Liter | Standard Deviation 4.79 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 2,n=12,6,5,9,9,6 | -3.7 International units per Liter | Standard Deviation 3.88 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 24,n=12,6,6,9,9,6 | 0.8 International units per Liter | Standard Deviation 5.34 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 24,n=12,6,6,9,9,6 | -0.7 International units per Liter | Standard Deviation 6.74 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 12,n=12,6,6,9,9,6 | -0.3 International units per Liter | Standard Deviation 5.09 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 26,n=12,6,6,9,9,6 | 0.2 International units per Liter | Standard Deviation 3.97 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 4,n=12,6,6,9,9,6 | 1.2 International units per Liter | Standard Deviation 3.43 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 24,n=12,6,6,9,9,6 | -1.8 International units per Liter | Standard Deviation 3.06 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 3,n=12,6,6,9,9,6 | 1.2 International units per Liter | Standard Deviation 4.96 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 12,n=12,6,6,9,9,6 | -2.0 International units per Liter | Standard Deviation 5.83 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 18,n=12,6,6,9,9,6 | -3.5 International units per Liter | Standard Deviation 6.8 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 26,n=12,6,6,9,9,6 | 2.5 International units per Liter | Standard Deviation 7.87 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 4,n=12,6,6,9,9,6 | -4.2 International units per Liter | Standard Deviation 5.91 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 4,n=12,6,6,9,9,6 | -2.8 International units per Liter | Standard Deviation 4.36 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 4,n=12,6,6,9,9,6 | -1.3 International units per Liter | Standard Deviation 6.09 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 5,n=12,6,6,9,9,6 | -2.0 International units per Liter | Standard Deviation 5.83 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 5,n=12,6,6,9,9,6 | -1.2 International units per Liter | Standard Deviation 5.12 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Day 4,n=12,6,6,9,9,6 | -3.3 International units per Liter | Standard Deviation 4.93 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 26,n=12,6,6,9,9,6 | -1.7 International units per Liter | Standard Deviation 6.02 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 8,n=12,6,6,9,9,6 | -3.0 International units per Liter | Standard Deviation 4.77 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 3,n=12,6,6,9,9,6 | 0.2 International units per Liter | Standard Deviation 5.88 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 2,n=12,6,6,9,9,6 | -0.7 International units per Liter | Standard Deviation 4.8 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 1,n=12,6,6,9,9,5 | -1.2 International units per Liter | Standard Deviation 7.53 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 2,n=12,6,6,9,9,6 | 3.0 International units per Liter | Standard Deviation 2.53 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | AST, Week 8,n=12,6,6,9,9,6 | -4.7 International units per Liter | Standard Deviation 4.5 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Day 2,n=12,6,5,9,9,6 | -0.7 International units per Liter | Standard Deviation 2.73 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 12,n=12,6,6,9,9,6 | -0.7 International units per Liter | Standard Deviation 2.66 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 32,n=6,6,6,0,0,6 | -3.0 International units per Liter | Standard Deviation 4.6 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 2,n=12,6,6,9,9,6 | -1.0 International units per Liter | Standard Deviation 8.32 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Day 2,n=12,6,5,9,9,6 | -1.5 International units per Liter | Standard Deviation 7.77 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALT, Week 1,n=12,6,6,9,9,5 | 1.2 International units per Liter | Standard Deviation 5.54 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Alkaline Phosphatase (ALP), Alanine Aminotransferase (ALT), and Aspartate Aminotransferase (AST) | ALP, Week 40,n=2,0,0,0,0,6 | -3.7 International units per Liter | Standard Deviation 9.48 |
Primary
Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine
Blood samples were collected at indicated time-points for analysis of clinical parameters like total bilirubin, direct bilirubin and creatinine. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 40,n=2,0,0,0,0,6 | 1.75 Micromoles per liter | Standard Deviation 2.475 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 32,n=6,6,6,0,0,6 | 0.7 Micromoles per liter | Standard Deviation 2.07 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 24,n=12,6,6,9,9,6 | 0.89 Micromoles per liter | Standard Deviation 4.393 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 32,n=6,6,6,0,0,6 | -0.3 Micromoles per liter | Standard Deviation 0.82 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 24,n=12,6,6,9,9,6 | -0.3 Micromoles per liter | Standard Deviation 0.78 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 8,n=12,6,6,9,9,6 | -1.2 Micromoles per liter | Standard Deviation 4.04 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 8,n=12,6,6,9,9,6 | -1.40 Micromoles per liter | Standard Deviation 6.462 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 4,n=12,6,6,9,9,6 | -0.7 Micromoles per liter | Standard Deviation 2.15 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 26,n=12,6,6,9,9,6 | -1.3 Micromoles per liter | Standard Deviation 4.7 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 36,n=6,0,0,9,9,0 | -0.60 Micromoles per liter | Standard Deviation 4.767 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 26,n=12,6,6,9,9,6 | -2.29 Micromoles per liter | Standard Deviation 5.633 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 12,n=12,6,6,9,9,6 | -1.3 Micromoles per liter | Standard Deviation 4.03 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 18,n=12,6,6,9,9,6 | -0.2 Micromoles per liter | Standard Deviation 1.03 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 24,n=12,6,6,9,9,6 | -0.8 Micromoles per liter | Standard Deviation 4.47 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 18,n=12,6,6,9,9,6 | -0.3 Micromoles per liter | Standard Deviation 3.7 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 4,n=12,6,6,9,9,6 | 0.29 Micromoles per liter | Standard Deviation 6.544 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 40,n=2,0,0,0,0,6 | -1.0 Micromoles per liter | Standard Deviation 1.41 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 12,n=12,6,6,9,9,6 | -0.5 Micromoles per liter | Standard Deviation 0.9 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 8,n=12,6,6,9,9,6 | -0.2 Micromoles per liter | Standard Deviation 1.03 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 4,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 0.85 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 12,n=12,6,6,9,9,6 | -0.30 Micromoles per liter | Standard Deviation 7.643 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 5,n=12,6,6,9,9,6 | -2.73 Micromoles per liter | Standard Deviation 5.166 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 36,n=6,0,0,9,9,0 | 0.0 Micromoles per liter | Standard Deviation 1.79 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 3,n=12,6,6,9,9,6 | -1.3 Micromoles per liter | Standard Deviation 3.45 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 2,n=12,6,6,9,9,6 | -0.3 Micromoles per liter | Standard Deviation 1.15 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 1,n=11,6,6,9,9,5 | -0.5 Micromoles per liter | Standard Deviation 0.93 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 26,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 1.21 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 1,n=11,6,6,9,9,5 | -2.49 Micromoles per liter | Standard Deviation 7.084 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 5,n=12,6,6,9,9,6 | -0.7 Micromoles per liter | Standard Deviation 0.98 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 4,n=12,6,6,9,9,6 | -0.5 Micromoles per liter | Standard Deviation 0.9 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 5,n=12,6,6,9,9,6 | -2.3 Micromoles per liter | Standard Deviation 4.58 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 2,n=12,6,6,9,9,6 | -1.12 Micromoles per liter | Standard Deviation 5.854 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 4,n=12,6,6,9,9,6 | -1.0 Micromoles per liter | Standard Deviation 3.13 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 18,n=12,6,6,9,9,6 | -1.27 Micromoles per liter | Standard Deviation 7.753 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 3,n=12,6,6,9,9,6 | -0.5 Micromoles per liter | Standard Deviation 0.9 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 4,n=12,6,6,9,9,6 | -1.28 Micromoles per liter | Standard Deviation 4.73 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 1,n=11,6,6,9,9,5 | -1.5 Micromoles per liter | Standard Deviation 4.82 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 3,n=12,6,6,9,9,6 | -3.48 Micromoles per liter | Standard Deviation 6.036 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 2,n=12,6,5,9,9,6 | -0.3 Micromoles per liter | Standard Deviation 1.15 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 40,n=2,0,0,0,0,6 | 2.0 Micromoles per liter | Standard Deviation 0 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 2,n=12,6,5,9,9,6 | -2.80 Micromoles per liter | Standard Deviation 5.501 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 32,n=6,6,6,0,0,6 | 0.00 Micromoles per liter | Standard Deviation 5.871 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 2,n=12,6,6,9,9,6 | -1.2 Micromoles per liter | Standard Deviation 3.46 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 2,n=12,6,5,9,9,6 | -0.8 Micromoles per liter | Standard Deviation 3.86 |
| Placebo | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 36,n=6,0,0,9,9,0 | -0.7 Micromoles per liter | Standard Deviation 7.12 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 4,n=12,6,6,9,9,6 | -2.7 Micromoles per liter | Standard Deviation 5.01 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 4,n=12,6,6,9,9,6 | -2.80 Micromoles per liter | Standard Deviation 3.839 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 2,n=12,6,5,9,9,6 | -1.03 Micromoles per liter | Standard Deviation 3.93 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 3,n=12,6,6,9,9,6 | -1.78 Micromoles per liter | Standard Deviation 3.571 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 4,n=12,6,6,9,9,6 | -0.73 Micromoles per liter | Standard Deviation 4.126 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 5,n=12,6,6,9,9,6 | 0.72 Micromoles per liter | Standard Deviation 1.883 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 2,n=12,6,6,9,9,6 | 1.47 Micromoles per liter | Standard Deviation 5.019 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 5,n=12,6,6,9,9,6 | -5.0 Micromoles per liter | Standard Deviation 5.76 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 32,n=6,6,6,0,0,6 | 0.87 Micromoles per liter | Standard Deviation 5.904 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 1,n=11,6,6,9,9,5 | -0.7 Micromoles per liter | Standard Deviation 4.5 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 2,n=12,6,6,9,9,6 | -2.3 Micromoles per liter | Standard Deviation 6.12 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 26,n=12,6,6,9,9,6 | -2.22 Micromoles per liter | Standard Deviation 5.017 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 8,n=12,6,6,9,9,6 | -1.0 Micromoles per liter | Standard Deviation 6.29 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 1,n=11,6,6,9,9,5 | 3.68 Micromoles per liter | Standard Deviation 4.892 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 12,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 2.19 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 3,n=12,6,6,9,9,6 | -1.7 Micromoles per liter | Standard Deviation 3.44 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 18,n=12,6,6,9,9,6 | -1.3 Micromoles per liter | Standard Deviation 6.53 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 24,n=12,6,6,9,9,6 | -1.3 Micromoles per liter | Standard Deviation 3.27 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 24,n=12,6,6,9,9,6 | 1.77 Micromoles per liter | Standard Deviation 5.597 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 26,n=12,6,6,9,9,6 | 2.7 Micromoles per liter | Standard Deviation 3.93 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 32,n=6,6,6,0,0,6 | -1.0 Micromoles per liter | Standard Deviation 5.62 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 2,n=12,6,5,9,9,6 | -0.7 Micromoles per liter | Standard Deviation 1.03 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 2,n=12,6,5,9,9,6 | -1.3 Micromoles per liter | Standard Deviation 3.27 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 18,n=12,6,6,9,9,6 | 1.75 Micromoles per liter | Standard Deviation 4.831 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 3,n=12,6,6,9,9,6 | -0.3 Micromoles per liter | Standard Deviation 0.82 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 4,n=12,6,6,9,9,6 | -0.3 Micromoles per liter | Standard Deviation 0.82 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 5,n=12,6,6,9,9,6 | -0.7 Micromoles per liter | Standard Deviation 1.03 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 4,n=12,6,6,9,9,6 | 0.3 Micromoles per liter | Standard Deviation 2.34 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 1,n=11,6,6,9,9,5 | -0.3 Micromoles per liter | Standard Deviation 0.82 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 12,n=12,6,6,9,9,6 | 0.88 Micromoles per liter | Standard Deviation 5.043 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 2,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 0 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 4,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 1.26 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 8,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 0 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 12,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 1.26 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 8,n=12,6,6,9,9,6 | 0.28 Micromoles per liter | Standard Deviation 5.062 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 18,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 1.26 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 24,n=12,6,6,9,9,6 | 0.3 Micromoles per liter | Standard Deviation 1.51 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 26,n=12,6,6,9,9,6 | 0.7 Micromoles per liter | Standard Deviation 1.03 |
| GSK3511294 2mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 32,n=6,6,6,0,0,6 | -0.3 Micromoles per liter | Standard Deviation 0.82 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 3,n=12,6,6,9,9,6 | -0.3 Micromoles per liter | Standard Deviation 0.82 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 2,n=12,6,5,9,9,6 | -1.42 Micromoles per liter | Standard Deviation 3.512 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 4,n=12,6,6,9,9,6 | 0.3 Micromoles per liter | Standard Deviation 0.82 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 1,n=11,6,6,9,9,5 | -2.08 Micromoles per liter | Standard Deviation 6.098 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 3,n=12,6,6,9,9,6 | -1.7 Micromoles per liter | Standard Deviation 4.97 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 24,n=12,6,6,9,9,6 | -0.3 Micromoles per liter | Standard Deviation 0.82 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 5,n=12,6,6,9,9,6 | -0.7 Micromoles per liter | Standard Deviation 1.03 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 26,n=12,6,6,9,9,6 | 0.3 Micromoles per liter | Standard Deviation 0.82 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 8,n=12,6,6,9,9,6 | 0.3 Micromoles per liter | Standard Deviation 0.82 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 1,n=11,6,6,9,9,5 | 1.7 Micromoles per liter | Standard Deviation 1.97 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 2,n=12,6,5,9,9,6 | -1.6 Micromoles per liter | Standard Deviation 4.34 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 8,n=12,6,6,9,9,6 | -1.20 Micromoles per liter | Standard Deviation 7.277 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 4,n=12,6,6,9,9,6 | -0.75 Micromoles per liter | Standard Deviation 7.123 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 12,n=12,6,6,9,9,6 | 1.03 Micromoles per liter | Standard Deviation 5.846 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 12,n=12,6,6,9,9,6 | 0.3 Micromoles per liter | Standard Deviation 0.82 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 32,n=6,6,6,0,0,6 | 6.60 Micromoles per liter | Standard Deviation 6.88 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 4,n=12,6,6,9,9,6 | -2.0 Micromoles per liter | Standard Deviation 7.48 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 1,n=11,6,6,9,9,5 | -0.3 Micromoles per liter | Standard Deviation 0.82 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 4,n=12,6,6,9,9,6 | 0.3 Micromoles per liter | Standard Deviation 1.97 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 18,n=12,6,6,9,9,6 | 2.0 Micromoles per liter | Standard Deviation 2.83 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 18,n=12,6,6,9,9,6 | 2.05 Micromoles per liter | Standard Deviation 7.131 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 2,n=12,6,5,9,9,6 | -0.4 Micromoles per liter | Standard Deviation 0.89 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 24,n=12,6,6,9,9,6 | 1.60 Micromoles per liter | Standard Deviation 5.877 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 12,n=12,6,6,9,9,6 | 4.3 Micromoles per liter | Standard Deviation 5.85 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 4,n=12,6,6,9,9,6 | 0.27 Micromoles per liter | Standard Deviation 3.837 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 24,n=12,6,6,9,9,6 | 1.7 Micromoles per liter | Standard Deviation 3.88 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 4,n=12,6,6,9,9,6 | -0.7 Micromoles per liter | Standard Deviation 1.03 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 5,n=12,6,6,9,9,6 | -2.0 Micromoles per liter | Standard Deviation 3.58 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 32,n=6,6,6,0,0,6 | -0.3 Micromoles per liter | Standard Deviation 1.51 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 26,n=12,6,6,9,9,6 | 0.3 Micromoles per liter | Standard Deviation 3.88 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 2,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 0 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 8,n=12,6,6,9,9,6 | 2.0 Micromoles per liter | Standard Deviation 2.83 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 3,n=12,6,6,9,9,6 | -2.95 Micromoles per liter | Standard Deviation 6.208 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 26,n=12,6,6,9,9,6 | 0.27 Micromoles per liter | Standard Deviation 15.342 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 18,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 0 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 32,n=6,6,6,0,0,6 | 0.0 Micromoles per liter | Standard Deviation 5.22 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 5,n=12,6,6,9,9,6 | -2.53 Micromoles per liter | Standard Deviation 4.541 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 2,n=12,6,6,9,9,6 | -0.90 Micromoles per liter | Standard Deviation 6.377 |
| GSK3511294 10mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 2,n=12,6,6,9,9,6 | 0.7 Micromoles per liter | Standard Deviation 2.73 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 36,n=6,0,0,9,9,0 | 0.4 Micromoles per liter | Standard Deviation 3.13 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 1,n=11,6,6,9,9,5 | -1.1 Micromoles per liter | Standard Deviation 4.91 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 18,n=12,6,6,9,9,6 | 0.7 Micromoles per liter | Standard Deviation 1 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 2,n=12,6,5,9,9,6 | -0.2 Micromoles per liter | Standard Deviation 1.2 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 4,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 4.47 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 3,n=12,6,6,9,9,6 | -1.58 Micromoles per liter | Standard Deviation 4.913 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 3,n=12,6,6,9,9,6 | 0.4 Micromoles per liter | Standard Deviation 1.67 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 5,n=12,6,6,9,9,6 | -0.9 Micromoles per liter | Standard Deviation 5.49 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 1,n=11,6,6,9,9,5 | -3.06 Micromoles per liter | Standard Deviation 6.393 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 4,n=12,6,6,9,9,6 | 0.2 Micromoles per liter | Standard Deviation 1.56 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 2,n=12,6,5,9,9,6 | -0.2 Micromoles per liter | Standard Deviation 3.23 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 12,n=12,6,6,9,9,6 | -0.41 Micromoles per liter | Standard Deviation 4.748 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 5,n=12,6,6,9,9,6 | 0.2 Micromoles per liter | Standard Deviation 1.56 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 24,n=12,6,6,9,9,6 | 0.2 Micromoles per liter | Standard Deviation 1.2 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 1,n=11,6,6,9,9,5 | 0.0 Micromoles per liter | Standard Deviation 1.41 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 36,n=6,0,0,9,9,0 | 2.57 Micromoles per liter | Standard Deviation 4.347 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 4,n=12,6,6,9,9,6 | 0.09 Micromoles per liter | Standard Deviation 6.843 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 5,n=12,6,6,9,9,6 | -4.63 Micromoles per liter | Standard Deviation 6.355 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 2,n=12,6,5,9,9,6 | -4.91 Micromoles per liter | Standard Deviation 4.835 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 2,n=12,6,6,9,9,6 | 0.7 Micromoles per liter | Standard Deviation 1.41 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 24,n=12,6,6,9,9,6 | 0.2 Micromoles per liter | Standard Deviation 2.54 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 4,n=12,6,6,9,9,6 | 0.2 Micromoles per liter | Standard Deviation 1.2 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 8,n=12,6,6,9,9,6 | 0.19 Micromoles per liter | Standard Deviation 3.718 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 4,n=12,6,6,9,9,6 | -4.64 Micromoles per liter | Standard Deviation 6.296 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 8,n=12,6,6,9,9,6 | 0.9 Micromoles per liter | Standard Deviation 1.45 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 3,n=12,6,6,9,9,6 | 0.2 Micromoles per liter | Standard Deviation 3.8 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 26,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 1.41 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 12,n=12,6,6,9,9,6 | 0.2 Micromoles per liter | Standard Deviation 1.2 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 24,n=12,6,6,9,9,6 | 7.07 Micromoles per liter | Standard Deviation 6.581 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 12,n=12,6,6,9,9,6 | -0.9 Micromoles per liter | Standard Deviation 2.03 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 18,n=12,6,6,9,9,6 | 0.7 Micromoles per liter | Standard Deviation 1.73 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 26,n=12,6,6,9,9,6 | 3.16 Micromoles per liter | Standard Deviation 6.62 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 36,n=6,0,0,9,9,0 | 0.0 Micromoles per liter | Standard Deviation 1 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 2,n=12,6,6,9,9,6 | -2.67 Micromoles per liter | Standard Deviation 5.702 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 8,n=12,6,6,9,9,6 | 2.2 Micromoles per liter | Standard Deviation 4.06 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 26,n=12,6,6,9,9,6 | -0.2 Micromoles per liter | Standard Deviation 3.8 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 4,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 2.45 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 18,n=12,6,6,9,9,6 | 2.83 Micromoles per liter | Standard Deviation 5.033 |
| GSK3511294 30mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 2,n=12,6,6,9,9,6 | 2.2 Micromoles per liter | Standard Deviation 2.91 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 12,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 4.69 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 24,n=12,6,6,9,9,6 | 1.6 Micromoles per liter | Standard Deviation 6.98 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 26,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 1 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 26,n=12,6,6,9,9,6 | 0.69 Micromoles per liter | Standard Deviation 3.857 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 2,n=12,6,5,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 5.2 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 3,n=12,6,6,9,9,6 | -0.4 Micromoles per liter | Standard Deviation 4.77 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 4,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 4.47 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 5,n=12,6,6,9,9,6 | -1.3 Micromoles per liter | Standard Deviation 2.45 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 1,n=11,6,6,9,9,5 | 0.4 Micromoles per liter | Standard Deviation 3.84 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 2,n=12,6,6,9,9,6 | 0.4 Micromoles per liter | Standard Deviation 5.55 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 4,n=12,6,6,9,9,6 | -0.4 Micromoles per liter | Standard Deviation 5.81 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 8,n=12,6,6,9,9,6 | 0.4 Micromoles per liter | Standard Deviation 5.46 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 18,n=12,6,6,9,9,6 | 0.4 Micromoles per liter | Standard Deviation 6.23 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 26,n=12,6,6,9,9,6 | -0.7 Micromoles per liter | Standard Deviation 4.12 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 36,n=6,0,0,9,9,0 | -1.1 Micromoles per liter | Standard Deviation 5.67 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 2,n=12,6,5,9,9,6 | 0.2 Micromoles per liter | Standard Deviation 1.2 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 3,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 1 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 4,n=12,6,6,9,9,6 | 0.2 Micromoles per liter | Standard Deviation 1.2 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 5,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 1 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 1,n=11,6,6,9,9,5 | 0.0 Micromoles per liter | Standard Deviation 1 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 2,n=12,6,6,9,9,6 | 0.2 Micromoles per liter | Standard Deviation 1.2 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 4,n=12,6,6,9,9,6 | 0.2 Micromoles per liter | Standard Deviation 1.2 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 8,n=12,6,6,9,9,6 | 0.4 Micromoles per liter | Standard Deviation 1.33 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 12,n=12,6,6,9,9,6 | 0.2 Micromoles per liter | Standard Deviation 1.2 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 18,n=12,6,6,9,9,6 | 0.4 Micromoles per liter | Standard Deviation 1.33 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 24,n=12,6,6,9,9,6 | 0.9 Micromoles per liter | Standard Deviation 1.76 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 36,n=6,0,0,9,9,0 | 0.4 Micromoles per liter | Standard Deviation 1.67 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 2,n=12,6,5,9,9,6 | -0.77 Micromoles per liter | Standard Deviation 4.863 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 3,n=12,6,6,9,9,6 | -1.87 Micromoles per liter | Standard Deviation 5.026 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 4,n=12,6,6,9,9,6 | -0.88 Micromoles per liter | Standard Deviation 3.18 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 5,n=12,6,6,9,9,6 | 0.39 Micromoles per liter | Standard Deviation 3.085 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 1,n=11,6,6,9,9,5 | 0.59 Micromoles per liter | Standard Deviation 4.303 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 2,n=12,6,6,9,9,6 | 2.27 Micromoles per liter | Standard Deviation 5.322 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 4,n=12,6,6,9,9,6 | 0.59 Micromoles per liter | Standard Deviation 5.989 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 8,n=12,6,6,9,9,6 | 6.00 Micromoles per liter | Standard Deviation 4.511 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 12,n=12,6,6,9,9,6 | 5.01 Micromoles per liter | Standard Deviation 3.82 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 18,n=12,6,6,9,9,6 | 4.42 Micromoles per liter | Standard Deviation 5.191 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 24,n=12,6,6,9,9,6 | 2.66 Micromoles per liter | Standard Deviation 6.005 |
| GSK3511294 100mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 36,n=6,0,0,9,9,0 | 10.42 Micromoles per liter | Standard Deviation 6.864 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 40,n=2,0,0,0,0,6 | -0.3 Micromoles per liter | Standard Deviation 0.82 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 32,n=6,6,6,0,0,6 | 0.0 Micromoles per liter | Standard Deviation 1.26 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 24,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 1.26 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 32,n=6,6,6,0,0,6 | 2.05 Micromoles per liter | Standard Deviation 2.474 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 4,n=12,6,6,9,9,6 | 6.05 Micromoles per liter | Standard Deviation 6.066 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 18,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 1.26 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 12,n=12,6,6,9,9,6 | -0.3 Micromoles per liter | Standard Deviation 1.51 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 8,n=12,6,6,9,9,6 | -0.7 Micromoles per liter | Standard Deviation 1.03 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 4,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 1.26 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 3,n=12,6,6,9,9,6 | 0.3 Micromoles per liter | Standard Deviation 2.34 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 8,n=12,6,6,9,9,6 | 1.63 Micromoles per liter | Standard Deviation 4.317 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 2,n=12,6,6,9,9,6 | 0.3 Micromoles per liter | Standard Deviation 1.51 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 1,n=11,6,6,9,9,5 | -0.8 Micromoles per liter | Standard Deviation 1.1 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 5,n=12,6,6,9,9,6 | -0.7 Micromoles per liter | Standard Deviation 1.03 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 4,n=12,6,6,9,9,6 | -0.3 Micromoles per liter | Standard Deviation 0.82 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 2,n=12,6,5,9,9,6 | 1.0 Micromoles per liter | Standard Deviation 3.03 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 12,n=12,6,6,9,9,6 | 0.72 Micromoles per liter | Standard Deviation 4.532 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 3,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 1.26 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Day 2,n=12,6,5,9,9,6 | 0.3 Micromoles per liter | Standard Deviation 0.82 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 40,n=2,0,0,0,0,6 | 0.7 Micromoles per liter | Standard Deviation 2.07 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 32,n=6,6,6,0,0,6 | 0.0 Micromoles per liter | Standard Deviation 4.9 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 40,n=2,0,0,0,0,6 | 1.60 Micromoles per liter | Standard Deviation 6.174 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 18,n=12,6,6,9,9,6 | 1.15 Micromoles per liter | Standard Deviation 6.297 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 26,n=12,6,6,9,9,6 | 1.7 Micromoles per liter | Standard Deviation 2.34 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 24,n=12,6,6,9,9,6 | 2.0 Micromoles per liter | Standard Deviation 4.56 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 18,n=12,6,6,9,9,6 | -1.0 Micromoles per liter | Standard Deviation 3.52 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 12,n=12,6,6,9,9,6 | -0.7 Micromoles per liter | Standard Deviation 4.5 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Direct bilirubin, Week 26,n=12,6,6,9,9,6 | 0.0 Micromoles per liter | Standard Deviation 1.26 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 24,n=12,6,6,9,9,6 | 2.20 Micromoles per liter | Standard Deviation 4.431 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 8,n=12,6,6,9,9,6 | -1.0 Micromoles per liter | Standard Deviation 4.69 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 4,n=12,6,6,9,9,6 | 1.0 Micromoles per liter | Standard Deviation 2.76 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 2,n=12,6,6,9,9,6 | 0.7 Micromoles per liter | Standard Deviation 2.42 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 26,n=12,6,6,9,9,6 | 3.22 Micromoles per liter | Standard Deviation 5.653 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Week 1,n=11,6,6,9,9,5 | -2.0 Micromoles per liter | Standard Deviation 2.83 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 5,n=12,6,6,9,9,6 | -0.7 Micromoles per liter | Standard Deviation 3.27 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 1,n=11,6,6,9,9,5 | -0.70 Micromoles per liter | Standard Deviation 7.736 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 5,n=12,6,6,9,9,6 | -1.62 Micromoles per liter | Standard Deviation 5.216 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 4,n=12,6,6,9,9,6 | 3.68 Micromoles per liter | Standard Deviation 7.962 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 3,n=12,6,6,9,9,6 | -1.20 Micromoles per liter | Standard Deviation 3.795 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Total bilirubin, Day 4,n=12,6,6,9,9,6 | 1.0 Micromoles per liter | Standard Deviation 3.29 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Week 2,n=12,6,6,9,9,6 | 0.73 Micromoles per liter | Standard Deviation 7.868 |
| GSK3511294 300mg | Change From Baseline in Clinical Chemistry Parameters Like Total Bilirubin, Direct Bilirubin and Creatinine | Creatinine, Day 2,n=12,6,5,9,9,6 | -1.63 Micromoles per liter | Standard Deviation 6.417 |
Primary
Change From Baseline in Heart Rate
Heart rate was assessed in a supine position after 5 minutes of rest. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at 2 and 8 hours at Day 1; Days 2, 3, 4 and 5; Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Heart Rate | 2 hours Day1,n=12,6,6,9,9,6 | 2.2 Beats per minute | Standard Deviation 13.62 |
| Placebo | Change From Baseline in Heart Rate | Week 32,n=6,6,6,0,0,6 | -1.0 Beats per minute | Standard Deviation 10.55 |
| Placebo | Change From Baseline in Heart Rate | Week 1,n=12,6,6,9,9,6 | -1.8 Beats per minute | Standard Deviation 6.03 |
| Placebo | Change From Baseline in Heart Rate | Week 12,n=12,6,6,9,9,6 | -1.2 Beats per minute | Standard Deviation 10.47 |
| Placebo | Change From Baseline in Heart Rate | 8 hours Day1,n=12,6,6,9,9,6 | -1.0 Beats per minute | Standard Deviation 7.05 |
| Placebo | Change From Baseline in Heart Rate | Week 2,n=12,6,6,9,9,6 | -4.8 Beats per minute | Standard Deviation 5.57 |
| Placebo | Change From Baseline in Heart Rate | Week 24,n=12,6,6,9,9,6 | -1.4 Beats per minute | Standard Deviation 10.03 |
| Placebo | Change From Baseline in Heart Rate | Day 2,n=12,6,6,9,9,6 | -1.2 Beats per minute | Standard Deviation 6.59 |
| Placebo | Change From Baseline in Heart Rate | Week 18,n=12,6,6,9,9,6 | -3.2 Beats per minute | Standard Deviation 8.56 |
| Placebo | Change From Baseline in Heart Rate | Week 8,n=12,6,6,9,9,6 | -0.2 Beats per minute | Standard Deviation 7.12 |
| Placebo | Change From Baseline in Heart Rate | Week 36,n=6,0,0,9,9,0 | 0.5 Beats per minute | Standard Deviation 11.59 |
| Placebo | Change From Baseline in Heart Rate | Day 3,n=12,6,6,9,9,6 | -0.2 Beats per minute | Standard Deviation 4.82 |
| Placebo | Change From Baseline in Heart Rate | Day 4,n=12,6,6,9,9,6 | 3.8 Beats per minute | Standard Deviation 7.53 |
| Placebo | Change From Baseline in Heart Rate | Week 26,n=12,6,6,9,9,6 | -2.7 Beats per minute | Standard Deviation 10.04 |
| Placebo | Change From Baseline in Heart Rate | Week 4,n=12,6,6,9,9,6 | -3.2 Beats per minute | Standard Deviation 8.46 |
| Placebo | Change From Baseline in Heart Rate | Day 5,n=12,6,6,9,9,6 | 1.1 Beats per minute | Standard Deviation 4.91 |
| Placebo | Change From Baseline in Heart Rate | Week 40,n=2,0,0,0,0,6 | -2.0 Beats per minute | Standard Deviation 2.83 |
| GSK3511294 2mg | Change From Baseline in Heart Rate | 8 hours Day1,n=12,6,6,9,9,6 | -2.0 Beats per minute | Standard Deviation 7.27 |
| GSK3511294 2mg | Change From Baseline in Heart Rate | Week 32,n=6,6,6,0,0,6 | -2.2 Beats per minute | Standard Deviation 5.19 |
| GSK3511294 2mg | Change From Baseline in Heart Rate | Week 26,n=12,6,6,9,9,6 | -0.2 Beats per minute | Standard Deviation 2.56 |
| GSK3511294 2mg | Change From Baseline in Heart Rate | Day 4,n=12,6,6,9,9,6 | 1.7 Beats per minute | Standard Deviation 4.84 |
| GSK3511294 2mg | Change From Baseline in Heart Rate | Week 1,n=12,6,6,9,9,6 | 0.0 Beats per minute | Standard Deviation 10.58 |
| GSK3511294 2mg | Change From Baseline in Heart Rate | Day 5,n=12,6,6,9,9,6 | 2.8 Beats per minute | Standard Deviation 8.61 |
| GSK3511294 2mg | Change From Baseline in Heart Rate | Week 2,n=12,6,6,9,9,6 | -1.3 Beats per minute | Standard Deviation 5.89 |
| GSK3511294 2mg | Change From Baseline in Heart Rate | Day 3,n=12,6,6,9,9,6 | 0.2 Beats per minute | Standard Deviation 5.88 |
| GSK3511294 2mg | Change From Baseline in Heart Rate | Week 18,n=12,6,6,9,9,6 | -2.0 Beats per minute | Standard Deviation 7.07 |
| GSK3511294 2mg | Change From Baseline in Heart Rate | Week 4,n=12,6,6,9,9,6 | -2.3 Beats per minute | Standard Deviation 2.88 |
| GSK3511294 2mg | Change From Baseline in Heart Rate | Week 24,n=12,6,6,9,9,6 | -0.8 Beats per minute | Standard Deviation 6.85 |
| GSK3511294 2mg | Change From Baseline in Heart Rate | Week 8,n=12,6,6,9,9,6 | -1.8 Beats per minute | Standard Deviation 7.14 |
| GSK3511294 2mg | Change From Baseline in Heart Rate | 2 hours Day1,n=12,6,6,9,9,6 | -4.2 Beats per minute | Standard Deviation 5.27 |
| GSK3511294 2mg | Change From Baseline in Heart Rate | Day 2,n=12,6,6,9,9,6 | -1.5 Beats per minute | Standard Deviation 2.81 |
| GSK3511294 2mg | Change From Baseline in Heart Rate | Week 12,n=12,6,6,9,9,6 | 3.3 Beats per minute | Standard Deviation 8.38 |
| GSK3511294 10mg | Change From Baseline in Heart Rate | Week 1,n=12,6,6,9,9,6 | -1.8 Beats per minute | Standard Deviation 7.05 |
| GSK3511294 10mg | Change From Baseline in Heart Rate | 2 hours Day1,n=12,6,6,9,9,6 | -3.3 Beats per minute | Standard Deviation 8.64 |
| GSK3511294 10mg | Change From Baseline in Heart Rate | Week 18,n=12,6,6,9,9,6 | -1.7 Beats per minute | Standard Deviation 5.5 |
| GSK3511294 10mg | Change From Baseline in Heart Rate | Week 24,n=12,6,6,9,9,6 | 1.8 Beats per minute | Standard Deviation 7.68 |
| GSK3511294 10mg | Change From Baseline in Heart Rate | Day 2,n=12,6,6,9,9,6 | -1.7 Beats per minute | Standard Deviation 3.83 |
| GSK3511294 10mg | Change From Baseline in Heart Rate | Day 3,n=12,6,6,9,9,6 | 1.3 Beats per minute | Standard Deviation 8.41 |
| GSK3511294 10mg | Change From Baseline in Heart Rate | Week 32,n=6,6,6,0,0,6 | 0.7 Beats per minute | Standard Deviation 6.06 |
| GSK3511294 10mg | Change From Baseline in Heart Rate | Day 4,n=12,6,6,9,9,6 | 4.7 Beats per minute | Standard Deviation 8.98 |
| GSK3511294 10mg | Change From Baseline in Heart Rate | Day 5,n=12,6,6,9,9,6 | 1.2 Beats per minute | Standard Deviation 7.83 |
| GSK3511294 10mg | Change From Baseline in Heart Rate | Week 12,n=12,6,6,9,9,6 | -2.3 Beats per minute | Standard Deviation 6.53 |
| GSK3511294 10mg | Change From Baseline in Heart Rate | Week 2,n=12,6,6,9,9,6 | -5.2 Beats per minute | Standard Deviation 5.23 |
| GSK3511294 10mg | Change From Baseline in Heart Rate | Week 26,n=12,6,6,9,9,6 | -0.7 Beats per minute | Standard Deviation 6.59 |
| GSK3511294 10mg | Change From Baseline in Heart Rate | Week 4,n=12,6,6,9,9,6 | -1.5 Beats per minute | Standard Deviation 5.96 |
| GSK3511294 10mg | Change From Baseline in Heart Rate | 8 hours Day1,n=12,6,6,9,9,6 | -3.2 Beats per minute | Standard Deviation 3.37 |
| GSK3511294 10mg | Change From Baseline in Heart Rate | Week 8,n=12,6,6,9,9,6 | -3.7 Beats per minute | Standard Deviation 5.79 |
| GSK3511294 30mg | Change From Baseline in Heart Rate | 8 hours Day1,n=12,6,6,9,9,6 | 0.3 Beats per minute | Standard Deviation 14.21 |
| GSK3511294 30mg | Change From Baseline in Heart Rate | Day 4,n=12,6,6,9,9,6 | -1.2 Beats per minute | Standard Deviation 11.62 |
| GSK3511294 30mg | Change From Baseline in Heart Rate | Day 3,n=12,6,6,9,9,6 | 0.7 Beats per minute | Standard Deviation 4.92 |
| GSK3511294 30mg | Change From Baseline in Heart Rate | Week 18,n=12,6,6,9,9,6 | 0.8 Beats per minute | Standard Deviation 10.84 |
| GSK3511294 30mg | Change From Baseline in Heart Rate | Week 4,n=12,6,6,9,9,6 | -1.1 Beats per minute | Standard Deviation 10.54 |
| GSK3511294 30mg | Change From Baseline in Heart Rate | Week 24,n=12,6,6,9,9,6 | -2.8 Beats per minute | Standard Deviation 12.04 |
| GSK3511294 30mg | Change From Baseline in Heart Rate | 2 hours Day1,n=12,6,6,9,9,6 | 0.8 Beats per minute | Standard Deviation 14.45 |
| GSK3511294 30mg | Change From Baseline in Heart Rate | Day 2,n=12,6,6,9,9,6 | -4.0 Beats per minute | Standard Deviation 11.03 |
| GSK3511294 30mg | Change From Baseline in Heart Rate | Week 36,n=6,0,0,9,9,0 | 0.0 Beats per minute | Standard Deviation 12.5 |
| GSK3511294 30mg | Change From Baseline in Heart Rate | Week 12,n=12,6,6,9,9,6 | 0.6 Beats per minute | Standard Deviation 16.41 |
| GSK3511294 30mg | Change From Baseline in Heart Rate | Week 26,n=12,6,6,9,9,6 | 2.0 Beats per minute | Standard Deviation 12.03 |
| GSK3511294 30mg | Change From Baseline in Heart Rate | Week 1,n=12,6,6,9,9,6 | -1.1 Beats per minute | Standard Deviation 10.8 |
| GSK3511294 30mg | Change From Baseline in Heart Rate | Week 8,n=12,6,6,9,9,6 | -4.9 Beats per minute | Standard Deviation 15.39 |
| GSK3511294 30mg | Change From Baseline in Heart Rate | Week 2,n=12,6,6,9,9,6 | 2.1 Beats per minute | Standard Deviation 12.38 |
| GSK3511294 30mg | Change From Baseline in Heart Rate | Day 5,n=12,6,6,9,9,6 | -0.1 Beats per minute | Standard Deviation 10.3 |
| GSK3511294 100mg | Change From Baseline in Heart Rate | Week 18,n=12,6,6,9,9,6 | 1.7 Beats per minute | Standard Deviation 9.1 |
| GSK3511294 100mg | Change From Baseline in Heart Rate | 2 hours Day1,n=12,6,6,9,9,6 | 0.9 Beats per minute | Standard Deviation 10.74 |
| GSK3511294 100mg | Change From Baseline in Heart Rate | 8 hours Day1,n=12,6,6,9,9,6 | 1.0 Beats per minute | Standard Deviation 11.62 |
| GSK3511294 100mg | Change From Baseline in Heart Rate | Day 2,n=12,6,6,9,9,6 | 2.7 Beats per minute | Standard Deviation 8.14 |
| GSK3511294 100mg | Change From Baseline in Heart Rate | Day 3,n=12,6,6,9,9,6 | 4.7 Beats per minute | Standard Deviation 3.94 |
| GSK3511294 100mg | Change From Baseline in Heart Rate | Day 4,n=12,6,6,9,9,6 | 3.6 Beats per minute | Standard Deviation 5.27 |
| GSK3511294 100mg | Change From Baseline in Heart Rate | Day 5,n=12,6,6,9,9,6 | 0.6 Beats per minute | Standard Deviation 4.28 |
| GSK3511294 100mg | Change From Baseline in Heart Rate | Week 1,n=12,6,6,9,9,6 | 1.4 Beats per minute | Standard Deviation 5.98 |
| GSK3511294 100mg | Change From Baseline in Heart Rate | Week 2,n=12,6,6,9,9,6 | 1.0 Beats per minute | Standard Deviation 10.51 |
| GSK3511294 100mg | Change From Baseline in Heart Rate | Week 4,n=12,6,6,9,9,6 | 0.8 Beats per minute | Standard Deviation 13.58 |
| GSK3511294 100mg | Change From Baseline in Heart Rate | Week 8,n=12,6,6,9,9,6 | -0.6 Beats per minute | Standard Deviation 6.52 |
| GSK3511294 100mg | Change From Baseline in Heart Rate | Week 12,n=12,6,6,9,9,6 | 1.0 Beats per minute | Standard Deviation 9.31 |
| GSK3511294 100mg | Change From Baseline in Heart Rate | Week 24,n=12,6,6,9,9,6 | 3.2 Beats per minute | Standard Deviation 9.28 |
| GSK3511294 100mg | Change From Baseline in Heart Rate | Week 26,n=12,6,6,9,9,6 | 1.6 Beats per minute | Standard Deviation 7.09 |
| GSK3511294 100mg | Change From Baseline in Heart Rate | Week 36,n=6,0,0,9,9,0 | 2.6 Beats per minute | Standard Deviation 6.29 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | Week 24,n=12,6,6,9,9,6 | 0.0 Beats per minute | Standard Deviation 4.82 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | Week 8,n=12,6,6,9,9,6 | -0.3 Beats per minute | Standard Deviation 4.72 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | Week 4,n=12,6,6,9,9,6 | 0.5 Beats per minute | Standard Deviation 9.35 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | Week 2,n=12,6,6,9,9,6 | 2.0 Beats per minute | Standard Deviation 6 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | Week 1,n=12,6,6,9,9,6 | 5.0 Beats per minute | Standard Deviation 9.21 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | 2 hours Day1,n=12,6,6,9,9,6 | 5.2 Beats per minute | Standard Deviation 5.46 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | Week 26,n=12,6,6,9,9,6 | 1.8 Beats per minute | Standard Deviation 4.58 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | Day 5,n=12,6,6,9,9,6 | 3.0 Beats per minute | Standard Deviation 4.47 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | Day 4,n=12,6,6,9,9,6 | 1.5 Beats per minute | Standard Deviation 3.33 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | Day 3,n=12,6,6,9,9,6 | -1.0 Beats per minute | Standard Deviation 7.4 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | Week 32,n=6,6,6,0,0,6 | 0.8 Beats per minute | Standard Deviation 7.28 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | Day 2,n=12,6,6,9,9,6 | -0.7 Beats per minute | Standard Deviation 3.5 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | 8 hours Day1,n=12,6,6,9,9,6 | 4.8 Beats per minute | Standard Deviation 8.06 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | Week 18,n=12,6,6,9,9,6 | 2.5 Beats per minute | Standard Deviation 7.23 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | Week 12,n=12,6,6,9,9,6 | 3.0 Beats per minute | Standard Deviation 7.38 |
| GSK3511294 300mg | Change From Baseline in Heart Rate | Week 40,n=2,0,0,0,0,6 | 2.8 Beats per minute | Standard Deviation 10.26 |
Primary
Change From Baseline in Heart Rate: Electrocardiogram (ECG)
12-lead ECG were performed in a supine position using an automated ECG machine that calculated the heart rate and measured PR, QRS, QT and corrected QT (QTc) intervals. ECG measurements were performed in triplicate. When multiple ECGs were performed at the same planned timepoint, the average value of each parameter was used. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at 2 and 8 hours on Day 1; Days 2, 3, 4 and 5; Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 32,n=6,6,6,0,0,6 | -2.7 Beats per minute | Standard Deviation 9.21 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 5,n=12,6,6,9,9,6 | 1.8 Beats per minute | Standard Deviation 4.78 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 3,n=12,6,6,9,9,6 | 1.5 Beats per minute | Standard Deviation 5.93 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | 8 hours Day1,n=12,6,6,9,9,6 | 0.1 Beats per minute | Standard Deviation 6.34 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 40,n=2,0,0,0,0,6 | -4.3 Beats per minute | Standard Deviation 0.47 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | 2 hours Day1,n=12,6,5,9,8,6 | 1.4 Beats per minute | Standard Deviation 11.13 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 8,n=12,6,6,9,9,6 | -0.8 Beats per minute | Standard Deviation 5.91 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 26,n=12,6,6,9,9,6 | -2.0 Beats per minute | Standard Deviation 9.35 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 4,n=12,6,6,9,9,6 | 3.5 Beats per minute | Standard Deviation 5.11 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 4,n=12,6,6,9,9,6 | -3.8 Beats per minute | Standard Deviation 7.01 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 2,n=12,6,6,9,9,6 | -4.2 Beats per minute | Standard Deviation 5.32 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 1,n=12,6,6,9,9,6 | -2.8 Beats per minute | Standard Deviation 5.74 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 18,n=12,6,6,9,9,6 | -3.4 Beats per minute | Standard Deviation 9.05 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 2,n=12,6,6,9,9,6 | 0.4 Beats per minute | Standard Deviation 4.68 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 12,n=12,6,6,9,9,6 | 0.3 Beats per minute | Standard Deviation 11.83 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 24,n=12,6,6,9,9,6 | -2.7 Beats per minute | Standard Deviation 7.95 |
| Placebo | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 36,n=6,0,0,9,9,0 | 1.5 Beats per minute | Standard Deviation 7.13 |
| GSK3511294 2mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | 8 hours Day1,n=12,6,6,9,9,6 | -0.8 Beats per minute | Standard Deviation 8.93 |
| GSK3511294 2mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 12,n=12,6,6,9,9,6 | -1.3 Beats per minute | Standard Deviation 6.24 |
| GSK3511294 2mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 4,n=12,6,6,9,9,6 | -1.6 Beats per minute | Standard Deviation 3.75 |
| GSK3511294 2mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 8,n=12,6,6,9,9,6 | -0.6 Beats per minute | Standard Deviation 6.22 |
| GSK3511294 2mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | 2 hours Day1,n=12,6,5,9,8,6 | -4.3 Beats per minute | Standard Deviation 7.81 |
| GSK3511294 2mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 32,n=6,6,6,0,0,6 | -4.6 Beats per minute | Standard Deviation 7.34 |
| GSK3511294 2mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 2,n=12,6,6,9,9,6 | -0.4 Beats per minute | Standard Deviation 5.67 |
| GSK3511294 2mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 3,n=12,6,6,9,9,6 | 0.3 Beats per minute | Standard Deviation 4.15 |
| GSK3511294 2mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 26,n=12,6,6,9,9,6 | -0.3 Beats per minute | Standard Deviation 5.16 |
| GSK3511294 2mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 4,n=12,6,6,9,9,6 | 1.5 Beats per minute | Standard Deviation 8.64 |
| GSK3511294 2mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 24,n=12,6,6,9,9,6 | -0.2 Beats per minute | Standard Deviation 8.28 |
| GSK3511294 2mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 5,n=12,6,6,9,9,6 | 1.5 Beats per minute | Standard Deviation 9.63 |
| GSK3511294 2mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 1,n=12,6,6,9,9,6 | 1.6 Beats per minute | Standard Deviation 5.76 |
| GSK3511294 2mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 18,n=12,6,6,9,9,6 | -0.4 Beats per minute | Standard Deviation 6.59 |
| GSK3511294 2mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 2,n=12,6,6,9,9,6 | -2.3 Beats per minute | Standard Deviation 5.02 |
| GSK3511294 10mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 4,n=12,6,6,9,9,6 | -1.2 Beats per minute | Standard Deviation 3.45 |
| GSK3511294 10mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 5,n=12,6,6,9,9,6 | 0.8 Beats per minute | Standard Deviation 5.24 |
| GSK3511294 10mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | 2 hours Day1,n=12,6,5,9,8,6 | -4.6 Beats per minute | Standard Deviation 4.56 |
| GSK3511294 10mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 2,n=12,6,6,9,9,6 | 0.8 Beats per minute | Standard Deviation 5.29 |
| GSK3511294 10mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 18,n=12,6,6,9,9,6 | -3.3 Beats per minute | Standard Deviation 5.2 |
| GSK3511294 10mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 32,n=6,6,6,0,0,6 | 0.7 Beats per minute | Standard Deviation 5.84 |
| GSK3511294 10mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 12,n=12,6,6,9,9,6 | -3.3 Beats per minute | Standard Deviation 6.35 |
| GSK3511294 10mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 1,n=12,6,6,9,9,6 | -2.4 Beats per minute | Standard Deviation 5.53 |
| GSK3511294 10mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 8,n=12,6,6,9,9,6 | -2.0 Beats per minute | Standard Deviation 6.02 |
| GSK3511294 10mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 2,n=12,6,6,9,9,6 | -5.9 Beats per minute | Standard Deviation 5.91 |
| GSK3511294 10mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 4,n=12,6,6,9,9,6 | 5.5 Beats per minute | Standard Deviation 9.13 |
| GSK3511294 10mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 3,n=12,6,6,9,9,6 | 0.4 Beats per minute | Standard Deviation 7.36 |
| GSK3511294 10mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 24,n=12,6,6,9,9,6 | 2.5 Beats per minute | Standard Deviation 8 |
| GSK3511294 10mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | 8 hours Day1,n=12,6,6,9,9,6 | -6.3 Beats per minute | Standard Deviation 6.1 |
| GSK3511294 10mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 26,n=12,6,6,9,9,6 | -1.5 Beats per minute | Standard Deviation 7.18 |
| GSK3511294 30mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 8,n=12,6,6,9,9,6 | -2.9 Beats per minute | Standard Deviation 7.5 |
| GSK3511294 30mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | 2 hours Day1,n=12,6,5,9,8,6 | 0.2 Beats per minute | Standard Deviation 11.06 |
| GSK3511294 30mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | 8 hours Day1,n=12,6,6,9,9,6 | -1.3 Beats per minute | Standard Deviation 6.23 |
| GSK3511294 30mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 2,n=12,6,6,9,9,6 | -1.4 Beats per minute | Standard Deviation 6.32 |
| GSK3511294 30mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 3,n=12,6,6,9,9,6 | 1.5 Beats per minute | Standard Deviation 7.03 |
| GSK3511294 30mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 4,n=12,6,6,9,9,6 | 3.1 Beats per minute | Standard Deviation 11.04 |
| GSK3511294 30mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 5,n=12,6,6,9,9,6 | 2.5 Beats per minute | Standard Deviation 5.29 |
| GSK3511294 30mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 1,n=12,6,6,9,9,6 | 2.4 Beats per minute | Standard Deviation 9.66 |
| GSK3511294 30mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 2,n=12,6,6,9,9,6 | 1.8 Beats per minute | Standard Deviation 10.26 |
| GSK3511294 30mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 4,n=12,6,6,9,9,6 | -1.6 Beats per minute | Standard Deviation 7.53 |
| GSK3511294 30mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 12,n=12,6,6,9,9,6 | 1.8 Beats per minute | Standard Deviation 15.28 |
| GSK3511294 30mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 18,n=12,6,6,9,9,6 | 1.6 Beats per minute | Standard Deviation 6.92 |
| GSK3511294 30mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 24,n=12,6,6,9,9,6 | -0.3 Beats per minute | Standard Deviation 9.13 |
| GSK3511294 30mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 26,n=12,6,6,9,9,6 | 2.5 Beats per minute | Standard Deviation 11.97 |
| GSK3511294 30mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 36,n=6,0,0,9,9,0 | -0.2 Beats per minute | Standard Deviation 10.26 |
| GSK3511294 100mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 12,n=12,6,6,9,9,6 | 0.4 Beats per minute | Standard Deviation 11.55 |
| GSK3511294 100mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 3,n=12,6,6,9,9,6 | 3.1 Beats per minute | Standard Deviation 3.48 |
| GSK3511294 100mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 5,n=12,6,6,9,9,6 | -0.4 Beats per minute | Standard Deviation 5.97 |
| GSK3511294 100mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | 2 hours Day1,n=12,6,5,9,8,6 | 0.3 Beats per minute | Standard Deviation 11.85 |
| GSK3511294 100mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 26,n=12,6,6,9,9,6 | 2.0 Beats per minute | Standard Deviation 8.22 |
| GSK3511294 100mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 1,n=12,6,6,9,9,6 | 2.0 Beats per minute | Standard Deviation 4.76 |
| GSK3511294 100mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 2,n=12,6,6,9,9,6 | -0.3 Beats per minute | Standard Deviation 7.34 |
| GSK3511294 100mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 4,n=12,6,6,9,9,6 | 2.6 Beats per minute | Standard Deviation 4.6 |
| GSK3511294 100mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | 8 hours Day1,n=12,6,6,9,9,6 | 0.0 Beats per minute | Standard Deviation 14.05 |
| GSK3511294 100mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 36,n=6,0,0,9,9,0 | 1.3 Beats per minute | Standard Deviation 5.74 |
| GSK3511294 100mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 24,n=12,6,6,9,9,6 | 1.7 Beats per minute | Standard Deviation 11.03 |
| GSK3511294 100mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 8,n=12,6,6,9,9,6 | -0.7 Beats per minute | Standard Deviation 9.14 |
| GSK3511294 100mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 18,n=12,6,6,9,9,6 | 0.6 Beats per minute | Standard Deviation 8.78 |
| GSK3511294 100mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 4,n=12,6,6,9,9,6 | -0.3 Beats per minute | Standard Deviation 14.55 |
| GSK3511294 100mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 2,n=12,6,6,9,9,6 | 1.7 Beats per minute | Standard Deviation 13.56 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 8,n=12,6,6,9,9,6 | 0.6 Beats per minute | Standard Deviation 4.97 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 2,n=12,6,6,9,9,6 | 1.7 Beats per minute | Standard Deviation 7.11 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | 2 hours Day1,n=12,6,5,9,8,6 | 6.8 Beats per minute | Standard Deviation 7.01 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 12,n=12,6,6,9,9,6 | 1.3 Beats per minute | Standard Deviation 6.44 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 1,n=12,6,6,9,9,6 | 4.9 Beats per minute | Standard Deviation 7.6 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 5,n=12,6,6,9,9,6 | 2.6 Beats per minute | Standard Deviation 4.75 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 40,n=2,0,0,0,0,6 | 3.6 Beats per minute | Standard Deviation 9.08 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 18,n=12,6,6,9,9,6 | 2.2 Beats per minute | Standard Deviation 4.65 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 4,n=12,6,6,9,9,6 | 3.2 Beats per minute | Standard Deviation 3.97 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 24,n=12,6,6,9,9,6 | 1.2 Beats per minute | Standard Deviation 6.47 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 3,n=12,6,6,9,9,6 | 1.9 Beats per minute | Standard Deviation 3.69 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Day 2,n=12,6,6,9,9,6 | 0.3 Beats per minute | Standard Deviation 1.06 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 26,n=12,6,6,9,9,6 | 0.3 Beats per minute | Standard Deviation 7.66 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | 8 hours Day1,n=12,6,6,9,9,6 | 4.1 Beats per minute | Standard Deviation 6.2 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 32,n=6,6,6,0,0,6 | 2.3 Beats per minute | Standard Deviation 6.46 |
| GSK3511294 300mg | Change From Baseline in Heart Rate: Electrocardiogram (ECG) | Week 4,n=12,6,6,9,9,6 | -0.9 Beats per minute | Standard Deviation 6.25 |
Primary
Change From Baseline in Hematocrit
Blood samples were collected at indicated time-points for analysis of hematology parameters like hematocrit. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Hematocrit | Day 2,n=12,6,6,9,9,6 | -0.007 Proportion of red blood cells in blood | Standard Deviation 0.01961 |
| Placebo | Change From Baseline in Hematocrit | Week 24,n=11,6,6,9,9,6 | -0.013 Proportion of red blood cells in blood | Standard Deviation 0.02108 |
| Placebo | Change From Baseline in Hematocrit | Week 32,n=6,6,6,0,0,6 | -0.005 Proportion of red blood cells in blood | Standard Deviation 0.01904 |
| Placebo | Change From Baseline in Hematocrit | Day 5,n=12,6,6,9,9,6 | -0.010 Proportion of red blood cells in blood | Standard Deviation 0.01509 |
| Placebo | Change From Baseline in Hematocrit | Week 4,n=12,6,5,9,9,6 | -0.011 Proportion of red blood cells in blood | Standard Deviation 0.0184 |
| Placebo | Change From Baseline in Hematocrit | Week 40,n=2,0,0,0,0,6 | -0.004 Proportion of red blood cells in blood | Standard Deviation 0.00495 |
| Placebo | Change From Baseline in Hematocrit | Week 18,n=12,6,6,9,9,6 | -0.004 Proportion of red blood cells in blood | Standard Deviation 0.0268 |
| Placebo | Change From Baseline in Hematocrit | Week 26,n=12,6,6,9,9,6 | -0.013 Proportion of red blood cells in blood | Standard Deviation 0.02378 |
| Placebo | Change From Baseline in Hematocrit | Week 12,n=12,6,6,9,9,5 | -0.010 Proportion of red blood cells in blood | Standard Deviation 0.01745 |
| Placebo | Change From Baseline in Hematocrit | Week 1,n=12,6,6,9,9,6 | -0.014 Proportion of red blood cells in blood | Standard Deviation 0.01894 |
| Placebo | Change From Baseline in Hematocrit | Day 4,n=12,6,6,8,8,6 | -0.003 Proportion of red blood cells in blood | Standard Deviation 0.01777 |
| Placebo | Change From Baseline in Hematocrit | Week 36,n=6,0,0,9,9,0 | 0.001 Proportion of red blood cells in blood | Standard Deviation 0.01862 |
| Placebo | Change From Baseline in Hematocrit | Week 8,n=12,6,6,9,9,6 | -0.001 Proportion of red blood cells in blood | Standard Deviation 0.02285 |
| Placebo | Change From Baseline in Hematocrit | Day 3,n=12,6,6,9,9,6 | 0.005 Proportion of red blood cells in blood | Standard Deviation 0.01925 |
| Placebo | Change From Baseline in Hematocrit | Week 2,n=12,6,6,9,9,6 | -0.010 Proportion of red blood cells in blood | Standard Deviation 0.0167 |
| GSK3511294 2mg | Change From Baseline in Hematocrit | Week 8,n=12,6,6,9,9,6 | -0.020 Proportion of red blood cells in blood | Standard Deviation 0.02119 |
| GSK3511294 2mg | Change From Baseline in Hematocrit | Week 4,n=12,6,5,9,9,6 | -0.032 Proportion of red blood cells in blood | Standard Deviation 0.01393 |
| GSK3511294 2mg | Change From Baseline in Hematocrit | Week 2,n=12,6,6,9,9,6 | -0.025 Proportion of red blood cells in blood | Standard Deviation 0.01626 |
| GSK3511294 2mg | Change From Baseline in Hematocrit | Week 32,n=6,6,6,0,0,6 | -0.015 Proportion of red blood cells in blood | Standard Deviation 0.0222 |
| GSK3511294 2mg | Change From Baseline in Hematocrit | Day 3,n=12,6,6,9,9,6 | -0.007 Proportion of red blood cells in blood | Standard Deviation 0.01374 |
| GSK3511294 2mg | Change From Baseline in Hematocrit | Week 26,n=12,6,6,9,9,6 | -0.029 Proportion of red blood cells in blood | Standard Deviation 0.02593 |
| GSK3511294 2mg | Change From Baseline in Hematocrit | Day 4,n=12,6,6,8,8,6 | -0.009 Proportion of red blood cells in blood | Standard Deviation 0.01803 |
| GSK3511294 2mg | Change From Baseline in Hematocrit | Day 2,n=12,6,6,9,9,6 | -0.001 Proportion of red blood cells in blood | Standard Deviation 0.01884 |
| GSK3511294 2mg | Change From Baseline in Hematocrit | Week 24,n=11,6,6,9,9,6 | -0.023 Proportion of red blood cells in blood | Standard Deviation 0.02325 |
| GSK3511294 2mg | Change From Baseline in Hematocrit | Week 18,n=12,6,6,9,9,6 | -0.020 Proportion of red blood cells in blood | Standard Deviation 0.0214 |
| GSK3511294 2mg | Change From Baseline in Hematocrit | Day 5,n=12,6,6,9,9,6 | -0.015 Proportion of red blood cells in blood | Standard Deviation 0.0134 |
| GSK3511294 2mg | Change From Baseline in Hematocrit | Week 12,n=12,6,6,9,9,5 | -0.025 Proportion of red blood cells in blood | Standard Deviation 0.01262 |
| GSK3511294 2mg | Change From Baseline in Hematocrit | Week 1,n=12,6,6,9,9,6 | -0.034 Proportion of red blood cells in blood | Standard Deviation 0.01549 |
| GSK3511294 10mg | Change From Baseline in Hematocrit | Day 2,n=12,6,6,9,9,6 | 0.009 Proportion of red blood cells in blood | Standard Deviation 0.02262 |
| GSK3511294 10mg | Change From Baseline in Hematocrit | Day 3,n=12,6,6,9,9,6 | 0.014 Proportion of red blood cells in blood | Standard Deviation 0.02667 |
| GSK3511294 10mg | Change From Baseline in Hematocrit | Day 4,n=12,6,6,8,8,6 | 0.005 Proportion of red blood cells in blood | Standard Deviation 0.0217 |
| GSK3511294 10mg | Change From Baseline in Hematocrit | Day 5,n=12,6,6,9,9,6 | -0.004 Proportion of red blood cells in blood | Standard Deviation 0.02743 |
| GSK3511294 10mg | Change From Baseline in Hematocrit | Week 1,n=12,6,6,9,9,6 | 0.000 Proportion of red blood cells in blood | Standard Deviation 0.02138 |
| GSK3511294 10mg | Change From Baseline in Hematocrit | Week 2,n=12,6,6,9,9,6 | -0.016 Proportion of red blood cells in blood | Standard Deviation 0.01928 |
| GSK3511294 10mg | Change From Baseline in Hematocrit | Week 4,n=12,6,5,9,9,6 | -0.010 Proportion of red blood cells in blood | Standard Deviation 0.02192 |
| GSK3511294 10mg | Change From Baseline in Hematocrit | Week 8,n=12,6,6,9,9,6 | -0.000 Proportion of red blood cells in blood | Standard Deviation 0.02367 |
| GSK3511294 10mg | Change From Baseline in Hematocrit | Week 12,n=12,6,6,9,9,5 | -0.001 Proportion of red blood cells in blood | Standard Deviation 0.02587 |
| GSK3511294 10mg | Change From Baseline in Hematocrit | Week 18,n=12,6,6,9,9,6 | -0.005 Proportion of red blood cells in blood | Standard Deviation 0.03041 |
| GSK3511294 10mg | Change From Baseline in Hematocrit | Week 24,n=11,6,6,9,9,6 | 0.001 Proportion of red blood cells in blood | Standard Deviation 0.01955 |
| GSK3511294 10mg | Change From Baseline in Hematocrit | Week 26,n=12,6,6,9,9,6 | -0.004 Proportion of red blood cells in blood | Standard Deviation 0.01813 |
| GSK3511294 10mg | Change From Baseline in Hematocrit | Week 32,n=6,6,6,0,0,6 | 0.009 Proportion of red blood cells in blood | Standard Deviation 0.02413 |
| GSK3511294 30mg | Change From Baseline in Hematocrit | Day 5,n=12,6,6,9,9,6 | 0.001 Proportion of red blood cells in blood | Standard Deviation 0.0197 |
| GSK3511294 30mg | Change From Baseline in Hematocrit | Day 2,n=12,6,6,9,9,6 | 0.000 Proportion of red blood cells in blood | Standard Deviation 0.015 |
| GSK3511294 30mg | Change From Baseline in Hematocrit | Week 36,n=6,0,0,9,9,0 | -0.001 Proportion of red blood cells in blood | Standard Deviation 0.01237 |
| GSK3511294 30mg | Change From Baseline in Hematocrit | Week 18,n=12,6,6,9,9,6 | -0.010 Proportion of red blood cells in blood | Standard Deviation 0.02016 |
| GSK3511294 30mg | Change From Baseline in Hematocrit | Week 2,n=12,6,6,9,9,6 | -0.009 Proportion of red blood cells in blood | Standard Deviation 0.0196 |
| GSK3511294 30mg | Change From Baseline in Hematocrit | Week 24,n=11,6,6,9,9,6 | -0.006 Proportion of red blood cells in blood | Standard Deviation 0.01726 |
| GSK3511294 30mg | Change From Baseline in Hematocrit | Day 3,n=12,6,6,9,9,6 | 0.001 Proportion of red blood cells in blood | Standard Deviation 0.01634 |
| GSK3511294 30mg | Change From Baseline in Hematocrit | Day 4,n=12,6,6,8,8,6 | -0.003 Proportion of red blood cells in blood | Standard Deviation 0.01663 |
| GSK3511294 30mg | Change From Baseline in Hematocrit | Week 4,n=12,6,5,9,9,6 | -0.010 Proportion of red blood cells in blood | Standard Deviation 0.02063 |
| GSK3511294 30mg | Change From Baseline in Hematocrit | Week 8,n=12,6,6,9,9,6 | -0.011 Proportion of red blood cells in blood | Standard Deviation 0.01889 |
| GSK3511294 30mg | Change From Baseline in Hematocrit | Week 12,n=12,6,6,9,9,5 | -0.005 Proportion of red blood cells in blood | Standard Deviation 0.02379 |
| GSK3511294 30mg | Change From Baseline in Hematocrit | Week 1,n=12,6,6,9,9,6 | -0.008 Proportion of red blood cells in blood | Standard Deviation 0.02644 |
| GSK3511294 30mg | Change From Baseline in Hematocrit | Week 26,n=12,6,6,9,9,6 | -0.007 Proportion of red blood cells in blood | Standard Deviation 0.01424 |
| GSK3511294 100mg | Change From Baseline in Hematocrit | Week 4,n=12,6,5,9,9,6 | 0.001 Proportion of red blood cells in blood | Standard Deviation 0.02962 |
| GSK3511294 100mg | Change From Baseline in Hematocrit | Week 1,n=12,6,6,9,9,6 | -0.001 Proportion of red blood cells in blood | Standard Deviation 0.02068 |
| GSK3511294 100mg | Change From Baseline in Hematocrit | Week 8,n=12,6,6,9,9,6 | 0.005 Proportion of red blood cells in blood | Standard Deviation 0.03084 |
| GSK3511294 100mg | Change From Baseline in Hematocrit | Day 5,n=12,6,6,9,9,6 | -0.001 Proportion of red blood cells in blood | Standard Deviation 0.03295 |
| GSK3511294 100mg | Change From Baseline in Hematocrit | Day 2,n=12,6,6,9,9,6 | 0.011 Proportion of red blood cells in blood | Standard Deviation 0.02356 |
| GSK3511294 100mg | Change From Baseline in Hematocrit | Week 12,n=12,6,6,9,9,5 | 0.006 Proportion of red blood cells in blood | Standard Deviation 0.02343 |
| GSK3511294 100mg | Change From Baseline in Hematocrit | Week 18,n=12,6,6,9,9,6 | 0.012 Proportion of red blood cells in blood | Standard Deviation 0.02972 |
| GSK3511294 100mg | Change From Baseline in Hematocrit | Day 4,n=12,6,6,8,8,6 | -0.004 Proportion of red blood cells in blood | Standard Deviation 0.01858 |
| GSK3511294 100mg | Change From Baseline in Hematocrit | Week 36,n=6,0,0,9,9,0 | 0.022 Proportion of red blood cells in blood | Standard Deviation 0.03464 |
| GSK3511294 100mg | Change From Baseline in Hematocrit | Week 24,n=11,6,6,9,9,6 | 0.001 Proportion of red blood cells in blood | Standard Deviation 0.02607 |
| GSK3511294 100mg | Change From Baseline in Hematocrit | Day 3,n=12,6,6,9,9,6 | -0.000 Proportion of red blood cells in blood | Standard Deviation 0.01198 |
| GSK3511294 100mg | Change From Baseline in Hematocrit | Week 26,n=12,6,6,9,9,6 | 0.008 Proportion of red blood cells in blood | Standard Deviation 0.01829 |
| GSK3511294 100mg | Change From Baseline in Hematocrit | Week 2,n=12,6,6,9,9,6 | 0.002 Proportion of red blood cells in blood | Standard Deviation 0.02469 |
| GSK3511294 300mg | Change From Baseline in Hematocrit | Week 40,n=2,0,0,0,0,6 | 0.016 Proportion of red blood cells in blood | Standard Deviation 0.00816 |
| GSK3511294 300mg | Change From Baseline in Hematocrit | Day 4,n=12,6,6,8,8,6 | 0.008 Proportion of red blood cells in blood | Standard Deviation 0.01251 |
| GSK3511294 300mg | Change From Baseline in Hematocrit | Week 12,n=12,6,6,9,9,5 | -0.006 Proportion of red blood cells in blood | Standard Deviation 0.01279 |
| GSK3511294 300mg | Change From Baseline in Hematocrit | Week 32,n=6,6,6,0,0,6 | 0.002 Proportion of red blood cells in blood | Standard Deviation 0.01851 |
| GSK3511294 300mg | Change From Baseline in Hematocrit | Week 26,n=12,6,6,9,9,6 | 0.006 Proportion of red blood cells in blood | Standard Deviation 0.01091 |
| GSK3511294 300mg | Change From Baseline in Hematocrit | Day 5,n=12,6,6,9,9,6 | 0.006 Proportion of red blood cells in blood | Standard Deviation 0.01061 |
| GSK3511294 300mg | Change From Baseline in Hematocrit | Day 2,n=12,6,6,9,9,6 | 0.007 Proportion of red blood cells in blood | Standard Deviation 0.02689 |
| GSK3511294 300mg | Change From Baseline in Hematocrit | Week 4,n=12,6,5,9,9,6 | -0.004 Proportion of red blood cells in blood | Standard Deviation 0.01315 |
| GSK3511294 300mg | Change From Baseline in Hematocrit | Week 2,n=12,6,6,9,9,6 | -0.011 Proportion of red blood cells in blood | Standard Deviation 0.01759 |
| GSK3511294 300mg | Change From Baseline in Hematocrit | Week 8,n=12,6,6,9,9,6 | 0.002 Proportion of red blood cells in blood | Standard Deviation 0.0075 |
| GSK3511294 300mg | Change From Baseline in Hematocrit | Week 18,n=12,6,6,9,9,6 | 0.008 Proportion of red blood cells in blood | Standard Deviation 0.01515 |
| GSK3511294 300mg | Change From Baseline in Hematocrit | Week 1,n=12,6,6,9,9,6 | -0.005 Proportion of red blood cells in blood | Standard Deviation 0.01076 |
| GSK3511294 300mg | Change From Baseline in Hematocrit | Week 24,n=11,6,6,9,9,6 | 0.009 Proportion of red blood cells in blood | Standard Deviation 0.01184 |
| GSK3511294 300mg | Change From Baseline in Hematocrit | Day 3,n=12,6,6,9,9,6 | 0.001 Proportion of red blood cells in blood | Standard Deviation 0.01584 |
Primary
Change From Baseline in Hemoglobin
Blood samples were collected at indicated time-points for analysis of hematology parameters like hemoglobin. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Hemoglobin | Week 8,n=12,6,6,9,9,6 | -1.1 Grams per liter | Standard Deviation 8.83 |
| Placebo | Change From Baseline in Hemoglobin | Week 36,n=6,0,0,9,9,0 | -1.8 Grams per liter | Standard Deviation 8.47 |
| Placebo | Change From Baseline in Hemoglobin | Week 4,n=12,6,5,9,9,6 | -4.2 Grams per liter | Standard Deviation 5.08 |
| Placebo | Change From Baseline in Hemoglobin | Week 32,n=6,6,6,0,0,6 | -1.7 Grams per liter | Standard Deviation 3.78 |
| Placebo | Change From Baseline in Hemoglobin | Day 3,n=12,6,6,9,9,6 | 1.6 Grams per liter | Standard Deviation 6.78 |
| Placebo | Change From Baseline in Hemoglobin | Day 2,n=12,6,6,9,9,6 | -2.4 Grams per liter | Standard Deviation 6.83 |
| Placebo | Change From Baseline in Hemoglobin | Week 26,n=12,6,6,9,9,6 | -4.6 Grams per liter | Standard Deviation 9.7 |
| Placebo | Change From Baseline in Hemoglobin | Day 4,n=12,6,6,8,8,6 | -0.8 Grams per liter | Standard Deviation 6.69 |
| Placebo | Change From Baseline in Hemoglobin | Week 24,n=11,6,6,9,9,6 | -5.3 Grams per liter | Standard Deviation 8.31 |
| Placebo | Change From Baseline in Hemoglobin | Day 5,n=12,6,6,9,9,6 | -5.0 Grams per liter | Standard Deviation 4.65 |
| Placebo | Change From Baseline in Hemoglobin | Week 18,n=12,6,6,9,9,6 | -1.6 Grams per liter | Standard Deviation 8.47 |
| Placebo | Change From Baseline in Hemoglobin | Week 12,n=12,6,6,9,9,5 | -4.3 Grams per liter | Standard Deviation 6.5 |
| Placebo | Change From Baseline in Hemoglobin | Week 1,n=12,6,6,9,9,6 | -4.9 Grams per liter | Standard Deviation 6.5 |
| Placebo | Change From Baseline in Hemoglobin | Week 40,n=2,0,0,0,0,6 | -3.5 Grams per liter | Standard Deviation 3.54 |
| Placebo | Change From Baseline in Hemoglobin | Week 2,n=12,6,6,9,9,6 | -3.3 Grams per liter | Standard Deviation 5.79 |
| GSK3511294 2mg | Change From Baseline in Hemoglobin | Week 4,n=12,6,5,9,9,6 | -8.0 Grams per liter | Standard Deviation 4.1 |
| GSK3511294 2mg | Change From Baseline in Hemoglobin | Week 8,n=12,6,6,9,9,6 | -4.8 Grams per liter | Standard Deviation 4.96 |
| GSK3511294 2mg | Change From Baseline in Hemoglobin | Week 2,n=12,6,6,9,9,6 | -6.2 Grams per liter | Standard Deviation 4.67 |
| GSK3511294 2mg | Change From Baseline in Hemoglobin | Day 4,n=12,6,6,8,8,6 | -1.3 Grams per liter | Standard Deviation 4.59 |
| GSK3511294 2mg | Change From Baseline in Hemoglobin | Week 12,n=12,6,6,9,9,5 | -4.8 Grams per liter | Standard Deviation 4.49 |
| GSK3511294 2mg | Change From Baseline in Hemoglobin | Week 32,n=6,6,6,0,0,6 | -1.8 Grams per liter | Standard Deviation 4.79 |
| GSK3511294 2mg | Change From Baseline in Hemoglobin | Week 18,n=12,6,6,9,9,6 | -1.8 Grams per liter | Standard Deviation 6.77 |
| GSK3511294 2mg | Change From Baseline in Hemoglobin | Week 1,n=12,6,6,9,9,6 | -8.3 Grams per liter | Standard Deviation 5.28 |
| GSK3511294 2mg | Change From Baseline in Hemoglobin | Day 3,n=12,6,6,9,9,6 | -0.5 Grams per liter | Standard Deviation 4.04 |
| GSK3511294 2mg | Change From Baseline in Hemoglobin | Day 5,n=12,6,6,9,9,6 | -4.8 Grams per liter | Standard Deviation 3.82 |
| GSK3511294 2mg | Change From Baseline in Hemoglobin | Week 26,n=12,6,6,9,9,6 | -4.5 Grams per liter | Standard Deviation 8.07 |
| GSK3511294 2mg | Change From Baseline in Hemoglobin | Day 2,n=12,6,6,9,9,6 | 0.3 Grams per liter | Standard Deviation 6.8 |
| GSK3511294 2mg | Change From Baseline in Hemoglobin | Week 24,n=11,6,6,9,9,6 | -3.2 Grams per liter | Standard Deviation 7.99 |
| GSK3511294 10mg | Change From Baseline in Hemoglobin | Day 5,n=12,6,6,9,9,6 | -0.3 Grams per liter | Standard Deviation 7.84 |
| GSK3511294 10mg | Change From Baseline in Hemoglobin | Day 2,n=12,6,6,9,9,6 | 3.7 Grams per liter | Standard Deviation 7.09 |
| GSK3511294 10mg | Change From Baseline in Hemoglobin | Day 3,n=12,6,6,9,9,6 | 5.8 Grams per liter | Standard Deviation 8.8 |
| GSK3511294 10mg | Change From Baseline in Hemoglobin | Day 4,n=12,6,6,8,8,6 | 3.7 Grams per liter | Standard Deviation 6.02 |
| GSK3511294 10mg | Change From Baseline in Hemoglobin | Week 1,n=12,6,6,9,9,6 | 0.2 Grams per liter | Standard Deviation 6.79 |
| GSK3511294 10mg | Change From Baseline in Hemoglobin | Week 2,n=12,6,6,9,9,6 | -3.7 Grams per liter | Standard Deviation 5.72 |
| GSK3511294 10mg | Change From Baseline in Hemoglobin | Week 4,n=12,6,5,9,9,6 | -3.0 Grams per liter | Standard Deviation 7.94 |
| GSK3511294 10mg | Change From Baseline in Hemoglobin | Week 8,n=12,6,6,9,9,6 | 1.5 Grams per liter | Standard Deviation 8.71 |
| GSK3511294 10mg | Change From Baseline in Hemoglobin | Week 12,n=12,6,6,9,9,5 | -0.2 Grams per liter | Standard Deviation 9.28 |
| GSK3511294 10mg | Change From Baseline in Hemoglobin | Week 18,n=12,6,6,9,9,6 | -2.3 Grams per liter | Standard Deviation 6.62 |
| GSK3511294 10mg | Change From Baseline in Hemoglobin | Week 24,n=11,6,6,9,9,6 | 0.5 Grams per liter | Standard Deviation 6.09 |
| GSK3511294 10mg | Change From Baseline in Hemoglobin | Week 26,n=12,6,6,9,9,6 | -1.0 Grams per liter | Standard Deviation 5.76 |
| GSK3511294 10mg | Change From Baseline in Hemoglobin | Week 32,n=6,6,6,0,0,6 | 5.2 Grams per liter | Standard Deviation 8.38 |
| GSK3511294 30mg | Change From Baseline in Hemoglobin | Week 12,n=12,6,6,9,9,5 | -2.8 Grams per liter | Standard Deviation 7.98 |
| GSK3511294 30mg | Change From Baseline in Hemoglobin | Week 26,n=12,6,6,9,9,6 | -2.2 Grams per liter | Standard Deviation 3.42 |
| GSK3511294 30mg | Change From Baseline in Hemoglobin | Week 36,n=6,0,0,9,9,0 | -2.4 Grams per liter | Standard Deviation 3.13 |
| GSK3511294 30mg | Change From Baseline in Hemoglobin | Week 18,n=12,6,6,9,9,6 | -2.4 Grams per liter | Standard Deviation 6.09 |
| GSK3511294 30mg | Change From Baseline in Hemoglobin | Day 4,n=12,6,6,8,8,6 | -1.0 Grams per liter | Standard Deviation 4.14 |
| GSK3511294 30mg | Change From Baseline in Hemoglobin | Week 1,n=12,6,6,9,9,6 | -1.4 Grams per liter | Standard Deviation 7 |
| GSK3511294 30mg | Change From Baseline in Hemoglobin | Day 2,n=12,6,6,9,9,6 | -0.4 Grams per liter | Standard Deviation 6 |
| GSK3511294 30mg | Change From Baseline in Hemoglobin | Week 2,n=12,6,6,9,9,6 | -2.4 Grams per liter | Standard Deviation 6.29 |
| GSK3511294 30mg | Change From Baseline in Hemoglobin | Week 8,n=12,6,6,9,9,6 | -5.6 Grams per liter | Standard Deviation 6.27 |
| GSK3511294 30mg | Change From Baseline in Hemoglobin | Week 24,n=11,6,6,9,9,6 | -1.7 Grams per liter | Standard Deviation 6.36 |
| GSK3511294 30mg | Change From Baseline in Hemoglobin | Day 5,n=12,6,6,9,9,6 | -2.9 Grams per liter | Standard Deviation 4.54 |
| GSK3511294 30mg | Change From Baseline in Hemoglobin | Week 4,n=12,6,5,9,9,6 | -4.2 Grams per liter | Standard Deviation 6.61 |
| GSK3511294 30mg | Change From Baseline in Hemoglobin | Day 3,n=12,6,6,9,9,6 | 0.1 Grams per liter | Standard Deviation 6.62 |
| GSK3511294 100mg | Change From Baseline in Hemoglobin | Day 3,n=12,6,6,9,9,6 | 2.2 Grams per liter | Standard Deviation 4.35 |
| GSK3511294 100mg | Change From Baseline in Hemoglobin | Week 26,n=12,6,6,9,9,6 | 2.9 Grams per liter | Standard Deviation 6.23 |
| GSK3511294 100mg | Change From Baseline in Hemoglobin | Day 2,n=12,6,6,9,9,6 | 4.3 Grams per liter | Standard Deviation 7.12 |
| GSK3511294 100mg | Change From Baseline in Hemoglobin | Week 2,n=12,6,6,9,9,6 | 3.3 Grams per liter | Standard Deviation 7.73 |
| GSK3511294 100mg | Change From Baseline in Hemoglobin | Week 12,n=12,6,6,9,9,5 | 5.9 Grams per liter | Standard Deviation 6.39 |
| GSK3511294 100mg | Change From Baseline in Hemoglobin | Week 4,n=12,6,5,9,9,6 | 2.6 Grams per liter | Standard Deviation 10.36 |
| GSK3511294 100mg | Change From Baseline in Hemoglobin | Week 8,n=12,6,6,9,9,6 | 4.9 Grams per liter | Standard Deviation 7.8 |
| GSK3511294 100mg | Change From Baseline in Hemoglobin | Week 18,n=12,6,6,9,9,6 | 8.3 Grams per liter | Standard Deviation 9.25 |
| GSK3511294 100mg | Change From Baseline in Hemoglobin | Day 4,n=12,6,6,8,8,6 | 1.4 Grams per liter | Standard Deviation 5.32 |
| GSK3511294 100mg | Change From Baseline in Hemoglobin | Week 1,n=12,6,6,9,9,6 | 2.0 Grams per liter | Standard Deviation 6.42 |
| GSK3511294 100mg | Change From Baseline in Hemoglobin | Week 36,n=6,0,0,9,9,0 | 6.9 Grams per liter | Standard Deviation 10.67 |
| GSK3511294 100mg | Change From Baseline in Hemoglobin | Week 24,n=11,6,6,9,9,6 | 2.4 Grams per liter | Standard Deviation 7.67 |
| GSK3511294 100mg | Change From Baseline in Hemoglobin | Day 5,n=12,6,6,9,9,6 | 0.8 Grams per liter | Standard Deviation 8.86 |
| GSK3511294 300mg | Change From Baseline in Hemoglobin | Day 3,n=12,6,6,9,9,6 | -0.5 Grams per liter | Standard Deviation 5.82 |
| GSK3511294 300mg | Change From Baseline in Hemoglobin | Week 32,n=6,6,6,0,0,6 | -1.8 Grams per liter | Standard Deviation 5.71 |
| GSK3511294 300mg | Change From Baseline in Hemoglobin | Week 8,n=12,6,6,9,9,6 | -0.2 Grams per liter | Standard Deviation 2.48 |
| GSK3511294 300mg | Change From Baseline in Hemoglobin | Day 5,n=12,6,6,9,9,6 | -0.3 Grams per liter | Standard Deviation 5.13 |
| GSK3511294 300mg | Change From Baseline in Hemoglobin | Week 12,n=12,6,6,9,9,5 | -3.6 Grams per liter | Standard Deviation 2.07 |
| GSK3511294 300mg | Change From Baseline in Hemoglobin | Day 4,n=12,6,6,8,8,6 | 3.2 Grams per liter | Standard Deviation 5.12 |
| GSK3511294 300mg | Change From Baseline in Hemoglobin | Week 18,n=12,6,6,9,9,6 | 0.5 Grams per liter | Standard Deviation 4.72 |
| GSK3511294 300mg | Change From Baseline in Hemoglobin | Week 4,n=12,6,5,9,9,6 | -2.5 Grams per liter | Standard Deviation 4.09 |
| GSK3511294 300mg | Change From Baseline in Hemoglobin | Week 24,n=11,6,6,9,9,6 | -0.2 Grams per liter | Standard Deviation 3.37 |
| GSK3511294 300mg | Change From Baseline in Hemoglobin | Week 26,n=12,6,6,9,9,6 | -2.7 Grams per liter | Standard Deviation 4.32 |
| GSK3511294 300mg | Change From Baseline in Hemoglobin | Day 2,n=12,6,6,9,9,6 | 0.2 Grams per liter | Standard Deviation 8.52 |
| GSK3511294 300mg | Change From Baseline in Hemoglobin | Week 2,n=12,6,6,9,9,6 | -3.5 Grams per liter | Standard Deviation 6.5 |
| GSK3511294 300mg | Change From Baseline in Hemoglobin | Week 1,n=12,6,6,9,9,6 | -1.5 Grams per liter | Standard Deviation 3.27 |
| GSK3511294 300mg | Change From Baseline in Hemoglobin | Week 40,n=2,0,0,0,0,6 | -0.2 Grams per liter | Standard Deviation 4.17 |
Primary
Change From Baseline in Mean Corpuscle Hemoglobin (MCH)
Blood samples were collected at indicated time-points for analysis of hematology parameters like MCH. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 8,n=12,6,6,9,9,6 | -0.06 Picograms | Standard Deviation 0.429 |
| Placebo | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 4,n=12,6,5,9,9,6 | 0.15 Picograms | Standard Deviation 1.153 |
| Placebo | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 3,n=12,6,6,9,9,6 | 0.13 Picograms | Standard Deviation 0.485 |
| Placebo | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 32,n=6,6,6,0,0,6 | 0.22 Picograms | Standard Deviation 0.975 |
| Placebo | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 26,n=12,6,6,9,9,6 | -0.27 Picograms | Standard Deviation 0.946 |
| Placebo | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 4,n=12,6,6,8,8,6 | 0.14 Picograms | Standard Deviation 0.542 |
| Placebo | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 40,n=2,0,0,0,0,6 | -0.55 Picograms | Standard Deviation 0.071 |
| Placebo | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 24,n=11,6,6,9,9,6 | -0.44 Picograms | Standard Deviation 0.883 |
| Placebo | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 5,n=12,6,6,9,9,6 | 0.08 Picograms | Standard Deviation 0.626 |
| Placebo | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 2,n=12,6,6,9,9,6 | 0.03 Picograms | Standard Deviation 0.588 |
| Placebo | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 18,n=12,6,6,9,9,6 | -0.13 Picograms | Standard Deviation 0.805 |
| Placebo | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 12,n=12,6,6,9,9,5 | -0.08 Picograms | Standard Deviation 0.583 |
| Placebo | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 1,n=12,6,6,9,9,5 | -0.07 Picograms | Standard Deviation 0.433 |
| Placebo | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 36,n=6,0,0,9,9,0 | -1.00 Picograms | Standard Deviation 0.525 |
| Placebo | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 2,n=12,6,6,9,9,6 | -0.02 Picograms | Standard Deviation 0.495 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 4,n=12,6,5,9,9,6 | 0.30 Picograms | Standard Deviation 0.374 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 1,n=12,6,6,9,9,5 | 0.38 Picograms | Standard Deviation 0.542 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 2,n=12,6,6,9,9,6 | 0.33 Picograms | Standard Deviation 0.516 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 32,n=6,6,6,0,0,6 | 0.67 Picograms | Standard Deviation 0.625 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 24,n=11,6,6,9,9,6 | 0.87 Picograms | Standard Deviation 0.799 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 8,n=12,6,6,9,9,6 | 0.25 Picograms | Standard Deviation 0.86 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 3,n=12,6,6,9,9,6 | 0.25 Picograms | Standard Deviation 0.389 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 2,n=12,6,6,9,9,6 | 0.23 Picograms | Standard Deviation 0.388 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 18,n=12,6,6,9,9,6 | 0.78 Picograms | Standard Deviation 0.382 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 26,n=12,6,6,9,9,6 | 1.05 Picograms | Standard Deviation 0.505 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 12,n=12,6,6,9,9,5 | 0.32 Picograms | Standard Deviation 0.882 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 5,n=12,6,6,9,9,6 | 0.17 Picograms | Standard Deviation 0.314 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 4,n=12,6,6,8,8,6 | 0.17 Picograms | Standard Deviation 0.48 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 5,n=12,6,6,9,9,6 | 0.22 Picograms | Standard Deviation 0.449 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 2,n=12,6,6,9,9,6 | 0.02 Picograms | Standard Deviation 0.299 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 3,n=12,6,6,9,9,6 | 0.10 Picograms | Standard Deviation 0.283 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 4,n=12,6,6,8,8,6 | 0.18 Picograms | Standard Deviation 0.299 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 1,n=12,6,6,9,9,5 | -0.07 Picograms | Standard Deviation 0.273 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 2,n=12,6,6,9,9,6 | 0.25 Picograms | Standard Deviation 0.418 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 4,n=12,6,5,9,9,6 | 0.12 Picograms | Standard Deviation 0.268 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 8,n=12,6,6,9,9,6 | 0.30 Picograms | Standard Deviation 0.41 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 12,n=12,6,6,9,9,5 | 0.02 Picograms | Standard Deviation 0.624 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 18,n=12,6,6,9,9,6 | -0.10 Picograms | Standard Deviation 0.616 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 24,n=11,6,6,9,9,6 | 0.23 Picograms | Standard Deviation 0.356 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 26,n=12,6,6,9,9,6 | 0.10 Picograms | Standard Deviation 0.473 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 32,n=6,6,6,0,0,6 | 0.53 Picograms | Standard Deviation 0.909 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 5,n=12,6,6,9,9,6 | -0.03 Picograms | Standard Deviation 0.346 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 2,n=12,6,6,9,9,6 | -0.04 Picograms | Standard Deviation 0.255 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 36,n=6,0,0,9,9,0 | -1.00 Picograms | Standard Deviation 0.403 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 18,n=12,6,6,9,9,6 | -0.37 Picograms | Standard Deviation 0.384 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 2,n=12,6,6,9,9,6 | -0.08 Picograms | Standard Deviation 0.331 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 24,n=11,6,6,9,9,6 | -0.37 Picograms | Standard Deviation 0.51 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 3,n=12,6,6,9,9,6 | -0.02 Picograms | Standard Deviation 0.228 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 4,n=12,6,6,8,8,6 | 0.05 Picograms | Standard Deviation 0.351 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 4,n=12,6,5,9,9,6 | -0.29 Picograms | Standard Deviation 0.404 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 8,n=12,6,6,9,9,6 | -0.30 Picograms | Standard Deviation 0.287 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 12,n=12,6,6,9,9,5 | -0.42 Picograms | Standard Deviation 0.415 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 1,n=12,6,6,9,9,5 | 0.00 Picograms | Standard Deviation 0.381 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 26,n=12,6,6,9,9,6 | -0.38 Picograms | Standard Deviation 0.432 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 4,n=12,6,5,9,9,6 | -0.06 Picograms | Standard Deviation 0.394 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 1,n=12,6,6,9,9,5 | 0.00 Picograms | Standard Deviation 0.427 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 8,n=12,6,6,9,9,6 | -0.11 Picograms | Standard Deviation 0.655 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 5,n=12,6,6,9,9,6 | 0.02 Picograms | Standard Deviation 0.331 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 2,n=12,6,6,9,9,6 | -0.02 Picograms | Standard Deviation 0.277 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 12,n=12,6,6,9,9,5 | -0.04 Picograms | Standard Deviation 0.541 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 18,n=12,6,6,9,9,6 | 0.01 Picograms | Standard Deviation 0.627 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 4,n=12,6,6,8,8,6 | 0.01 Picograms | Standard Deviation 0.432 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 36,n=6,0,0,9,9,0 | -0.68 Picograms | Standard Deviation 0.438 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 24,n=11,6,6,9,9,6 | -0.37 Picograms | Standard Deviation 0.632 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 3,n=12,6,6,9,9,6 | 0.20 Picograms | Standard Deviation 0.444 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 26,n=12,6,6,9,9,6 | -0.71 Picograms | Standard Deviation 0.818 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 2,n=12,6,6,9,9,6 | -0.04 Picograms | Standard Deviation 0.088 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 40,n=2,0,0,0,0,6 | -0.68 Picograms | Standard Deviation 0.232 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 4,n=12,6,6,8,8,6 | 0.12 Picograms | Standard Deviation 0.325 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 12,n=12,6,6,9,9,5 | -0.60 Picograms | Standard Deviation 0.561 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 32,n=6,6,6,0,0,6 | -0.58 Picograms | Standard Deviation 0.331 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 26,n=12,6,6,9,9,6 | -1.07 Picograms | Standard Deviation 0.393 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 5,n=12,6,6,9,9,6 | -0.22 Picograms | Standard Deviation 0.24 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 2,n=12,6,6,9,9,6 | -0.07 Picograms | Standard Deviation 0.45 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 4,n=12,6,5,9,9,6 | -0.22 Picograms | Standard Deviation 0.343 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 2,n=12,6,6,9,9,6 | -0.02 Picograms | Standard Deviation 0.24 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 8,n=12,6,6,9,9,6 | -0.22 Picograms | Standard Deviation 0.286 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 18,n=12,6,6,9,9,6 | -0.78 Picograms | Standard Deviation 0.382 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 1,n=12,6,6,9,9,5 | -0.08 Picograms | Standard Deviation 0.553 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Week 24,n=11,6,6,9,9,6 | -0.90 Picograms | Standard Deviation 0.237 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Hemoglobin (MCH) | Day 3,n=12,6,6,9,9,6 | -0.08 Picograms | Standard Deviation 0.172 |
Primary
Change From Baseline in Mean Corpuscle Volume (MCV)
Blood samples were collected at indicated time-points for analysis of hematology parameters like MCV. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 26,n=12,6,6,9,9,6 | -0.5 Femtoliters | Standard Deviation 2.24 |
| Placebo | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 18,n=12,6,6,9,9,6 | -0.4 Femtoliters | Standard Deviation 1.73 |
| Placebo | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 4,n=12,6,6,8,8,6 | 0.3 Femtoliters | Standard Deviation 0.78 |
| Placebo | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 36,n=6,0,0,9,9,0 | -1.5 Femtoliters | Standard Deviation 1.05 |
| Placebo | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 8,n=12,6,6,9,9,6 | 0.3 Femtoliters | Standard Deviation 1.23 |
| Placebo | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 40,n=2,0,0,0,0,6 | -0.5 Femtoliters | Standard Deviation 0.71 |
| Placebo | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 12,n=12,6,6,9,9,5 | 0.5 Femtoliters | Standard Deviation 1.09 |
| Placebo | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 4,n=12,6,5,9,9,6 | 0.7 Femtoliters | Standard Deviation 2.39 |
| Placebo | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 24,n=11,6,6,9,9,6 | -0.8 Femtoliters | Standard Deviation 1.78 |
| Placebo | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 2,n=12,6,6,9,9,6 | 0.2 Femtoliters | Standard Deviation 0.94 |
| Placebo | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 32,n=6,6,6,0,0,6 | 0.5 Femtoliters | Standard Deviation 1.38 |
| Placebo | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 1,n=12,6,6,9,9,6 | -0.2 Femtoliters | Standard Deviation 0.94 |
| Placebo | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 2,n=12,6,6,9,9,6 | 0.0 Femtoliters | Standard Deviation 1.28 |
| Placebo | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 5,n=12,6,6,9,9,6 | 1.3 Femtoliters | Standard Deviation 1.92 |
| Placebo | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 3,n=12,6,6,9,9,6 | 0.7 Femtoliters | Standard Deviation 1.07 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 12,n=12,6,6,9,9,5 | -1.2 Femtoliters | Standard Deviation 1.94 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 2,n=12,6,6,9,9,6 | 0.2 Femtoliters | Standard Deviation 0.75 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 24,n=11,6,6,9,9,6 | -0.3 Femtoliters | Standard Deviation 1.86 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 3,n=12,6,6,9,9,6 | -0.3 Femtoliters | Standard Deviation 0.82 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 4,n=12,6,6,8,8,6 | -0.5 Femtoliters | Standard Deviation 1.05 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 5,n=12,6,6,9,9,6 | 0.5 Femtoliters | Standard Deviation 0.55 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 32,n=6,6,6,0,0,6 | 0.0 Femtoliters | Standard Deviation 2.45 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 1,n=12,6,6,9,9,6 | -0.8 Femtoliters | Standard Deviation 1.33 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 18,n=12,6,6,9,9,6 | -0.8 Femtoliters | Standard Deviation 1.33 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 2,n=12,6,6,9,9,6 | -0.3 Femtoliters | Standard Deviation 1.51 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 4,n=12,6,5,9,9,6 | -0.8 Femtoliters | Standard Deviation 2.14 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 8,n=12,6,6,9,9,6 | -0.3 Femtoliters | Standard Deviation 1.51 |
| GSK3511294 2mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 26,n=12,6,6,9,9,6 | 0.0 Femtoliters | Standard Deviation 2.1 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 5,n=12,6,6,9,9,6 | 0.3 Femtoliters | Standard Deviation 0.82 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 8,n=12,6,6,9,9,6 | 0.2 Femtoliters | Standard Deviation 0.75 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 1,n=12,6,6,9,9,6 | 0.2 Femtoliters | Standard Deviation 0.75 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 24,n=11,6,6,9,9,6 | 0.8 Femtoliters | Standard Deviation 1.72 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 2,n=12,6,6,9,9,6 | 0.2 Femtoliters | Standard Deviation 0.75 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 2,n=12,6,6,9,9,6 | 0.2 Femtoliters | Standard Deviation 0.75 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 12,n=12,6,6,9,9,5 | 0.2 Femtoliters | Standard Deviation 0.75 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 4,n=12,6,5,9,9,6 | 0.2 Femtoliters | Standard Deviation 0.45 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 26,n=12,6,6,9,9,6 | 0.5 Femtoliters | Standard Deviation 0.84 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 4,n=12,6,6,8,8,6 | 0.0 Femtoliters | Standard Deviation 1.26 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 3,n=12,6,6,9,9,6 | 0.2 Femtoliters | Standard Deviation 0.75 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 32,n=6,6,6,0,0,6 | 0.8 Femtoliters | Standard Deviation 1.47 |
| GSK3511294 10mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 18,n=12,6,6,9,9,6 | 0.5 Femtoliters | Standard Deviation 1.64 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 24,n=11,6,6,9,9,6 | -1.6 Femtoliters | Standard Deviation 1.51 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 12,n=12,6,6,9,9,5 | -0.7 Femtoliters | Standard Deviation 1.87 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 2,n=12,6,6,9,9,6 | 0.1 Femtoliters | Standard Deviation 2.85 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 4,n=12,6,6,8,8,6 | -0.1 Femtoliters | Standard Deviation 0.83 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 36,n=6,0,0,9,9,0 | -1.9 Femtoliters | Standard Deviation 1.05 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 1,n=12,6,6,9,9,6 | -1.2 Femtoliters | Standard Deviation 1.2 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 8,n=12,6,6,9,9,6 | 0.0 Femtoliters | Standard Deviation 1.12 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 18,n=12,6,6,9,9,6 | -1.9 Femtoliters | Standard Deviation 1.05 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 4,n=12,6,5,9,9,6 | -0.7 Femtoliters | Standard Deviation 0.87 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 3,n=12,6,6,9,9,6 | 0.0 Femtoliters | Standard Deviation 1.32 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 2,n=12,6,6,9,9,6 | -0.9 Femtoliters | Standard Deviation 1.17 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 5,n=12,6,6,9,9,6 | 2.0 Femtoliters | Standard Deviation 2.92 |
| GSK3511294 30mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 26,n=12,6,6,9,9,6 | -1.7 Femtoliters | Standard Deviation 1.58 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 18,n=12,6,6,9,9,6 | -2.8 Femtoliters | Standard Deviation 3.07 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 5,n=12,6,6,9,9,6 | -1.0 Femtoliters | Standard Deviation 3.5 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 24,n=11,6,6,9,9,6 | -2.4 Femtoliters | Standard Deviation 3.54 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 2,n=12,6,6,9,9,6 | -0.3 Femtoliters | Standard Deviation 1 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 3,n=12,6,6,9,9,6 | -1.0 Femtoliters | Standard Deviation 1.41 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 4,n=12,6,6,8,8,6 | -1.8 Femtoliters | Standard Deviation 0.89 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 1,n=12,6,6,9,9,6 | -1.7 Femtoliters | Standard Deviation 2.06 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 2,n=12,6,6,9,9,6 | -1.4 Femtoliters | Standard Deviation 2.51 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 4,n=12,6,5,9,9,6 | -1.6 Femtoliters | Standard Deviation 2.13 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 8,n=12,6,6,9,9,6 | -2.2 Femtoliters | Standard Deviation 2.91 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 12,n=12,6,6,9,9,5 | -2.4 Femtoliters | Standard Deviation 2.55 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 26,n=12,6,6,9,9,6 | -2.3 Femtoliters | Standard Deviation 3.04 |
| GSK3511294 100mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 36,n=6,0,0,9,9,0 | -1.8 Femtoliters | Standard Deviation 2.44 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 8,n=12,6,6,9,9,6 | -0.2 Femtoliters | Standard Deviation 1.17 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 4,n=12,6,5,9,9,6 | -0.2 Femtoliters | Standard Deviation 0.98 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 2,n=12,6,6,9,9,6 | -0.3 Femtoliters | Standard Deviation 1.63 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 24,n=11,6,6,9,9,6 | -0.7 Femtoliters | Standard Deviation 1.03 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 26,n=12,6,6,9,9,6 | -0.3 Femtoliters | Standard Deviation 1.03 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 1,n=12,6,6,9,9,6 | -0.7 Femtoliters | Standard Deviation 1.21 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 5,n=12,6,6,9,9,6 | 0.7 Femtoliters | Standard Deviation 1.75 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 4,n=12,6,6,8,8,6 | 0.2 Femtoliters | Standard Deviation 0.98 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 32,n=6,6,6,0,0,6 | -0.2 Femtoliters | Standard Deviation 0.98 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 3,n=12,6,6,9,9,6 | 0.3 Femtoliters | Standard Deviation 1.37 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Day 2,n=12,6,6,9,9,6 | 1.3 Femtoliters | Standard Deviation 2.16 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 40,n=2,0,0,0,0,6 | 1.2 Femtoliters | Standard Deviation 0.75 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 18,n=12,6,6,9,9,6 | -1.0 Femtoliters | Standard Deviation 1.1 |
| GSK3511294 300mg | Change From Baseline in Mean Corpuscle Volume (MCV) | Week 12,n=12,6,6,9,9,5 | -1.2 Femtoliters | Standard Deviation 0.84 |
Primary
Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count
Blood samples were collected at indicated time-points for analysis of hematology parameters like platelet count, neutrophils, lymphocytes, monocytes, eosinophils and basophils. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 4,n=12,6,5,9,9,6 | -0.189 Giga cells per liter | Standard Deviation 0.4616 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 8,n=12,6,6,9,9,6 | -0.057 Giga cells per liter | Standard Deviation 0.4665 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 2,n=12,5,5,9,9,6 | -9.7 Giga cells per liter | Standard Deviation 19 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 12,n=12,5,6,9,9,5 | 0.007 Giga cells per liter | Standard Deviation 0.1042 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 12,n=12,5,6,9,9,5 | -0.142 Giga cells per liter | Standard Deviation 0.4107 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 8,n=12,6,6,9,9,6 | 0.048 Giga cells per liter | Standard Deviation 0.1377 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 18,n=12,6,6,9,9,6 | -0.212 Giga cells per liter | Standard Deviation 0.4094 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 4,n=12,6,5,9,9,6 | -0.540 Giga cells per liter | Standard Deviation 0.4797 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 4,n=12,6,5,9,9,6 | 0.001 Giga cells per liter | Standard Deviation 0.0757 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 24,n=11,6,6,9,9,6 | -0.179 Giga cells per liter | Standard Deviation 0.3876 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 2,n=12,6,5,9,9,6 | 0.013 Giga cells per liter | Standard Deviation 0.0945 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 26,n=12,6,6,9,9,6 | -0.088 Giga cells per liter | Standard Deviation 0.4361 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 32,n=6,6,6,0,0,6 | -0.165 Giga cells per liter | Standard Deviation 0.6851 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 1,n=12,6,6,9,9,5 | 0.006 Giga cells per liter | Standard Deviation 0.0998 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 36,n=6,0,0,9,9,0 | 0.007 Giga cells per liter | Standard Deviation 0.1838 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 24,n=11,6,6,9,9,6 | -0.326 Giga cells per liter | Standard Deviation 0.4501 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 40,n=2,0,0,0,0,6 | 0.285 Giga cells per liter | Standard Deviation 0.3465 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 2,n=12,6,6,8,9,6 | -0.002 Giga cells per liter | Standard Deviation 0.0914 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 5,n=11,6,6,9,9,6 | -0.034 Giga cells per liter | Standard Deviation 0.0841 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 4,n=12,6,6,8,8,6 | 0.032 Giga cells per liter | Standard Deviation 0.0936 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 2,n=12,6,6,8,9,6 | -0.006 Giga cells per liter | Standard Deviation 0.0247 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 18,n=12,6,6,9,9,6 | -0.093 Giga cells per liter | Standard Deviation 0.9727 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 3,n=12,6,6,9,9,6 | 0.002 Giga cells per liter | Standard Deviation 0.0356 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 4,n=12,6,6,8,8,6 | -0.003 Giga cells per liter | Standard Deviation 0.0296 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 3,n=12,5,6,9,9,6 | -2.8 Giga cells per liter | Standard Deviation 16.72 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 12,n=12,5,6,9,9,5 | 0.043 Giga cells per liter | Standard Deviation 0.9639 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 5,n=11,6,6,9,9,6 | -0.020 Giga cells per liter | Standard Deviation 0.0224 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 8,n=12,5,5,9,9,6 | 4.3 Giga cells per liter | Standard Deviation 22.85 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 1,n=12,6,6,9,9,5 | -0.001 Giga cells per liter | Standard Deviation 0.0257 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 8,n=12,6,6,9,9,6 | -0.218 Giga cells per liter | Standard Deviation 0.7893 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 2,n=12,6,5,9,9,6 | -0.006 Giga cells per liter | Standard Deviation 0.0215 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 4,n=12,6,5,9,9,6 | -0.010 Giga cells per liter | Standard Deviation 0.0316 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 40,n=2,0,0,0,0,6 | -0.005 Giga cells per liter | Standard Deviation 0.1061 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 2,n=12,6,5,9,9,6 | -0.209 Giga cells per liter | Standard Deviation 0.4662 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 8,n=12,6,6,9,9,6 | 0.005 Giga cells per liter | Standard Deviation 0.0183 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 1,n=12,6,6,9,9,5 | -0.179 Giga cells per liter | Standard Deviation 0.6365 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 12,n=12,5,6,9,9,5 | 0.002 Giga cells per liter | Standard Deviation 0.0229 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 18,n=12,6,6,9,9,6 | -0.002 Giga cells per liter | Standard Deviation 0.0229 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 4,n=12,6,6,8,8,6 | 0.006 Giga cells per liter | Standard Deviation 0.4963 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 5,n=11,6,6,9,9,6 | 0.155 Giga cells per liter | Standard Deviation 0.7789 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 24,n=11,6,6,9,9,6 | -0.005 Giga cells per liter | Standard Deviation 0.0157 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 36,n=6,0,0,9,9,0 | -0.163 Giga cells per liter | Standard Deviation 0.8441 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 4,n=12,6,6,8,8,6 | 0.390 Giga cells per liter | Standard Deviation 0.4832 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 26,n=12,6,6,9,9,6 | -0.004 Giga cells per liter | Standard Deviation 0.0284 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 2,n=12,6,6,8,9,6 | -0.078 Giga cells per liter | Standard Deviation 0.8813 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 32,n=6,6,6,0,0,6 | -0.002 Giga cells per liter | Standard Deviation 0.0376 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 36,n=6,0,0,9,9,0 | -0.002 Giga cells per liter | Standard Deviation 0.0214 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 40,n=2,0,0,0,0,6 | 0.000 Giga cells per liter | Standard Deviation 0 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 2,n=12,6,6,8,9,6 | 0.024 Giga cells per liter | Standard Deviation 0.1412 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 24,n=10,5,6,9,9,6 | -1.9 Giga cells per liter | Standard Deviation 14.81 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 3,n=12,6,6,9,9,6 | -0.001 Giga cells per liter | Standard Deviation 0.1986 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 18,n=12,5,6,9,9,6 | -8.6 Giga cells per liter | Standard Deviation 21.65 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 4,n=12,6,6,8,8,6 | 0.014 Giga cells per liter | Standard Deviation 0.195 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 5,n=11,6,6,9,9,6 | -0.034 Giga cells per liter | Standard Deviation 0.1529 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 12,n=12,5,6,9,9,5 | -14.8 Giga cells per liter | Standard Deviation 26.42 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 1,n=12,6,6,9,9,5 | 0.033 Giga cells per liter | Standard Deviation 0.1461 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 32,n=6,6,6,0,0,6 | -0.393 Giga cells per liter | Standard Deviation 0.8219 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 4,n=12,5,4,9,9,6 | -11.5 Giga cells per liter | Standard Deviation 26.1 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 2,n=12,6,5,9,9,6 | 0.072 Giga cells per liter | Standard Deviation 0.1809 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 26,n=12,5,6,9,9,6 | 2.4 Giga cells per liter | Standard Deviation 30.14 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 2,n=12,5,6,9,9,6 | 3.5 Giga cells per liter | Standard Deviation 16.51 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 4,n=12,6,5,9,9,6 | 0.025 Giga cells per liter | Standard Deviation 0.1635 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 8,n=12,6,6,9,9,6 | 0.036 Giga cells per liter | Standard Deviation 0.1486 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 32,n=6,5,6,0,0,6 | 5.5 Giga cells per liter | Standard Deviation 18.71 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 1,n=12,5,6,9,8,6 | -0.9 Giga cells per liter | Standard Deviation 20.21 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 12,n=12,5,6,9,9,5 | 0.025 Giga cells per liter | Standard Deviation 0.1566 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 5,n=12,5,6,9,9,6 | -7.6 Giga cells per liter | Standard Deviation 17.59 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 18,n=12,6,6,9,9,6 | 0.029 Giga cells per liter | Standard Deviation 0.1263 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 24,n=11,6,6,9,9,6 | -0.021 Giga cells per liter | Standard Deviation 0.1436 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 4,n=12,5,5,8,8,6 | -5.6 Giga cells per liter | Standard Deviation 18.64 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 26,n=12,6,6,9,9,6 | 0.035 Giga cells per liter | Standard Deviation 0.1812 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 36,n=6,0,0,9,9,0 | -1.8 Giga cells per liter | Standard Deviation 25.65 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 40,n=2,0,0,0,0,6 | 0.040 Giga cells per liter | Standard Deviation 0.0566 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 32,n=6,6,6,0,0,6 | 0.008 Giga cells per liter | Standard Deviation 0.0935 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 36,n=6,0,0,9,9,0 | 0.067 Giga cells per liter | Standard Deviation 0.0717 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 36,n=6,0,0,9,9,0 | -0.045 Giga cells per liter | Standard Deviation 0.1758 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 40,n=2,0,0,0,0,6 | -20.0 Giga cells per liter | Standard Deviation 2.83 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 40,n=2,0,0,0,0,6 | 0.245 Giga cells per liter | Standard Deviation 0.1344 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 2,n=12,6,6,8,9,6 | -0.010 Giga cells per liter | Standard Deviation 0.3897 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 32,n=6,6,6,0,0,6 | -0.035 Giga cells per liter | Standard Deviation 0.0817 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 3,n=12,6,6,9,9,6 | 0.064 Giga cells per liter | Standard Deviation 0.4447 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 18,n=12,6,6,9,9,6 | 0.042 Giga cells per liter | Standard Deviation 0.0897 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 26,n=12,6,6,9,9,6 | -0.105 Giga cells per liter | Standard Deviation 0.7933 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 26,n=12,6,6,9,9,6 | 0.040 Giga cells per liter | Standard Deviation 0.0888 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 5,n=11,6,6,9,9,6 | -0.077 Giga cells per liter | Standard Deviation 0.4746 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 1,n=12,6,6,9,9,5 | 0.048 Giga cells per liter | Standard Deviation 0.4628 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 3,n=12,6,6,9,9,6 | 0.161 Giga cells per liter | Standard Deviation 0.4542 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 3,n=12,6,6,9,9,6 | 0.029 Giga cells per liter | Standard Deviation 0.1001 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 2,n=12,6,5,9,9,6 | -0.133 Giga cells per liter | Standard Deviation 0.4107 |
| Placebo | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 24,n=11,6,6,9,9,6 | 0.028 Giga cells per liter | Standard Deviation 0.1181 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 2,n=12,6,6,8,9,6 | 0.135 Giga cells per liter | Standard Deviation 0.2886 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 12,n=12,5,6,9,9,5 | 0.228 Giga cells per liter | Standard Deviation 0.1968 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 24,n=10,5,6,9,9,6 | -7.8 Giga cells per liter | Standard Deviation 18.35 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 4,n=12,6,6,8,8,6 | 0.560 Giga cells per liter | Standard Deviation 0.4666 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 5,n=11,6,6,9,9,6 | 0.108 Giga cells per liter | Standard Deviation 0.2319 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 32,n=6,6,6,0,0,6 | 0.042 Giga cells per liter | Standard Deviation 0.1153 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 2,n=12,6,5,9,9,6 | -0.212 Giga cells per liter | Standard Deviation 0.0895 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 18,n=12,6,6,9,9,6 | -0.032 Giga cells per liter | Standard Deviation 0.2213 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 2,n=12,6,6,8,9,6 | -0.120 Giga cells per liter | Standard Deviation 0.0587 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 24,n=11,6,6,9,9,6 | 0.002 Giga cells per liter | Standard Deviation 0.0264 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 4,n=12,6,5,9,9,6 | 0.103 Giga cells per liter | Standard Deviation 0.1382 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 26,n=12,6,6,9,9,6 | -0.527 Giga cells per liter | Standard Deviation 0.6332 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 2,n=12,5,6,9,9,6 | 2.8 Giga cells per liter | Standard Deviation 13.59 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 24,n=11,6,6,9,9,6 | -0.028 Giga cells per liter | Standard Deviation 0.3616 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 1,n=12,6,6,9,9,5 | -0.483 Giga cells per liter | Standard Deviation 1.2069 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 4,n=12,6,5,9,9,6 | -0.768 Giga cells per liter | Standard Deviation 0.781 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 3,n=12,6,6,9,9,6 | 0.015 Giga cells per liter | Standard Deviation 0.6691 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 1,n=12,6,6,9,9,5 | 0.295 Giga cells per liter | Standard Deviation 0.2404 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 26,n=12,6,6,9,9,6 | -0.042 Giga cells per liter | Standard Deviation 0.0571 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 26,n=12,6,6,9,9,6 | -0.223 Giga cells per liter | Standard Deviation 0.3808 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 5,n=11,6,6,9,9,6 | 0.085 Giga cells per liter | Standard Deviation 0.6109 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 24,n=11,6,6,9,9,6 | -0.752 Giga cells per liter | Standard Deviation 0.9422 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 3,n=12,6,6,9,9,6 | -0.167 Giga cells per liter | Standard Deviation 0.0755 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 1,n=12,6,6,9,9,5 | 0.072 Giga cells per liter | Standard Deviation 0.1127 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 4,n=12,6,5,9,9,6 | -0.227 Giga cells per liter | Standard Deviation 0.0712 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 32,n=6,6,6,0,0,6 | -0.057 Giga cells per liter | Standard Deviation 0.2842 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 8,n=12,6,6,9,9,6 | 0.007 Giga cells per liter | Standard Deviation 0.0266 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 8,n=12,6,6,9,9,6 | 0.123 Giga cells per liter | Standard Deviation 0.1681 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 26,n=12,5,6,9,9,6 | -13.8 Giga cells per liter | Standard Deviation 17.7 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 18,n=12,5,6,9,9,6 | -13.4 Giga cells per liter | Standard Deviation 20.42 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 26,n=12,6,6,9,9,6 | 0.002 Giga cells per liter | Standard Deviation 0.0306 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 1,n=12,5,6,9,8,6 | -10.2 Giga cells per liter | Standard Deviation 11.3 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 5,n=11,6,6,9,9,6 | -0.025 Giga cells per liter | Standard Deviation 0.0701 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 18,n=12,6,6,9,9,6 | 0.010 Giga cells per liter | Standard Deviation 0.031 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 2,n=12,6,6,8,9,6 | 0.017 Giga cells per liter | Standard Deviation 0.1357 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 4,n=12,6,6,8,8,6 | -0.172 Giga cells per liter | Standard Deviation 0.0749 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 8,n=12,6,6,9,9,6 | -0.230 Giga cells per liter | Standard Deviation 0.0769 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 32,n=6,6,6,0,0,6 | -0.708 Giga cells per liter | Standard Deviation 0.7757 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 2,n=12,6,5,9,9,6 | 0.050 Giga cells per liter | Standard Deviation 0.1621 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 4,n=12,6,6,8,8,6 | -0.002 Giga cells per liter | Standard Deviation 0.1258 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 12,n=12,5,6,9,9,5 | -6.0 Giga cells per liter | Standard Deviation 16.63 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 3,n=12,6,6,9,9,6 | 0.330 Giga cells per liter | Standard Deviation 0.3571 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 2,n=12,6,6,8,9,6 | -0.020 Giga cells per liter | Standard Deviation 0.0297 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 2,n=12,6,6,8,9,6 | 0.413 Giga cells per liter | Standard Deviation 0.6493 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 5,n=11,6,6,9,9,6 | -0.202 Giga cells per liter | Standard Deviation 0.0799 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 18,n=12,6,6,9,9,6 | -0.158 Giga cells per liter | Standard Deviation 0.7786 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 24,n=11,6,6,9,9,6 | -0.072 Giga cells per liter | Standard Deviation 0.0662 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 3,n=12,6,6,9,9,6 | 0.028 Giga cells per liter | Standard Deviation 0.1533 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 3,n=12,6,6,9,9,6 | 0.003 Giga cells per liter | Standard Deviation 0.045 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 2,n=12,5,5,9,9,6 | -6.8 Giga cells per liter | Standard Deviation 10.4 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 32,n=6,6,6,0,0,6 | -0.013 Giga cells per liter | Standard Deviation 0.16 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 1,n=12,6,6,9,9,5 | -0.195 Giga cells per liter | Standard Deviation 0.0609 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 12,n=12,5,6,9,9,5 | -0.712 Giga cells per liter | Standard Deviation 0.589 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 4,n=12,6,5,9,9,6 | 0.088 Giga cells per liter | Standard Deviation 0.2938 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 4,n=12,6,6,8,8,6 | 0.002 Giga cells per liter | Standard Deviation 0.0214 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 32,n=6,6,6,0,0,6 | 0.010 Giga cells per liter | Standard Deviation 0.021 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 12,n=12,5,6,9,9,5 | -0.174 Giga cells per liter | Standard Deviation 0.0777 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 12,n=12,5,6,9,9,5 | -0.014 Giga cells per liter | Standard Deviation 0.0297 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 18,n=12,6,6,9,9,6 | -0.040 Giga cells per liter | Standard Deviation 0.1362 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 32,n=6,5,6,0,0,6 | -0.6 Giga cells per liter | Standard Deviation 15.37 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 5,n=11,6,6,9,9,6 | -0.008 Giga cells per liter | Standard Deviation 0.0204 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 24,n=11,6,6,9,9,6 | -0.013 Giga cells per liter | Standard Deviation 0.0989 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 3,n=12,5,6,9,9,6 | -9.4 Giga cells per liter | Standard Deviation 8.29 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 5,n=12,5,6,9,9,6 | -3.6 Giga cells per liter | Standard Deviation 13.89 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 8,n=12,6,6,9,9,6 | 0.497 Giga cells per liter | Standard Deviation 1.6165 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 26,n=12,6,6,9,9,6 | -0.037 Giga cells per liter | Standard Deviation 0.1129 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 1,n=12,6,6,9,9,5 | -0.017 Giga cells per liter | Standard Deviation 0.0207 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 4,n=12,5,5,8,8,6 | -5.8 Giga cells per liter | Standard Deviation 3.63 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 8,n=12,6,6,9,9,6 | 0.105 Giga cells per liter | Standard Deviation 0.267 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 4,n=12,6,6,8,8,6 | 0.193 Giga cells per liter | Standard Deviation 0.3242 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 8,n=12,5,5,9,9,6 | 11.6 Giga cells per liter | Standard Deviation 23.71 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 18,n=12,6,6,9,9,6 | -0.148 Giga cells per liter | Standard Deviation 0.0685 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 2,n=12,6,5,9,9,6 | -0.018 Giga cells per liter | Standard Deviation 0.0204 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 2,n=12,6,5,9,9,6 | 0.222 Giga cells per liter | Standard Deviation 0.3543 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 12,n=12,5,6,9,9,5 | 0.050 Giga cells per liter | Standard Deviation 0.0561 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 4,n=12,5,4,9,9,6 | -6.8 Giga cells per liter | Standard Deviation 20.93 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 2,n=12,6,5,9,9,6 | -0.738 Giga cells per liter | Standard Deviation 0.711 |
| GSK3511294 2mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 4,n=12,6,5,9,9,6 | -0.002 Giga cells per liter | Standard Deviation 0.0232 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 18,n=12,6,6,9,9,6 | -0.208 Giga cells per liter | Standard Deviation 0.1153 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 4,n=12,6,5,9,9,6 | -0.004 Giga cells per liter | Standard Deviation 0.0167 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 32,n=6,5,6,0,0,6 | -6.3 Giga cells per liter | Standard Deviation 10.39 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 4,n=12,5,5,8,8,6 | 6.6 Giga cells per liter | Standard Deviation 15.66 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 1,n=12,6,6,9,9,5 | -0.160 Giga cells per liter | Standard Deviation 0.328 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 8,n=12,6,6,9,9,6 | -0.022 Giga cells per liter | Standard Deviation 0.0271 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 4,n=12,6,6,8,8,6 | 0.172 Giga cells per liter | Standard Deviation 0.3474 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 12,n=12,5,6,9,9,5 | -0.008 Giga cells per liter | Standard Deviation 0.0147 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 8,n=12,5,5,9,9,6 | 2.6 Giga cells per liter | Standard Deviation 29.01 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 5,n=11,6,6,9,9,6 | -0.003 Giga cells per liter | Standard Deviation 0.3494 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 24,n=11,6,6,9,9,6 | -0.103 Giga cells per liter | Standard Deviation 0.1916 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 18,n=12,6,6,9,9,6 | -0.012 Giga cells per liter | Standard Deviation 0.016 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 26,n=12,6,6,9,9,6 | -0.622 Giga cells per liter | Standard Deviation 0.6065 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 4,n=12,6,6,8,8,6 | 0.438 Giga cells per liter | Standard Deviation 0.9293 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 3,n=12,5,6,9,9,6 | 5.7 Giga cells per liter | Standard Deviation 13 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 24,n=11,6,6,9,9,6 | -0.005 Giga cells per liter | Standard Deviation 0.0288 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 2,n=12,6,6,8,9,6 | -0.005 Giga cells per liter | Standard Deviation 0.9228 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 26,n=12,6,6,9,9,6 | -0.037 Giga cells per liter | Standard Deviation 0.2813 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 26,n=12,6,6,9,9,6 | 0.000 Giga cells per liter | Standard Deviation 0.0219 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 24,n=11,6,6,9,9,6 | 0.070 Giga cells per liter | Standard Deviation 0.0921 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 32,n=6,6,6,0,0,6 | 0.005 Giga cells per liter | Standard Deviation 0.0339 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 26,n=12,5,6,9,9,6 | -19.3 Giga cells per liter | Standard Deviation 13.81 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 18,n=12,6,6,9,9,6 | -0.045 Giga cells per liter | Standard Deviation 0.0944 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 32,n=6,6,6,0,0,6 | 0.880 Giga cells per liter | Standard Deviation 1.9211 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 2,n=12,6,6,8,9,6 | -0.145 Giga cells per liter | Standard Deviation 0.0797 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 24,n=10,5,6,9,9,6 | -10.0 Giga cells per liter | Standard Deviation 14.97 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 32,n=6,6,6,0,0,6 | 0.003 Giga cells per liter | Standard Deviation 0.2467 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 18,n=12,5,6,9,9,6 | -14.0 Giga cells per liter | Standard Deviation 9.53 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 5,n=11,6,6,9,9,6 | 0.085 Giga cells per liter | Standard Deviation 0.1302 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 3,n=12,6,6,9,9,6 | -0.203 Giga cells per liter | Standard Deviation 0.0876 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 24,n=11,6,6,9,9,6 | -0.370 Giga cells per liter | Standard Deviation 0.3746 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 3,n=12,6,6,9,9,6 | 0.100 Giga cells per liter | Standard Deviation 0.1235 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 12,n=12,5,6,9,9,5 | -9.0 Giga cells per liter | Standard Deviation 26.83 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 32,n=6,6,6,0,0,6 | 0.098 Giga cells per liter | Standard Deviation 0.0783 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 5,n=11,6,6,9,9,6 | -0.235 Giga cells per liter | Standard Deviation 0.1117 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 4,n=12,5,4,9,9,6 | 1.3 Giga cells per liter | Standard Deviation 37.07 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 4,n=12,6,5,9,9,6 | 0.056 Giga cells per liter | Standard Deviation 0.2899 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 3,n=12,6,6,9,9,6 | 0.225 Giga cells per liter | Standard Deviation 0.685 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 12,n=12,5,6,9,9,5 | -0.013 Giga cells per liter | Standard Deviation 0.0841 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 1,n=12,6,6,9,9,5 | -0.242 Giga cells per liter | Standard Deviation 0.1189 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 8,n=12,6,6,9,9,6 | -0.107 Giga cells per liter | Standard Deviation 0.3584 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 12,n=12,5,6,9,9,5 | 0.072 Giga cells per liter | Standard Deviation 0.4113 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 2,n=12,6,6,8,9,6 | 0.108 Giga cells per liter | Standard Deviation 0.2185 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 4,n=12,6,5,9,9,6 | -0.018 Giga cells per liter | Standard Deviation 0.0817 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 18,n=12,6,6,9,9,6 | -0.042 Giga cells per liter | Standard Deviation 0.3612 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 2,n=12,6,5,9,9,6 | -0.210 Giga cells per liter | Standard Deviation 0.0886 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 24,n=11,6,6,9,9,6 | -0.040 Giga cells per liter | Standard Deviation 0.2744 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 2,n=12,6,5,9,9,6 | 0.056 Giga cells per liter | Standard Deviation 0.0451 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 26,n=12,6,6,9,9,6 | 0.010 Giga cells per liter | Standard Deviation 0.0551 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 26,n=12,6,6,9,9,6 | -0.138 Giga cells per liter | Standard Deviation 0.3577 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 1,n=12,6,6,9,9,5 | 0.057 Giga cells per liter | Standard Deviation 0.1786 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 32,n=6,6,6,0,0,6 | -0.197 Giga cells per liter | Standard Deviation 0.5467 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 4,n=12,6,5,9,9,6 | -0.238 Giga cells per liter | Standard Deviation 0.115 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 1,n=12,5,6,9,8,6 | 5.0 Giga cells per liter | Standard Deviation 21.08 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 5,n=11,6,6,9,9,6 | 0.053 Giga cells per liter | Standard Deviation 0.1299 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 1,n=12,6,6,9,9,5 | 0.058 Giga cells per liter | Standard Deviation 0.4116 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 2,n=12,6,6,8,9,6 | 0.123 Giga cells per liter | Standard Deviation 0.124 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 18,n=12,6,6,9,9,6 | 0.015 Giga cells per liter | Standard Deviation 0.7474 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 8,n=12,6,6,9,9,6 | -0.280 Giga cells per liter | Standard Deviation 0.1202 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 4,n=12,6,6,8,8,6 | 0.118 Giga cells per liter | Standard Deviation 0.1057 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 2,n=12,6,6,8,9,6 | 0.003 Giga cells per liter | Standard Deviation 0.0103 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 2,n=12,5,5,9,9,6 | -6.4 Giga cells per liter | Standard Deviation 15.27 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 3,n=12,6,6,9,9,6 | 0.143 Giga cells per liter | Standard Deviation 0.181 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 5,n=12,5,6,9,9,6 | -3.0 Giga cells per liter | Standard Deviation 18.11 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 3,n=12,6,6,9,9,6 | 0.010 Giga cells per liter | Standard Deviation 0.0126 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 4,n=12,6,6,8,8,6 | -0.212 Giga cells per liter | Standard Deviation 0.1144 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 12,n=12,5,6,9,9,5 | 0.053 Giga cells per liter | Standard Deviation 1.0187 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 2,n=12,6,5,9,9,6 | 0.096 Giga cells per liter | Standard Deviation 0.4117 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 4,n=12,6,6,8,8,6 | -0.008 Giga cells per liter | Standard Deviation 0.0325 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 12,n=12,5,6,9,9,5 | -0.262 Giga cells per liter | Standard Deviation 0.1087 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 8,n=12,6,6,9,9,6 | -0.277 Giga cells per liter | Standard Deviation 0.9128 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 5,n=11,6,6,9,9,6 | -0.020 Giga cells per liter | Standard Deviation 0.0141 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 1,n=12,6,6,9,9,5 | -0.018 Giga cells per liter | Standard Deviation 0.0306 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 2,n=12,5,6,9,9,6 | -6.3 Giga cells per liter | Standard Deviation 29.38 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 4,n=12,6,5,9,9,6 | -0.156 Giga cells per liter | Standard Deviation 0.9674 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 2,n=12,6,5,9,9,6 | 0.000 Giga cells per liter | Standard Deviation 0.0274 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 8,n=12,6,6,9,9,6 | -0.053 Giga cells per liter | Standard Deviation 0.0484 |
| GSK3511294 10mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 2,n=12,6,5,9,9,6 | -0.142 Giga cells per liter | Standard Deviation 1.0604 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 5,n=11,6,6,9,9,6 | 0.041 Giga cells per liter | Standard Deviation 0.7075 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 5,n=11,6,6,9,9,6 | -0.326 Giga cells per liter | Standard Deviation 0.1385 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 2,n=12,5,5,9,9,6 | -6.8 Giga cells per liter | Standard Deviation 17.99 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 3,n=12,5,6,9,9,6 | -7.1 Giga cells per liter | Standard Deviation 19.98 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 2,n=12,5,6,9,9,6 | -0.9 Giga cells per liter | Standard Deviation 25.09 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 8,n=12,5,5,9,9,6 | -11.3 Giga cells per liter | Standard Deviation 21.03 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 18,n=12,5,6,9,9,6 | 1.6 Giga cells per liter | Standard Deviation 19.51 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 24,n=10,5,6,9,9,6 | -1.6 Giga cells per liter | Standard Deviation 19.94 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 2,n=12,6,6,8,9,6 | 0.301 Giga cells per liter | Standard Deviation 0.5042 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 3,n=12,6,6,9,9,6 | 0.077 Giga cells per liter | Standard Deviation 0.9525 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 2,n=12,6,6,8,9,6 | -0.003 Giga cells per liter | Standard Deviation 0.0238 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 3,n=12,6,6,9,9,6 | -0.003 Giga cells per liter | Standard Deviation 0.026 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 4,n=12,6,6,8,8,6 | -0.004 Giga cells per liter | Standard Deviation 0.0207 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 5,n=11,6,6,9,9,6 | -0.009 Giga cells per liter | Standard Deviation 0.0196 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 4,n=12,6,6,8,8,6 | -0.038 Giga cells per liter | Standard Deviation 0.0927 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 1,n=12,6,6,9,9,5 | 0.002 Giga cells per liter | Standard Deviation 0.0291 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 2,n=12,6,5,9,9,6 | -0.004 Giga cells per liter | Standard Deviation 0.0224 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 4,n=12,6,5,9,9,6 | 0.002 Giga cells per liter | Standard Deviation 0.0172 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 8,n=12,6,6,9,9,6 | -0.010 Giga cells per liter | Standard Deviation 0.0122 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 12,n=12,5,6,9,9,5 | -0.003 Giga cells per liter | Standard Deviation 0.0245 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 18,n=12,6,6,9,9,6 | -0.001 Giga cells per liter | Standard Deviation 0.0267 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 24,n=11,6,6,9,9,6 | -0.004 Giga cells per liter | Standard Deviation 0.0313 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 26,n=12,6,6,9,9,6 | 0.008 Giga cells per liter | Standard Deviation 0.0383 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 36,n=6,0,0,9,9,0 | 0.021 Giga cells per liter | Standard Deviation 0.0247 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 2,n=12,6,6,8,9,6 | -0.251 Giga cells per liter | Standard Deviation 0.1504 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 3,n=12,6,6,9,9,6 | -0.289 Giga cells per liter | Standard Deviation 0.0987 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 4,n=12,6,6,8,8,6 | -0.348 Giga cells per liter | Standard Deviation 0.1149 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 1,n=12,6,6,9,9,5 | -0.324 Giga cells per liter | Standard Deviation 0.135 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 2,n=12,6,5,9,9,6 | -0.344 Giga cells per liter | Standard Deviation 0.1334 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 4,n=12,6,5,9,9,6 | -0.366 Giga cells per liter | Standard Deviation 0.1466 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 8,n=12,6,6,9,9,6 | -0.379 Giga cells per liter | Standard Deviation 0.1519 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 12,n=12,5,6,9,9,5 | -0.371 Giga cells per liter | Standard Deviation 0.1484 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 18,n=12,6,6,9,9,6 | -0.359 Giga cells per liter | Standard Deviation 0.1445 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 24,n=11,6,6,9,9,6 | -0.300 Giga cells per liter | Standard Deviation 0.1546 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 26,n=12,6,6,9,9,6 | -0.273 Giga cells per liter | Standard Deviation 0.1773 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 36,n=6,0,0,9,9,0 | -0.041 Giga cells per liter | Standard Deviation 0.2734 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 2,n=12,6,6,8,9,6 | -0.061 Giga cells per liter | Standard Deviation 0.3165 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 3,n=12,6,6,9,9,6 | -0.140 Giga cells per liter | Standard Deviation 0.2382 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 4,n=12,6,6,8,8,6 | 0.005 Giga cells per liter | Standard Deviation 0.1753 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 5,n=11,6,6,9,9,6 | -0.253 Giga cells per liter | Standard Deviation 0.2983 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 1,n=12,6,6,9,9,5 | -0.060 Giga cells per liter | Standard Deviation 0.3248 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 2,n=12,6,5,9,9,6 | -0.120 Giga cells per liter | Standard Deviation 0.3304 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 4,n=12,6,5,9,9,6 | -0.062 Giga cells per liter | Standard Deviation 0.2346 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 8,n=12,6,6,9,9,6 | -0.188 Giga cells per liter | Standard Deviation 0.2277 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 12,n=12,5,6,9,9,5 | 0.014 Giga cells per liter | Standard Deviation 0.249 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 18,n=12,6,6,9,9,6 | -0.097 Giga cells per liter | Standard Deviation 0.4088 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 24,n=11,6,6,9,9,6 | -0.070 Giga cells per liter | Standard Deviation 0.3102 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 26,n=12,6,6,9,9,6 | -0.116 Giga cells per liter | Standard Deviation 0.4946 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 36,n=6,0,0,9,9,0 | -0.043 Giga cells per liter | Standard Deviation 0.4393 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 5,n=11,6,6,9,9,6 | -0.100 Giga cells per liter | Standard Deviation 0.147 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 1,n=12,6,6,9,9,5 | 0.032 Giga cells per liter | Standard Deviation 0.0578 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 2,n=12,6,5,9,9,6 | 0.004 Giga cells per liter | Standard Deviation 0.0975 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 4,n=12,6,5,9,9,6 | 0.042 Giga cells per liter | Standard Deviation 0.0559 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 2,n=12,6,6,8,9,6 | 0.015 Giga cells per liter | Standard Deviation 0.1176 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 12,n=12,5,6,9,9,5 | 0.059 Giga cells per liter | Standard Deviation 0.0864 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 18,n=12,6,6,9,9,6 | 0.018 Giga cells per liter | Standard Deviation 0.1475 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 24,n=11,6,6,9,9,6 | 0.047 Giga cells per liter | Standard Deviation 0.1301 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 3,n=12,6,6,9,9,6 | -0.028 Giga cells per liter | Standard Deviation 0.0753 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 26,n=12,6,6,9,9,6 | 0.036 Giga cells per liter | Standard Deviation 0.1267 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 36,n=6,0,0,9,9,0 | 0.053 Giga cells per liter | Standard Deviation 0.1624 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 4,n=12,5,5,8,8,6 | -0.4 Giga cells per liter | Standard Deviation 18.86 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 5,n=12,5,6,9,9,6 | -4.6 Giga cells per liter | Standard Deviation 19.09 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 1,n=12,5,6,9,8,6 | -3.9 Giga cells per liter | Standard Deviation 12.41 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 4,n=12,5,4,9,9,6 | -1.6 Giga cells per liter | Standard Deviation 17.61 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 12,n=12,5,6,9,9,5 | -10.8 Giga cells per liter | Standard Deviation 10.15 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 26,n=12,5,6,9,9,6 | -2.4 Giga cells per liter | Standard Deviation 12.21 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 36,n=6,0,0,9,9,0 | -0.3 Giga cells per liter | Standard Deviation 12.37 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 4,n=12,6,6,8,8,6 | 0.151 Giga cells per liter | Standard Deviation 0.9472 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 1,n=12,6,6,9,9,5 | -0.151 Giga cells per liter | Standard Deviation 0.5955 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 2,n=12,6,5,9,9,6 | -0.192 Giga cells per liter | Standard Deviation 0.9481 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 4,n=12,6,5,9,9,6 | -0.279 Giga cells per liter | Standard Deviation 0.5859 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 8,n=12,6,6,9,9,6 | -0.069 Giga cells per liter | Standard Deviation 1.0047 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 12,n=12,5,6,9,9,5 | -0.180 Giga cells per liter | Standard Deviation 0.476 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 18,n=12,6,6,9,9,6 | -0.012 Giga cells per liter | Standard Deviation 0.8076 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 24,n=11,6,6,9,9,6 | -0.144 Giga cells per liter | Standard Deviation 0.5243 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 26,n=12,6,6,9,9,6 | -0.259 Giga cells per liter | Standard Deviation 0.9389 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 36,n=6,0,0,9,9,0 | -0.384 Giga cells per liter | Standard Deviation 0.4763 |
| GSK3511294 30mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 8,n=12,6,6,9,9,6 | -0.006 Giga cells per liter | Standard Deviation 0.0648 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 26,n=12,5,6,9,9,6 | 11.8 Giga cells per liter | Standard Deviation 36.37 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 3,n=12,6,6,9,9,6 | -0.081 Giga cells per liter | Standard Deviation 0.4131 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 24,n=10,5,6,9,9,6 | 19.7 Giga cells per liter | Standard Deviation 30.07 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 36,n=6,0,0,9,9,0 | 13.9 Giga cells per liter | Standard Deviation 24.15 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 4,n=12,5,5,8,8,6 | -1.1 Giga cells per liter | Standard Deviation 21.56 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 26,n=12,6,6,9,9,6 | -0.002 Giga cells per liter | Standard Deviation 0.0199 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 2,n=12,6,5,9,9,6 | -0.068 Giga cells per liter | Standard Deviation 0.4104 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 3,n=12,6,6,9,9,6 | 0.217 Giga cells per liter | Standard Deviation 1.1014 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 4,n=12,6,5,9,9,6 | -0.052 Giga cells per liter | Standard Deviation 0.5189 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 24,n=11,6,6,9,9,6 | -0.001 Giga cells per liter | Standard Deviation 0.0154 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 12,n=12,5,6,9,9,5 | -0.336 Giga cells per liter | Standard Deviation 0.1895 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 18,n=12,5,6,9,9,6 | 15.9 Giga cells per liter | Standard Deviation 22.45 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 4,n=12,6,6,8,8,6 | 0.130 Giga cells per liter | Standard Deviation 1.0414 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 26,n=12,6,6,9,9,6 | 0.121 Giga cells per liter | Standard Deviation 0.15 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 18,n=12,6,6,9,9,6 | 0.010 Giga cells per liter | Standard Deviation 0.0278 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 12,n=12,5,6,9,9,5 | 0.140 Giga cells per liter | Standard Deviation 0.1734 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 12,n=12,5,6,9,9,5 | -0.004 Giga cells per liter | Standard Deviation 0.0142 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 5,n=11,6,6,9,9,6 | -0.003 Giga cells per liter | Standard Deviation 0.0255 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 5,n=11,6,6,9,9,6 | 0.184 Giga cells per liter | Standard Deviation 1.0809 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 5,n=12,5,6,9,9,6 | 6.2 Giga cells per liter | Standard Deviation 22.9 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 2,n=12,6,6,8,9,6 | -0.157 Giga cells per liter | Standard Deviation 0.3336 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 8,n=12,6,6,9,9,6 | -0.002 Giga cells per liter | Standard Deviation 0.0186 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 8,n=12,6,6,9,9,6 | -0.343 Giga cells per liter | Standard Deviation 0.1841 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 1,n=12,6,6,9,9,5 | -0.018 Giga cells per liter | Standard Deviation 0.4217 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 1,n=12,6,6,9,9,5 | 0.174 Giga cells per liter | Standard Deviation 0.8992 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 4,n=12,6,5,9,9,6 | -0.321 Giga cells per liter | Standard Deviation 0.1969 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 4,n=12,6,5,9,9,6 | -0.006 Giga cells per liter | Standard Deviation 0.0265 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 36,n=6,0,0,9,9,0 | -0.258 Giga cells per liter | Standard Deviation 0.1594 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 2,n=12,6,5,9,9,6 | -0.007 Giga cells per liter | Standard Deviation 0.0158 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 8,n=12,5,5,9,9,6 | 22.0 Giga cells per liter | Standard Deviation 30.81 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 2,n=12,6,5,9,9,6 | 0.229 Giga cells per liter | Standard Deviation 0.8853 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 1,n=12,5,6,9,8,6 | 16.8 Giga cells per liter | Standard Deviation 25.37 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 24,n=11,6,6,9,9,6 | 0.140 Giga cells per liter | Standard Deviation 0.5795 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 5,n=11,6,6,9,9,6 | 0.104 Giga cells per liter | Standard Deviation 0.4463 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 4,n=12,6,5,9,9,6 | -0.340 Giga cells per liter | Standard Deviation 0.7049 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 2,n=12,6,5,9,9,6 | -0.307 Giga cells per liter | Standard Deviation 0.1602 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 1,n=12,6,6,9,9,5 | 0.001 Giga cells per liter | Standard Deviation 0.0162 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 2,n=12,6,6,8,9,6 | 0.241 Giga cells per liter | Standard Deviation 0.8219 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 36,n=6,0,0,9,9,0 | 0.158 Giga cells per liter | Standard Deviation 0.2126 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 36,n=6,0,0,9,9,0 | -0.004 Giga cells per liter | Standard Deviation 0.908 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 8,n=12,6,6,9,9,6 | -0.127 Giga cells per liter | Standard Deviation 0.5829 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 1,n=12,6,6,9,9,5 | -0.298 Giga cells per liter | Standard Deviation 0.1824 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 4,n=12,6,6,8,8,6 | -0.001 Giga cells per liter | Standard Deviation 0.0136 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 18,n=12,6,6,9,9,6 | 0.092 Giga cells per liter | Standard Deviation 0.0874 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 3,n=12,6,6,9,9,6 | -0.003 Giga cells per liter | Standard Deviation 0.0224 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 2,n=12,5,6,9,9,6 | 25.0 Giga cells per liter | Standard Deviation 38.64 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 12,n=12,5,6,9,9,5 | -0.344 Giga cells per liter | Standard Deviation 0.484 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 26,n=12,6,6,9,9,6 | 0.104 Giga cells per liter | Standard Deviation 0.7127 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 4,n=12,5,4,9,9,6 | 12.3 Giga cells per liter | Standard Deviation 35.87 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 2,n=12,6,6,8,9,6 | 0.019 Giga cells per liter | Standard Deviation 0.0715 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 4,n=12,6,6,8,8,6 | 0.068 Giga cells per liter | Standard Deviation 0.1074 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 26,n=12,6,6,9,9,6 | -0.319 Giga cells per liter | Standard Deviation 0.1724 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 36,n=6,0,0,9,9,0 | 0.006 Giga cells per liter | Standard Deviation 0.4176 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 2,n=12,6,6,8,9,6 | 0.001 Giga cells per liter | Standard Deviation 0.0302 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 5,n=11,6,6,9,9,6 | 0.074 Giga cells per liter | Standard Deviation 0.1874 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 5,n=11,6,6,9,9,6 | -0.276 Giga cells per liter | Standard Deviation 0.1351 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 2,n=12,5,5,9,9,6 | 6.1 Giga cells per liter | Standard Deviation 22.05 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 4,n=12,6,6,8,8,6 | -0.300 Giga cells per liter | Standard Deviation 0.1829 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 26,n=12,6,6,9,9,6 | 0.018 Giga cells per liter | Standard Deviation 0.5392 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 4,n=12,6,5,9,9,6 | 0.041 Giga cells per liter | Standard Deviation 0.1014 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 1,n=12,6,6,9,9,5 | 0.101 Giga cells per liter | Standard Deviation 0.1039 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 12,n=12,5,6,9,9,5 | 27.4 Giga cells per liter | Standard Deviation 43.23 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 24,n=11,6,6,9,9,6 | 0.159 Giga cells per liter | Standard Deviation 0.2567 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 24,n=11,6,6,9,9,6 | 0.052 Giga cells per liter | Standard Deviation 0.9838 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 3,n=12,5,6,9,9,6 | 1.7 Giga cells per liter | Standard Deviation 19.24 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 2,n=12,6,5,9,9,6 | 0.118 Giga cells per liter | Standard Deviation 0.1738 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 3,n=12,6,6,9,9,6 | -0.287 Giga cells per liter | Standard Deviation 0.1744 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 3,n=12,6,6,9,9,6 | 0.032 Giga cells per liter | Standard Deviation 0.0952 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 18,n=12,6,6,9,9,6 | 0.050 Giga cells per liter | Standard Deviation 0.4539 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 24,n=11,6,6,9,9,6 | -0.334 Giga cells per liter | Standard Deviation 0.1769 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 18,n=12,6,6,9,9,6 | -0.151 Giga cells per liter | Standard Deviation 0.5728 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 2,n=12,6,6,8,9,6 | -0.208 Giga cells per liter | Standard Deviation 0.1685 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 12,n=12,5,6,9,9,5 | 0.048 Giga cells per liter | Standard Deviation 0.3231 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 36,n=6,0,0,9,9,0 | -0.002 Giga cells per liter | Standard Deviation 0.0199 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 8,n=12,6,6,9,9,6 | 0.080 Giga cells per liter | Standard Deviation 0.1211 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 4,n=12,6,6,8,8,6 | 0.005 Giga cells per liter | Standard Deviation 0.3798 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 18,n=12,6,6,9,9,6 | -0.338 Giga cells per liter | Standard Deviation 0.1786 |
| GSK3511294 100mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 8,n=12,6,6,9,9,6 | 0.052 Giga cells per liter | Standard Deviation 0.3287 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 18,n=12,6,6,9,9,6 | -0.063 Giga cells per liter | Standard Deviation 0.1788 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 12,n=12,5,6,9,9,5 | -0.388 Giga cells per liter | Standard Deviation 0.2237 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 4,n=12,6,5,9,9,6 | -0.003 Giga cells per liter | Standard Deviation 0.1201 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 18,n=12,6,6,9,9,6 | -0.027 Giga cells per liter | Standard Deviation 0.6629 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 8,n=12,6,6,9,9,6 | 0.058 Giga cells per liter | Standard Deviation 0.1509 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 8,n=12,6,6,9,9,6 | -0.075 Giga cells per liter | Standard Deviation 0.0672 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 26,n=12,6,6,9,9,6 | -0.188 Giga cells per liter | Standard Deviation 0.2566 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 12,n=12,5,6,9,9,5 | 0.084 Giga cells per liter | Standard Deviation 0.168 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 2,n=12,6,5,9,9,6 | 0.047 Giga cells per liter | Standard Deviation 0.1189 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 18,n=12,6,6,9,9,6 | 0.043 Giga cells per liter | Standard Deviation 0.1516 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 2,n=12,6,6,8,9,6 | 0.052 Giga cells per liter | Standard Deviation 0.1947 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 1,n=12,6,6,9,9,5 | -0.154 Giga cells per liter | Standard Deviation 0.2587 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 5,n=11,6,6,9,9,6 | 0.047 Giga cells per liter | Standard Deviation 0.1226 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 4,n=12,6,6,8,8,6 | 0.210 Giga cells per liter | Standard Deviation 0.2772 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 2,n=12,6,6,8,9,6 | 0.102 Giga cells per liter | Standard Deviation 0.463 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 24,n=11,6,6,9,9,6 | 0.037 Giga cells per liter | Standard Deviation 0.0975 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 2,n=12,6,6,8,9,6 | 0.100 Giga cells per liter | Standard Deviation 0.2804 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 24,n=11,6,6,9,9,6 | -0.128 Giga cells per liter | Standard Deviation 0.4311 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 26,n=12,6,6,9,9,6 | 0.013 Giga cells per liter | Standard Deviation 0.072 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 40,n=2,0,0,0,0,6 | -0.222 Giga cells per liter | Standard Deviation 0.1196 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 32,n=6,6,6,0,0,6 | -0.012 Giga cells per liter | Standard Deviation 0.0662 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 32,n=6,6,6,0,0,6 | -0.235 Giga cells per liter | Standard Deviation 0.1205 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 26,n=12,6,6,9,9,6 | -0.252 Giga cells per liter | Standard Deviation 0.092 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 40,n=2,0,0,0,0,6 | -0.032 Giga cells per liter | Standard Deviation 0.0873 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 2,n=12,5,5,9,9,6 | -1.5 Giga cells per liter | Standard Deviation 19.32 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 24,n=11,6,6,9,9,6 | -0.245 Giga cells per liter | Standard Deviation 0.1017 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 3,n=12,5,6,9,9,6 | -0.8 Giga cells per liter | Standard Deviation 19.6 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 18,n=12,6,6,9,9,6 | -0.253 Giga cells per liter | Standard Deviation 0.1067 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 40,n=2,0,0,0,0,6 | -11.7 Giga cells per liter | Standard Deviation 30.8 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 4,n=12,5,5,8,8,6 | -0.2 Giga cells per liter | Standard Deviation 6.62 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 12,n=12,5,6,9,9,5 | -0.250 Giga cells per liter | Standard Deviation 0.1245 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 8,n=12,6,6,9,9,6 | -0.252 Giga cells per liter | Standard Deviation 0.1007 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 32,n=6,5,6,0,0,6 | -15.7 Giga cells per liter | Standard Deviation 51.15 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Day 5,n=12,5,6,9,9,6 | -2.8 Giga cells per liter | Standard Deviation 18.62 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 4,n=12,6,5,9,9,6 | -0.253 Giga cells per liter | Standard Deviation 0.0855 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Day 3,n=12,6,6,9,9,6 | 0.143 Giga cells per liter | Standard Deviation 0.3296 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 1,n=12,5,6,9,8,6 | -13.8 Giga cells per liter | Standard Deviation 28.69 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 2,n=12,6,5,9,9,6 | -0.223 Giga cells per liter | Standard Deviation 0.0952 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 2,n=12,5,6,9,9,6 | -15.5 Giga cells per liter | Standard Deviation 39.81 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Week 1,n=12,6,6,9,9,5 | -0.206 Giga cells per liter | Standard Deviation 0.0568 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 5,n=11,6,6,9,9,6 | -0.210 Giga cells per liter | Standard Deviation 0.0767 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 4,n=12,5,4,9,9,6 | -5.0 Giga cells per liter | Standard Deviation 22.8 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 8,n=12,5,5,9,9,6 | -3.5 Giga cells per liter | Standard Deviation 23.89 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 4,n=12,6,6,8,8,6 | -0.192 Giga cells per liter | Standard Deviation 0.0643 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 26,n=12,6,6,9,9,6 | -0.295 Giga cells per liter | Standard Deviation 0.2855 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 12,n=12,5,6,9,9,5 | -25.6 Giga cells per liter | Standard Deviation 24.39 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 3,n=12,6,6,9,9,6 | -0.182 Giga cells per liter | Standard Deviation 0.092 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Eosinophils, Day 2,n=12,6,6,8,9,6 | -0.152 Giga cells per liter | Standard Deviation 0.0794 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 18,n=12,5,6,9,9,6 | 2.2 Giga cells per liter | Standard Deviation 28.92 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 32,n=6,6,6,0,0,6 | -0.008 Giga cells per liter | Standard Deviation 0.0117 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 24,n=10,5,6,9,9,6 | -5.7 Giga cells per liter | Standard Deviation 39.38 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Platelet, Week 26,n=12,5,6,9,9,6 | -6.8 Giga cells per liter | Standard Deviation 17.38 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 26,n=12,6,6,9,9,6 | -0.008 Giga cells per liter | Standard Deviation 0.0133 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 24,n=11,6,6,9,9,6 | -0.018 Giga cells per liter | Standard Deviation 0.0117 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 3,n=12,6,6,9,9,6 | 0.038 Giga cells per liter | Standard Deviation 0.5158 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 18,n=12,6,6,9,9,6 | -0.005 Giga cells per liter | Standard Deviation 0.0105 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 4,n=12,6,6,8,8,6 | 0.215 Giga cells per liter | Standard Deviation 0.4194 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 12,n=12,5,6,9,9,5 | -0.006 Giga cells per liter | Standard Deviation 0.0055 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Day 5,n=11,6,6,9,9,6 | 0.103 Giga cells per liter | Standard Deviation 0.2639 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 8,n=12,6,6,9,9,6 | -0.015 Giga cells per liter | Standard Deviation 0.0138 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 4,n=12,6,5,9,9,6 | -0.010 Giga cells per liter | Standard Deviation 0.0126 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 32,n=6,6,6,0,0,6 | -0.360 Giga cells per liter | Standard Deviation 0.3275 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 1,n=12,6,6,9,9,5 | 0.070 Giga cells per liter | Standard Deviation 0.4346 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 2,n=12,6,5,9,9,6 | -0.007 Giga cells per liter | Standard Deviation 0.0137 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 2,n=12,6,5,9,9,6 | -0.310 Giga cells per liter | Standard Deviation 0.6362 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 1,n=12,6,6,9,9,5 | -0.006 Giga cells per liter | Standard Deviation 0.0055 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Week 40,n=2,0,0,0,0,6 | -0.012 Giga cells per liter | Standard Deviation 0.0313 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 4,n=12,6,5,9,9,6 | 0.023 Giga cells per liter | Standard Deviation 0.7539 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 5,n=11,6,6,9,9,6 | -0.025 Giga cells per liter | Standard Deviation 0.0164 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 4,n=12,6,6,8,8,6 | 0.002 Giga cells per liter | Standard Deviation 0.0214 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 8,n=12,6,6,9,9,6 | 0.258 Giga cells per liter | Standard Deviation 0.5218 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 3,n=12,6,6,9,9,6 | -0.007 Giga cells per liter | Standard Deviation 0.0121 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 12,n=12,5,6,9,9,5 | -0.362 Giga cells per liter | Standard Deviation 0.5607 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Basophils, Day 2,n=12,6,6,8,9,6 | -0.018 Giga cells per liter | Standard Deviation 0.016 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 4,n=12,6,6,8,8,6 | 0.050 Giga cells per liter | Standard Deviation 0.0434 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 40,n=2,0,0,0,0,6 | -0.125 Giga cells per liter | Standard Deviation 0.2966 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 5,n=11,6,6,9,9,6 | -0.035 Giga cells per liter | Standard Deviation 0.0766 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 32,n=6,6,6,0,0,6 | -0.148 Giga cells per liter | Standard Deviation 0.2017 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 4,n=12,6,5,9,9,6 | -0.137 Giga cells per liter | Standard Deviation 0.2103 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Day 3,n=12,6,6,9,9,6 | 0.018 Giga cells per liter | Standard Deviation 0.1514 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 1,n=12,6,6,9,9,5 | -0.012 Giga cells per liter | Standard Deviation 0.0926 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Lymphocytes, Week 24,n=11,6,6,9,9,6 | -0.132 Giga cells per liter | Standard Deviation 0.1619 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Neutrophil, Week 40,n=2,0,0,0,0,6 | 0.332 Giga cells per liter | Standard Deviation 0.3452 |
| GSK3511294 300mg | Change From Baseline in Neutrophil, Lymphocyte, Monocyte, Eosinophil, Basophil and Platelet Count | Monocytes, Week 2,n=12,6,5,9,9,6 | 0.090 Giga cells per liter | Standard Deviation 0.2697 |
Primary
Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval
12-lead ECG were performed in a supine position using an automated ECG machine that calculated PR interval, QRS interval, QT interval and QTcF interval. ECG measurements were performed in triplicate. When multiple ECGs were performed at the same planned timepoint, the average value of each parameter was used. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at 2 and 8 hours on Day 1; Days 2, 3, 4 and 5; Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 4,n=12,6,6,8,9,6 | 9.4 Milliseconds | Standard Deviation 20.43 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 26,n=12,6,6,9,9,6 | -1.9 Milliseconds | Standard Deviation 16.58 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 24,n=12,6,6,9,9,6 | 1.4 Milliseconds | Standard Deviation 15.42 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 18,n=12,6,6,9,9,6 | -0.5 Milliseconds | Standard Deviation 11.73 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 12,n=12,6,6,9,9,6 | -6.4 Milliseconds | Standard Deviation 14.39 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval, Day 3,n=12,6,6,9,9,6 | -6.8 Milliseconds | Standard Deviation 14.99 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 5,n=12,6,6,9,9,6 | -5.9 Milliseconds | Standard Deviation 14.18 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 8,n=12,6,6,9,9,6 | -2.8 Milliseconds | Standard Deviation 13.76 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 4,n=12,6,6,8,9,6 | -0.6 Milliseconds | Standard Deviation 11.22 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 2,n=12,6,6,9,9,6 | 0.9 Milliseconds | Standard Deviation 16.4 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 1,n=12,6,6,9,9,6 | -0.2 Milliseconds | Standard Deviation 10.95 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 4,n=12,6,6,9,9,6 | -4.9 Milliseconds | Standard Deviation 14.08 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 36,n=6,0,0,9,9,0 | -3.7 Milliseconds | Standard Deviation 6.19 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 5,n=12,6,6,9,9,6 | -1.7 Milliseconds | Standard Deviation 11.97 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 32,n=6,6,6,0,0,6 | 2.9 Milliseconds | Standard Deviation 5.78 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 26,n=12,6,6,9,9,6 | 0.0 Milliseconds | Standard Deviation 4.61 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 24,n=12,6,6,9,9,6 | 0.6 Milliseconds | Standard Deviation 5.94 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 8,n=12,6,6,9,9,6 | -0.6 Milliseconds | Standard Deviation 20.74 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 4,n=12,6,6,9,9,6 | -12.3 Milliseconds | Standard Deviation 17.15 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 18,n=12,6,6,9,9,6 | 0.6 Milliseconds | Standard Deviation 3.9 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 12,n=12,6,6,9,9,6 | 1.6 Milliseconds | Standard Deviation 4.2 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 8,n=12,6,6,9,9,6 | 1.9 Milliseconds | Standard Deviation 7.27 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 4,n=12,6,6,8,9,6 | 2.0 Milliseconds | Standard Deviation 6.49 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 12,n=12,6,6,9,9,6 | -6.8 Milliseconds | Standard Deviation 20.64 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval, Day 3,n=12,6,6,9,9,6 | -10.1 Milliseconds | Standard Deviation 19.82 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 2,n=12,6,6,9,9,6 | 2.1 Milliseconds | Standard Deviation 3.76 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 1,n=12,6,6,9,9,6 | 2.3 Milliseconds | Standard Deviation 5.05 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 5,n=12,6,6,9,9,6 | -0.5 Milliseconds | Standard Deviation 4.05 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 4,n=12,6,6,9,9,6 | 0.4 Milliseconds | Standard Deviation 3.78 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 18,n=12,6,6,9,9,6 | 7.3 Milliseconds | Standard Deviation 22.44 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 2,n=12,6,6,9,9,6 | 9.4 Milliseconds | Standard Deviation 16.23 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval, Day 3,n=12,6,6,9,9,6 | 1.4 Milliseconds | Standard Deviation 3.44 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 2,n=12,6,6,9,9,6 | 1.8 Milliseconds | Standard Deviation 4.64 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,8 hours Day1,n=12,6,6,9,9,6 | -0.3 Milliseconds | Standard Deviation 6.83 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,2 hours Day1,n=12,6,5,9,8,6 | 1.1 Milliseconds | Standard Deviation 4.87 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 24,n=12,6,6,9,9,6 | 7.1 Milliseconds | Standard Deviation 23.22 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 1,n=12,6,6,9,9,6 | 5.3 Milliseconds | Standard Deviation 17.3 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 40,n=2,0,0,0,0,6 | -13.7 Milliseconds | Standard Deviation 6.6 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 36,n=6,0,0,9,9,0 | -0.5 Milliseconds | Standard Deviation 8.26 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 32,n=6,6,6,0,0,6 | -4.3 Milliseconds | Standard Deviation 8.16 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 26,n=12,6,6,9,9,6 | 1.1 Milliseconds | Standard Deviation 6.2 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 26,n=12,6,6,9,9,6 | 2.3 Milliseconds | Standard Deviation 27.36 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 2,n=12,6,6,9,9,6 | -4.9 Milliseconds | Standard Deviation 19.32 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 24,n=12,6,6,9,9,6 | 2.3 Milliseconds | Standard Deviation 7.98 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 18,n=12,6,6,9,9,6 | 1.5 Milliseconds | Standard Deviation 10.74 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 12,n=12,6,6,9,9,6 | -2.4 Milliseconds | Standard Deviation 7.87 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 32,n=6,6,6,0,0,6 | 5.7 Milliseconds | Standard Deviation 20.32 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,8 hours Day1,n=12,6,6,9,9,6 | -7.5 Milliseconds | Standard Deviation 16.46 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 8,n=12,6,6,9,9,6 | -3.1 Milliseconds | Standard Deviation 8.27 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 4,n=12,6,6,8,9,6 | 1.7 Milliseconds | Standard Deviation 10.27 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 36,n=6,0,0,9,9,0 | -6.4 Milliseconds | Standard Deviation 41.25 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 2,n=12,6,6,9,9,6 | -1.0 Milliseconds | Standard Deviation 8.62 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 1,n=12,6,6,9,9,6 | -0.3 Milliseconds | Standard Deviation 8.12 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 40,n=2,0,0,0,0,6 | 23.5 Milliseconds | Standard Deviation 17.68 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 5,n=12,6,6,9,9,6 | 1.3 Milliseconds | Standard Deviation 6.22 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,2 hours Day1,n=12,6,5,9,8,6 | -0.6 Milliseconds | Standard Deviation 9.11 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,2 hours Day1,n=12,6,5,9,8,6 | -2.6 Milliseconds | Standard Deviation 22.55 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 4,n=12,6,6,9,9,6 | -0.6 Milliseconds | Standard Deviation 6.8 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval, Day 3,n=12,6,6,9,9,6 | 2.3 Milliseconds | Standard Deviation 6.68 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 2,n=12,6,6,9,9,6 | -2.7 Milliseconds | Standard Deviation 11.51 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,8 hours Day1,n=12,6,6,9,9,6 | -4.1 Milliseconds | Standard Deviation 8.49 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,8 hours Day1,n=12,6,6,9,9,6 | -6.8 Milliseconds | Standard Deviation 12.97 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 40,n=2,0,0,0,0,6 | 0.0 Milliseconds | Standard Deviation 0.47 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,2 hours Day1,n=12,6,5,9,8,6 | -4.5 Milliseconds | Standard Deviation 9.46 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 40,n=2,0,0,0,0,6 | 12.0 Milliseconds | Standard Deviation 17.44 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 36,n=6,0,0,9,9,0 | -3.7 Milliseconds | Standard Deviation 24.89 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 32,n=6,6,6,0,0,6 | 0.4 Milliseconds | Standard Deviation 10.98 |
| Placebo | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 2,n=12,6,6,9,9,6 | -4.0 Milliseconds | Standard Deviation 11.78 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 1,n=12,6,6,9,9,6 | 8.7 Milliseconds | Standard Deviation 14.19 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 2,n=12,6,6,9,9,6 | 12.9 Milliseconds | Standard Deviation 8.14 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 4,n=12,6,6,8,9,6 | 11.0 Milliseconds | Standard Deviation 4.78 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 8,n=12,6,6,9,9,6 | 6.9 Milliseconds | Standard Deviation 9.28 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 12,n=12,6,6,9,9,6 | 8.1 Milliseconds | Standard Deviation 16.21 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 18,n=12,6,6,9,9,6 | 6.3 Milliseconds | Standard Deviation 15 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 24,n=12,6,6,9,9,6 | 4.2 Milliseconds | Standard Deviation 18.11 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 26,n=12,6,6,9,9,6 | 10.2 Milliseconds | Standard Deviation 12.92 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 32,n=6,6,6,0,0,6 | 12.9 Milliseconds | Standard Deviation 12.12 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,2 hours Day1,n=12,6,5,9,8,6 | 4.1 Milliseconds | Standard Deviation 8.67 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,8 hours Day1,n=12,6,6,9,9,6 | 4.3 Milliseconds | Standard Deviation 7.93 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 2,n=12,6,6,9,9,6 | 2.6 Milliseconds | Standard Deviation 8.43 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval, Day 3,n=12,6,6,9,9,6 | 0.4 Milliseconds | Standard Deviation 5.82 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 4,n=12,6,6,9,9,6 | 0.7 Milliseconds | Standard Deviation 7.62 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 5,n=12,6,6,9,9,6 | 1.5 Milliseconds | Standard Deviation 14.24 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 1,n=12,6,6,9,9,6 | 10.3 Milliseconds | Standard Deviation 7.33 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 2,n=12,6,6,9,9,6 | 6.3 Milliseconds | Standard Deviation 6.98 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 4,n=12,6,6,8,9,6 | 7.3 Milliseconds | Standard Deviation 7.1 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 8,n=12,6,6,9,9,6 | 5.2 Milliseconds | Standard Deviation 9.28 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 12,n=12,6,6,9,9,6 | 5.9 Milliseconds | Standard Deviation 13.5 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 18,n=12,6,6,9,9,6 | 4.8 Milliseconds | Standard Deviation 6.79 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 24,n=12,6,6,9,9,6 | 3.0 Milliseconds | Standard Deviation 10.83 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 26,n=12,6,6,9,9,6 | 9.6 Milliseconds | Standard Deviation 9.37 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 32,n=6,6,6,0,0,6 | 1.3 Milliseconds | Standard Deviation 7.93 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,2 hours Day1,n=12,6,5,9,8,6 | 3.9 Milliseconds | Standard Deviation 2.85 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,8 hours Day1,n=12,6,6,9,9,6 | 3.1 Milliseconds | Standard Deviation 6.02 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 2,n=12,6,6,9,9,6 | 2.0 Milliseconds | Standard Deviation 4.11 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval, Day 3,n=12,6,6,9,9,6 | 5.2 Milliseconds | Standard Deviation 4.29 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 4,n=12,6,6,9,9,6 | 8.1 Milliseconds | Standard Deviation 5.21 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 5,n=12,6,6,9,9,6 | 8.3 Milliseconds | Standard Deviation 8.22 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 1,n=12,6,6,9,9,6 | 0.8 Milliseconds | Standard Deviation 5.58 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 2,n=12,6,6,9,9,6 | 5.3 Milliseconds | Standard Deviation 6.6 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 4,n=12,6,6,8,9,6 | 5.2 Milliseconds | Standard Deviation 3.37 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 8,n=12,6,6,9,9,6 | 3.2 Milliseconds | Standard Deviation 9.65 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 12,n=12,6,6,9,9,6 | 3.9 Milliseconds | Standard Deviation 10.53 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 18,n=12,6,6,9,9,6 | 1.5 Milliseconds | Standard Deviation 3.99 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 24,n=12,6,6,9,9,6 | 1.4 Milliseconds | Standard Deviation 3.91 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 26,n=12,6,6,9,9,6 | 3.0 Milliseconds | Standard Deviation 4.67 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 32,n=6,6,6,0,0,6 | 5.4 Milliseconds | Standard Deviation 7.23 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,2 hours Day1,n=12,6,5,9,8,6 | 0.2 Milliseconds | Standard Deviation 4.63 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,8 hours Day1,n=12,6,6,9,9,6 | -0.2 Milliseconds | Standard Deviation 6.81 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 2,n=12,6,6,9,9,6 | 0.5 Milliseconds | Standard Deviation 4.63 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval, Day 3,n=12,6,6,9,9,6 | 1.4 Milliseconds | Standard Deviation 4.18 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 4,n=12,6,6,9,9,6 | 1.9 Milliseconds | Standard Deviation 3.72 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 5,n=12,6,6,9,9,6 | 0.2 Milliseconds | Standard Deviation 5.85 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 1,n=12,6,6,9,9,6 | 0.6 Milliseconds | Standard Deviation 5.85 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 2,n=12,6,6,9,9,6 | 2.1 Milliseconds | Standard Deviation 4.82 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 4,n=12,6,6,8,9,6 | 1.8 Milliseconds | Standard Deviation 7.34 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 8,n=12,6,6,9,9,6 | -1.0 Milliseconds | Standard Deviation 4.35 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 12,n=12,6,6,9,9,6 | 3.1 Milliseconds | Standard Deviation 3.28 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 18,n=12,6,6,9,9,6 | 1.8 Milliseconds | Standard Deviation 2.79 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 24,n=12,6,6,9,9,6 | 1.8 Milliseconds | Standard Deviation 6.53 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 26,n=12,6,6,9,9,6 | 2.1 Milliseconds | Standard Deviation 4.64 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 32,n=6,6,6,0,0,6 | 2.0 Milliseconds | Standard Deviation 5.17 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,2 hours Day1,n=12,6,5,9,8,6 | 14.8 Milliseconds | Standard Deviation 16.65 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,8 hours Day1,n=12,6,6,9,9,6 | 6.7 Milliseconds | Standard Deviation 16.22 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 2,n=12,6,6,9,9,6 | 4.3 Milliseconds | Standard Deviation 14.01 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval, Day 3,n=12,6,6,9,9,6 | -0.9 Milliseconds | Standard Deviation 10.33 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 4,n=12,6,6,9,9,6 | -2.2 Milliseconds | Standard Deviation 14.32 |
| GSK3511294 2mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 5,n=12,6,6,9,9,6 | -2.2 Milliseconds | Standard Deviation 21.88 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 4,n=12,6,6,8,9,6 | -6.5 Milliseconds | Standard Deviation 7.76 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 2,n=12,6,6,9,9,6 | -8.3 Milliseconds | Standard Deviation 8.21 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 1,n=12,6,6,9,9,6 | -3.7 Milliseconds | Standard Deviation 6.18 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 8,n=12,6,6,9,9,6 | -3.6 Milliseconds | Standard Deviation 5.23 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 2,n=12,6,6,9,9,6 | 5.5 Milliseconds | Standard Deviation 10.34 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval, Day 3,n=12,6,6,9,9,6 | -6.5 Milliseconds | Standard Deviation 9.14 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 1,n=12,6,6,9,9,6 | 0.0 Milliseconds | Standard Deviation 21.14 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 12,n=12,6,6,9,9,6 | 4.2 Milliseconds | Standard Deviation 22.53 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 1,n=12,6,6,9,9,6 | -6.7 Milliseconds | Standard Deviation 12.72 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 2,n=12,6,6,9,9,6 | -12.8 Milliseconds | Standard Deviation 10.87 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 4,n=12,6,6,8,9,6 | 1.8 Milliseconds | Standard Deviation 12.71 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 26,n=12,6,6,9,9,6 | -3.9 Milliseconds | Standard Deviation 14.54 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 2,n=12,6,6,9,9,6 | -3.9 Milliseconds | Standard Deviation 4.76 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 32,n=6,6,6,0,0,6 | -6.1 Milliseconds | Standard Deviation 4.5 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 32,n=6,6,6,0,0,6 | -14.4 Milliseconds | Standard Deviation 17.64 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 4,n=12,6,6,9,9,6 | -7.8 Milliseconds | Standard Deviation 5.52 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 8,n=12,6,6,9,9,6 | -2.6 Milliseconds | Standard Deviation 10.27 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 18,n=12,6,6,9,9,6 | -2.8 Milliseconds | Standard Deviation 15.12 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 12,n=12,6,6,9,9,6 | -5.3 Milliseconds | Standard Deviation 10.66 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 5,n=12,6,6,9,9,6 | -13.6 Milliseconds | Standard Deviation 11.17 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 4,n=12,6,6,9,9,6 | -6.1 Milliseconds | Standard Deviation 7.1 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 2,n=12,6,6,9,9,6 | 7.8 Milliseconds | Standard Deviation 17.65 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 12,n=12,6,6,9,9,6 | -4.4 Milliseconds | Standard Deviation 12.18 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval, Day 3,n=12,6,6,9,9,6 | 0.5 Milliseconds | Standard Deviation 5.62 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,8 hours Day1,n=12,6,6,9,9,6 | -3.6 Milliseconds | Standard Deviation 12.32 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 24,n=12,6,6,9,9,6 | -7.2 Milliseconds | Standard Deviation 12.14 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 18,n=12,6,6,9,9,6 | -10.4 Milliseconds | Standard Deviation 9.42 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,2 hours Day1,n=12,6,5,9,8,6 | 6.0 Milliseconds | Standard Deviation 11.28 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 18,n=12,6,6,9,9,6 | 0.1 Milliseconds | Standard Deviation 7.74 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 4,n=12,6,6,8,9,6 | -6.6 Milliseconds | Standard Deviation 20.63 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,2 hours Day1,n=12,6,5,9,8,6 | 3.5 Milliseconds | Standard Deviation 8.47 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,2 hours Day1,n=12,6,5,9,8,6 | -5.5 Milliseconds | Standard Deviation 8.11 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 26,n=12,6,6,9,9,6 | 0.9 Milliseconds | Standard Deviation 29.72 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 2,n=12,6,6,9,9,6 | -14.1 Milliseconds | Standard Deviation 16.26 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 24,n=12,6,6,9,9,6 | 3.7 Milliseconds | Standard Deviation 7.25 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 4,n=12,6,6,9,9,6 | -15.9 Milliseconds | Standard Deviation 21.55 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 4,n=12,6,6,9,9,6 | -2.5 Milliseconds | Standard Deviation 6.12 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 2,n=12,6,6,9,9,6 | 1.4 Milliseconds | Standard Deviation 3.95 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 26,n=12,6,6,9,9,6 | -5.5 Milliseconds | Standard Deviation 5.75 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 5,n=12,6,6,9,9,6 | -14.3 Milliseconds | Standard Deviation 13.83 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 26,n=12,6,6,9,9,6 | 3.7 Milliseconds | Standard Deviation 11.62 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 4,n=12,6,6,8,9,6 | -3.6 Milliseconds | Standard Deviation 24.5 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval, Day 3,n=12,6,6,9,9,6 | -6.9 Milliseconds | Standard Deviation 14.95 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 5,n=12,6,6,9,9,6 | -7.3 Milliseconds | Standard Deviation 4.79 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 5,n=12,6,6,9,9,6 | 3.5 Milliseconds | Standard Deviation 10.05 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 8,n=12,6,6,9,9,6 | -4.8 Milliseconds | Standard Deviation 14.7 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 32,n=6,6,6,0,0,6 | 0.0 Milliseconds | Standard Deviation 7.99 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval, Day 3,n=12,6,6,9,9,6 | -1.3 Milliseconds | Standard Deviation 3.14 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 32,n=6,6,6,0,0,6 | -13.8 Milliseconds | Standard Deviation 8.76 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 2,n=12,6,6,9,9,6 | -4.9 Milliseconds | Standard Deviation 4.6 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 12,n=12,6,6,9,9,6 | -4.4 Milliseconds | Standard Deviation 6.04 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 24,n=12,6,6,9,9,6 | -9.9 Milliseconds | Standard Deviation 27.45 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 24,n=12,6,6,9,9,6 | -6.5 Milliseconds | Standard Deviation 5.56 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,8 hours Day1,n=12,6,6,9,9,6 | 12.6 Milliseconds | Standard Deviation 18.53 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 18,n=12,6,6,9,9,6 | -5.0 Milliseconds | Standard Deviation 5.43 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,2 hours Day1,n=12,6,5,9,8,6 | -7.2 Milliseconds | Standard Deviation 4.97 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 1,n=12,6,6,9,9,6 | 2.2 Milliseconds | Standard Deviation 5.69 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,8 hours Day1,n=12,6,6,9,9,6 | -1.8 Milliseconds | Standard Deviation 3.72 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 8,n=12,6,6,9,9,6 | 1.0 Milliseconds | Standard Deviation 23.62 |
| GSK3511294 10mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,8 hours Day1,n=12,6,6,9,9,6 | -4.0 Milliseconds | Standard Deviation 6.18 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,8 hours Day1,n=12,6,6,9,9,6 | -4.5 Milliseconds | Standard Deviation 11.76 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,8 hours Day1,n=12,6,6,9,9,6 | -1.1 Milliseconds | Standard Deviation 3.18 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 18,n=12,6,6,9,9,6 | -4.5 Milliseconds | Standard Deviation 19.1 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 4,n=12,6,6,9,9,6 | -11.6 Milliseconds | Standard Deviation 25.81 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 2,n=12,6,6,9,9,6 | -2.7 Milliseconds | Standard Deviation 5.28 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 36,n=6,0,0,9,9,0 | 0.7 Milliseconds | Standard Deviation 5.14 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 8,n=12,6,6,9,9,6 | 4.6 Milliseconds | Standard Deviation 19.06 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval, Day 3,n=12,6,6,9,9,6 | -0.6 Milliseconds | Standard Deviation 4.03 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 26,n=12,6,6,9,9,6 | -1.7 Milliseconds | Standard Deviation 10.65 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 8,n=12,6,6,9,9,6 | 0.9 Milliseconds | Standard Deviation 4.12 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval, Day 3,n=12,6,6,9,9,6 | -7.6 Milliseconds | Standard Deviation 18.49 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 4,n=12,6,6,9,9,6 | 1.1 Milliseconds | Standard Deviation 5.28 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 2,n=12,6,6,9,9,6 | -4.4 Milliseconds | Standard Deviation 9.86 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 5,n=12,6,6,9,9,6 | -0.2 Milliseconds | Standard Deviation 5.4 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 18,n=12,6,6,9,9,6 | -0.6 Milliseconds | Standard Deviation 12.29 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 4,n=12,6,6,8,9,6 | 1.9 Milliseconds | Standard Deviation 4.79 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 12,n=12,6,6,9,9,6 | -6.5 Milliseconds | Standard Deviation 28.72 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 1,n=12,6,6,9,9,6 | 0.6 Milliseconds | Standard Deviation 4.9 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,2 hours Day1,n=12,6,5,9,8,6 | -3.4 Milliseconds | Standard Deviation 6.4 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 2,n=12,6,6,9,9,6 | 0.9 Milliseconds | Standard Deviation 2.86 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 4,n=12,6,6,8,9,6 | 0.5 Milliseconds | Standard Deviation 10.86 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval, Day 3,n=12,6,6,9,9,6 | -3.6 Milliseconds | Standard Deviation 11.96 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 2,n=12,6,6,9,9,6 | 1.0 Milliseconds | Standard Deviation 22.66 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 4,n=12,6,6,9,9,6 | -2.3 Milliseconds | Standard Deviation 8.88 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval, Day 3,n=12,6,6,9,9,6 | -5.3 Milliseconds | Standard Deviation 9.95 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 5,n=12,6,6,9,9,6 | -9.5 Milliseconds | Standard Deviation 14.97 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 5,n=12,6,6,9,9,6 | -0.2 Milliseconds | Standard Deviation 4.54 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 2,n=12,6,6,9,9,6 | 3.7 Milliseconds | Standard Deviation 19.35 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 12,n=12,6,6,9,9,6 | -5.9 Milliseconds | Standard Deviation 10.93 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 1,n=12,6,6,9,9,6 | -3.2 Milliseconds | Standard Deviation 12.26 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 2,n=12,6,6,9,9,6 | -6.9 Milliseconds | Standard Deviation 9.34 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 36,n=6,0,0,9,9,0 | -3.4 Milliseconds | Standard Deviation 29.83 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,8 hours Day1,n=12,6,6,9,9,6 | 1.5 Milliseconds | Standard Deviation 14.29 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 2,n=12,6,6,9,9,6 | 1.8 Milliseconds | Standard Deviation 12.19 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 36,n=6,0,0,9,9,0 | -4.3 Milliseconds | Standard Deviation 13.45 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 1,n=12,6,6,9,9,6 | -5.4 Milliseconds | Standard Deviation 8.38 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 4,n=12,6,6,8,9,6 | -1.8 Milliseconds | Standard Deviation 15.25 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,8 hours Day1,n=12,6,6,9,9,6 | -1.4 Milliseconds | Standard Deviation 9.87 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 5,n=12,6,6,9,9,6 | -4.7 Milliseconds | Standard Deviation 9.86 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 8,n=12,6,6,9,9,6 | -3.6 Milliseconds | Standard Deviation 10.33 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 12,n=12,6,6,9,9,6 | -3.8 Milliseconds | Standard Deviation 13.26 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 4,n=12,6,6,9,9,6 | -7.7 Milliseconds | Standard Deviation 12.56 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 26,n=12,6,6,9,9,6 | -6.1 Milliseconds | Standard Deviation 22.91 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 18,n=12,6,6,9,9,6 | -5.6 Milliseconds | Standard Deviation 11.87 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 4,n=12,6,6,8,9,6 | 3.3 Milliseconds | Standard Deviation 17.8 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 24,n=12,6,6,9,9,6 | -7.4 Milliseconds | Standard Deviation 11.56 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,2 hours Day1,n=12,6,5,9,8,6 | -4.3 Milliseconds | Standard Deviation 9.1 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 26,n=12,6,6,9,9,6 | 0.4 Milliseconds | Standard Deviation 5.55 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 2,n=12,6,6,9,9,6 | -3.0 Milliseconds | Standard Deviation 18.8 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 26,n=12,6,6,9,9,6 | -3.2 Milliseconds | Standard Deviation 13.01 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 24,n=12,6,6,9,9,6 | 0.4 Milliseconds | Standard Deviation 7.96 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 1,n=12,6,6,9,9,6 | -9.4 Milliseconds | Standard Deviation 19.82 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 8,n=12,6,6,9,9,6 | -1.7 Milliseconds | Standard Deviation 11.96 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 24,n=12,6,6,9,9,6 | -1.1 Milliseconds | Standard Deviation 3.76 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 24,n=12,6,6,9,9,6 | 0.7 Milliseconds | Standard Deviation 19.24 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 36,n=6,0,0,9,9,0 | -3.7 Milliseconds | Standard Deviation 8.49 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,2 hours Day1,n=12,6,5,9,8,6 | -2.9 Milliseconds | Standard Deviation 20.19 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 18,n=12,6,6,9,9,6 | 0.4 Milliseconds | Standard Deviation 3.16 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,2 hours Day1,n=12,6,5,9,8,6 | 0.0 Milliseconds | Standard Deviation 4.43 |
| GSK3511294 30mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 12,n=12,6,6,9,9,6 | -0.1 Milliseconds | Standard Deviation 5.23 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval, Day 3,n=12,6,6,9,9,6 | -6.3 Milliseconds | Standard Deviation 10.71 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 24,n=12,6,6,9,9,6 | -3.9 Milliseconds | Standard Deviation 12.69 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 2,n=12,6,6,9,9,6 | -6.1 Milliseconds | Standard Deviation 17.1 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 26,n=12,6,6,9,9,6 | -4.4 Milliseconds | Standard Deviation 12.21 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,8 hours Day1,n=12,6,6,9,9,6 | -0.4 Milliseconds | Standard Deviation 8.32 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 36,n=6,0,0,9,9,0 | -5.5 Milliseconds | Standard Deviation 14.23 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,2 hours Day1,n=12,6,5,9,8,6 | 3.7 Milliseconds | Standard Deviation 1.075 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,8 hours Day1,n=12,6,6,9,9,6 | 1.9 Milliseconds | Standard Deviation 11.39 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,2 hours Day1,n=12,6,5,9,8,6 | -2.3 Milliseconds | Standard Deviation 5.38 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,2 hours Day1,n=12,6,5,9,8,6 | -3.7 Milliseconds | Standard Deviation 23.95 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 2,n=12,6,6,9,9,6 | 6.2 Milliseconds | Standard Deviation 11.05 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval, Day 3,n=12,6,6,9,9,6 | 6.0 Milliseconds | Standard Deviation 7.6 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 4,n=12,6,6,9,9,6 | 8.6 Milliseconds | Standard Deviation 10.17 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 5,n=12,6,6,9,9,6 | 10.0 Milliseconds | Standard Deviation 8.44 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 36,n=6,0,0,9,9,0 | -9.3 Milliseconds | Standard Deviation 16 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 1,n=12,6,6,9,9,6 | 7.0 Milliseconds | Standard Deviation 6.62 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 2,n=12,6,6,9,9,6 | 2.0 Milliseconds | Standard Deviation 12.64 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,8 hours Day1,n=12,6,6,9,9,6 | -0.7 Milliseconds | Standard Deviation 29.93 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 4,n=12,6,6,8,9,6 | 3.9 Milliseconds | Standard Deviation 11.28 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 8,n=12,6,6,9,9,6 | 3.4 Milliseconds | Standard Deviation 8.1 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 12,n=12,6,6,9,9,6 | 9.4 Milliseconds | Standard Deviation 8.33 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 5,n=12,6,6,9,9,6 | -4.1 Milliseconds | Standard Deviation 18.72 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 18,n=12,6,6,9,9,6 | 7.3 Milliseconds | Standard Deviation 13.34 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 24,n=12,6,6,9,9,6 | 5.5 Milliseconds | Standard Deviation 12.45 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 26,n=12,6,6,9,9,6 | 6.9 Milliseconds | Standard Deviation 11.36 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 24,n=12,6,6,9,9,6 | -8.6 Milliseconds | Standard Deviation 19 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 2,n=12,6,6,9,9,6 | -6.1 Milliseconds | Standard Deviation 15.86 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 36,n=6,0,0,9,9,0 | 2.9 Milliseconds | Standard Deviation 12.08 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,2 hours Day1,n=12,6,5,9,8,6 | -1.5 Milliseconds | Standard Deviation 6.14 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 18,n=12,6,6,9,9,6 | -6.7 Milliseconds | Standard Deviation 23.77 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,8 hours Day1,n=12,6,6,9,9,6 | -2.8 Milliseconds | Standard Deviation 5.03 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 2,n=12,6,6,9,9,6 | -3.0 Milliseconds | Standard Deviation 6.27 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval, Day 3,n=12,6,6,9,9,6 | -2.6 Milliseconds | Standard Deviation 5.15 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 4,n=12,6,6,9,9,6 | -0.7 Milliseconds | Standard Deviation 5.24 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 12,n=12,6,6,9,9,6 | -2.1 Milliseconds | Standard Deviation 26.69 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval, Day 3,n=12,6,6,9,9,6 | -13.2 Milliseconds | Standard Deviation 15.2 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 5,n=12,6,6,9,9,6 | 0.7 Milliseconds | Standard Deviation 5.09 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 1,n=12,6,6,9,9,6 | -2.4 Milliseconds | Standard Deviation 5.61 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 1,n=12,6,6,9,9,6 | -1.0 Milliseconds | Standard Deviation 22.22 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 2,n=12,6,6,9,9,6 | -3.0 Milliseconds | Standard Deviation 5.47 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 4,n=12,6,6,8,9,6 | -2.6 Milliseconds | Standard Deviation 4.98 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 8,n=12,6,6,9,9,6 | -2.0 Milliseconds | Standard Deviation 20.79 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 8,n=12,6,6,9,9,6 | 0.5 Milliseconds | Standard Deviation 5.71 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 12,n=12,6,6,9,9,6 | -2.5 Milliseconds | Standard Deviation 3.11 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 4,n=12,6,6,9,9,6 | -10.9 Milliseconds | Standard Deviation 11.99 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 18,n=12,6,6,9,9,6 | -2.9 Milliseconds | Standard Deviation 4.53 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 24,n=12,6,6,9,9,6 | -3.1 Milliseconds | Standard Deviation 2.01 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 4,n=12,6,6,8,9,6 | 1.7 Milliseconds | Standard Deviation 34.52 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 26,n=12,6,6,9,9,6 | -2.7 Milliseconds | Standard Deviation 6.57 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 4,n=12,6,6,9,9,6 | -4.8 Milliseconds | Standard Deviation 10.75 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 26,n=12,6,6,9,9,6 | -9.8 Milliseconds | Standard Deviation 18.29 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 5,n=12,6,6,9,9,6 | -4.4 Milliseconds | Standard Deviation 14.31 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 1,n=12,6,6,9,9,6 | 2.8 Milliseconds | Standard Deviation 12.12 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 2,n=12,6,6,9,9,6 | -2.3 Milliseconds | Standard Deviation 12.64 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 4,n=12,6,6,8,9,6 | -0.7 Milliseconds | Standard Deviation 10.97 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 8,n=12,6,6,9,9,6 | -2.9 Milliseconds | Standard Deviation 14.1 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 36,n=6,0,0,9,9,0 | -3.9 Milliseconds | Standard Deviation 4.84 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 12,n=12,6,6,9,9,6 | -1.1 Milliseconds | Standard Deviation 11.91 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 2,n=12,6,6,9,9,6 | -5.9 Milliseconds | Standard Deviation 5.7 |
| GSK3511294 100mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 18,n=12,6,6,9,9,6 | -5.2 Milliseconds | Standard Deviation 12.81 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,2 hours Day1,n=12,6,5,9,8,6 | -7.5 Milliseconds | Standard Deviation 12.23 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 2,n=12,6,6,9,9,6 | -0.6 Milliseconds | Standard Deviation 11.09 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 18,n=12,6,6,9,9,6 | 0.5 Milliseconds | Standard Deviation 12.14 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,8 hours Day1,n=12,6,6,9,9,6 | 2.1 Milliseconds | Standard Deviation 13.97 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 18,n=12,6,6,9,9,6 | -1.6 Milliseconds | Standard Deviation 4.17 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 4,n=12,6,6,8,9,6 | 14.0 Milliseconds | Standard Deviation 18.29 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 4,n=12,6,6,9,9,6 | -3.2 Milliseconds | Standard Deviation 17.05 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 40,n=2,0,0,0,0,6 | -3.6 Milliseconds | Standard Deviation 8.56 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 32,n=6,6,6,0,0,6 | -3.3 Milliseconds | Standard Deviation 11.91 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 8,n=12,6,6,9,9,6 | 8.1 Milliseconds | Standard Deviation 20.96 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 24,n=12,6,6,9,9,6 | -1.8 Milliseconds | Standard Deviation 5.12 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 2,n=12,6,6,9,9,6 | -0.2 Milliseconds | Standard Deviation 10.66 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 26,n=12,6,6,9,9,6 | -4.8 Milliseconds | Standard Deviation 11.69 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 24,n=12,6,6,9,9,6 | 7.9 Milliseconds | Standard Deviation 23.8 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 24,n=12,6,6,9,9,6 | -5.6 Milliseconds | Standard Deviation 7.87 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 26,n=12,6,6,9,9,6 | 12.8 Milliseconds | Standard Deviation 8.59 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 26,n=12,6,6,9,9,6 | 0.4 Milliseconds | Standard Deviation 3.4 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 18,n=12,6,6,9,9,6 | -2.0 Milliseconds | Standard Deviation 9.72 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 12,n=12,6,6,9,9,6 | -2.1 Milliseconds | Standard Deviation 10.04 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 40,n=2,0,0,0,0,6 | 7.5 Milliseconds | Standard Deviation 14.62 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 4,n=12,6,6,9,9,6 | 3.5 Milliseconds | Standard Deviation 17.05 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 26,n=12,6,6,9,9,6 | 13.2 Milliseconds | Standard Deviation 20.96 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 32,n=6,6,6,0,0,6 | 11.7 Milliseconds | Standard Deviation 13.74 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 8,n=12,6,6,9,9,6 | -1.9 Milliseconds | Standard Deviation 9.55 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,8 hours Day1,n=12,6,6,9,9,6 | -7.6 Milliseconds | Standard Deviation 22.43 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 24,n=12,6,6,9,9,6 | 10.1 Milliseconds | Standard Deviation 15.15 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Day 5,n=12,6,6,9,9,6 | 3.9 Milliseconds | Standard Deviation 16.06 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval, Day 3,n=12,6,6,9,9,6 | 1.9 Milliseconds | Standard Deviation 14.28 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 4,n=12,6,6,8,9,6 | -4.0 Milliseconds | Standard Deviation 17.49 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 32,n=6,6,6,0,0,6 | 5.3 Milliseconds | Standard Deviation 14.64 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 2,n=12,6,6,9,9,6 | 1.0 Milliseconds | Standard Deviation 2.97 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 12,n=12,6,6,9,9,6 | 4.7 Milliseconds | Standard Deviation 10.23 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 1,n=12,6,6,9,9,6 | 5.5 Milliseconds | Standard Deviation 13.8 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 40,n=2,0,0,0,0,6 | -3.0 Milliseconds | Standard Deviation 3.47 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 32,n=6,6,6,0,0,6 | -1.3 Milliseconds | Standard Deviation 2.56 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Week 1,n=12,6,6,9,9,6 | 4.5 Milliseconds | Standard Deviation 6.73 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 5,n=12,6,6,9,9,6 | -1.2 Milliseconds | Standard Deviation 4.91 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 18,n=12,6,6,9,9,6 | 5.9 Milliseconds | Standard Deviation 11.16 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 2,n=12,6,6,9,9,6 | 11.5 Milliseconds | Standard Deviation 12.63 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 40,n=2,0,0,0,0,6 | -0.9 Milliseconds | Standard Deviation 24.13 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 4,n=12,6,6,9,9,6 | -4.3 Milliseconds | Standard Deviation 7.54 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval, Day 3,n=12,6,6,9,9,6 | -1.4 Milliseconds | Standard Deviation 8.82 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,2 hours Day1,n=12,6,5,9,8,6 | -9.2 Milliseconds | Standard Deviation 18.68 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 2,n=12,6,6,9,9,6 | 8.3 Milliseconds | Standard Deviation 20.06 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 2,n=12,6,6,9,9,6 | -1.4 Milliseconds | Standard Deviation 3.11 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 8,n=12,6,6,9,9,6 | 6.0 Milliseconds | Standard Deviation 15.76 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 1,n=12,6,6,9,9,6 | -2.8 Milliseconds | Standard Deviation 4.2 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval, Day 3,n=12,6,6,9,9,6 | -2.4 Milliseconds | Standard Deviation 9.29 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 5,n=12,6,6,9,9,6 | -2.9 Milliseconds | Standard Deviation 2.35 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,Week 4,n=12,6,6,8,9,6 | 11.4 Milliseconds | Standard Deviation 6.33 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 4,n=12,6,6,8,9,6 | -3.3 Milliseconds | Standard Deviation 3.39 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,Day 2,n=12,6,6,9,9,6 | -4.1 Milliseconds | Standard Deviation 11.25 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 4,n=12,6,6,9,9,6 | -2.2 Milliseconds | Standard Deviation 3.38 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 12,n=12,6,6,9,9,6 | 1.1 Milliseconds | Standard Deviation 14.24 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval, Day 3,n=12,6,6,9,9,6 | -2.6 Milliseconds | Standard Deviation 1.54 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | PR Interval,8 hours Day1,n=12,6,6,9,9,6 | -3.3 Milliseconds | Standard Deviation 10.88 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 8,n=12,6,6,9,9,6 | -1.9 Milliseconds | Standard Deviation 1.83 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Day 2,n=12,6,6,9,9,6 | -3.7 Milliseconds | Standard Deviation 4.62 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Day 5,n=12,6,6,9,9,6 | -1.3 Milliseconds | Standard Deviation 11.57 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,8 hours Day1,n=12,6,6,9,9,6 | -3.1 Milliseconds | Standard Deviation 4.42 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QT Interval,Week 1,n=12,6,6,9,9,6 | -5.6 Milliseconds | Standard Deviation 23.13 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QTcF Interval,2 hours Day1,n=12,6,5,9,8,6 | 6.4 Milliseconds | Standard Deviation 5.17 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,Week 12,n=12,6,6,9,9,6 | -1.1 Milliseconds | Standard Deviation 3.21 |
| GSK3511294 300mg | Change From Baseline in PR Interval, QRS Interval, QT Interval and QT Interval Corrected by Fridericia's Formula (QTcF) Interval | QRS Interval,2 hours Day1,n=12,6,5,9,8,6 | -1.2 Milliseconds | Standard Deviation 3.62 |
Primary
Change From Baseline in Red Blood Cell Count (RBC)
Blood samples were collected at indicated time-points for analysis of hematology parameters like RBC count. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Red Blood Cell Count (RBC) | Week 1,n=12,6,6,9,9,5 | -0.15 Trillion cells per liter | Standard Deviation 0.215 |
| Placebo | Change From Baseline in Red Blood Cell Count (RBC) | Week 4,n=12,6,5,9,9,6 | -0.18 Trillion cells per liter | Standard Deviation 0.248 |
| Placebo | Change From Baseline in Red Blood Cell Count (RBC) | Week 2,n=12,6,6,9,9,6 | -0.11 Trillion cells per liter | Standard Deviation 0.156 |
| Placebo | Change From Baseline in Red Blood Cell Count (RBC) | Week 36,n=6,0,0,9,9,0 | 0.12 Trillion cells per liter | Standard Deviation 0.232 |
| Placebo | Change From Baseline in Red Blood Cell Count (RBC) | Week 32,n=6,6,6,0,0,6 | -0.10 Trillion cells per liter | Standard Deviation 0.237 |
| Placebo | Change From Baseline in Red Blood Cell Count (RBC) | Day 3,n=12,6,6,9,9,6 | 0.03 Trillion cells per liter | Standard Deviation 0.214 |
| Placebo | Change From Baseline in Red Blood Cell Count (RBC) | Week 40,n=2,0,0,0,0,6 | -0.05 Trillion cells per liter | Standard Deviation 0.071 |
| Placebo | Change From Baseline in Red Blood Cell Count (RBC) | Week 26,n=12,6,6,9,9,6 | -0.12 Trillion cells per liter | Standard Deviation 0.301 |
| Placebo | Change From Baseline in Red Blood Cell Count (RBC) | Day 4,n=12,6,6,8,8,6 | -0.04 Trillion cells per liter | Standard Deviation 0.211 |
| Placebo | Change From Baseline in Red Blood Cell Count (RBC) | Day 2,n=12,6,6,9,9,6 | -0.08 Trillion cells per liter | Standard Deviation 0.212 |
| Placebo | Change From Baseline in Red Blood Cell Count (RBC) | Week 18,n=12,6,6,9,9,6 | -0.02 Trillion cells per liter | Standard Deviation 0.292 |
| Placebo | Change From Baseline in Red Blood Cell Count (RBC) | Week 12,n=12,6,6,9,9,5 | -0.13 Trillion cells per liter | Standard Deviation 0.176 |
| Placebo | Change From Baseline in Red Blood Cell Count (RBC) | Day 5,n=12,6,6,9,9,6 | -0.18 Trillion cells per liter | Standard Deviation 0.175 |
| Placebo | Change From Baseline in Red Blood Cell Count (RBC) | Week 8,n=12,6,6,9,9,6 | -0.03 Trillion cells per liter | Standard Deviation 0.253 |
| Placebo | Change From Baseline in Red Blood Cell Count (RBC) | Week 24,n=11,6,6,9,9,6 | -0.11 Trillion cells per liter | Standard Deviation 0.221 |
| GSK3511294 2mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 1,n=12,6,6,9,9,5 | -0.37 Trillion cells per liter | Standard Deviation 0.175 |
| GSK3511294 2mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 8,n=12,6,6,9,9,6 | -0.23 Trillion cells per liter | Standard Deviation 0.186 |
| GSK3511294 2mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 18,n=12,6,6,9,9,6 | -0.20 Trillion cells per liter | Standard Deviation 0.219 |
| GSK3511294 2mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 2,n=12,6,6,9,9,6 | -0.28 Trillion cells per liter | Standard Deviation 0.133 |
| GSK3511294 2mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 4,n=12,6,5,9,9,6 | -0.35 Trillion cells per liter | Standard Deviation 0.055 |
| GSK3511294 2mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 24,n=11,6,6,9,9,6 | -0.27 Trillion cells per liter | Standard Deviation 0.175 |
| GSK3511294 2mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 4,n=12,6,6,8,8,6 | -0.08 Trillion cells per liter | Standard Deviation 0.133 |
| GSK3511294 2mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 32,n=6,6,6,0,0,6 | -0.18 Trillion cells per liter | Standard Deviation 0.183 |
| GSK3511294 2mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 5,n=12,6,6,9,9,6 | -0.22 Trillion cells per liter | Standard Deviation 0.133 |
| GSK3511294 2mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 2,n=12,6,6,9,9,6 | -0.07 Trillion cells per liter | Standard Deviation 0.197 |
| GSK3511294 2mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 3,n=12,6,6,9,9,6 | -0.08 Trillion cells per liter | Standard Deviation 0.133 |
| GSK3511294 2mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 12,n=12,6,6,9,9,5 | -0.25 Trillion cells per liter | Standard Deviation 0.138 |
| GSK3511294 2mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 26,n=12,6,6,9,9,6 | -0.33 Trillion cells per liter | Standard Deviation 0.216 |
| GSK3511294 10mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 1,n=12,6,6,9,9,5 | 0.00 Trillion cells per liter | Standard Deviation 0.19 |
| GSK3511294 10mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 24,n=11,6,6,9,9,6 | -0.05 Trillion cells per liter | Standard Deviation 0.164 |
| GSK3511294 10mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 2,n=12,6,6,9,9,6 | 0.08 Trillion cells per liter | Standard Deviation 0.223 |
| GSK3511294 10mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 3,n=12,6,6,9,9,6 | 0.13 Trillion cells per liter | Standard Deviation 0.242 |
| GSK3511294 10mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 4,n=12,6,6,8,8,6 | 0.10 Trillion cells per liter | Standard Deviation 0.179 |
| GSK3511294 10mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 5,n=12,6,6,9,9,6 | -0.10 Trillion cells per liter | Standard Deviation 0.261 |
| GSK3511294 10mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 2,n=12,6,6,9,9,6 | -0.18 Trillion cells per liter | Standard Deviation 0.183 |
| GSK3511294 10mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 4,n=12,6,5,9,9,6 | -0.16 Trillion cells per liter | Standard Deviation 0.23 |
| GSK3511294 10mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 8,n=12,6,6,9,9,6 | -0.02 Trillion cells per liter | Standard Deviation 0.248 |
| GSK3511294 10mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 12,n=12,6,6,9,9,5 | -0.05 Trillion cells per liter | Standard Deviation 0.251 |
| GSK3511294 10mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 18,n=12,6,6,9,9,6 | -0.08 Trillion cells per liter | Standard Deviation 0.271 |
| GSK3511294 10mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 26,n=12,6,6,9,9,6 | -0.08 Trillion cells per liter | Standard Deviation 0.204 |
| GSK3511294 10mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 32,n=6,6,6,0,0,6 | 0.08 Trillion cells per liter | Standard Deviation 0.248 |
| GSK3511294 30mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 1,n=12,6,6,9,9,5 | -0.03 Trillion cells per liter | Standard Deviation 0.218 |
| GSK3511294 30mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 4,n=12,6,5,9,9,6 | -0.08 Trillion cells per liter | Standard Deviation 0.192 |
| GSK3511294 30mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 5,n=12,6,6,9,9,6 | -0.08 Trillion cells per liter | Standard Deviation 0.12 |
| GSK3511294 30mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 2,n=12,6,6,9,9,6 | 0.00 Trillion cells per liter | Standard Deviation 0.194 |
| GSK3511294 30mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 8,n=12,6,6,9,9,6 | -0.13 Trillion cells per liter | Standard Deviation 0.2 |
| GSK3511294 30mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 36,n=6,0,0,9,9,0 | 0.10 Trillion cells per liter | Standard Deviation 0.122 |
| GSK3511294 30mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 12,n=12,6,6,9,9,5 | -0.01 Trillion cells per liter | Standard Deviation 0.237 |
| GSK3511294 30mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 4,n=12,6,6,8,8,6 | -0.03 Trillion cells per liter | Standard Deviation 0.149 |
| GSK3511294 30mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 18,n=12,6,6,9,9,6 | -0.02 Trillion cells per liter | Standard Deviation 0.228 |
| GSK3511294 30mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 3,n=12,6,6,9,9,6 | 0.01 Trillion cells per liter | Standard Deviation 0.19 |
| GSK3511294 30mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 24,n=11,6,6,9,9,6 | 0.01 Trillion cells per liter | Standard Deviation 0.169 |
| GSK3511294 30mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 26,n=12,6,6,9,9,6 | -0.02 Trillion cells per liter | Standard Deviation 0.12 |
| GSK3511294 30mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 2,n=12,6,6,9,9,6 | -0.07 Trillion cells per liter | Standard Deviation 0.206 |
| GSK3511294 100mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 2,n=12,6,6,9,9,6 | 0.16 Trillion cells per liter | Standard Deviation 0.246 |
| GSK3511294 100mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 12,n=12,6,6,9,9,5 | 0.19 Trillion cells per liter | Standard Deviation 0.237 |
| GSK3511294 100mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 1,n=12,6,6,9,9,5 | 0.07 Trillion cells per liter | Standard Deviation 0.18 |
| GSK3511294 100mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 36,n=6,0,0,9,9,0 | 0.33 Trillion cells per liter | Standard Deviation 0.357 |
| GSK3511294 100mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 18,n=12,6,6,9,9,6 | 0.27 Trillion cells per liter | Standard Deviation 0.283 |
| GSK3511294 100mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 24,n=11,6,6,9,9,6 | 0.13 Trillion cells per liter | Standard Deviation 0.229 |
| GSK3511294 100mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 3,n=12,6,6,9,9,6 | 0.06 Trillion cells per liter | Standard Deviation 0.133 |
| GSK3511294 100mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 2,n=12,6,6,9,9,6 | 0.11 Trillion cells per liter | Standard Deviation 0.232 |
| GSK3511294 100mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 4,n=12,6,5,9,9,6 | 0.09 Trillion cells per liter | Standard Deviation 0.293 |
| GSK3511294 100mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 5,n=12,6,6,9,9,6 | 0.03 Trillion cells per liter | Standard Deviation 0.316 |
| GSK3511294 100mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 26,n=12,6,6,9,9,6 | 0.20 Trillion cells per liter | Standard Deviation 0.194 |
| GSK3511294 100mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 8,n=12,6,6,9,9,6 | 0.18 Trillion cells per liter | Standard Deviation 0.277 |
| GSK3511294 100mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 4,n=12,6,6,8,8,6 | 0.04 Trillion cells per liter | Standard Deviation 0.185 |
| GSK3511294 300mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 5,n=12,6,6,9,9,6 | 0.05 Trillion cells per liter | Standard Deviation 0.187 |
| GSK3511294 300mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 26,n=12,6,6,9,9,6 | 0.12 Trillion cells per liter | Standard Deviation 0.117 |
| GSK3511294 300mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 1,n=12,6,6,9,9,5 | -0.02 Trillion cells per liter | Standard Deviation 0.147 |
| GSK3511294 300mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 32,n=6,6,6,0,0,6 | 0.05 Trillion cells per liter | Standard Deviation 0.176 |
| GSK3511294 300mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 12,n=12,6,6,9,9,5 | 0.00 Trillion cells per liter | Standard Deviation 0.141 |
| GSK3511294 300mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 2,n=12,6,6,9,9,6 | -0.08 Trillion cells per liter | Standard Deviation 0.194 |
| GSK3511294 300mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 3,n=12,6,6,9,9,6 | 0.03 Trillion cells per liter | Standard Deviation 0.186 |
| GSK3511294 300mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 2,n=12,6,6,9,9,6 | 0.05 Trillion cells per liter | Standard Deviation 0.243 |
| GSK3511294 300mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 40,n=2,0,0,0,0,6 | 0.12 Trillion cells per liter | Standard Deviation 0.098 |
| GSK3511294 300mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 4,n=12,6,5,9,9,6 | -0.03 Trillion cells per liter | Standard Deviation 0.137 |
| GSK3511294 300mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 18,n=12,6,6,9,9,6 | 0.17 Trillion cells per liter | Standard Deviation 0.163 |
| GSK3511294 300mg | Change From Baseline in Red Blood Cell Count (RBC) | Day 4,n=12,6,6,8,8,6 | 0.10 Trillion cells per liter | Standard Deviation 0.141 |
| GSK3511294 300mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 24,n=11,6,6,9,9,6 | 0.17 Trillion cells per liter | Standard Deviation 0.151 |
| GSK3511294 300mg | Change From Baseline in Red Blood Cell Count (RBC) | Week 8,n=12,6,6,9,9,6 | 0.07 Trillion cells per liter | Standard Deviation 0.103 |
Primary
Change From Baseline in Respiration Rate
Respiration rate was assessed in a supine position after 5 minutes of rest. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at 2 and 8 hours at Day 1; Days 2, 3, 4 and 5; Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Respiration Rate | Week 36,n=6,0,0,9,9,0 | 0.2 Breaths per minute | Standard Deviation 1.83 |
| Placebo | Change From Baseline in Respiration Rate | Day 3,n=12,6,6,9,9,6 | -1.0 Breaths per minute | Standard Deviation 2.83 |
| Placebo | Change From Baseline in Respiration Rate | Week 18,n=12,6,6,9,9,6 | 0.5 Breaths per minute | Standard Deviation 3.66 |
| Placebo | Change From Baseline in Respiration Rate | Week 40,n=2,0,0,0,0,6 | -2.0 Breaths per minute | Standard Deviation 1.41 |
| Placebo | Change From Baseline in Respiration Rate | Day 4,n=12,6,6,9,9,6 | -0.1 Breaths per minute | Standard Deviation 3.06 |
| Placebo | Change From Baseline in Respiration Rate | Week 12,n=12,6,6,9,9,6 | 0.0 Breaths per minute | Standard Deviation 3.49 |
| Placebo | Change From Baseline in Respiration Rate | Week 4,n=12,6,6,9,9,6 | 0.5 Breaths per minute | Standard Deviation 3.18 |
| Placebo | Change From Baseline in Respiration Rate | Week 2,n=12,6,6,9,9,6 | -0.3 Breaths per minute | Standard Deviation 2.15 |
| Placebo | Change From Baseline in Respiration Rate | 2 hours Day1,n=12,6,6,9,9,6 | 0.8 Breaths per minute | Standard Deviation 2.42 |
| Placebo | Change From Baseline in Respiration Rate | Week 1,n=12,6,6,9,9,6 | -0.5 Breaths per minute | Standard Deviation 3.45 |
| Placebo | Change From Baseline in Respiration Rate | Week 24,n=12,6,6,9,9,6 | -0.8 Breaths per minute | Standard Deviation 2.59 |
| Placebo | Change From Baseline in Respiration Rate | Week 26,n=12,6,6,9,9,6 | -1.1 Breaths per minute | Standard Deviation 2.43 |
| Placebo | Change From Baseline in Respiration Rate | Day 2,n=12,6,6,9,9,6 | -0.7 Breaths per minute | Standard Deviation 2.64 |
| Placebo | Change From Baseline in Respiration Rate | Week 8,n=12,6,6,9,9,6 | -0.5 Breaths per minute | Standard Deviation 2.71 |
| Placebo | Change From Baseline in Respiration Rate | Week 32,n=6,6,6,0,0,6 | -1.5 Breaths per minute | Standard Deviation 1.76 |
| Placebo | Change From Baseline in Respiration Rate | 8 hours Day1,n=12,6,6,9,9,6 | -0.1 Breaths per minute | Standard Deviation 2.19 |
| Placebo | Change From Baseline in Respiration Rate | Day 5,n=12,6,6,9,9,6 | -1.1 Breaths per minute | Standard Deviation 2.39 |
| GSK3511294 2mg | Change From Baseline in Respiration Rate | Week 12,n=12,6,6,9,9,6 | 0.7 Breaths per minute | Standard Deviation 4.63 |
| GSK3511294 2mg | Change From Baseline in Respiration Rate | Week 18,n=12,6,6,9,9,6 | -0.2 Breaths per minute | Standard Deviation 3.06 |
| GSK3511294 2mg | Change From Baseline in Respiration Rate | Week 24,n=12,6,6,9,9,6 | -0.7 Breaths per minute | Standard Deviation 4.41 |
| GSK3511294 2mg | Change From Baseline in Respiration Rate | Day 2,n=12,6,6,9,9,6 | 1.7 Breaths per minute | Standard Deviation 2.58 |
| GSK3511294 2mg | Change From Baseline in Respiration Rate | Day 3,n=12,6,6,9,9,6 | 1.5 Breaths per minute | Standard Deviation 3.27 |
| GSK3511294 2mg | Change From Baseline in Respiration Rate | 2 hours Day1,n=12,6,6,9,9,6 | 1.2 Breaths per minute | Standard Deviation 1.83 |
| GSK3511294 2mg | Change From Baseline in Respiration Rate | Day 4,n=12,6,6,9,9,6 | -1.0 Breaths per minute | Standard Deviation 3.03 |
| GSK3511294 2mg | Change From Baseline in Respiration Rate | Week 32,n=6,6,6,0,0,6 | 1.3 Breaths per minute | Standard Deviation 3.01 |
| GSK3511294 2mg | Change From Baseline in Respiration Rate | Day 5,n=12,6,6,9,9,6 | 0.7 Breaths per minute | Standard Deviation 3.2 |
| GSK3511294 2mg | Change From Baseline in Respiration Rate | Week 1,n=12,6,6,9,9,6 | 0.7 Breaths per minute | Standard Deviation 3.67 |
| GSK3511294 2mg | Change From Baseline in Respiration Rate | 8 hours Day1,n=12,6,6,9,9,6 | 0.5 Breaths per minute | Standard Deviation 3.27 |
| GSK3511294 2mg | Change From Baseline in Respiration Rate | Week 2,n=12,6,6,9,9,6 | 0.7 Breaths per minute | Standard Deviation 4.08 |
| GSK3511294 2mg | Change From Baseline in Respiration Rate | Week 4,n=12,6,6,9,9,6 | 1.5 Breaths per minute | Standard Deviation 2.59 |
| GSK3511294 2mg | Change From Baseline in Respiration Rate | Week 26,n=12,6,6,9,9,6 | 0.5 Breaths per minute | Standard Deviation 3.02 |
| GSK3511294 2mg | Change From Baseline in Respiration Rate | Week 8,n=12,6,6,9,9,6 | 0.5 Breaths per minute | Standard Deviation 2.81 |
| GSK3511294 10mg | Change From Baseline in Respiration Rate | Week 12,n=12,6,6,9,9,6 | 0.7 Breaths per minute | Standard Deviation 2.16 |
| GSK3511294 10mg | Change From Baseline in Respiration Rate | Day 2,n=12,6,6,9,9,6 | -1.2 Breaths per minute | Standard Deviation 1.47 |
| GSK3511294 10mg | Change From Baseline in Respiration Rate | Week 24,n=12,6,6,9,9,6 | -0.7 Breaths per minute | Standard Deviation 1.51 |
| GSK3511294 10mg | Change From Baseline in Respiration Rate | Week 8,n=12,6,6,9,9,6 | 0.3 Breaths per minute | Standard Deviation 2.42 |
| GSK3511294 10mg | Change From Baseline in Respiration Rate | Week 1,n=12,6,6,9,9,6 | -0.2 Breaths per minute | Standard Deviation 1.33 |
| GSK3511294 10mg | Change From Baseline in Respiration Rate | 2 hours Day1,n=12,6,6,9,9,6 | 0.0 Breaths per minute | Standard Deviation 2.53 |
| GSK3511294 10mg | Change From Baseline in Respiration Rate | Week 2,n=12,6,6,9,9,6 | 0.2 Breaths per minute | Standard Deviation 2.23 |
| GSK3511294 10mg | Change From Baseline in Respiration Rate | 8 hours Day1,n=12,6,6,9,9,6 | -1.0 Breaths per minute | Standard Deviation 1.79 |
| GSK3511294 10mg | Change From Baseline in Respiration Rate | Week 26,n=12,6,6,9,9,6 | -0.7 Breaths per minute | Standard Deviation 1.51 |
| GSK3511294 10mg | Change From Baseline in Respiration Rate | Week 18,n=12,6,6,9,9,6 | -0.7 Breaths per minute | Standard Deviation 1.97 |
| GSK3511294 10mg | Change From Baseline in Respiration Rate | Week 4,n=12,6,6,9,9,6 | 1.5 Breaths per minute | Standard Deviation 1.22 |
| GSK3511294 10mg | Change From Baseline in Respiration Rate | Week 32,n=6,6,6,0,0,6 | 0.7 Breaths per minute | Standard Deviation 2.34 |
| GSK3511294 10mg | Change From Baseline in Respiration Rate | Day 4,n=12,6,6,9,9,6 | 0.7 Breaths per minute | Standard Deviation 1.21 |
| GSK3511294 10mg | Change From Baseline in Respiration Rate | Day 3,n=12,6,6,9,9,6 | -0.2 Breaths per minute | Standard Deviation 2.4 |
| GSK3511294 10mg | Change From Baseline in Respiration Rate | Day 5,n=12,6,6,9,9,6 | -1.5 Breaths per minute | Standard Deviation 1.05 |
| GSK3511294 30mg | Change From Baseline in Respiration Rate | Week 12,n=12,6,6,9,9,6 | 1.2 Breaths per minute | Standard Deviation 2.86 |
| GSK3511294 30mg | Change From Baseline in Respiration Rate | Day 5,n=12,6,6,9,9,6 | 0.0 Breaths per minute | Standard Deviation 2.55 |
| GSK3511294 30mg | Change From Baseline in Respiration Rate | Day 2,n=12,6,6,9,9,6 | 1.9 Breaths per minute | Standard Deviation 1.96 |
| GSK3511294 30mg | Change From Baseline in Respiration Rate | Week 24,n=12,6,6,9,9,6 | 1.4 Breaths per minute | Standard Deviation 2.13 |
| GSK3511294 30mg | Change From Baseline in Respiration Rate | Week 36,n=6,0,0,9,9,0 | 0.2 Breaths per minute | Standard Deviation 2.64 |
| GSK3511294 30mg | Change From Baseline in Respiration Rate | Day 4,n=12,6,6,9,9,6 | 0.3 Breaths per minute | Standard Deviation 2.24 |
| GSK3511294 30mg | Change From Baseline in Respiration Rate | Week 4,n=12,6,6,9,9,6 | 0.4 Breaths per minute | Standard Deviation 1.88 |
| GSK3511294 30mg | Change From Baseline in Respiration Rate | Week 1,n=12,6,6,9,9,6 | -0.6 Breaths per minute | Standard Deviation 1.67 |
| GSK3511294 30mg | Change From Baseline in Respiration Rate | Week 8,n=12,6,6,9,9,6 | 0.1 Breaths per minute | Standard Deviation 3.41 |
| GSK3511294 30mg | Change From Baseline in Respiration Rate | Week 26,n=12,6,6,9,9,6 | 0.6 Breaths per minute | Standard Deviation 2.01 |
| GSK3511294 30mg | Change From Baseline in Respiration Rate | Week 18,n=12,6,6,9,9,6 | 1.4 Breaths per minute | Standard Deviation 2.07 |
| GSK3511294 30mg | Change From Baseline in Respiration Rate | 8 hours Day1,n=12,6,6,9,9,6 | 1.0 Breaths per minute | Standard Deviation 3.28 |
| GSK3511294 30mg | Change From Baseline in Respiration Rate | 2 hours Day1,n=12,6,6,9,9,6 | 0.3 Breaths per minute | Standard Deviation 2.65 |
| GSK3511294 30mg | Change From Baseline in Respiration Rate | Week 2,n=12,6,6,9,9,6 | 1.1 Breaths per minute | Standard Deviation 2.76 |
| GSK3511294 30mg | Change From Baseline in Respiration Rate | Day 3,n=12,6,6,9,9,6 | 1.1 Breaths per minute | Standard Deviation 2.8 |
| GSK3511294 100mg | Change From Baseline in Respiration Rate | Week 18,n=12,6,6,9,9,6 | 1.4 Breaths per minute | Standard Deviation 1.42 |
| GSK3511294 100mg | Change From Baseline in Respiration Rate | 2 hours Day1,n=12,6,6,9,9,6 | 0.8 Breaths per minute | Standard Deviation 1.72 |
| GSK3511294 100mg | Change From Baseline in Respiration Rate | 8 hours Day1,n=12,6,6,9,9,6 | 2.1 Breaths per minute | Standard Deviation 1.83 |
| GSK3511294 100mg | Change From Baseline in Respiration Rate | Day 2,n=12,6,6,9,9,6 | 1.8 Breaths per minute | Standard Deviation 1.3 |
| GSK3511294 100mg | Change From Baseline in Respiration Rate | Day 3,n=12,6,6,9,9,6 | 1.2 Breaths per minute | Standard Deviation 2.11 |
| GSK3511294 100mg | Change From Baseline in Respiration Rate | Day 4,n=12,6,6,9,9,6 | 2.3 Breaths per minute | Standard Deviation 1.87 |
| GSK3511294 100mg | Change From Baseline in Respiration Rate | Day 5,n=12,6,6,9,9,6 | 1.3 Breaths per minute | Standard Deviation 2.18 |
| GSK3511294 100mg | Change From Baseline in Respiration Rate | Week 1,n=12,6,6,9,9,6 | 0.4 Breaths per minute | Standard Deviation 1.81 |
| GSK3511294 100mg | Change From Baseline in Respiration Rate | Week 2,n=12,6,6,9,9,6 | 0.9 Breaths per minute | Standard Deviation 2.98 |
| GSK3511294 100mg | Change From Baseline in Respiration Rate | Week 4,n=12,6,6,9,9,6 | 1.2 Breaths per minute | Standard Deviation 2.17 |
| GSK3511294 100mg | Change From Baseline in Respiration Rate | Week 8,n=12,6,6,9,9,6 | 2.3 Breaths per minute | Standard Deviation 2.18 |
| GSK3511294 100mg | Change From Baseline in Respiration Rate | Week 12,n=12,6,6,9,9,6 | 0.9 Breaths per minute | Standard Deviation 1.69 |
| GSK3511294 100mg | Change From Baseline in Respiration Rate | Week 24,n=12,6,6,9,9,6 | 0.7 Breaths per minute | Standard Deviation 2.4 |
| GSK3511294 100mg | Change From Baseline in Respiration Rate | Week 26,n=12,6,6,9,9,6 | 1.6 Breaths per minute | Standard Deviation 2.19 |
| GSK3511294 100mg | Change From Baseline in Respiration Rate | Week 36,n=6,0,0,9,9,0 | 1.3 Breaths per minute | Standard Deviation 1.5 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | Week 24,n=12,6,6,9,9,6 | 0.8 Breaths per minute | Standard Deviation 1.94 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | Week 8,n=12,6,6,9,9,6 | 0.7 Breaths per minute | Standard Deviation 2.8 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | Week 4,n=12,6,6,9,9,6 | -0.5 Breaths per minute | Standard Deviation 3.89 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | Week 2,n=12,6,6,9,9,6 | -0.2 Breaths per minute | Standard Deviation 3.06 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | Week 1,n=12,6,6,9,9,6 | -1.8 Breaths per minute | Standard Deviation 2.71 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | 2 hours Day1,n=12,6,6,9,9,6 | 2.2 Breaths per minute | Standard Deviation 3.31 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | Week 26,n=12,6,6,9,9,6 | 0.3 Breaths per minute | Standard Deviation 3.01 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | Day 5,n=12,6,6,9,9,6 | 0.0 Breaths per minute | Standard Deviation 1.41 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | Day 4,n=12,6,6,9,9,6 | 0.2 Breaths per minute | Standard Deviation 2.71 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | Day 3,n=12,6,6,9,9,6 | 0.7 Breaths per minute | Standard Deviation 3.5 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | Week 32,n=6,6,6,0,0,6 | 1.0 Breaths per minute | Standard Deviation 3.1 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | Day 2,n=12,6,6,9,9,6 | 1.5 Breaths per minute | Standard Deviation 2.07 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | 8 hours Day1,n=12,6,6,9,9,6 | 0.3 Breaths per minute | Standard Deviation 1.63 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | Week 18,n=12,6,6,9,9,6 | 1.2 Breaths per minute | Standard Deviation 3.25 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | Week 12,n=12,6,6,9,9,6 | -0.3 Breaths per minute | Standard Deviation 2.88 |
| GSK3511294 300mg | Change From Baseline in Respiration Rate | Week 40,n=2,0,0,0,0,6 | -0.3 Breaths per minute | Standard Deviation 1.86 |
Primary
Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP)
SBP and DBP were assessed in a supine position after 5 minutes of rest. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at 2 and 8 hours at Day 1; Days 2, 3, 4 and 5; Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 3,n=12,6,6,9,9,6 | 0.6 Millimeters of mercury | Standard Deviation 3.99 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 32,n=6,6,6,0,0,6 | 3.0 Millimeters of mercury | Standard Deviation 6.9 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 24,n=12,6,6,9,9,6 | -0.8 Millimeters of mercury | Standard Deviation 8.22 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 18,n=12,6,6,9,9,6 | -0.6 Millimeters of mercury | Standard Deviation 6.86 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 40,n=2,0,0,0,0,6 | 0.5 Millimeters of mercury | Standard Deviation 4.95 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 26,n=12,6,6,9,9,6 | -0.5 Millimeters of mercury | Standard Deviation 7.23 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 24,n=12,6,6,9,9,6 | -1.6 Millimeters of mercury | Standard Deviation 7.77 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, 8 hours Day1,n=12,6,6,9,9,6 | 0.0 Millimeters of mercury | Standard Deviation 6 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 36,n=6,0,0,9,9,0 | 2.3 Millimeters of mercury | Standard Deviation 13.13 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 18,n=12,6,6,9,9,6 | -2.1 Millimeters of mercury | Standard Deviation 6.63 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 2,n=12,6,6,9,9,6 | -2.5 Millimeters of mercury | Standard Deviation 7 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 12,n=12,6,6,9,9,6 | 0.9 Millimeters of mercury | Standard Deviation 6.29 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 4,n=12,6,6,9,9,6 | 0.3 Millimeters of mercury | Standard Deviation 6.17 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 3,n=12,6,6,9,9,6 | 2.6 Millimeters of mercury | Standard Deviation 9.21 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 2,n=12,6,6,9,9,6 | -0.2 Millimeters of mercury | Standard Deviation 4.47 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 2,n=12,6,6,9,9,6 | 1.1 Millimeters of mercury | Standard Deviation 6.23 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 4,n=12,6,6,9,9,6 | 0.8 Millimeters of mercury | Standard Deviation 5.75 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 32,n=6,6,6,0,0,6 | 1.3 Millimeters of mercury | Standard Deviation 2.34 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 1,n=12,6,6,9,9,6 | 0.6 Millimeters of mercury | Standard Deviation 5.37 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 5,n=12,6,6,9,9,6 | -3.0 Millimeters of mercury | Standard Deviation 6.05 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 5,n=12,6,6,9,9,6 | -1.4 Millimeters of mercury | Standard Deviation 4.4 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 4,n=12,6,6,9,9,6 | -0.1 Millimeters of mercury | Standard Deviation 5.04 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 1,n=12,6,6,9,9,6 | -0.3 Millimeters of mercury | Standard Deviation 8.86 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, 2 hours Day1,n=12,6,6,9,9,6 | -0.3 Millimeters of mercury | Standard Deviation 6.08 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 2,n=12,6,6,9,9,6 | -2.6 Millimeters of mercury | Standard Deviation 5.9 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 8,n=12,6,6,9,9,6 | 1.3 Millimeters of mercury | Standard Deviation 3.73 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, 8 hours Day1,n=12,6,6,9,9,6 | -0.6 Millimeters of mercury | Standard Deviation 4.34 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, 2 hours Day1,n=12,6,6,9,9,6 | -2.9 Millimeters of mercury | Standard Deviation 5 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 4,n=12,6,6,9,9,6 | -1.6 Millimeters of mercury | Standard Deviation 8.8 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 40,n=2,0,0,0,0,6 | -15.0 Millimeters of mercury | Standard Deviation 14.14 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 36,n=6,0,0,9,9,0 | -3.5 Millimeters of mercury | Standard Deviation 13.72 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 8,n=12,6,6,9,9,6 | 0.7 Millimeters of mercury | Standard Deviation 9.71 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 26,n=12,6,6,9,9,6 | 3.0 Millimeters of mercury | Standard Deviation 11.95 |
| Placebo | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 12,n=12,6,6,9,9,6 | -0.8 Millimeters of mercury | Standard Deviation 5.13 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 26,n=12,6,6,9,9,6 | 3.2 Millimeters of mercury | Standard Deviation 6.11 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 2,n=12,6,6,9,9,6 | 0.8 Millimeters of mercury | Standard Deviation 4.49 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 4,n=12,6,6,9,9,6 | -2.2 Millimeters of mercury | Standard Deviation 6.24 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 12,n=12,6,6,9,9,6 | 1.2 Millimeters of mercury | Standard Deviation 5.19 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, 2 hours Day1,n=12,6,6,9,9,6 | -2.2 Millimeters of mercury | Standard Deviation 7.47 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 24,n=12,6,6,9,9,6 | 9.3 Millimeters of mercury | Standard Deviation 10.42 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, 8 hours Day1,n=12,6,6,9,9,6 | 2.0 Millimeters of mercury | Standard Deviation 7.46 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 18,n=12,6,6,9,9,6 | 4.2 Millimeters of mercury | Standard Deviation 9.15 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 1,n=12,6,6,9,9,6 | 3.7 Millimeters of mercury | Standard Deviation 6.98 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 8,n=12,6,6,9,9,6 | 0.0 Millimeters of mercury | Standard Deviation 9.27 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 5,n=12,6,6,9,9,6 | 4.8 Millimeters of mercury | Standard Deviation 6.49 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 24,n=12,6,6,9,9,6 | 6.3 Millimeters of mercury | Standard Deviation 5.35 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 2,n=12,6,6,9,9,6 | 1.0 Millimeters of mercury | Standard Deviation 10.22 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 5,n=12,6,6,9,9,6 | 0.8 Millimeters of mercury | Standard Deviation 6.82 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, 8 hours Day1,n=12,6,6,9,9,6 | 4.2 Millimeters of mercury | Standard Deviation 10.01 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 26,n=12,6,6,9,9,6 | 3.2 Millimeters of mercury | Standard Deviation 4.36 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 18,n=12,6,6,9,9,6 | 3.3 Millimeters of mercury | Standard Deviation 5.68 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 4,n=12,6,6,9,9,6 | 0.3 Millimeters of mercury | Standard Deviation 8.82 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 12,n=12,6,6,9,9,6 | 3.2 Millimeters of mercury | Standard Deviation 5.91 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 4,n=12,6,6,9,9,6 | 2.3 Millimeters of mercury | Standard Deviation 4.8 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 2,n=12,6,6,9,9,6 | -0.8 Millimeters of mercury | Standard Deviation 8.08 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 32,n=6,6,6,0,0,6 | -0.2 Millimeters of mercury | Standard Deviation 6.49 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 8,n=12,6,6,9,9,6 | 5.2 Millimeters of mercury | Standard Deviation 5.49 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 4,n=12,6,6,9,9,6 | 1.3 Millimeters of mercury | Standard Deviation 7.74 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, 2 hours Day1,n=12,6,6,9,9,6 | 3.3 Millimeters of mercury | Standard Deviation 4.89 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 1,n=12,6,6,9,9,6 | 0.3 Millimeters of mercury | Standard Deviation 7.5 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 3,n=12,6,6,9,9,6 | -2.2 Millimeters of mercury | Standard Deviation 7.36 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 3,n=12,6,6,9,9,6 | -1.3 Millimeters of mercury | Standard Deviation 7.26 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 2,n=12,6,6,9,9,6 | 4.7 Millimeters of mercury | Standard Deviation 5.65 |
| GSK3511294 2mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 32,n=6,6,6,0,0,6 | -3.8 Millimeters of mercury | Standard Deviation 12.45 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 1,n=12,6,6,9,9,6 | 1.5 Millimeters of mercury | Standard Deviation 6.6 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, 2 hours Day1,n=12,6,6,9,9,6 | 3.3 Millimeters of mercury | Standard Deviation 7.37 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, 8 hours Day1,n=12,6,6,9,9,6 | 3.0 Millimeters of mercury | Standard Deviation 8.46 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 2,n=12,6,6,9,9,6 | 6.0 Millimeters of mercury | Standard Deviation 4.86 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 3,n=12,6,6,9,9,6 | 3.7 Millimeters of mercury | Standard Deviation 9.16 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 4,n=12,6,6,9,9,6 | 2.3 Millimeters of mercury | Standard Deviation 8.09 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 5,n=12,6,6,9,9,6 | 1.0 Millimeters of mercury | Standard Deviation 7.72 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 2,n=12,6,6,9,9,6 | 5.8 Millimeters of mercury | Standard Deviation 5.85 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 4,n=12,6,6,9,9,6 | 7.0 Millimeters of mercury | Standard Deviation 11.26 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 8,n=12,6,6,9,9,6 | 2.0 Millimeters of mercury | Standard Deviation 12.66 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 12,n=12,6,6,9,9,6 | 2.3 Millimeters of mercury | Standard Deviation 9.97 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 18,n=12,6,6,9,9,6 | 3.8 Millimeters of mercury | Standard Deviation 13.33 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 24,n=12,6,6,9,9,6 | 3.7 Millimeters of mercury | Standard Deviation 6.59 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 26,n=12,6,6,9,9,6 | 3.2 Millimeters of mercury | Standard Deviation 5.91 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 32,n=6,6,6,0,0,6 | 8.7 Millimeters of mercury | Standard Deviation 10.61 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, 2 hours Day1,n=12,6,6,9,9,6 | 4.3 Millimeters of mercury | Standard Deviation 9.14 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, 8 hours Day1,n=12,6,6,9,9,6 | 0.5 Millimeters of mercury | Standard Deviation 9.52 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 2,n=12,6,6,9,9,6 | 3.0 Millimeters of mercury | Standard Deviation 5.83 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 3,n=12,6,6,9,9,6 | 3.0 Millimeters of mercury | Standard Deviation 7.04 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 4,n=12,6,6,9,9,6 | -1.0 Millimeters of mercury | Standard Deviation 5.69 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 5,n=12,6,6,9,9,6 | 0.7 Millimeters of mercury | Standard Deviation 8.09 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 1,n=12,6,6,9,9,6 | 4.3 Millimeters of mercury | Standard Deviation 9.27 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 2,n=12,6,6,9,9,6 | 6.0 Millimeters of mercury | Standard Deviation 8.99 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 4,n=12,6,6,9,9,6 | 4.2 Millimeters of mercury | Standard Deviation 11.36 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 8,n=12,6,6,9,9,6 | 5.5 Millimeters of mercury | Standard Deviation 13.28 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 12,n=12,6,6,9,9,6 | 1.7 Millimeters of mercury | Standard Deviation 14.15 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 18,n=12,6,6,9,9,6 | 3.0 Millimeters of mercury | Standard Deviation 12.65 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 24,n=12,6,6,9,9,6 | 4.0 Millimeters of mercury | Standard Deviation 9.78 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 26,n=12,6,6,9,9,6 | 3.8 Millimeters of mercury | Standard Deviation 9.45 |
| GSK3511294 10mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 32,n=6,6,6,0,0,6 | 7.0 Millimeters of mercury | Standard Deviation 4.34 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, 8 hours Day1,n=12,6,6,9,9,6 | 1.7 Millimeters of mercury | Standard Deviation 10.69 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 5,n=12,6,6,9,9,6 | -2.8 Millimeters of mercury | Standard Deviation 9.81 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 12,n=12,6,6,9,9,6 | 3.4 Millimeters of mercury | Standard Deviation 5.39 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 2,n=12,6,6,9,9,6 | 1.8 Millimeters of mercury | Standard Deviation 9.11 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 5,n=12,6,6,9,9,6 | -4.1 Millimeters of mercury | Standard Deviation 7.29 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 24,n=12,6,6,9,9,6 | 5.3 Millimeters of mercury | Standard Deviation 6.56 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 8,n=12,6,6,9,9,6 | 3.3 Millimeters of mercury | Standard Deviation 4.95 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 8,n=12,6,6,9,9,6 | 3.1 Millimeters of mercury | Standard Deviation 8.52 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 4,n=12,6,6,9,9,6 | 0.3 Millimeters of mercury | Standard Deviation 6.91 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 4,n=12,6,6,9,9,6 | -0.2 Millimeters of mercury | Standard Deviation 5.14 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 1,n=12,6,6,9,9,6 | -0.4 Millimeters of mercury | Standard Deviation 5.68 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, 8 hours Day1,n=12,6,6,9,9,6 | -1.3 Millimeters of mercury | Standard Deviation 4.58 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 4,n=12,6,6,9,9,6 | 3.1 Millimeters of mercury | Standard Deviation 6.09 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 4,n=12,6,6,9,9,6 | 3.2 Millimeters of mercury | Standard Deviation 14.09 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 3,n=12,6,6,9,9,6 | 1.0 Millimeters of mercury | Standard Deviation 10.68 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 2,n=12,6,6,9,9,6 | 1.6 Millimeters of mercury | Standard Deviation 4.36 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 26,n=12,6,6,9,9,6 | 7.9 Millimeters of mercury | Standard Deviation 10.13 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 24,n=12,6,6,9,9,6 | 2.9 Millimeters of mercury | Standard Deviation 9.91 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 2,n=12,6,6,9,9,6 | -1.1 Millimeters of mercury | Standard Deviation 5.67 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 36,n=6,0,0,9,9,0 | 2.8 Millimeters of mercury | Standard Deviation 9.59 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 12,n=12,6,6,9,9,6 | 5.4 Millimeters of mercury | Standard Deviation 9.41 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 1,n=12,6,6,9,9,6 | -2.7 Millimeters of mercury | Standard Deviation 9.06 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 18,n=12,6,6,9,9,6 | 2.0 Millimeters of mercury | Standard Deviation 8.76 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 26,n=12,6,6,9,9,6 | 6.6 Millimeters of mercury | Standard Deviation 8.38 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 3,n=12,6,6,9,9,6 | -2.6 Millimeters of mercury | Standard Deviation 5.41 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, 2 hours Day1,n=12,6,6,9,9,6 | -0.9 Millimeters of mercury | Standard Deviation 7.18 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 18,n=12,6,6,9,9,6 | 0.7 Millimeters of mercury | Standard Deviation 6.84 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 36,n=6,0,0,9,9,0 | 3.6 Millimeters of mercury | Standard Deviation 5.64 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, 2 hours Day1,n=12,6,6,9,9,6 | -2.2 Millimeters of mercury | Standard Deviation 4.18 |
| GSK3511294 30mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 2,n=12,6,6,9,9,6 | 4.2 Millimeters of mercury | Standard Deviation 10.45 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 18,n=12,6,6,9,9,6 | 3.8 Millimeters of mercury | Standard Deviation 8.07 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 4,n=12,6,6,9,9,6 | 0.9 Millimeters of mercury | Standard Deviation 6.11 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 36,n=6,0,0,9,9,0 | 2.8 Millimeters of mercury | Standard Deviation 7.77 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 2,n=12,6,6,9,9,6 | 0.8 Millimeters of mercury | Standard Deviation 11.04 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 4,n=12,6,6,9,9,6 | 0.1 Millimeters of mercury | Standard Deviation 3.76 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, 8 hours Day1,n=12,6,6,9,9,6 | -2.0 Millimeters of mercury | Standard Deviation 5.74 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 1,n=12,6,6,9,9,6 | 1.7 Millimeters of mercury | Standard Deviation 5.02 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, 2 hours Day1,n=12,6,6,9,9,6 | -2.2 Millimeters of mercury | Standard Deviation 6.14 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 2,n=12,6,6,9,9,6 | 4.7 Millimeters of mercury | Standard Deviation 4.18 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 3,n=12,6,6,9,9,6 | -0.3 Millimeters of mercury | Standard Deviation 4.3 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 5,n=12,6,6,9,9,6 | 0.4 Millimeters of mercury | Standard Deviation 3.91 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 26,n=12,6,6,9,9,6 | 1.8 Millimeters of mercury | Standard Deviation 8.61 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 5,n=12,6,6,9,9,6 | 0.9 Millimeters of mercury | Standard Deviation 4.23 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 4,n=12,6,6,9,9,6 | 2.9 Millimeters of mercury | Standard Deviation 6.86 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 1,n=12,6,6,9,9,6 | 0.8 Millimeters of mercury | Standard Deviation 3.38 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 3,n=12,6,6,9,9,6 | -0.1 Millimeters of mercury | Standard Deviation 4.43 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 2,n=12,6,6,9,9,6 | 1.9 Millimeters of mercury | Standard Deviation 6.92 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 2,n=12,6,6,9,9,6 | 6.3 Millimeters of mercury | Standard Deviation 7.42 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 4,n=12,6,6,9,9,6 | 1.6 Millimeters of mercury | Standard Deviation 5.41 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 8,n=12,6,6,9,9,6 | 0.7 Millimeters of mercury | Standard Deviation 4.21 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 12,n=12,6,6,9,9,6 | 3.6 Millimeters of mercury | Standard Deviation 4.72 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, 8 hours Day1,n=12,6,6,9,9,6 | 4.9 Millimeters of mercury | Standard Deviation 7.52 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, 2 hours Day1,n=12,6,6,9,9,6 | -1.8 Millimeters of mercury | Standard Deviation 7.19 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 36,n=6,0,0,9,9,0 | 2.3 Millimeters of mercury | Standard Deviation 8.82 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 18,n=12,6,6,9,9,6 | 2.1 Millimeters of mercury | Standard Deviation 9.52 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 12,n=12,6,6,9,9,6 | 0.0 Millimeters of mercury | Standard Deviation 7.37 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 24,n=12,6,6,9,9,6 | 1.9 Millimeters of mercury | Standard Deviation 12.06 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 8,n=12,6,6,9,9,6 | -1.4 Millimeters of mercury | Standard Deviation 6.6 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 24,n=12,6,6,9,9,6 | 1.1 Millimeters of mercury | Standard Deviation 9.12 |
| GSK3511294 100mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 26,n=12,6,6,9,9,6 | 2.9 Millimeters of mercury | Standard Deviation 7.56 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, 8 hours Day1,n=12,6,6,9,9,6 | -2.2 Millimeters of mercury | Standard Deviation 5.64 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, 2 hours Day1,n=12,6,6,9,9,6 | -3.8 Millimeters of mercury | Standard Deviation 1.94 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 4,n=12,6,6,9,9,6 | -3.3 Millimeters of mercury | Standard Deviation 7.39 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 4,n=12,6,6,9,9,6 | -2.3 Millimeters of mercury | Standard Deviation 7.15 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 12,n=12,6,6,9,9,6 | 1.3 Millimeters of mercury | Standard Deviation 5.09 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 24,n=12,6,6,9,9,6 | -2.2 Millimeters of mercury | Standard Deviation 6.46 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 4,n=12,6,6,9,9,6 | -2.8 Millimeters of mercury | Standard Deviation 3.82 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 5,n=12,6,6,9,9,6 | -4.7 Millimeters of mercury | Standard Deviation 4.46 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 3,n=12,6,6,9,9,6 | -0.3 Millimeters of mercury | Standard Deviation 6.44 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 24,n=12,6,6,9,9,6 | 2.0 Millimeters of mercury | Standard Deviation 5.66 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 18,n=12,6,6,9,9,6 | 0.5 Millimeters of mercury | Standard Deviation 7.5 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, 2 hours Day1,n=12,6,6,9,9,6 | -2.0 Millimeters of mercury | Standard Deviation 8.58 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 8,n=12,6,6,9,9,6 | -1.8 Millimeters of mercury | Standard Deviation 5.91 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 12,n=12,6,6,9,9,6 | -4.2 Millimeters of mercury | Standard Deviation 11.18 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 26,n=12,6,6,9,9,6 | -5.8 Millimeters of mercury | Standard Deviation 6.11 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 3,n=12,6,6,9,9,6 | -5.0 Millimeters of mercury | Standard Deviation 6 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 32,n=6,6,6,0,0,6 | -3.3 Millimeters of mercury | Standard Deviation 6.89 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 18,n=12,6,6,9,9,6 | -7.3 Millimeters of mercury | Standard Deviation 15.49 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, 8 hours Day1,n=12,6,6,9,9,6 | -1.8 Millimeters of mercury | Standard Deviation 5.56 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 40,n=2,0,0,0,0,6 | -5.8 Millimeters of mercury | Standard Deviation 17.52 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 2,n=12,6,6,9,9,6 | 0.2 Millimeters of mercury | Standard Deviation 4.62 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Day 2,n=12,6,6,9,9,6 | -5.3 Millimeters of mercury | Standard Deviation 4.37 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 2,n=12,6,6,9,9,6 | 0.0 Millimeters of mercury | Standard Deviation 4.94 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 40,n=2,0,0,0,0,6 | -3.5 Millimeters of mercury | Standard Deviation 6.95 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 1,n=12,6,6,9,9,6 | 0.0 Millimeters of mercury | Standard Deviation 5.44 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 1,n=12,6,6,9,9,6 | 0.2 Millimeters of mercury | Standard Deviation 8.13 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 4,n=12,6,6,9,9,6 | 3.8 Millimeters of mercury | Standard Deviation 4.4 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 32,n=6,6,6,0,0,6 | 2.0 Millimeters of mercury | Standard Deviation 7.64 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Day 5,n=12,6,6,9,9,6 | -1.5 Millimeters of mercury | Standard Deviation 2.81 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | SBP, Week 2,n=12,6,6,9,9,6 | -2.8 Millimeters of mercury | Standard Deviation 9.83 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 8,n=12,6,6,9,9,6 | 0.5 Millimeters of mercury | Standard Deviation 3.94 |
| GSK3511294 300mg | Change From Baseline in Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP) | DBP, Week 26,n=12,6,6,9,9,6 | 0.2 Millimeters of mercury | Standard Deviation 3.97 |
Primary
Change From Baseline in Temperature
Temperature was assessed in a supine position after 5 minutes of rest. Baseline was defined as latest pre-dose assessment with a non-missing value. Change from Baseline was defined as post-dose visit value minus Baseline value.
Time frame: Baseline and at 2 and 8 hours at Day 1; Days 2, 3, 4 and 5; Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Change From Baseline in Temperature | Week 24,n=12,6,6,9,9,6 | -0.07 Degree Celsius | Standard Deviation 0.396 |
| Placebo | Change From Baseline in Temperature | Week 1,n=12,6,6,9,9,6 | -0.13 Degree Celsius | Standard Deviation 0.293 |
| Placebo | Change From Baseline in Temperature | Week 8,n=12,6,6,9,9,6 | 0.00 Degree Celsius | Standard Deviation 0.28 |
| Placebo | Change From Baseline in Temperature | Week 36,n=6,0,0,9,9,0 | 0.22 Degree Celsius | Standard Deviation 0.366 |
| Placebo | Change From Baseline in Temperature | Day 3,n=12,6,6,9,9,6 | -0.10 Degree Celsius | Standard Deviation 0.402 |
| Placebo | Change From Baseline in Temperature | Week 40,n=2,0,0,0,0,6 | -0.10 Degree Celsius | Standard Deviation 0.566 |
| Placebo | Change From Baseline in Temperature | Week 32,n=6,6,6,0,0,6 | -0.30 Degree Celsius | Standard Deviation 0.569 |
| Placebo | Change From Baseline in Temperature | Day 5,n=12,6,6,9,9,6 | -0.08 Degree Celsius | Standard Deviation 0.171 |
| Placebo | Change From Baseline in Temperature | Day 4,n=12,6,6,9,9,6 | -0.03 Degree Celsius | Standard Deviation 0.26 |
| Placebo | Change From Baseline in Temperature | Week 18,n=12,6,6,9,9,6 | -0.07 Degree Celsius | Standard Deviation 0.267 |
| Placebo | Change From Baseline in Temperature | Week 2,n=12,6,6,9,9,6 | -0.29 Degree Celsius | Standard Deviation 0.448 |
| Placebo | Change From Baseline in Temperature | 2 hours Day1,n=12,6,6,9,9,6 | 0.05 Degree Celsius | Standard Deviation 0.419 |
| Placebo | Change From Baseline in Temperature | Week 26,n=12,6,6,9,9,6 | -0.08 Degree Celsius | Standard Deviation 0.311 |
| Placebo | Change From Baseline in Temperature | Week 12,n=12,6,6,9,9,6 | -0.10 Degree Celsius | Standard Deviation 0.386 |
| Placebo | Change From Baseline in Temperature | Category title 2. 8 hours Day1,n=12,6,6,9,9,6 | 0.13 Degree Celsius | Standard Deviation 0.405 |
| Placebo | Change From Baseline in Temperature | Category title 3. Day 2,n=12,6,6,9,9,6 | -0.01 Degree Celsius | Standard Deviation 0.312 |
| Placebo | Change From Baseline in Temperature | Week 4,n=12,6,6,9,9,6 | -0.23 Degree Celsius | Standard Deviation 0.172 |
| GSK3511294 2mg | Change From Baseline in Temperature | Week 18,n=12,6,6,9,9,6 | 0.18 Degree Celsius | Standard Deviation 0.662 |
| GSK3511294 2mg | Change From Baseline in Temperature | Week 4,n=12,6,6,9,9,6 | 0.20 Degree Celsius | Standard Deviation 0.4 |
| GSK3511294 2mg | Change From Baseline in Temperature | Week 26,n=12,6,6,9,9,6 | 0.03 Degree Celsius | Standard Deviation 0.441 |
| GSK3511294 2mg | Change From Baseline in Temperature | Week 8,n=12,6,6,9,9,6 | 0.32 Degree Celsius | Standard Deviation 0.397 |
| GSK3511294 2mg | Change From Baseline in Temperature | Category title 2. 8 hours Day1,n=12,6,6,9,9,6 | 0.40 Degree Celsius | Standard Deviation 0.41 |
| GSK3511294 2mg | Change From Baseline in Temperature | Week 12,n=12,6,6,9,9,6 | 0.17 Degree Celsius | Standard Deviation 0.356 |
| GSK3511294 2mg | Change From Baseline in Temperature | Category title 3. Day 2,n=12,6,6,9,9,6 | 0.23 Degree Celsius | Standard Deviation 0.437 |
| GSK3511294 2mg | Change From Baseline in Temperature | 2 hours Day1,n=12,6,6,9,9,6 | 0.32 Degree Celsius | Standard Deviation 0.293 |
| GSK3511294 2mg | Change From Baseline in Temperature | Day 3,n=12,6,6,9,9,6 | 0.02 Degree Celsius | Standard Deviation 0.538 |
| GSK3511294 2mg | Change From Baseline in Temperature | Day 4,n=12,6,6,9,9,6 | 0.15 Degree Celsius | Standard Deviation 0.554 |
| GSK3511294 2mg | Change From Baseline in Temperature | Week 32,n=6,6,6,0,0,6 | 0.48 Degree Celsius | Standard Deviation 1.363 |
| GSK3511294 2mg | Change From Baseline in Temperature | Day 5,n=12,6,6,9,9,6 | 0.13 Degree Celsius | Standard Deviation 0.516 |
| GSK3511294 2mg | Change From Baseline in Temperature | Week 1,n=12,6,6,9,9,6 | 0.32 Degree Celsius | Standard Deviation 0.492 |
| GSK3511294 2mg | Change From Baseline in Temperature | Week 24,n=12,6,6,9,9,6 | 0.08 Degree Celsius | Standard Deviation 0.488 |
| GSK3511294 2mg | Change From Baseline in Temperature | Week 2,n=12,6,6,9,9,6 | 0.30 Degree Celsius | Standard Deviation 0.46 |
| GSK3511294 10mg | Change From Baseline in Temperature | Week 26,n=12,6,6,9,9,6 | -0.02 Degree Celsius | Standard Deviation 0.504 |
| GSK3511294 10mg | Change From Baseline in Temperature | Category title 2. 8 hours Day1,n=12,6,6,9,9,6 | 0.07 Degree Celsius | Standard Deviation 0.234 |
| GSK3511294 10mg | Change From Baseline in Temperature | Week 4,n=12,6,6,9,9,6 | -0.02 Degree Celsius | Standard Deviation 0.387 |
| GSK3511294 10mg | Change From Baseline in Temperature | Day 3,n=12,6,6,9,9,6 | 0.02 Degree Celsius | Standard Deviation 0.256 |
| GSK3511294 10mg | Change From Baseline in Temperature | Week 18,n=12,6,6,9,9,6 | 0.02 Degree Celsius | Standard Deviation 0.407 |
| GSK3511294 10mg | Change From Baseline in Temperature | Week 2,n=12,6,6,9,9,6 | 0.03 Degree Celsius | Standard Deviation 0.333 |
| GSK3511294 10mg | Change From Baseline in Temperature | Week 1,n=12,6,6,9,9,6 | 0.18 Degree Celsius | Standard Deviation 0.147 |
| GSK3511294 10mg | Change From Baseline in Temperature | Week 24,n=12,6,6,9,9,6 | 0.08 Degree Celsius | Standard Deviation 0.319 |
| GSK3511294 10mg | Change From Baseline in Temperature | Category title 3. Day 2,n=12,6,6,9,9,6 | 0.10 Degree Celsius | Standard Deviation 0.429 |
| GSK3511294 10mg | Change From Baseline in Temperature | Week 32,n=6,6,6,0,0,6 | 0.02 Degree Celsius | Standard Deviation 0.306 |
| GSK3511294 10mg | Change From Baseline in Temperature | 2 hours Day1,n=12,6,6,9,9,6 | 0.13 Degree Celsius | Standard Deviation 0.163 |
| GSK3511294 10mg | Change From Baseline in Temperature | Week 8,n=12,6,6,9,9,6 | -0.18 Degree Celsius | Standard Deviation 0.504 |
| GSK3511294 10mg | Change From Baseline in Temperature | Day 4,n=12,6,6,9,9,6 | 0.08 Degree Celsius | Standard Deviation 0.293 |
| GSK3511294 10mg | Change From Baseline in Temperature | Day 5,n=12,6,6,9,9,6 | 0.25 Degree Celsius | Standard Deviation 0.464 |
| GSK3511294 10mg | Change From Baseline in Temperature | Week 12,n=12,6,6,9,9,6 | -0.15 Degree Celsius | Standard Deviation 0.187 |
| GSK3511294 30mg | Change From Baseline in Temperature | 2 hours Day1,n=12,6,6,9,9,6 | 0.30 Degree Celsius | Standard Deviation 0.474 |
| GSK3511294 30mg | Change From Baseline in Temperature | Week 12,n=12,6,6,9,9,6 | 0.09 Degree Celsius | Standard Deviation 0.337 |
| GSK3511294 30mg | Change From Baseline in Temperature | Week 24,n=12,6,6,9,9,6 | -0.02 Degree Celsius | Standard Deviation 0.367 |
| GSK3511294 30mg | Change From Baseline in Temperature | Week 18,n=12,6,6,9,9,6 | 0.13 Degree Celsius | Standard Deviation 0.512 |
| GSK3511294 30mg | Change From Baseline in Temperature | Category title 2. 8 hours Day1,n=12,6,6,9,9,6 | 0.24 Degree Celsius | Standard Deviation 0.513 |
| GSK3511294 30mg | Change From Baseline in Temperature | Week 36,n=6,0,0,9,9,0 | 0.14 Degree Celsius | Standard Deviation 0.433 |
| GSK3511294 30mg | Change From Baseline in Temperature | Category title 3. Day 2,n=12,6,6,9,9,6 | -0.03 Degree Celsius | Standard Deviation 0.559 |
| GSK3511294 30mg | Change From Baseline in Temperature | Day 3,n=12,6,6,9,9,6 | 0.13 Degree Celsius | Standard Deviation 0.439 |
| GSK3511294 30mg | Change From Baseline in Temperature | Day 4,n=12,6,6,9,9,6 | 0.11 Degree Celsius | Standard Deviation 0.382 |
| GSK3511294 30mg | Change From Baseline in Temperature | Week 1,n=12,6,6,9,9,6 | 0.12 Degree Celsius | Standard Deviation 0.399 |
| GSK3511294 30mg | Change From Baseline in Temperature | Day 5,n=12,6,6,9,9,6 | -0.07 Degree Celsius | Standard Deviation 0.3 |
| GSK3511294 30mg | Change From Baseline in Temperature | Week 26,n=12,6,6,9,9,6 | 0.08 Degree Celsius | Standard Deviation 0.424 |
| GSK3511294 30mg | Change From Baseline in Temperature | Week 2,n=12,6,6,9,9,6 | 0.04 Degree Celsius | Standard Deviation 0.34 |
| GSK3511294 30mg | Change From Baseline in Temperature | Week 4,n=12,6,6,9,9,6 | -0.09 Degree Celsius | Standard Deviation 0.302 |
| GSK3511294 30mg | Change From Baseline in Temperature | Week 8,n=12,6,6,9,9,6 | 0.09 Degree Celsius | Standard Deviation 0.446 |
| GSK3511294 100mg | Change From Baseline in Temperature | Week 18,n=12,6,6,9,9,6 | 0.07 Degree Celsius | Standard Deviation 0.283 |
| GSK3511294 100mg | Change From Baseline in Temperature | Day 5,n=12,6,6,9,9,6 | -0.04 Degree Celsius | Standard Deviation 0.255 |
| GSK3511294 100mg | Change From Baseline in Temperature | 2 hours Day1,n=12,6,6,9,9,6 | 0.03 Degree Celsius | Standard Deviation 0.328 |
| GSK3511294 100mg | Change From Baseline in Temperature | Category title 2. 8 hours Day1,n=12,6,6,9,9,6 | 0.18 Degree Celsius | Standard Deviation 0.291 |
| GSK3511294 100mg | Change From Baseline in Temperature | Category title 3. Day 2,n=12,6,6,9,9,6 | -0.01 Degree Celsius | Standard Deviation 0.333 |
| GSK3511294 100mg | Change From Baseline in Temperature | Day 3,n=12,6,6,9,9,6 | 0.02 Degree Celsius | Standard Deviation 0.315 |
| GSK3511294 100mg | Change From Baseline in Temperature | Day 4,n=12,6,6,9,9,6 | 0.22 Degree Celsius | Standard Deviation 0.239 |
| GSK3511294 100mg | Change From Baseline in Temperature | Week 1,n=12,6,6,9,9,6 | 0.01 Degree Celsius | Standard Deviation 0.359 |
| GSK3511294 100mg | Change From Baseline in Temperature | Week 2,n=12,6,6,9,9,6 | 0.08 Degree Celsius | Standard Deviation 0.441 |
| GSK3511294 100mg | Change From Baseline in Temperature | Week 4,n=12,6,6,9,9,6 | 0.00 Degree Celsius | Standard Deviation 0.671 |
| GSK3511294 100mg | Change From Baseline in Temperature | Week 8,n=12,6,6,9,9,6 | 0.02 Degree Celsius | Standard Deviation 0.282 |
| GSK3511294 100mg | Change From Baseline in Temperature | Week 12,n=12,6,6,9,9,6 | -0.09 Degree Celsius | Standard Deviation 0.355 |
| GSK3511294 100mg | Change From Baseline in Temperature | Week 24,n=12,6,6,9,9,6 | -0.07 Degree Celsius | Standard Deviation 0.316 |
| GSK3511294 100mg | Change From Baseline in Temperature | Week 26,n=12,6,6,9,9,6 | 0.00 Degree Celsius | Standard Deviation 0.442 |
| GSK3511294 100mg | Change From Baseline in Temperature | Week 36,n=6,0,0,9,9,0 | -0.03 Degree Celsius | Standard Deviation 0.212 |
| GSK3511294 300mg | Change From Baseline in Temperature | Week 24,n=12,6,6,9,9,6 | -0.02 Degree Celsius | Standard Deviation 0.133 |
| GSK3511294 300mg | Change From Baseline in Temperature | Week 8,n=12,6,6,9,9,6 | 0.13 Degree Celsius | Standard Deviation 0.197 |
| GSK3511294 300mg | Change From Baseline in Temperature | Week 4,n=12,6,6,9,9,6 | -0.03 Degree Celsius | Standard Deviation 0.258 |
| GSK3511294 300mg | Change From Baseline in Temperature | Week 2,n=12,6,6,9,9,6 | -0.08 Degree Celsius | Standard Deviation 0.319 |
| GSK3511294 300mg | Change From Baseline in Temperature | Week 1,n=12,6,6,9,9,6 | 0.18 Degree Celsius | Standard Deviation 0.232 |
| GSK3511294 300mg | Change From Baseline in Temperature | 2 hours Day1,n=12,6,6,9,9,6 | 0.00 Degree Celsius | Standard Deviation 0.42 |
| GSK3511294 300mg | Change From Baseline in Temperature | Week 26,n=12,6,6,9,9,6 | -0.22 Degree Celsius | Standard Deviation 0.117 |
| GSK3511294 300mg | Change From Baseline in Temperature | Day 5,n=12,6,6,9,9,6 | 0.12 Degree Celsius | Standard Deviation 0.293 |
| GSK3511294 300mg | Change From Baseline in Temperature | Day 4,n=12,6,6,9,9,6 | 0.02 Degree Celsius | Standard Deviation 0.397 |
| GSK3511294 300mg | Change From Baseline in Temperature | Day 3,n=12,6,6,9,9,6 | 0.12 Degree Celsius | Standard Deviation 0.343 |
| GSK3511294 300mg | Change From Baseline in Temperature | Week 32,n=6,6,6,0,0,6 | 0.08 Degree Celsius | Standard Deviation 0.331 |
| GSK3511294 300mg | Change From Baseline in Temperature | Category title 3. Day 2,n=12,6,6,9,9,6 | -0.05 Degree Celsius | Standard Deviation 0.259 |
| GSK3511294 300mg | Change From Baseline in Temperature | Category title 2. 8 hours Day1,n=12,6,6,9,9,6 | 0.35 Degree Celsius | Standard Deviation 0.589 |
| GSK3511294 300mg | Change From Baseline in Temperature | Week 18,n=12,6,6,9,9,6 | -0.05 Degree Celsius | Standard Deviation 0.399 |
| GSK3511294 300mg | Change From Baseline in Temperature | Week 12,n=12,6,6,9,9,6 | 0.00 Degree Celsius | Standard Deviation 0.369 |
| GSK3511294 300mg | Change From Baseline in Temperature | Week 40,n=2,0,0,0,0,6 | -0.05 Degree Celsius | Standard Deviation 0.084 |
Primary
Number of Participants With Adverse Events (AEs) and Serious AEs (SAE)
An AE is any untoward medical occurrence in a clinical study participant, temporally associated with the use of a study intervention, whether or not considered related to the study intervention. An SAE is defined as any untoward medical occurrence that, at any dose: results in death; is life-threatening; requires inpatient hospitalization or prolongation of existing hospitalization; results in persistent disability/incapacity; is a congenital anomaly/birth defect; other important medical events that may jeopardize the participant or may require medical or surgical intervention to prevent one of the other outcomes listed before; is associated with liver injury and impaired liver function.
Time frame: Up to Week 40
Population: Safety Population comprised of all randomized participants who received at least one dose of the study treatment.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Placebo | Number of Participants With Adverse Events (AEs) and Serious AEs (SAE) | Any AE | 11 Participants |
| Placebo | Number of Participants With Adverse Events (AEs) and Serious AEs (SAE) | Any SAE | 0 Participants |
| GSK3511294 2mg | Number of Participants With Adverse Events (AEs) and Serious AEs (SAE) | Any AE | 2 Participants |
| GSK3511294 2mg | Number of Participants With Adverse Events (AEs) and Serious AEs (SAE) | Any SAE | 0 Participants |
| GSK3511294 10mg | Number of Participants With Adverse Events (AEs) and Serious AEs (SAE) | Any AE | 6 Participants |
| GSK3511294 10mg | Number of Participants With Adverse Events (AEs) and Serious AEs (SAE) | Any SAE | 0 Participants |
| GSK3511294 30mg | Number of Participants With Adverse Events (AEs) and Serious AEs (SAE) | Any AE | 8 Participants |
| GSK3511294 30mg | Number of Participants With Adverse Events (AEs) and Serious AEs (SAE) | Any SAE | 0 Participants |
| GSK3511294 100mg | Number of Participants With Adverse Events (AEs) and Serious AEs (SAE) | Any AE | 9 Participants |
| GSK3511294 100mg | Number of Participants With Adverse Events (AEs) and Serious AEs (SAE) | Any SAE | 0 Participants |
| GSK3511294 300mg | Number of Participants With Adverse Events (AEs) and Serious AEs (SAE) | Any AE | 4 Participants |
| GSK3511294 300mg | Number of Participants With Adverse Events (AEs) and Serious AEs (SAE) | Any SAE | 0 Participants |
Primary
Number of Participants With Adverse Events of Special Interest (AESI)
AESIs were defined as Hypersensitivity (narrow) and Injection site reactions like hematoma and swelling.
Time frame: Up to Week 40
Population: Safety Population.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Placebo | Number of Participants With Adverse Events of Special Interest (AESI) | Injection Site Reaction: hematoma | 1 Participants |
| Placebo | Number of Participants With Adverse Events of Special Interest (AESI) | Hypersensitivity | 0 Participants |
| Placebo | Number of Participants With Adverse Events of Special Interest (AESI) | Injection Site Reaction: swelling | 1 Participants |
| GSK3511294 2mg | Number of Participants With Adverse Events of Special Interest (AESI) | Injection Site Reaction: hematoma | 0 Participants |
| GSK3511294 2mg | Number of Participants With Adverse Events of Special Interest (AESI) | Hypersensitivity | 0 Participants |
| GSK3511294 2mg | Number of Participants With Adverse Events of Special Interest (AESI) | Injection Site Reaction: swelling | 0 Participants |
| GSK3511294 10mg | Number of Participants With Adverse Events of Special Interest (AESI) | Injection Site Reaction: hematoma | 0 Participants |
| GSK3511294 10mg | Number of Participants With Adverse Events of Special Interest (AESI) | Hypersensitivity | 0 Participants |
| GSK3511294 10mg | Number of Participants With Adverse Events of Special Interest (AESI) | Injection Site Reaction: swelling | 0 Participants |
| GSK3511294 30mg | Number of Participants With Adverse Events of Special Interest (AESI) | Injection Site Reaction: hematoma | 0 Participants |
| GSK3511294 30mg | Number of Participants With Adverse Events of Special Interest (AESI) | Hypersensitivity | 1 Participants |
| GSK3511294 30mg | Number of Participants With Adverse Events of Special Interest (AESI) | Injection Site Reaction: swelling | 0 Participants |
| GSK3511294 100mg | Number of Participants With Adverse Events of Special Interest (AESI) | Injection Site Reaction: hematoma | 0 Participants |
| GSK3511294 100mg | Number of Participants With Adverse Events of Special Interest (AESI) | Hypersensitivity | 0 Participants |
| GSK3511294 100mg | Number of Participants With Adverse Events of Special Interest (AESI) | Injection Site Reaction: swelling | 0 Participants |
| GSK3511294 300mg | Number of Participants With Adverse Events of Special Interest (AESI) | Hypersensitivity | 0 Participants |
| GSK3511294 300mg | Number of Participants With Adverse Events of Special Interest (AESI) | Injection Site Reaction: swelling | 1 Participants |
| GSK3511294 300mg | Number of Participants With Adverse Events of Special Interest (AESI) | Injection Site Reaction: hematoma | 1 Participants |
Primary
Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein
Urine samples were collected to analyze presence of ketones, occult blood, glucose, and protein in urine. In this dipstick test, the level of occult blood, glucose, ketones and urine protein in urine samples were recorded as negative, trace, 1+ and 2+ indicating proportional concentrations in urine. Only categories with abnormal significant values have been presented.
Time frame: Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Placebo | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 4,n=2,1,1,5,0,0 | 1 Participants |
| Placebo | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 18,n=2,1,0,1,0,0 | 1 Participants |
| Placebo | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace,Week 32,n=1,0,0,0,0,0 | 1 Participants |
| Placebo | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Protein, Trace, Week 8,n=1,0,0,2,0,0 | 1 Participants |
| Placebo | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 1,n=2,1,1,3,0,0 | 1 Participants |
| Placebo | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Occult blood, Trace,Week 4,n=2,1,1,5,0,1 | 1 Participants |
| Placebo | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace,Day 2,n=1,2,0,2,0,0 | 1 Participants |
| Placebo | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Day 5,n=2,0,0,2,1,0 | 1 Participants |
| Placebo | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 24,n=1,1,0,4,0,0 | 1 Participants |
| Placebo | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Protein, 2+, Week 4,n=2,1,1,5,0,1 | 1 Participants |
| Placebo | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 2,n=1,0,0,3,1,0 | 1 Participants |
| Placebo | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Protein, Trace, Week 18,n=2,1,0,1,0,0 | 1 Participants |
| GSK3511294 2mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 4,n=2,1,1,5,0,0 | 0 Participants |
| GSK3511294 2mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 1,n=2,1,1,3,0,0 | 0 Participants |
| GSK3511294 2mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace,Day 2,n=1,2,0,2,0,0 | 0 Participants |
| GSK3511294 2mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 18,n=2,1,0,1,0,0 | 0 Participants |
| GSK3511294 2mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 24,n=1,1,0,4,0,0 | 0 Participants |
| GSK3511294 2mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Occult blood, Trace,Week 4,n=2,1,1,5,0,1 | 0 Participants |
| GSK3511294 2mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Protein, 2+, Week 4,n=2,1,1,5,0,1 | 0 Participants |
| GSK3511294 2mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Protein, Trace, Week 18,n=2,1,0,1,0,0 | 0 Participants |
| GSK3511294 10mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 18,n=2,1,0,1,0,0 | 0 Participants |
| GSK3511294 10mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 1,n=2,1,1,3,0,0 | 1 Participants |
| GSK3511294 10mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Occult blood, Trace,Week 4,n=2,1,1,5,0,1 | 0 Participants |
| GSK3511294 10mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 4,n=2,1,1,5,0,0 | 1 Participants |
| GSK3511294 10mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Protein, 2+, Week 4,n=2,1,1,5,0,1 | 0 Participants |
| GSK3511294 10mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Day 4,n=0,0,1,1,0,0 | 1 Participants |
| GSK3511294 10mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 24,n=1,1,0,4,0,0 | 0 Participants |
| GSK3511294 30mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Protein, Trace, Week 18,n=2,1,0,1,0,0 | 0 Participants |
| GSK3511294 30mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Day 4,n=0,0,1,1,0,0 | 0 Participants |
| GSK3511294 30mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 18,n=2,1,0,1,0,0 | 0 Participants |
| GSK3511294 30mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Protein, 2+, Week 4,n=2,1,1,5,0,1 | 0 Participants |
| GSK3511294 30mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Occult blood, Trace,Week 4,n=2,1,1,5,0,1 | 0 Participants |
| GSK3511294 30mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace,Day 2,n=1,2,0,2,0,0 | 0 Participants |
| GSK3511294 30mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Day 5,n=2,0,0,2,1,0 | 0 Participants |
| GSK3511294 30mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 1,n=2,1,1,3,0,0 | 0 Participants |
| GSK3511294 30mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 2,n=1,0,0,3,1,0 | 1 Participants |
| GSK3511294 30mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 4,n=2,1,1,5,0,0 | 0 Participants |
| GSK3511294 30mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 24,n=1,1,0,4,0,0 | 0 Participants |
| GSK3511294 30mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 26,n=0,0,0,2,0,0 | 1 Participants |
| GSK3511294 30mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Protein, Trace, Week 8,n=1,0,0,2,0,0 | 0 Participants |
| GSK3511294 100mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Week 2,n=1,0,0,3,1,0 | 0 Participants |
| GSK3511294 100mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, Trace, Day 5,n=2,0,0,2,1,0 | 0 Participants |
| GSK3511294 300mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Ketone, 1+, Week 40,n=0,0,0,0,0,1 | 1 Participants |
| GSK3511294 300mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Occult blood, Trace,Week 4,n=2,1,1,5,0,1 | 0 Participants |
| GSK3511294 300mg | Number of Participants With Presence of Ketones, Glucose, Occult Blood, and Protein | Urine Protein, 2+, Week 4,n=2,1,1,5,0,1 | 0 Participants |
Primary
Urine Potential of Hydrogen (pH) Analysis by Dipstick Method
Urinary pH measurement is a routine part of urinalysis. Urine pH is an acid-base measurement. pH is measured on a numeric scale ranging from 0 to 14; values on the scale refer to the degree of alkalinity or acidity. A pH of 7 is neutral. A pH less than 7 is acidic, and a pH greater than 7 is basic. Normal urine has a slightly acid pH (5.0 - 6.0).
Time frame: Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 18,n=3,1,0,1,0,0 | 5.67 pH | Standard Deviation 0.577 |
| Placebo | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Day 3,n=3,0,0,1,0,0 | 6.00 pH | Standard Deviation 0.5 |
| Placebo | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 8,n=1,0,0,2,0,0 | 5.50 pH | — |
| Placebo | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 32,n=1,0,0,0,0,0 | 7.50 pH | — |
| Placebo | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 4,n=3,1,1,5,0,1 | 6.50 pH | Standard Deviation 0.866 |
| Placebo | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 1,n=2,1,1,3,0,0 | 5.50 pH | Standard Deviation 0 |
| Placebo | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 2,n=1,0,0,4,1,0 | 5.50 pH | — |
| Placebo | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 24,n=1,1,0,4,0,0 | 6.00 pH | — |
| Placebo | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Day 2,n=1,1,0,2,0,0 | 5.00 pH | — |
| Placebo | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Day 5,n=2,0,0,2,1,0 | 5.50 pH | Standard Deviation 0.707 |
| GSK3511294 2mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 18,n=3,1,0,1,0,0 | 7.00 pH | — |
| GSK3511294 2mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 12,n=0,1,0,1,0,0 | 6.50 pH | — |
| GSK3511294 2mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 24,n=1,1,0,4,0,0 | 6.50 pH | — |
| GSK3511294 2mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 1,n=2,1,1,3,0,0 | 7.00 pH | — |
| GSK3511294 2mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Day 2,n=1,1,0,2,0,0 | 7.00 pH | — |
| GSK3511294 2mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 4,n=3,1,1,5,0,1 | 8.00 pH | — |
| GSK3511294 10mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 1,n=2,1,1,3,0,0 | 6.00 pH | — |
| GSK3511294 10mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 4,n=3,1,1,5,0,1 | 5.50 pH | — |
| GSK3511294 10mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Day 4,n=0,0,1,1,0,0 | 6.50 pH | — |
| GSK3511294 30mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Day 4,n=0,0,1,1,0,0 | 5.00 pH | — |
| GSK3511294 30mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 2,n=1,0,0,4,1,0 | 5.63 pH | Standard Deviation 0.479 |
| GSK3511294 30mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 12,n=0,1,0,1,0,0 | 5.00 pH | — |
| GSK3511294 30mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 8,n=1,0,0,2,0,0 | 5.50 pH | Standard Deviation 0 |
| GSK3511294 30mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 1,n=2,1,1,3,0,0 | 5.50 pH | Standard Deviation 0.5 |
| GSK3511294 30mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Day 5,n=2,0,0,2,1,0 | 5.75 pH | Standard Deviation 1.061 |
| GSK3511294 30mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 4,n=3,1,1,5,0,1 | 6.00 pH | Standard Deviation 0.707 |
| GSK3511294 30mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Day 3,n=3,0,0,1,0,0 | 5.00 pH | — |
| GSK3511294 30mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Day 2,n=1,1,0,2,0,0 | 6.50 pH | Standard Deviation 1.414 |
| GSK3511294 30mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 26,n=0,0,0,2,0,0 | 5.50 pH | Standard Deviation 0 |
| GSK3511294 30mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 18,n=3,1,0,1,0,0 | 5.00 pH | — |
| GSK3511294 30mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 24,n=1,1,0,4,0,0 | 5.38 pH | Standard Deviation 0.479 |
| GSK3511294 100mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 2,n=1,0,0,4,1,0 | 8.50 pH | — |
| GSK3511294 100mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Day 5,n=2,0,0,2,1,0 | 5.50 pH | — |
| GSK3511294 300mg | Urine Potential of Hydrogen (pH) Analysis by Dipstick Method | Week 4,n=3,1,1,5,0,1 | 5.00 pH | — |
Primary
Urine Specific Gravity Analysis by Dipstick Method
Urinary specific gravity measurement is a routine part of urinalysis. Urine specific gravity is a measure of the concentration of solutes in the urine and provides information on the kidney's ability to concentrate urine. The concentration of the excreted molecules determines the urine's specific gravity.
Time frame: Baseline and at Days 2, 3, 4 and 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36 and 40
Population: Safety Population. Only those participants with planned assessments at that particular time point has been presented (represented by n= X in the category titles).
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Placebo | Urine Specific Gravity Analysis by Dipstick Method | Week 32,n=1,0,0,0,0,0 | 1.0150 Ratio | — |
| Placebo | Urine Specific Gravity Analysis by Dipstick Method | Day 2,n=1,2,0,2,0,0 | 1.0200 Ratio | — |
| Placebo | Urine Specific Gravity Analysis by Dipstick Method | Day 3,n=2,0,0,1,0,0 | 1.0265 Ratio | Standard Deviation 0.00212 |
| Placebo | Urine Specific Gravity Analysis by Dipstick Method | Day 5,n=2,0,0,2,1,0 | 1.0275 Ratio | Standard Deviation 0.00354 |
| Placebo | Urine Specific Gravity Analysis by Dipstick Method | Week 1,n=2,1,1,3,0,0 | 1.0235 Ratio | Standard Deviation 0.00212 |
| Placebo | Urine Specific Gravity Analysis by Dipstick Method | Week 2,n=1,0,0,4,1,0 | 1.0250 Ratio | — |
| Placebo | Urine Specific Gravity Analysis by Dipstick Method | Week 4,n=3,1,1,5,0,1 | 1.0193 Ratio | Standard Deviation 0.00839 |
| Placebo | Urine Specific Gravity Analysis by Dipstick Method | Week 8,n=1,0,0,2,0,0 | 1.0300 Ratio | — |
| Placebo | Urine Specific Gravity Analysis by Dipstick Method | Week 18,n=3,1,0,1,0,0 | 1.0260 Ratio | Standard Deviation 0.00265 |
| Placebo | Urine Specific Gravity Analysis by Dipstick Method | Week 24,n=1,1,0,4,0,0 | 1.0200 Ratio | — |
| GSK3511294 2mg | Urine Specific Gravity Analysis by Dipstick Method | Day 2,n=1,2,0,2,0,0 | 1.0125 Ratio | Standard Deviation 0.00354 |
| GSK3511294 2mg | Urine Specific Gravity Analysis by Dipstick Method | Week 12,n=0,1,0,1,0,0 | 1.0180 Ratio | — |
| GSK3511294 2mg | Urine Specific Gravity Analysis by Dipstick Method | Week 1,n=2,1,1,3,0,0 | 1.0260 Ratio | — |
| GSK3511294 2mg | Urine Specific Gravity Analysis by Dipstick Method | Week 24,n=1,1,0,4,0,0 | 1.0230 Ratio | — |
| GSK3511294 2mg | Urine Specific Gravity Analysis by Dipstick Method | Week 4,n=3,1,1,5,0,1 | 1.0150 Ratio | — |
| GSK3511294 2mg | Urine Specific Gravity Analysis by Dipstick Method | Week 18,n=3,1,0,1,0,0 | 1.0180 Ratio | — |
| GSK3511294 10mg | Urine Specific Gravity Analysis by Dipstick Method | Week 1,n=2,1,1,3,0,0 | 1.0250 Ratio | — |
| GSK3511294 10mg | Urine Specific Gravity Analysis by Dipstick Method | Week 4,n=3,1,1,5,0,1 | 1.0250 Ratio | — |
| GSK3511294 10mg | Urine Specific Gravity Analysis by Dipstick Method | Day 4,n=0,0,1,1,0,0 | 1.0150 Ratio | — |
| GSK3511294 30mg | Urine Specific Gravity Analysis by Dipstick Method | Day 4,n=0,0,1,1,0,0 | 1.0290 Ratio | — |
| GSK3511294 30mg | Urine Specific Gravity Analysis by Dipstick Method | Day 5,n=2,0,0,2,1,0 | 1.0205 Ratio | Standard Deviation 0.00919 |
| GSK3511294 30mg | Urine Specific Gravity Analysis by Dipstick Method | Week 26,n=0,0,0,2,0,0 | 1.0240 Ratio | Standard Deviation 0.00566 |
| GSK3511294 30mg | Urine Specific Gravity Analysis by Dipstick Method | Week 1,n=2,1,1,3,0,0 | 1.0197 Ratio | Standard Deviation 0.00751 |
| GSK3511294 30mg | Urine Specific Gravity Analysis by Dipstick Method | Week 2,n=1,0,0,4,1,0 | 1.0218 Ratio | Standard Deviation 0.00822 |
| GSK3511294 30mg | Urine Specific Gravity Analysis by Dipstick Method | Week 4,n=3,1,1,5,0,1 | 1.0158 Ratio | Standard Deviation 0.01052 |
| GSK3511294 30mg | Urine Specific Gravity Analysis by Dipstick Method | Day 2,n=1,2,0,2,0,0 | 1.0120 Ratio | Standard Deviation 0.00283 |
| GSK3511294 30mg | Urine Specific Gravity Analysis by Dipstick Method | Week 8,n=1,0,0,2,0,0 | 1.0220 Ratio | Standard Deviation 0.00566 |
| GSK3511294 30mg | Urine Specific Gravity Analysis by Dipstick Method | Week 12,n=0,1,0,1,0,0 | 1.0230 Ratio | — |
| GSK3511294 30mg | Urine Specific Gravity Analysis by Dipstick Method | Week 18,n=3,1,0,1,0,0 | 1.0230 Ratio | — |
| GSK3511294 30mg | Urine Specific Gravity Analysis by Dipstick Method | Day 3,n=2,0,0,1,0,0 | 1.0280 Ratio | — |
| GSK3511294 30mg | Urine Specific Gravity Analysis by Dipstick Method | Week 24,n=1,1,0,4,0,0 | 1.0200 Ratio | Standard Deviation 0.00374 |
| GSK3511294 100mg | Urine Specific Gravity Analysis by Dipstick Method | Week 2,n=1,0,0,4,1,0 | 1.0130 Ratio | — |
| GSK3511294 100mg | Urine Specific Gravity Analysis by Dipstick Method | Day 5,n=2,0,0,2,1,0 | 1.0140 Ratio | — |
| GSK3511294 300mg | Urine Specific Gravity Analysis by Dipstick Method | Week 4,n=3,1,1,5,0,1 | 1.0270 Ratio | — |
Secondary
Apparent Clearance Following Subcutaneous Dosing (CL/F) of GSK3511294 2 mg and 10 mg
Blood samples were collected from participants at indicated time points and analyzed for CL/F. CL/F was calculated as dose divided by AUC(0-inf). Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Apparent Clearance Following Subcutaneous Dosing (CL/F) of GSK3511294 2 mg and 10 mg | 0.08066 Liters per day | Geometric Coefficient of Variation 51.6 |
| GSK3511294 2mg | Apparent Clearance Following Subcutaneous Dosing (CL/F) of GSK3511294 2 mg and 10 mg | 0.14513 Liters per day | Geometric Coefficient of Variation 23.6 |
Secondary
Apparent Volume of Distribution After Subcutaneous Administration (Vd/F) of GSK3511294 2 mg and 10 mg
Blood samples were collected from participants at indicated time points and analyzed for Vd/F. Vd/F was calculated as dose divided by terminal elimination rate constant (lambda\_z) \*AUC(0-inf). Pharmacokinetic parameters were calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Apparent Volume of Distribution After Subcutaneous Administration (Vd/F) of GSK3511294 2 mg and 10 mg | 6.113 Liters | Geometric Coefficient of Variation 37.6 |
| GSK3511294 2mg | Apparent Volume of Distribution After Subcutaneous Administration (Vd/F) of GSK3511294 2 mg and 10 mg | 9.193 Liters | Geometric Coefficient of Variation 34.7 |
Secondary
Area Under the Concentration-time Curve From Time Zero to Week 12 (AUC[0-Week 12]) of GSK3511294
Blood samples were collected from participants at indicated time points and analyzed for AUC (0-Week 12). Pharmacokinetic parameters were calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8 and 12 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Area Under the Concentration-time Curve From Time Zero to Week 12 (AUC[0-Week 12]) of GSK3511294 | 16.102 Day*microgram per milliliter | Geometric Coefficient of Variation 37.1 |
| GSK3511294 2mg | Area Under the Concentration-time Curve From Time Zero to Week 12 (AUC[0-Week 12]) of GSK3511294 | 48.389 Day*microgram per milliliter | Geometric Coefficient of Variation 22.7 |
| GSK3511294 10mg | Area Under the Concentration-time Curve From Time Zero to Week 12 (AUC[0-Week 12]) of GSK3511294 | 148.798 Day*microgram per milliliter | Geometric Coefficient of Variation 37.8 |
| GSK3511294 30mg | Area Under the Concentration-time Curve From Time Zero to Week 12 (AUC[0-Week 12]) of GSK3511294 | 663.984 Day*microgram per milliliter | Geometric Coefficient of Variation 8.1 |
| GSK3511294 100mg | Area Under the Concentration-time Curve From Time Zero to Week 12 (AUC[0-Week 12]) of GSK3511294 | 1445.726 Day*microgram per milliliter | Geometric Coefficient of Variation 23.8 |
Secondary
Area Under the Concentration-time Curve From Time Zero to Week 26 (AUC [0-Week 26]) of GSK3511294
Blood samples were collected from participants at indicated time points and analyzed for AUC (0-Week 26). Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24 and 26 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Area Under the Concentration-time Curve From Time Zero to Week 26 (AUC [0-Week 26]) of GSK3511294 | 21.829 Day*microgram per milliliter | Geometric Coefficient of Variation 42.7 |
| GSK3511294 2mg | Area Under the Concentration-time Curve From Time Zero to Week 26 (AUC [0-Week 26]) of GSK3511294 | 64.453 Day*microgram per milliliter | Geometric Coefficient of Variation 24.3 |
| GSK3511294 10mg | Area Under the Concentration-time Curve From Time Zero to Week 26 (AUC [0-Week 26]) of GSK3511294 | 199.893 Day*microgram per milliliter | Geometric Coefficient of Variation 39.9 |
| GSK3511294 30mg | Area Under the Concentration-time Curve From Time Zero to Week 26 (AUC [0-Week 26]) of GSK3511294 | 805.359 Day*microgram per milliliter | Geometric Coefficient of Variation 7.7 |
| GSK3511294 100mg | Area Under the Concentration-time Curve From Time Zero to Week 26 (AUC [0-Week 26]) of GSK3511294 | 1789.451 Day*microgram per milliliter | Geometric Coefficient of Variation 26.3 |
Secondary
Area Under the Concentration-time Curve From Time Zero to Week 4 (AUC[0-Week 4]) of GSK3511294
Blood samples were collected from participants at indicated time points and analyzed for AUC (0-Week 4). Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, and 4 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Area Under the Concentration-time Curve From Time Zero to Week 4 (AUC[0-Week 4]) of GSK3511294 | 6.856 Day*microgram per milliliter | Geometric Coefficient of Variation 22 |
| GSK3511294 2mg | Area Under the Concentration-time Curve From Time Zero to Week 4 (AUC[0-Week 4]) of GSK3511294 | 19.685 Day*microgram per milliliter | Geometric Coefficient of Variation 14 |
| GSK3511294 10mg | Area Under the Concentration-time Curve From Time Zero to Week 4 (AUC[0-Week 4]) of GSK3511294 | 62.994 Day*microgram per milliliter | Geometric Coefficient of Variation 40.6 |
| GSK3511294 30mg | Area Under the Concentration-time Curve From Time Zero to Week 4 (AUC[0-Week 4]) of GSK3511294 | 292.698 Day*microgram per milliliter | Geometric Coefficient of Variation 11 |
| GSK3511294 100mg | Area Under the Concentration-time Curve From Time Zero to Week 4 (AUC[0-Week 4]) of GSK3511294 | 676.055 Day*microgram per milliliter | Geometric Coefficient of Variation 22.7 |
Secondary
Area Under the Curve From Time Zero to Infinity (AUC[0-inf]) of GSK3511294 2 mg and 10 mg
Blood samples were collected from participants at indicated time points and analyzed for AUC (0-inf). Pharmacokinetic parameters were calculated by standard non compartmental analysis. Pharmacokinetic Population included participants in the Safety population for whom a pharmcokinetic sample was obtained and analyzed.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose
Population: Pharmacokinetic Population.
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Area Under the Curve From Time Zero to Infinity (AUC[0-inf]) of GSK3511294 2 mg and 10 mg | 24.795 Day*microgram per milliliter | Geometric Coefficient of Variation 51.6 |
| GSK3511294 2mg | Area Under the Curve From Time Zero to Infinity (AUC[0-inf]) of GSK3511294 2 mg and 10 mg | 68.904 Day*microgram per milliliter | Geometric Coefficient of Variation 23.6 |
Secondary
Area Under the Curve From Time Zero to the Last Measurable Concentration (AUC[0-t]) of GSK3511294 2 mg and 10 mg
Blood samples were collected from participants at indicated time points and analyzed for AUC (0-t). Pharmacokinetic parameters were calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose
Population: Pharmacokinetic Population.
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Area Under the Curve From Time Zero to the Last Measurable Concentration (AUC[0-t]) of GSK3511294 2 mg and 10 mg | 18.369 Day*microgram per milliliter | Geometric Coefficient of Variation 59.2 |
| GSK3511294 2mg | Area Under the Curve From Time Zero to the Last Measurable Concentration (AUC[0-t]) of GSK3511294 2 mg and 10 mg | 62.101 Day*microgram per milliliter | Geometric Coefficient of Variation 28.4 |
Secondary
AUC(0-inf) of GSK3511294 300 mg
Blood samples were collected from participants at indicated time points and analyzed for AUC (0-inf). Pharmacokinetic parameters were calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose
Population: Pharmacokinetic Population.
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | AUC(0-inf) of GSK3511294 300 mg | 1873.657 Day*microgram per milliliter | Geometric Coefficient of Variation 25.5 |
Secondary
AUC(0-inf) of GSK3511294 30 mg and 100 mg
Blood samples were collected from participants at indicated time points and analyzed for AUC (0-inf). Pharmacokinetic parameters were calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose
Population: Pharmacokinetic Population.
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | AUC(0-inf) of GSK3511294 30 mg and 100 mg | 208.308 Day*microgram per milliliter | Geometric Coefficient of Variation 39.6 |
| GSK3511294 2mg | AUC(0-inf) of GSK3511294 30 mg and 100 mg | 846.686 Day*microgram per milliliter | Geometric Coefficient of Variation 7.3 |
Secondary
AUC(0-t) of GSK3511294 300 mg
Blood samples were collected from participants at indicated time points and analyzed for AUC (0-t). Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | AUC(0-t) of GSK3511294 300 mg | 1855.619 Day*microgram per milliliter | Geometric Coefficient of Variation 25.8 |
Secondary
AUC(0-t) of GSK3511294 30 mg and 100 mg
Blood samples were collected from participants at indicated time points and analyzed for AUC (0-t). Pharmacokinetic parameters were calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | AUC(0-t) of GSK3511294 30 mg and 100 mg | 201.434 Day*microgram per milliliter | Geometric Coefficient of Variation 41.1 |
| GSK3511294 2mg | AUC(0-t) of GSK3511294 30 mg and 100 mg | 830.245 Day*microgram per milliliter | Geometric Coefficient of Variation 7.4 |
Secondary
%AUCex of GSK3511294 300 mg
Blood samples were collected from participants at indicated time points and analyzed for %AUCex. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | %AUCex of GSK3511294 300 mg | 0.9096 Percentage of AUCex | Geometric Coefficient of Variation 35.1 |
Secondary
%AUCex of GSK3511294 30 mg and 100 mg
Blood samples were collected from participants at indicated time points and analyzed for %AUCex. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | %AUCex of GSK3511294 30 mg and 100 mg | 2.9636 Percentage of AUCex | Geometric Coefficient of Variation 55.6 |
| GSK3511294 2mg | %AUCex of GSK3511294 30 mg and 100 mg | 1.4162 Percentage of AUCex | Geometric Coefficient of Variation 88.3 |
Secondary
CL/F of GSK3511294 300 mg
Blood samples were collected from participants at indicated time points and analyzed for CL/F. CL/F was calculated as dose divided by AUC(0-inf). Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | CL/F of GSK3511294 300 mg | 0.16011 Liters per day | Geometric Coefficient of Variation 25.5 |
Secondary
CL/F of GSK3511294 30 mg and 100 mg
Blood samples were collected from participants at indicated time points and analyzed for CL/F. CL/F was calculated as dose divided by AUC(0-inf). Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | CL/F of GSK3511294 30 mg and 100 mg | 0.14402 Liters per day | Geometric Coefficient of Variation 39.6 |
| GSK3511294 2mg | CL/F of GSK3511294 30 mg and 100 mg | 0.11811 Liters per day | Geometric Coefficient of Variation 7.3 |
Secondary
Cmax of GSK3511294 300 mg
Blood samples were collected from participants at indicated time points and analyzed for Cmax. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Cmax of GSK3511294 300 mg | 28.5987 Microgram per milliliter | Geometric Coefficient of Variation 23.3 |
Secondary
Cmax of GSK3511294 30 mg and 100 mg
Blood samples were collected from participants at indicated time points and analyzed for Cmax. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Cmax of GSK3511294 30 mg and 100 mg | 2.8101 Microgram per milliliter | Geometric Coefficient of Variation 41.1 |
| GSK3511294 2mg | Cmax of GSK3511294 30 mg and 100 mg | 12.2471 Microgram per milliliter | Geometric Coefficient of Variation 15.9 |
Secondary
Lambda_z of GSK3511294 300 mg
Blood samples were collected from participants at indicated time points and analyzed for lambda\_z. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Lambda_z of GSK3511294 300 mg | 0.017148 Day^-1 | Geometric Coefficient of Variation 6.3 |
Secondary
Lambda_z of GSK3511294 30 mg and 100 mg
Blood samples were collected from participants at indicated time points and analyzed for lambda\_z. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Lambda_z of GSK3511294 30 mg and 100 mg | 0.018435 Day^-1 | Geometric Coefficient of Variation 10.7 |
| GSK3511294 2mg | Lambda_z of GSK3511294 30 mg and 100 mg | 0.017813 Day^-1 | Geometric Coefficient of Variation 11.7 |
Secondary
Maximum Observed Concentration (Cmax) of GSK3511294 2 mg and 10 mg
Blood samples were collected from participants at indicated time points and analyzed for Cmax. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Maximum Observed Concentration (Cmax) of GSK3511294 2 mg and 10 mg | 0.3400 Microgram per milliliter | Geometric Coefficient of Variation 25.3 |
| GSK3511294 2mg | Maximum Observed Concentration (Cmax) of GSK3511294 2 mg and 10 mg | 0.8759 Microgram per milliliter | Geometric Coefficient of Variation 18.3 |
Secondary
Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294
Serum samples were collected to determine the presence of anti-GSK3511294 binding antibodies using a validated bioanalytical method. Data for any time post-Baseline is reported. The results were categorized as negative, transient positive (defined as a single confirmatory positive immunogenic response that does not occur at the final study assessment) and persistent positive (defined as a confirmatory positive immunogenic response for at least 2 consecutive assessments or a single result at the final study assessment).
Time frame: Up to Week 40
Population: Safety Population.
| Arm | Measure | Group | Value (COUNT_OF_PARTICIPANTS) |
|---|---|---|---|
| Placebo | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Transient positive | 0 Participants |
| Placebo | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Negative | 12 Participants |
| Placebo | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Persistent positive | 0 Participants |
| GSK3511294 2mg | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Transient positive | 0 Participants |
| GSK3511294 2mg | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Negative | 6 Participants |
| GSK3511294 2mg | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Persistent positive | 0 Participants |
| GSK3511294 10mg | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Transient positive | 0 Participants |
| GSK3511294 10mg | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Negative | 5 Participants |
| GSK3511294 10mg | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Persistent positive | 1 Participants |
| GSK3511294 30mg | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Transient positive | 0 Participants |
| GSK3511294 30mg | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Negative | 4 Participants |
| GSK3511294 30mg | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Persistent positive | 5 Participants |
| GSK3511294 100mg | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Transient positive | 1 Participants |
| GSK3511294 100mg | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Negative | 7 Participants |
| GSK3511294 100mg | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Persistent positive | 1 Participants |
| GSK3511294 300mg | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Negative | 5 Participants |
| GSK3511294 300mg | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Persistent positive | 1 Participants |
| GSK3511294 300mg | Number of Participants With Anti-drug Antibody (ADA) Binding to GSK3511294 | Transient positive | 0 Participants |
Secondary
Percentage of AUC (0-inf) Obtained by Extrapolation (%AUCex) of GSK3511294 2 mg and 10 mg
Blood samples were collected from participants at indicated time points and analyzed for %AUCex. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Percentage of AUC (0-inf) Obtained by Extrapolation (%AUCex) of GSK3511294 2 mg and 10 mg | 24.3560 Percentage of AUCex | Geometric Coefficient of Variation 35.8 |
| GSK3511294 2mg | Percentage of AUC (0-inf) Obtained by Extrapolation (%AUCex) of GSK3511294 2 mg and 10 mg | 7.7705 Percentage of AUCex | Geometric Coefficient of Variation 81.6 |
Secondary
Ratio to Baseline in Absolute Blood Eosinophil Count
Blood samples were collected at indicated time-points. Analysis was performed using a mixed model repeated measures analysis (MMRM) model on log-transformed data with fixed categorical effects of treatment, planned timepoint and treatment-by-planned timepoint interaction and fixed continuous covariates of log Baseline blood eosinophil count and log Baseline blood eosinophil count-by-planned timepoint interaction. Baseline is defined as the latest predose non-missing blood eosinophil count. Ratio to Baseline is defined as post-dose visit value divided by Baseline value. Pharmacodynamic Population included participants in the 'Safety' population for whom a post-dose pharmacodynamic (ie blood eosinophil) sample was obtained and analyzed.
Time frame: Baseline, Days 2, 3, 4, 5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32, 36, and 40
Population: Pharmacodynamic Population. Only those participants with planned assessments at that particular time point has been presented (represented by n=X in category titles)
| Arm | Measure | Group | Value (LEAST_SQUARES_MEAN) |
|---|---|---|---|
| Placebo | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 8, n=12, 6, 6, 9, 9, 6 | 1.095 Ratio of eosinophils in blood |
| Placebo | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 4,n=12, 6, 5, 9, 9, 6 | 1.062 Ratio of eosinophils in blood |
| Placebo | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 3, n=12, 6, 6, 9, 9, 6 | 0.977 Ratio of eosinophils in blood |
| Placebo | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 32, n=6, 6, 6, 0, 0, 6 | 0.912 Ratio of eosinophils in blood |
| Placebo | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 26, n=12, 6, 6, 9, 9, 6 | 1.119 Ratio of eosinophils in blood |
| Placebo | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 4, n=12, 6, 6, 8, 8, 6 | 1.008 Ratio of eosinophils in blood |
| Placebo | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 40, n=2, 0, 0, 0, 0, 6 | 1.210 Ratio of eosinophils in blood |
| Placebo | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 24, n=11, 6, 6, 9, 9, 6 | 1.005 Ratio of eosinophils in blood |
| Placebo | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 5, n=11, 6, 6, 9, 9, 6 | 0.927 Ratio of eosinophils in blood |
| Placebo | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 2, n=12, 6, 6, 8, 9, 6 | 1.083 Ratio of eosinophils in blood |
| Placebo | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 18, n=12, 6, 6, 9, 9, 6 | 1.079 Ratio of eosinophils in blood |
| Placebo | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 12, n=12, 5, 6, 9, 9, 5 | 1.031 Ratio of eosinophils in blood |
| Placebo | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 1, n=12, 6, 6, 9, 9, 5 | 1.136 Ratio of eosinophils in blood |
| Placebo | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 36, n=6, 0, 0, 9, 9, 0 | 0.975 Ratio of eosinophils in blood |
| Placebo | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 2, n=12, 6, 5, 9, 9, 6 | 1.174 Ratio of eosinophils in blood |
| GSK3511294 2mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 4,n=12, 6, 5, 9, 9, 6 | 0.198 Ratio of eosinophils in blood |
| GSK3511294 2mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 1, n=12, 6, 6, 9, 9, 5 | 0.304 Ratio of eosinophils in blood |
| GSK3511294 2mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 2, n=12, 6, 5, 9, 9, 6 | 0.274 Ratio of eosinophils in blood |
| GSK3511294 2mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 32, n=6, 6, 6, 0, 0, 6 | 0.968 Ratio of eosinophils in blood |
| GSK3511294 2mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 24, n=11, 6, 6, 9, 9, 6 | 0.661 Ratio of eosinophils in blood |
| GSK3511294 2mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 8, n=12, 6, 6, 9, 9, 6 | 0.201 Ratio of eosinophils in blood |
| GSK3511294 2mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 3, n=12, 6, 6, 9, 9, 6 | 0.431 Ratio of eosinophils in blood |
| GSK3511294 2mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 2, n=12, 6, 6, 8, 9, 6 | 0.562 Ratio of eosinophils in blood |
| GSK3511294 2mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 18, n=12, 6, 6, 9, 9, 6 | 0.466 Ratio of eosinophils in blood |
| GSK3511294 2mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 26, n=12, 6, 6, 9, 9, 6 | 0.776 Ratio of eosinophils in blood |
| GSK3511294 2mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 12, n=12, 5, 6, 9, 9, 5 | 0.373 Ratio of eosinophils in blood |
| GSK3511294 2mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 5, n=11, 6, 6, 9, 9, 6 | 0.300 Ratio of eosinophils in blood |
| GSK3511294 2mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 4, n=12, 6, 6, 8, 8, 6 | 0.400 Ratio of eosinophils in blood |
| GSK3511294 10mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 5, n=11, 6, 6, 9, 9, 6 | 0.267 Ratio of eosinophils in blood |
| GSK3511294 10mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 2, n=12, 6, 6, 8, 9, 6 | 0.522 Ratio of eosinophils in blood |
| GSK3511294 10mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 3, n=12, 6, 6, 9, 9, 6 | 0.350 Ratio of eosinophils in blood |
| GSK3511294 10mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 4, n=12, 6, 6, 8, 8, 6 | 0.340 Ratio of eosinophils in blood |
| GSK3511294 10mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 1, n=12, 6, 6, 9, 9, 5 | 0.223 Ratio of eosinophils in blood |
| GSK3511294 10mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 2, n=12, 6, 5, 9, 9, 6 | 0.225 Ratio of eosinophils in blood |
| GSK3511294 10mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 4,n=12, 6, 5, 9, 9, 6 | 0.195 Ratio of eosinophils in blood |
| GSK3511294 10mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 8, n=12, 6, 6, 9, 9, 6 | 0.129 Ratio of eosinophils in blood |
| GSK3511294 10mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 12, n=12, 5, 6, 9, 9, 5 | 0.171 Ratio of eosinophils in blood |
| GSK3511294 10mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 18, n=12, 6, 6, 9, 9, 6 | 0.314 Ratio of eosinophils in blood |
| GSK3511294 10mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 24, n=11, 6, 6, 9, 9, 6 | 0.563 Ratio of eosinophils in blood |
| GSK3511294 10mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 26, n=12, 6, 6, 9, 9, 6 | 0.663 Ratio of eosinophils in blood |
| GSK3511294 10mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 32, n=6, 6, 6, 0, 0, 6 | 0.837 Ratio of eosinophils in blood |
| GSK3511294 30mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 5, n=11, 6, 6, 9, 9, 6 | 0.219 Ratio of eosinophils in blood |
| GSK3511294 30mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 2, n=12, 6, 6, 8, 9, 6 | 0.434 Ratio of eosinophils in blood |
| GSK3511294 30mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 36, n=6, 0, 0, 9, 9, 0 | 0.858 Ratio of eosinophils in blood |
| GSK3511294 30mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 18, n=12, 6, 6, 9, 9, 6 | 0.152 Ratio of eosinophils in blood |
| GSK3511294 30mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 2, n=12, 6, 5, 9, 9, 6 | 0.170 Ratio of eosinophils in blood |
| GSK3511294 30mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 24, n=11, 6, 6, 9, 9, 6 | 0.285 Ratio of eosinophils in blood |
| GSK3511294 30mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 3, n=12, 6, 6, 9, 9, 6 | 0.281 Ratio of eosinophils in blood |
| GSK3511294 30mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 4, n=12, 6, 6, 8, 8, 6 | 0.215 Ratio of eosinophils in blood |
| GSK3511294 30mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 4,n=12, 6, 5, 9, 9, 6 | 0.131 Ratio of eosinophils in blood |
| GSK3511294 30mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 8, n=12, 6, 6, 9, 9, 6 | 0.102 Ratio of eosinophils in blood |
| GSK3511294 30mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 12, n=12, 5, 6, 9, 9, 5 | 0.123 Ratio of eosinophils in blood |
| GSK3511294 30mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 1, n=12, 6, 6, 9, 9, 5 | 0.226 Ratio of eosinophils in blood |
| GSK3511294 30mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 26, n=12, 6, 6, 9, 9, 6 | 0.317 Ratio of eosinophils in blood |
| GSK3511294 100mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 4,n=12, 6, 5, 9, 9, 6 | 0.185 Ratio of eosinophils in blood |
| GSK3511294 100mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 1, n=12, 6, 6, 9, 9, 5 | 0.237 Ratio of eosinophils in blood |
| GSK3511294 100mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 8, n=12, 6, 6, 9, 9, 6 | 0.126 Ratio of eosinophils in blood |
| GSK3511294 100mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 5, n=11, 6, 6, 9, 9, 6 | 0.280 Ratio of eosinophils in blood |
| GSK3511294 100mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 2, n=12, 6, 6, 8, 9, 6 | 0.496 Ratio of eosinophils in blood |
| GSK3511294 100mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 12, n=12, 5, 6, 9, 9, 5 | 0.161 Ratio of eosinophils in blood |
| GSK3511294 100mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 18, n=12, 6, 6, 9, 9, 6 | 0.139 Ratio of eosinophils in blood |
| GSK3511294 100mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 4, n=12, 6, 6, 8, 8, 6 | 0.250 Ratio of eosinophils in blood |
| GSK3511294 100mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 36, n=6, 0, 0, 9, 9, 0 | 0.374 Ratio of eosinophils in blood |
| GSK3511294 100mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 24, n=11, 6, 6, 9, 9, 6 | 0.149 Ratio of eosinophils in blood |
| GSK3511294 100mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 3, n=12, 6, 6, 9, 9, 6 | 0.262 Ratio of eosinophils in blood |
| GSK3511294 100mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 26, n=12, 6, 6, 9, 9, 6 | 0.199 Ratio of eosinophils in blood |
| GSK3511294 100mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 2, n=12, 6, 5, 9, 9, 6 | 0.214 Ratio of eosinophils in blood |
| GSK3511294 300mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 40, n=2, 0, 0, 0, 0, 6 | 0.258 Ratio of eosinophils in blood |
| GSK3511294 300mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 4, n=12, 6, 6, 8, 8, 6 | 0.360 Ratio of eosinophils in blood |
| GSK3511294 300mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 12, n=12, 5, 6, 9, 9, 5 | 0.164 Ratio of eosinophils in blood |
| GSK3511294 300mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 32, n=6, 6, 6, 0, 0, 6 | 0.210 Ratio of eosinophils in blood |
| GSK3511294 300mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 26, n=12, 6, 6, 9, 9, 6 | 0.186 Ratio of eosinophils in blood |
| GSK3511294 300mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 5, n=11, 6, 6, 9, 9, 6 | 0.299 Ratio of eosinophils in blood |
| GSK3511294 300mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 2, n=12, 6, 6, 8, 9, 6 | 0.466 Ratio of eosinophils in blood |
| GSK3511294 300mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 4,n=12, 6, 5, 9, 9, 6 | 0.180 Ratio of eosinophils in blood |
| GSK3511294 300mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 2, n=12, 6, 5, 9, 9, 6 | 0.265 Ratio of eosinophils in blood |
| GSK3511294 300mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 8, n=12, 6, 6, 9, 9, 6 | 0.178 Ratio of eosinophils in blood |
| GSK3511294 300mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 18, n=12, 6, 6, 9, 9, 6 | 0.179 Ratio of eosinophils in blood |
| GSK3511294 300mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 1, n=12, 6, 6, 9, 9, 5 | 0.250 Ratio of eosinophils in blood |
| GSK3511294 300mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Week 24, n=11, 6, 6, 9, 9, 6 | 0.202 Ratio of eosinophils in blood |
| GSK3511294 300mg | Ratio to Baseline in Absolute Blood Eosinophil Count | Day 3, n=12, 6, 6, 9, 9, 6 | 0.403 Ratio of eosinophils in blood |
Secondary
T1/2 of GSK3511294 300 mg
Blood samples were collected from participants at indicated time points and analyzed for t1/2. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | T1/2 of GSK3511294 300 mg | 40.422 Days | Geometric Coefficient of Variation 6.3 |
Secondary
T1/2 of GSK3511294 30 mg and 100 mg
Blood samples were collected from participants at indicated time points and analyzed for t1/2. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | T1/2 of GSK3511294 30 mg and 100 mg | 37.599 Days | Geometric Coefficient of Variation 10.7 |
| GSK3511294 2mg | T1/2 of GSK3511294 30 mg and 100 mg | 38.913 Days | Geometric Coefficient of Variation 11.7 |
Secondary
Terminal Phase Elimination Rate Constant (Lambda_z) of GSK3511294 2 mg and 10 mg
Blood samples were collected from participants at indicated time points and analyzed for lambda\_z. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Terminal Phase Elimination Rate Constant (Lambda_z) of GSK3511294 2 mg and 10 mg | 0.013195 Day^-1 | Geometric Coefficient of Variation 37.3 |
| GSK3511294 2mg | Terminal Phase Elimination Rate Constant (Lambda_z) of GSK3511294 2 mg and 10 mg | 0.015787 Day^-1 | Geometric Coefficient of Variation 16.2 |
Secondary
Terminal Phase Half-life (t1/2) of GSK3511294 2 mg and 10 mg
Blood samples were collected from participants at indicated time points and analyzed for t1/2. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Terminal Phase Half-life (t1/2) of GSK3511294 2 mg and 10 mg | 52.531 Days | Geometric Coefficient of Variation 37.3 |
| GSK3511294 2mg | Terminal Phase Half-life (t1/2) of GSK3511294 2 mg and 10 mg | 43.907 Days | Geometric Coefficient of Variation 16.2 |
Secondary
Time of Last Quantifiable Concentration (Tlast) of GSK3511294 2 mg and 10 mg
Blood samples were collected from participants at indicated time points and analyzed for Tlast. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| Placebo | Time of Last Quantifiable Concentration (Tlast) of GSK3511294 2 mg and 10 mg | 84.47 Days |
| GSK3511294 2mg | Time of Last Quantifiable Concentration (Tlast) of GSK3511294 2 mg and 10 mg | 176.46 Days |
Secondary
Time of Occurrence of Cmax (Tmax) of GSK3511294 2 mg and 10 mg
Blood samples were collected from participants at indicated time points and analyzed for Tmax. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, and 26 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| Placebo | Time of Occurrence of Cmax (Tmax) of GSK3511294 2 mg and 10 mg | 10.966 Days |
| GSK3511294 2mg | Time of Occurrence of Cmax (Tmax) of GSK3511294 2 mg and 10 mg | 7.956 Days |
Secondary
Titers of Binding ADA to GSK3511294
Serum samples were collected to determine the presence of anti-GSK3511294 binding antibodies using a validated bioanalytical method. Data for any time post-Baseline is reported. Titer was only measured when a positive result was found.
Time frame: Up to Week 40
Population: Safety Population. Only participants with positive results for ADA were analyzed.
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| GSK3511294 10mg | Titers of Binding ADA to GSK3511294 | 80.0 Titer |
| GSK3511294 30mg | Titers of Binding ADA to GSK3511294 | 160.0 Titer |
| GSK3511294 100mg | Titers of Binding ADA to GSK3511294 | 80.0 Titer |
| GSK3511294 300mg | Titers of Binding ADA to GSK3511294 | 80.0 Titer |
Secondary
Tlast of GSK3511294 300 mg
Blood samples were collected from participants at indicated time points and analyzed for Tlast. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| Placebo | Tlast of GSK3511294 300 mg | 279.99 Days |
Secondary
Tlast of GSK3511294 30 mg and 100 mg
Blood samples were collected from participants at indicated time points and analyzed for Tlast. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose
Population: Pharmacokinetic Population.
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| Placebo | Tlast of GSK3511294 30 mg and 100 mg | 182.01 Days |
| GSK3511294 2mg | Tlast of GSK3511294 30 mg and 100 mg | 252.00 Days |
Secondary
Tmax of GSK3511294 300 mg
Blood samples were collected from participants at indicated time points and analyzed for Tmax. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| Placebo | Tmax of GSK3511294 300 mg | 13.909 Days |
Secondary
Tmax of GSK3511294 30 mg and 100 mg
Blood samples were collected from participants at indicated time points and analyzed for Tmax. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| Placebo | Tmax of GSK3511294 30 mg and 100 mg | 13.943 Days |
| GSK3511294 2mg | Tmax of GSK3511294 30 mg and 100 mg | 13.970 Days |
Secondary
Vd/F of GSK3511294 300 mg
Blood samples were collected from participants at indicated time points and analyzed for Vd/F. Vd/F was calculated as dose divided by \[lambda\_z \*AUC(0-inf)\]. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26, 32 and 40 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Vd/F of GSK3511294 300 mg | 9.337 Liters | Geometric Coefficient of Variation 30.6 |
Secondary
Vd/F of GSK3511294 30 mg and 100 mg
Blood samples were collected from participants at indicated time points and analyzed for Vd/F. Vd/F was calculated as dose divided by \[lambda\_z \*AUC(0-inf)\]. Pharmacokinetic parameters was calculated by standard non compartmental analysis.
Time frame: Pre-dose, 2 and 8 hours on Day 1; Days 2,3,5, Weeks 1, 2, 4, 8, 12, 18, 24, 26 and 36 post-dose
Population: Pharmacokinetic Population
| Arm | Measure | Value (GEOMETRIC_MEAN) | Dispersion |
|---|---|---|---|
| Placebo | Vd/F of GSK3511294 30 mg and 100 mg | 7.812 Liters | Geometric Coefficient of Variation 40.4 |
| GSK3511294 2mg | Vd/F of GSK3511294 30 mg and 100 mg | 6.630 Liters | Geometric Coefficient of Variation 12.1 |