Use of Peppermint Oil During Screening Colonoscopy to Improve Visibility

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03286764

Enrollment

Registered

2017-09-18

Start date

2016-11-30

Completion date

2019-09-10

Last updated

2020-04-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Enhancement of the ADR During Colonoscopy

Brief summary

The investigators hypothesize that spraying peppermint oil containing L-menthol onto the colonic mucosa during colonoscopy will relax smooth muscle allowing better colonic visualization.

Interventions

OTHERPeppermint Oil

OTHERDistilled water

Distilled water spray as a placebo during Colonoscopy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

50 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Screening colonoscopy * Age 50 years and older * Able to give consent

Exclusion criteria

* No consent obtained or adult lacking capacity to consent * Do not reach cecum on colonoscopy * Renal impairment (defined as CrCl \<30 ml/min) * Allergy to study peppermint oil solution * History of colon resection * Inflammatory bowel disease * Known colorectal neoplasia * Non-correctable coagulopathy * Pregnancy or lactating * Prisoners

Design outcomes

Primary

Measure	Time frame
Determination of Adenoma Detection Rate during Colonoscopy Procedure	2 hours

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026