Autism Spectrum Disorder
Conditions
Keywords
eye tracking, visual preference
Brief summary
The main aim of the present study is to examine eye-tracking based markers for social processing deficits in children with autism spectrum disorder (ASD). To this end a battery of five eye-tracking paradigms will be administered to young children with ASD and typically developing children. To additionally evaluate the specificity of the eye-tracking markers a group of children with disorders of delayed development other than ASD will be included.
Detailed description
During an initial screening session all participants will undergo the Autism Diagnostic Observation Schedule (ADOS). ASD-related symptomatology and levels of impairments will be further characterized using the Social Responsibilities Scale 2 (SRS 2), Caregiver Strain Questionnaire (CSQ), Aberrant Behavior Checklist (ABC), Social Communication Questionnaire (SCQ), and Repetitive Behaviour Scale Revised (RBS-R). Subsequently all participants will be administered the following eye-tracking paradigms: (1) dynamic social and non-social visual preference paradigm during which dynamic geometric images (DGI) and dynamic social images (DSI) will be presented, (2) non-biological versus biological motion paradigm, (3) social attention and sharing of enjoyment paradigm, (4) preference for real versus schematic emotional face stimuli paradigm during which photographs of human faces and emoticons will be presented, (5) shared social attention and gaze direction paradigm.
Interventions
OTHERAdministration of five eye-tracking paradigms
All subjects will undergo the battery of five eye-tracking paradigms to determine potential markers for autism.
Sponsors
University of Electronic Science and Technology of China
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
12 Months to 10 Years
Healthy volunteers
Yes
Exclusion criteria
for all participants: * visual, auditory or motor impairments * use of medication Inclusion criteria for all participants: * written informed consent from parents / caregiver * age: 1-10 years Additional inclusion criterion for the ASD group: \- diagnosis of Autism Spectrum Disorder according to DSM-5 Additional inclusion criteria for typically developing children in the control group: * no symptoms of developmental disorders * no current or history of psychological disorder Additional inclusion criterion for the unspecific disorder of delayed development children in the additional control group: \- disorder of delayed development other than ASD
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Global eye-gaze characteristics | Single assessment, total duration 20 minutes | Global eye-gaze patterns between the three groups will be compared to determine ASD specific alterations |
| Feature-specific eye-gaze characteristics | Single assessment, total duration 20 minutes | Localized feature-specific eye-gaze patterns will be compared between the three groups to determine ASD specific alterations |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Global eye-gaze characteristics and associations with symptom severity | Single assessment, total duration 20 minutes | Associations between global eye-gaze characteristics and severity of ASD symptoms |
| Feature-specific eye-gaze characteristics and associations with symptom severity | Single assessment, total duration 20 minutes | Associations between localized feature-specific eye-gaze patterns and severity of ASD symptoms |
Countries
China
Outcome results
None listed