Diet, Polyphenols, Flavonoids, Stilbenes, Aged, Dementia, Alzheimer's Disease, Epidemiology
Conditions
Brief summary
This project aims to leverage existing data from a large observational prospective study on dementia, the Three-City study, to investigate the relationship between intakes of polyphenols and the risk to develop dementia in the 12 years following dietary assessment.
Detailed description
The study sample includes 1,329 subjects followed for up to 12 years fro dementia after dietary assessment. The aim is to identify a pattern of polyphenol intake (based on 26 flavonoid and non-flavonoid polyphenol subclasses ascertained using a 24-hour dietary recall) associated with the risk of dementia and AD over 12 years in the 3C Bordeaux cohort.
Interventions
Statistical association between adherence to a pattern of polyphenol intake and the risk to develop dementia and Alzheimer's disease over 12 years
Sponsors
Jean-François Dartigues
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 65 years or more, live in Bordeaux area (France)
Exclusion criteria
* with dementia at the time of dietary assessment in year 2001-2002
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| incidence of dementia | 12 years | incident cases of dementia diagnosed by the expert committee of neurologists at follow-up visits |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| incidence of Alzheimer's disease | 12 years | dementia with probable or possible Alzheimer etiology |
Outcome results
None listed