Chronic Kidney Disease Mineral and Bone Disorder
Conditions
Keywords
CKD, Dialysis, calcium, mineral and bone disorder (MBD), calcification, DXA, peripheral quantitative CT scan (pqCT)
Brief summary
This is a novel, non-invasive method of assessing Ca balance by natural Ca isotope fractionation.
Detailed description
Detailed description and study protocol will be available to individuals on request.
Interventions
DIAGNOSTIC_TESTCollection of blood, urine and stool samples
Collection of blood, urine and stool samples, diet diary and bone scans
Sponsors
University of Kiel
Athens General Children's Hospital Pan. & Aglaia Kyriakou
Cukurova University
Great Ormond Street Hospital for Children NHS Foundation Trust
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
Yes
Inclusion criteria
I - For healthy children Inclusion criteria * All children \<18 years * Normal renal function (eGFR 90-120ml/min/1.73m2 \[calculated by Schwartz formula\] in children \>1 year and serum creatinine \<35μMol/L in children \<1 year) * Weight, height and BMI within 2 SD of normal using WHO growth charts In order to make this study as 'real-life' as possible, free-living UK children on their usual diet and dietary supplementation (including Ca and Vit D), if any, will be included, but analysis will account for medication doses and blood levels.
Exclusion criteria
* Pre-existing bone disease - inherited or acquired * Fractures in the preceding 6 months * Glucocorticoid therapy in the preceding year, or a lifetime cumulative steroid exposure ≥6 months * Bisphosphonate therapy at any time in the past * Any acute illness in the preceding 2 weeks (when the child is unable to maintain their usual diet or has bed rest) II - For CKD and dialysis children Inclusion criteria * Children of all ages with an eGFR \<60ml/min/1.73m2, including those on dialysis.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Calcium isotope fractionation in blood, urine and stool in healthy children and those with CKD | 24 months | available on request |
| number of children with fractures, and clinical and biochemical correlates of fractures | 12 months | available on request |
| Bone scans - whole body & lumbar spine DEXA, bone mineral density on tibial peripheral quantitative CT scan | 24 months | available on request |
Countries
United Kingdom
Outcome results
None listed