Type 2 Diabetes
Conditions
Keywords
GPR120, Adipose tissue, Type 2 diabetes
Brief summary
G-protein coupled receptor 120 (GPR120) is a G-protein-coupled receptor whose endogenous ligands have been identified as long-chain fatty acids. Recently, it has been shown that GPR120 expression in human adipose tissue is higher in obese than in lean individuals. Interestingly, a GPR120 deficient mouse model presents an unfavorable phenotype when fed a high-fat diet with obesity, glucose intolerance and fatty liver, characteristics also found in type 2 diabetes (T2D). Moreover, in obese subjects, a single nucleotide polymorphism (R270H) has been identified that inhibits GPR120 signaling activity. The investigators now want to investigate if GPR120 expression in adipose tissue may be altered in patients with T2D compared to non-diabetic subjects and might contribute to diabetes-associated metabolic changes. Additionally, the investigators want to assess the frequency of the R270H mutant in T2D.
Interventions
None listed
Sponsors
German Diabetes Center
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
20 Years to 69 Years
Healthy volunteers
Yes
Inclusion criteria
* Type 2 diabetes mellitus / normoglycemia * BMI \< 27,5 or \> 30 kg/m2 * Age 20 - 69 years
Exclusion criteria
* severe chronic diseases * anemia * medication altering fatty acid metabolism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| GPR120 expression in adipose tissue | Expression measured at baseline (day 1) | GPR expression is measured in adipose tissue of recently diagnosed type 2 diabetic patients and age- and BMI-matched normoglycemic controls |
Countries
Germany
Outcome results
None listed