Does Placenta Pathology Predict Outcome of Neonates With Hypoxic Ischemic Encephalopathy?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT03284528

Enrollment

100

Registered

2017-09-15

Start date

2011-01-01

Completion date

2017-01-01

Last updated

2017-09-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Asphyxia Neonatorum

Brief summary

The histology of the placenta of newborn infants with perinatal asphyxia and hypoxic-ischaemic encephalopathy is analysed. There will be an evaluation if placenta could be a biomarker for neurodevelopmental outcome at 18-24 months of age.

Interventions

OTHERhypothermia therapy

newborn infants with hypoxic-ischaemic encephalopathy are cooled for 72 hours with a target temperature of 33-34°C (whole body cooling).

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Days to 4 Days

Healthy volunteers

Inclusion criteria

all newborn infants with APGAR \<5 at 10minutes, pH\<7.0, lactate \>12mmol/L, base excess \>16, resuscitation \>10min after birth, gestational age \>35 weeks and an encephalopathy -

Exclusion criteria

Design outcomes

Primary

Measure	Time frame	Description
neurodevelopmental outcome at 18-24 month of Age	7 years	The investigators will analyse if there is a correlation of placenta histology and neurodevelopmental outcome

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026