Systemic Inflammatory Response Syndrome
Conditions
Keywords
breast cancer, menstrual cycle, breast surgery, systemic responses to trauma
Brief summary
It is aimed to evaluate pathophysiology of systemic responses to trauma via using interleukin (IL) -1 and IL-6 levels and determining timing of surgery through phases of menstrual cycle.
Detailed description
89 female breast cancer patient who underwent modified radical mastectomy included into study. Menstrual history and hormone levels were used to determine menstrual phase: luteal, follicular, and other. IL-1β and IL-6 levels, which are related to severeness of inflammation, were measured one day before and one day after surgery. Those are statistically analysed to show effect of timing of breast surgery on responses to trauma in postmenopausal and premenopausal women during different phases of their menstrual cycles
Interventions
PROCEDUREmodified radical mastectomy
systemic responses to trauma are compared with evaluating inflammatory cytokine levels between premenopausal and postmenopausal patient groups with different estrogen levels who underwent modified radical mastectomy.
Sponsors
Kocaeli University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
HEALTH_SERVICES_RESEARCH
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
Yes
Inclusion criteria
* female patients * who underwent modified radical mastectomy for breast cancer * who signed informed consent forms
Exclusion criteria
* For premenopausal patients taking oral contraceptives * for postmenopausal patients taking hormone replacement therapy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| IL-1 and IL-6 levels | 5 month | evaluate pathophysiology of systemic responses to trauma via using IL-1 and IL-6 levels. |
Outcome results
None listed