Acute Pancreatitis, Organ Failure, Multiple
Conditions
Brief summary
In this study, the investgatiors aimed to investigate the associations between serum levels of stearoyl-CoA desaturase-1（SCD-1） and the disease severity as well as the presence of adverse clinical events, such as local complications, organ failure, mortality and so on.In this prospective study, participants were divided into two groups based on serum SCD-1 concentration on admission and prospectively observe the disease severity and clinical outcomes of them.
Interventions
None listed
Sponsors
Nanjing University School of Medicine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
1. Diagnosis of acute pancreatitis (Atlanta standard), abdominal pain occurred within one week of admission; 2. APACHEII score is more than 8 and Ranson score is greater than 3; 3. Age 18-75; 4. Obtaining informed consent.
Exclusion criteria
1. Pregnancy pancreatitis; 2. Patients with the following disease history: severe cardiac, pulmonary, renal, liver function insufficiency or immunodeficiency disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the incidence rate of infected pancreatic necrosis | 2-4 week after disease onset |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the incidence rate of organ failure | 1-2 week after disease onset | the incidence rate of organ failure (transient or persistent) |
| the incidence rate of local complications | 1-2 week after disease onset | acute peripancreatic fluid collections, pancreatic pseudocycts, acute necrotic collections and walled-off necrosis |
Outcome results
None listed