Preconditioning of One-lung Ventilation

Preconditioning of One-lung Ventilation for Lung Protection

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT03282032

Enrollment

136

Registered

2017-09-13

Start date

2017-11-22

Completion date

2018-10-13

Last updated

2018-11-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

One Lung Ventilation

Brief summary

To observe the effect of one-lung ventilation (OLV) preconditioning on perioperative oxygenation during thoracic surgery.

Detailed description

For lung isolation and better surgical view, one-lung ventilation(OLV) is essential for thoracic surgery. However, OLV may cause serious pulmonary complications due to intraoperative hypoxia. Animal studies showed a positive effect of OLV preconditioning (Intermittent OLV before surgical intervention) on perioperative pulmonary oxygenation. Thus, we designed a study to observe the effect of OLV preconditioning on perioperative oxygenation during thoracic surgery

Interventions

OTHEROne-lung ventilation

The patient undergoing thoracic surgery is intubated with double lumen tube after induction of general anesthesia with propofol and remifentanil. In the intervention group, 5 cycles of one-lung ventilation preconditioning (2-min of one-lung ventilation and 2-min of two-lung ventilation for 1 cycle) is performed before surgical incision. One-lung ventilation is done at dependent lung with FiO2 100% and tidal volume 6 ml kg-1. Two-lung ventilation is done with FiO2 50%, tidal volume 8 ml kg-1.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Caregiver, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Elective thoracic surgery which requires one-lung ventilation with lateral decubitus position

Exclusion criteria

* Patients with severe cardiopulmonary disease, COPD, previous surgical history of pulmonary disease * Thoracic surgery for pneumonectomy

Design outcomes

Primary

Measure	Time frame	Description
Incidence of hypoxemia	during one-lung ventilation, up to 5 hours	SpO2 \< 95%
P/F ratio	30min after surgical incision	PaO2/FIO2 ratio

Secondary

Measure	Time frame	Description
Pulmonary complications	6, 24, 48 hours after surgery, during hospital stay.	Acute lung injury, acute respiratory distress syndrome, atelectasis, pneumonia

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026